Dr. Burhan Ferhanoglu is specialized in areas of lymphoma, Hematological Malignancies and multiple myeloma. He is a member of many national and international scientific societies, including the Turkish Hematology Association, American Society of Hematology, European Bone Marrow Transplantation Society and International Society of hematology. In 1998, he became the chief of the Hematology Department of V.K.V American Hospital in Istanbul. Currently, he serves as head of the Department of Internal Medicine at Koç Üniversitesi School of Medicine in Turkey, Istanbul.

Azra Raza, author of The First Cell: And the Human Costs of Pursuing Cancer to the Last, oncologist and professor of medicine at Columbia University, and 3QD editor, decided to speak to more than 20 leading cancer investigators and ask each of them the same five questions listed below. She videotaped the interviews and over the next months we will be posting them here one at a time each Monday. Please keep in mind that Azra and the rest of us at 3QD neither endorse nor oppose any of the answers given by the researchers as part of this project. Their views are their own. One can browse all previous interviews here.

1. We were treating acute myeloid leukemia (AML) with 7+3 (7 days of the drug cytosine arabinoside and 3 days of daunomycin) in 1977. We are still doing the same in 2019. What is the best way forward to change it by 2028?

2. There are 3.5 million papers on cancer, 135,000 in 2017 alone. There is a staggering disconnect between great scientific insights and translation to improved therapy. What are we doing wrong?

3. The fact that children respond to the same treatment better than adults seems to suggest that the cancer biology is different and also that the host is different. Since most cancers increase with age, even having good therapy may not matter as the host is decrepit. Solution?

4. You have great knowledge and experience in the field. If you were given limitless resources to plan a cure for cancer, what will you do?

5. Offering patients with advanced stage non-curable cancer, palliative but toxic treatments is a service or disservice in the current therapeutic landscape?

by Tamuira Reid

Mom, why are we always at the doctor? Every week we come here. Are you dying?

No, baby.

Why are we always here then?

If you grow-up in NYC with a single mom at the helm, then you grow-up in waiting rooms. And every kid knows what waiting rooms really are: babysitters. And they all pretty much look the same. Books with pages missing. Cartoons on a television jutting out of the wall. And if you’re lucky, an entire vat of dum-dums in every flavor known to man.

This is a special kind of doctor. A doctor that takes care of my brain.

Your brain is sick?

Yeah, a little. I guess you could say that.

Like my dad’s?

Not that sick.

I’ve become very good at self-editing. Hiding what needs to be hidden, saying what needs to be said. The fact that there is a rhino-sized pit in my stomach is my business. No one needs to peer into the bowels of my brokenness.

Ollie looks at me through his coke-rimmed glasses, so dirty I can barely see his big green eyes. He’s waiting for more information. I can feel him processing. Read more »

by Mindy Clegg

In issue 85 of The Big Takeover, regular contributor Tim Sommer declared in his editorial that we continue to get punk wrong. Rather than a singular historical event, split between NYC and London, he argued for two different events with a shared name happening in each place.¹ He advocates for something like a polygenist theory of punk, which he argues only stabilized in definition in the early 1990s with the popularity of Green Day and the like. There is much to like about his argument, most notably the acknowledgment that people often attempt to shoehorn a neat and tidy narrative onto the past in a way that does little justice to history. Without meaning to perhaps, he mostly points out the divergence between histories written by music critics (often, but not always, in service to the mainstream of the recording industry) and those written by historians seeking to better understand change over time.

The corporate-driven narratives some more mainstream critics produce represents the kind of bad history he’s rebelling against here, histories that assume and anticipate outcomes and progress. In these sorts of historical accounts, the end is already established and all roads lead to the Rock & Roll Hall of Fame. Sommer hovers around that, while not precisely coming out and saying it. After all, he very well knows the problems with the mainstream music industry dominating the narrative. I wish to springboard off Sommer’s insights to highlight a more nuanced view of the history of punk rock, one of the two most important musical movements in the last quarter of the twentieth century (the other being hip hop). Read more »

