The Genetic Book of the Dead – the great biologist’s swansong

Adam Rutherford in The Guardian:

All things must pass, but some leave legacies. That is the story of life on Earth. Fossilised remains of organisms represent just one of the various treasure troves of information about how life used to be, one set of clues to why it is the way it is today. In the early 20th century, genes entered the storehouse of evidence for evolution, first as theoretical particles, later as the unit of selection, and today with molecular precision. Some 165 years after Darwin’s Origin of Species, evolution by natural selection is incontrovertible, the proof of it irrefutable and bounteous.

Richard Dawkins has done the lord’s work in sharing this radical idea for more than a third of that time, partly through research, but with wider impact in his general writing. This book, one of nearly a dozen he has written about evolution, looks set to be his last (he has called a tour to support it The Final Bow).

More here.

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Rohini Subrahmanyam in The Scientist:

Aging is inevitable for most cell types in the human body, but hematopoietic stem cells (HSCs) seem to defy the process. They retain their self-renewing ability almost throughout an organism’s lifetime and exhibit a delayed onset of typical hallmarks of aging like DNA damage or protein aggregation. “Stem cells are really remarkable in their longevity,” said Andre Catic, a researcher working on aging at the Baylor College of Medicine.

Previously, scientists found that one reason contributing to HSC longevity was that they could exist in a functionally inactive state for prolonged periods.1 Now, Catic and his team found another clue as to how these cells maintain their youth. In a study published recently in Nature Cell Biology, they reported that HSCs contain high levels of a protein cyclophilin A which prevents these cells from rapid aging.2 Understanding mechanisms of how HSCs  avoid the wear and tear of senescence has wide-ranging implications, from figuring out cells’ fundamental anti-aging secrets to determining how these mechanisms breaking down could lead to leukemia.

More here.

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The AI Art Turing Test

One of these two pretty hillsides is by one of history’s greatest artists. The other is soulless AI slop. Can you tell which is which?

Scott Alexander at Astral Codex Ten:

Last month, I challenged 11,000 people to classify fifty pictures as either human art or AI-generated images.

I originally planned five human and five AI pictures in each of four styles: Renaissance, 19th Century, Abstract/Modern, and Digital, for a total of forty. After receiving many exceptionally good submissions from local AI artists, I fudged a little and made it fifty. The final set included paintings by Domenichino, Gauguin, Basquiat, and others, plus a host of digital artists and AI hobbyists.

1: Most People Had A Hard Time Identifying AI Art

Since there were two choices (human or AI), blind chance would produce a score of 50%, and perfect skill a score of 100%.

The median score on the test was 60%, only a little above chance. The mean was 60.6%. Participants said the task was harder than expected (median difficulty 4 on a 1-5 scale).

How meaningful is this? I tried to make the test as fair as possible by including only the best works from each category; on the human side, that meant taking prestigious works that had survived the test of time; on the AI side, it meant tossing the many submissions that had garbled text, misshapen hands, or some similar deformity. But this makes it unrepresentative of a world where many AI images will have these errors.

More here.

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The quest for fusion energy

Raymond Zhong in the New York Times:

Big-name investors including Bill Gates, Jeff Bezos, Vinod Khosla and Sam Altman have staked hundreds of millions of dollars on this, fusion’s potential Kitty Hawk moment: the one that shows that the limits of our species’ mastery have once again been catapulted forward.

Today’s fusion start-ups aren’t just preparing for this moment in the lab. They are signing presale deals with customers, developing supply chains, cultivating a work force, talking with regulators — all the elements that will be needed to make fusion an affordable, practical power source, not just a science experiment.

And yet, closer than ever does not necessarily mean close. Fusion’s history is a graveyard of missed deadlines and thwarted milestones, bursts of excitement followed by bruising disappointments.

The sunny view is that the start-ups are moving more quickly than government labs ever could. They can try, fail and try again.

More here.

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Review of “V13” by Emmanuel Carrère – harrowing account of the Paris attacks trial

Chris Power in The Guardian:

In the early evening of 12 November 2015, three cars left Charleroi in Belgium, arriving a few hours later at a rented house in the northern suburbs of Paris. The occupants of the cars – or “the death convoy”, as they called it – were Islamic State terrorists who, the following night, rampaged through the French capital. Three attacked the Stade de France, where a football friendly between France and Germany was being played. Arriving late, they were denied entry to the stadium and blew themselves up outside.

