by Ashutosh Jogalekar
There has long been a temptation in science to imagine one system that can explain everything. For a while, that dream belonged to physics, whose practitioners, armed with a handful of equations, could describe the orbits of planets and the spin of electrons. In recent years, the torch has been seized by artificial intelligence. With enough data, we are told, the machine will learn the world. If this sounds like a passing of the crown, it has also become, in a curious way, a rivalry. Like the cinematic conflict between vampires and werewolves in the Underworld franchise, AI and physics have been cast as two immortal powers fighting for dominion over knowledge. AI enthusiasts claim that the laws of nature will simply fall out of sufficiently large data sets. Physicists counter that data without principle is merely glorified curve-fitting.
A recent experiment brought this tension into sharp relief. Researchers trained an AI model on the motions of the planets and found that it could predict their positions with exquisite precision. Yet when they looked inside the model, it had discovered no sign of Newton’s law of gravitation — no trace of the famous inverse-square relation that binds the solar system together. The machine had mastered the music of the spheres but not the score. It had memorized the universe, not understood it.
This distinction between reproducing a pattern and understanding its cause may sound philosophical, but it has real consequences. Nowhere is that clearer than in the difficult art of discovering new drugs.
Every effective drug is, at heart, a tiny piece of molecular architecture. Most are small organic molecules that perform their work by binding to a protein in the body, often one that is overactive or misshapen in disease. The drug’s role is to fit into a cavity in that protein, like a key slipping into a lock, and alter its function.
Finding such a key, however, is far from easy. A drug must not only fit snugly in its target but must also reach it, survive long enough to act, and leave the body without causing harm. These competing demands make drug discovery one of the most intricate intellectual endeavors humans have attempted. For centuries, we relied on accident and observation. Willow bark yielded aspirin; cinchona bark gave us quinine. Then, as chemistry, molecular biology, and computing matured in the latter half of the twentieth century, the process became more deliberate. Once we could see the structure of a protein – thanks to x-ray crystallography – we could begin to design molecules that might bind to it. Read more »

The smallest spider I’ve ever seen is slowly descending from the little metal lampshade above my computer. She’s so tiny, a millimeter wide at most, I have to look twice to make sure she isn’t just a speck of dust. The only reason I can be certain that she’s not is that she’s dropping straight down instead of floating at random.
Naotaka Hiro. Untitled (Tide), 2024.
In a previous essay, 
Isn’t it time we talk about you?


To be alive is to maintain a coherent structure in a variable environment. Entropy favors the dispersal of energy, like heat diffusing into the surroundings. Cells, like fridges, resist this drift only by expending energy. At the base of the food chain, energy is harvested from the sun; at the next layer, it is consumed and transferred, and so begins the game of predation. Yet predation need not always be aggressive or zero-sum. Mutualistic interactions abound. Species collaborate when it conserves energy. For example, whistling-thorn trees in Kenya trade food and shelter to ants for protection. Ants patrol the tree, fending off herbivores from insects to elephants. When an organism cannot provide a resource or service without risking its own survival, opportunities for cooperative exchange are limited. Beyond the cooperative, predation emerges in its more familiar, competitive form. At every level, the imperative is the same: accumulate enough energy to maintain and reproduce. How this energy is obtained, conserved, or defended produces the rich diversity of strategies observed in nature.



We humans think we’re so smart. But a
Giant Tarantulas 

by Steve Szilagyi
Jaffer Kolb. Lake Mývatn, October 13th, 12:08 am.