by Brooks Riley

by Samia Altaf

When we were young and living in Sialkot, we went frequently, almost once a week, to Lahore, the grand and hip city just a two-hour drive away. The trips were ostensibly for some real work—father, a district court lawyer, was appearing in a case being heard in the High Court or, his tuxedo in the trunk, was heading to a meeting of the Freemasons. Or it was for mother, who had critical shopping at Haji Karim Buksh, for crystal fruit bowls or the latest coffee cups, things not to be found in Sialkot, or was going to Hanif’s for a hair trim. Mother in the early 1960s sported a Jackie Kennedy cut that needed serious maintenance and only Hanif’s could manage that. For the children it might be to see doctors or dentists at Sir Ganga Ram Hospital—deflected septum (one of the boys was an avid boxer), enlarged tonsils, persistent skin rash, and such. And of course the routine checkups for father’s hypertension. Sialkot at the time did not have specialist doctors or reliable surgical facilities. (Interestingly enough it still does not, despite being a manufacturer and exporter of surgical goods.)

SGRH and Fatima Jinnah Medical College for Women were where mother’s sister worked as a young doctor, and where the best doctors were, as far as we were concerned. It was there that we sat on high stools in the college canteen and sipped Coca-Cola on the rocks. Rocks! At a time when ice cubes had barely made their way into our lives. Coca-Cola in tall glasses through paper straws—even the paper straw a novelty, what to say of the nose-tingling fizzy drink. Thrown in would be a visit to grandma for a rest and wash and maybe a sleepover. Grandma lived on Waris Road and in addition to encouraging comments on how one had grown—since last week!—we got to eat oodles of delicious food, homemade mango ice cream in summer and piping hot gajar halwa in winter, and to flirt with the curly-haired shy cousins on holiday from Karachi. Usually an evening trip to the zoo in Lawrence Gardens, named after John Lawrence, one of the viceroys, was a bonus. (Lawrence Gardens has now morphed into Bagh-e-Jinnah.)

But in reality all of these were just excuses to go to Lahore, that grand and glorious city full of throbbing and thrilling life, of sin and splendor, of glamorous women in sleeveless, waistless blouses worn with chiffon saris and men with Brylcreemed hair in bow ties congregating at the Gymkhana Club or Services Club, or the Saturday night jam session at Falleti’s Hotel. Read more »

by Katie Poore

A few weeks ago, one of my closest friends finished a thru-hike of the Pacific Crest Trail, the 2,650-mile footpath that snakes its way from Campo, California on the Mexican border to Mansfield Park, a few miles into Canada. It follows—as the name suggests—the crests of some of the West’s grandest mountain ranges: the Cascades in the Pacific Northwest, the Sierra Nevadas further south. It meanders through the Mojave Desert in southern California.

Ever since I read Cheryl Strayed’s 2012 memoir Wild: From Lost to Found on the Pacific Crest Trail as a fourteen-year-old, this footpath has occupied something of a sacred space in my imagination. And I am, evidently, not the only one. The trail granted 4,000 long-distance permits in 2016, the majority given to those intending to thru-hike—or walk the entire length of—the trail. Outside Magazine reports that the release of Wild’s 2014 film adaptation resulted in a 300% increase in web traffic on the official PCT website. If you’ve watched Netflix’s new installment of Gilmore Girls, you might recall a few scenes where Lorelai decides to remake her over-complicated life by following in Strayed’s footsteps. As she staggers to the PCT trailhead, however, she is greeted by a hoard of middle-aged divorcées and otherwise unsatisfied women with precisely the same idea. “Book or movie?” they ask each other. Gilmore Girls paints this journey as a kitschy one, the modern woman’s cliché strategy for shrugging off a mid-life crisis and walking off crappy ex-husbands. But here’s what’s true about those women, and the real people who hike this trail: most of them are there to remake themselves, to realize something, even if they don’t know what that something is just yet.