At the same time, another group opened fire on cafes and bars in the city centre. Two members fled, while another walked into a restaurant and detonated his suicide vest. Meanwhile, the remaining trio entered the Bataclan theatre, where a crowd of 1,500 were attending a gig by the US rock band Eagles of Death Metal. The attack and subsequent siege lasted two and a half hours and ended with all three terrorists dead. Across the city, 130 people had been murdered and hundreds more injured.

Five years later, in the autumn of 2020, on the eve of publishing his new book, Yoga, and reeling from a difficult few years – mental illness, divorce, legal battles – Emmanuel Carrère was hunting for a subject.

More here.

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Wednesday Poem

Dawn

Clouds rise from their nests
with flapping wings, they whisper
of worn leather, bracken, long
horizons, and the manes of dark
horses. In the waking stream
the stones lie like chestnuts
in a glass bowl. I pass the bones
of an old harrow thrown on its side
in the ditch.

Now the sun appears.
It is a fish wrapped in straw.
Its scales fall on the sleeping
town with its eyeless granaries
and necklace of boxcars. Soon
the blue wind will flatten the roads
with a metallic palm, the glitter
of granite will blind the eyes.

But not yet. The beetle still
stares from the riding moon, the ship
of death stands motionless on
frozen waves: I hear
the silence of early morning
rise from the rocks.

by George Hitchcock
from
Poetic Outlaws

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Should India Speak a Single Language?

Samanth Subramanian at the New Yorker:

Version 1.0.0

In some Indian languages, the word for “language” is bhasha—the vowels long and warm, as in “car” or “tar.” It has a formal weight and a refined spirit. It comes to us from the classical heights of Sanskrit, and it evokes a language with a script and a literature, with newspapers and codified grammar and chauvinists and textbooks. But there is another word, boli. It, too, refers to language, but its more accurate meaning is “that which is spoken.” In its sense of the oral, it hints at colloquialisms, hybridity, and a demotic that belongs to the streets. The insinuation is that a bhasha is grander and more sophisticated than a boli. The language of language infects how we think about language.

For more than forty years, the distance between these two words has preoccupied the literary scholar Ganesh Devy. He knows precisely when it all began. In 1979, as he was completing his Ph.D. in English literature at Shivaji University, in the Indian city of Kolhapur, he found in the library a commentary on India’s censuses. The 1961 census had identified sixteen hundred and fifty-two “mother tongues”—many of them, like Betuli or Khawathlang, with speakers numbering in the single digits.

more here.

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Tuesday, November 19, 2024

A revealing portrait of novelist Thomas Hardy as a womanizer

Charlotte Gordon in The Washington Post:

The Monty Python sketch of Thomas Hardy writing “The Return of the Native” takes place inside a packed soccer stadium with an announcer providing play-by-play analysis of the author’s glacial writing process. In hushed tones, the announcer says that Hardy has started to write, but wait, “oh no, it’s a doodle … a piece of meaningless scribble.” At last, Hardy writes “the,” but then crosses it out. In the time it takes to play an entire soccer match, he barely produces a sentence. In fact, Hardy was a speedy writer. He created “The Mayor of Casterbridge” so quickly that if he were outside, he “would scribble on large dead leaves or pieces of stone or slate that came to hand,” Paula Byrne writes in a new biography, “Hardy Women.”

Artists at work, whether Paul McCartney hashing out the chords to “Let It Be” or Jane Austen drafting “Pride and Prejudice,” are a fascinating bunch. And yet, much as I love Hardy’s novels, I’d never imagined how (or why) he composed anything. In fact, I scarcely thought of Hardy as a person; I focused entirely on his heroines — Tess, Eustacia Vye, Sue Bridehead — the ultimate compliment for a novelist. But now, thanks to Byrne’s magnificent book, I’ve learned that Hardy (1840-1928) was as strange and compelling as the women he wrote about.

More here.

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The Neural Circuity Driving Cancer-Related Wasting Disease

Sahana Sitaraman in The Scientist:

Cancer cachexia, or the wasting syndrome, is a catastrophic condition that causes dramatic and involuntary loss of muscle mass, fat and weight, alongside extreme fatigue, anorexia and anemia in patients with cancer.1 This severe stress reduces the body’s ability to respond to treatments, worsening prognosis and drastically accelerating death.

“More often than not, if you have two patients that have the exact same stage of disease, pathology of disease, but one of those cancers figured out how to promote wasting in the body, [that person] will live half as long as the other person,” said Puneeth Iyengar, a radiation oncologist at Memorial Sloan Kettering Cancer Center. Cachexia affects approximately 50 to 80 percent of patients with cancer and is the primary cause of death in 30 percent of patients. Yet, robust remedies for the condition are lacking. “We don’t know enough about [cancer cachexia] biology. It’s a very complex problem,” Iyengar said.

More here.

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Ayad Akhtar Wants Writers to Reckon with AI

Ronald K. Fried at The Millions:

McNeal, the new play by Ayad Akhtar, who won the Pulitzer Prize for Disgraced, focuses on an egocentric, self-destructive white male novelist, played by Robert Downey, Jr. The fictional Jacob McNeal—think Mailer or Roth at their worst—wins the Nobel Prize early in the play, but he’s guarding a secret: his latest novel was composed with an uncredited coauthor, an AI chatbot. The production, which considers the controversial notion that artificial intelligence might be a useful creative tool, closes on November 24 after a nearly sold-out run at Lincoln Center. Despite a largely negative critical reception, the show has touched a nerve, which in my view is one of the jobs of a serious writer.

I talked with Akhtar about his new play, the future of AI, and why he dislikes the advice to “show, don’t tell.”

Ronald K. Fried: When did you first think you could write something dramatic about A.I.?

Ayad Akhtar: February of ‘23. GPT had been live for about three months. And it was already clear to me that the future was going to be seriously impacted. And by April of ‘23, I saw a few things in Hollywood that shocked and astonished me. It was clear to me that the technology was far more powerful than we realized from a story point of view, and it was just a matter of time before this technology was going to start affecting the production of writing, creative writing.

More here.

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A new nuclear arms race is beginning and it will be far more dangerous than the last one

Jessica T Mathews in The Guardian:

Decades of agonisingly difficult negotiations built up a dense structure of treaties, agreements and even a few unilateral moves dealing with offensive and defensive nuclear weapons of short, medium and long range, with provisions for testing, inspections and an overflight regime for mutual observation. Often the two sides would only give up systems they no longer wanted. Frequently the language of the agreements was the basis of future friction. On the US side, the political price of securing Senate ratification of treaties could be extremely high.

But for all its shortcomings, arms control brought down the total number of nuclear weapons held by the two countries from 60,000 to roughly 11,000 today. (The exact number is classified.) Under the most recent treaty, New Start (strategic arms reduction treaty), signed in 2010, each side is limited to 1,550 deployed weapons, with the rest in storage. By any accounting, that 80% drop (95% counting just deployed weapons) is – or was – a notable achievement.

Unfortunately, the past tense is correct, because since the US withdrew from the anti-ballistic missile (ABM) treaty in 2002 – thereby legitimising the unilateral renunciation of an agreement by one party if it no longer finds the restrictions to its taste – the other agreements have fallen one by one.

More here.

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“Multiple Worlds Vying to Exist”: Philip K. Dick and Palestine

Jonathan Lethem at The Paris Review:

Dick’s use of the name New Israel in Martian Time-Slip is pretty stock. Dick traveled beyond North America only once, to a conference in Metz, France, where he delivered a legendary speech titled “If You Find This World Bad, You Should See Some of the Others”—baffling his French fans by opening an early window into the mystical, visionary search that would preoccupy him for the remainder of his life. Then he went home to Orange County, California. His impression of Israel may essentially be derived from Leon Uris’s Exodus, or from some other heroic fifties representation; he principally employs the Israelis in Martian Time-Slip as an anonymous and implacable counterpoint to the abject ineptitude of the U.S. colonists—to highlight the haplessness of their attempts to farm and irrigate the harsh Martian desertscape. As in the excerpt above, the Israelis present a mirror for shame. This matches, of course, a typical midcentury U.S. liberal’s reaction formation, after the discovery of the German and Polish death camps: the Jew as shame trigger, with the survivors idealized for their resilience and strength.

More here.

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How Kepler Invented Science Fiction and Defended His Mother in a Witchcraft Trial…

Maria Popova at The Marginalian:

The year is 1617. His name is Johannes Kepler (December 27, 1571–November 15, 1630) — perhaps the unluckiest man in the world, perhaps the greatest scientist who ever lived. He inhabits a world in which God is mightier than nature, the Devil realer and more omnipresent than gravity. All around him, people believe that the sun revolves around the Earth every twenty-four hours, set into perfect circular motion by an omnipotent creator; the few who dare support the tendentious idea that the Earth rotates around its axis while revolving around the sun believe that it moves along a perfectly circular orbit. Kepler would disprove both beliefs, coin the word orbit, and quarry the marble out of which classical physics would be sculpted. He would be the first astronomer to develop a scientific method of predicting eclipses and the first to link mathematical astronomy to material reality — the first astrophysicist — by demonstrating that physical forces move the heavenly bodies in calculable ellipses. All of this he would accomplish while drawing horoscopes, espousing the spontaneous creation of new animal species rising from bogs and oozing from tree bark, and believing the Earth itself to be an ensouled body that has digestion, that suffers illness, that inhales and exhales like a living organism.

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Exhuming Dracula’s Ancestors

Ed Simon at Lit Hub:

The vampire as it’s developed over the past century of popular culture, from Dracula onward, is different from the folkloric eastern European creature—a gloaming animal of the night, subaltern to humanity—though elements have obviously been preserved. Stoker’s titular count is arguably as super-human as he is monstrous. “I am Dracula; and I bid you welcome,” the Transylvanian count tells Jonathan Harker, the English solicitor organizing the sale of London real estate to the undead aristocrat. “Come in, the night air is chill, and you must need to eat and rest.” Where the skeletons in that Bulgarian basement were of people understood (fairly or not) by their neighbors as feral, rabid, and wild, Dracula is urbane and sophisticated, cosmopolitan and sexy.

Endlessly beguiling, evocative, intoxicating, and charismatic, Dracula is the rare monster whom somebody would actually want to imitate, actually want to be. Nobody desires to be Frankenstein’s monster, hobbled together from putrid, stinking cadaver sections, or a mummy wrapped in bandages, whereas Dracula remains a gothic touchstone for a reason.

more here.

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Monday, November 18, 2024

The nature of natural laws

Mario Hubert in Aeon:

The Sun rises every day. Water boils at 100°C. Apples fall to the ground. We live in a world in which objects behave the same given the same circumstances. We can imagine living in a different world: a world that constantly changes, a world in which the Sun does not rise every day, a world in which water one day boils at 50°C, and at 120°C another day, a world in which apples sometimes fall from trees and sometimes rise into the sky. Only because we live in a world that displays stable regularities are we able to reliably shape our environment and plan our lives.

We have an intuition that these regularities are due to laws of nature, but we normally do not interrogate what these laws are and how they work in any basic metaphysical sense. Instead, we assume that science not only provides these laws but also elucidates their structure and metaphysical status, even when the answers seem partial at best. In short, we assume that, thanks to science, there is a recipe of sorts for how the laws of nature work. You take the state of the Universe at a given moment – every single fact about every single aspect of it – and combine it with the laws of nature, then assume that these will reveal, or at least determine, the state of the Universe in the moment that comes next.

I refer to this as the layer-cake model of the Universe, which dates back to the 17th-century philosopher René Descartes.

More here.

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A.I. Chatbots Defeated Doctors at Diagnosing Illness

Gina Kolata in the New York Times:

Dr. Adam Rodman, an expert in internal medicine at Beth Israel Deaconess Medical Center in Boston, confidently expected that chatbots built to use artificial intelligence would help doctors diagnose illnesses.

He was wrong.

Instead, in a study Dr. Rodman helped design, doctors who were given ChatGPT-4 along with conventional resources did only slightly better than doctors who did not have access to the bot. And, to the researchers’ surprise, ChatGPT alone outperformed the doctors.

“I was shocked,” Dr. Rodman said.

The chatbot, from the company OpenAI, scored an average of 90 percent when diagnosing a medical condition from a case report and explaining its reasoning. Doctors randomly assigned to use the chatbot got an average score of 76 percent. Those randomly assigned not to use it had an average score of 74 percent.

More here.

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