One can believe or not believe in this kind of spiritual journey, but it’s nonetheless an idea whose roots run deep in American soil. Think of Henry David Thoreau and Ralph Waldo Emerson and John Muir, of Robert Frost and Emily Dickinson and Walt Whitman. Consider Annie Dillard. Wendell Berry. Mary Oliver, whom the New York Times calls “one of the best-selling poets in the country.” Narratives of a redemptive natural world are everywhere. American wilderness, it seems, is nothing if not a spiritual and intellectual treasure trove. Where the flora and fauna run wild, these writers suggest, so may our souls. Read more »

Vapor trail left by some people flying by behind the mountains to the west of Franzensfeste at sunset in December of 2019.

by Robert Frodeman and Evelyn Brister

People sometimes express confusion about what public philosophy is. We see the point as straightforward: it’s a matter of location. Public philosophy consists of all those efforts that aren’t centered on university life. Public philosophers write op-eds for newspapers, work on disability issues and penal reform, serve on expert committees for government agencies, teach in prisons and schools, and help community groups balance considerations of justice with economic development. But while the possibilities for public philosophy are infinite, the distinction is clear: are your attentions directed toward other philosophers? That’s academic philosophy. Are your efforts aimed at the wider world? That’s public philosophy.

We’re pluralists in our attitude toward public philosophy: all of these varieties are useful in a world that too often assumes that the answers to societal questions come down to science or economics. But we want to emphasize one particular strain of public philosophy: what we call field philosophy. By analogy with field science, field philosophers work on-site with non-philosophers over an extended period of time. These are philosophers who are not simply writing about public problems but are engaged in projects, working alongside people as they confront real-world issues.

In a recent 3QD piece, Scott F. Aikin and Robert B. Talisse sound dubious about the usefulness of public philosophy. They claim that public philosophy has a distressing retrospective quality: by commenting on a situation philosophers are likely to affect that situation, and so are engaged in a continual process of catch-up. We grant the point, but we fail to see it as a problem. Public philosophy does not only consist of external, after-the-fact historical commentary. Particularly in the case of field philosophy, it actively participates in making sense of unfolding cultural events and reveals the conflicting pulls that make for difficult decisions. This iterative loop forms part of the dynamics of thinking, where an account adjusts to changed circumstances. The philosopher thinks with the scientist, the engineer, the businessperson, or the stakeholders’ group. Adjustment in the face of real-world conditions is how things are supposed to work. Read more »

Charles “Teenie” Harris. Girl Reading on Stack of Pittsburgh Courier Newspaper, 1940.

In the current “Truthiness and News” exhibition at DeCordova Museum, Lincoln, MA.

Silver gelatin print.

Truthiness and the News explores the evidentiary role of photography, from the heyday of newsprint in the first half of the twentieth century to the current age of post-truth politics. Presaging the contemporary turn to “alternative facts” and “fake news,” photographs in print journalism have always offered a multiplicity of truths depending on when and how editors chose to print them. Featuring works from the 1940s to the present, this exhibition highlights photojournalists and socially engaged photographers, such as Charles “Teenie” Harris and Barbara Norfleet, alongside spreads from the newspapers and magazines that published their photographs, and contemporary works responding to the dissemination of the news today.

More here, here, and here.

by Rafaël Newman

And the children of the moon / Were like a fork shoved on a spoon

Hedwig and the Angry Inch

1.

The goddess Demeter, having received the Earth as her domain in the post-Titanic dispensation that followed the parricidal murder of her father Kronos, had mated with her brother Zeus, lord of the Sky, and borne a daughter, Persephone, whom she adored. Their brother Hades, meanwhile, whose dominion was the Underworld, was as yet without a wife; and his gaze now fell on his niece, Persephone. With his brother Zeus’s connivance he kidnapped the object of his desire, whereupon her mother Demeter subsided into melancholy and perpetual winter was visited upon the Earth: until an agreement was reached, to forestall the death of all creatures, and Persephone was allowed to return to the surface, on condition that she not have eaten anything while below. But Hades had in fact persuaded her to swallow six pomegranate seeds; and thus she was condemned to return to the Underworld henceforth for six months of the year, during which period her mother, Demeter, mourned for her, and the Earth was cast into darkness, and cold.

My daughter saw it immediately. We had just spent a week in Istanbul, and our daily dose of nar suyu, fresh-squeezed pomegranate juice, was still a pleasant sense memory; so she was primed to spot the plump fruit on the poster in the lobby of the cinema where we had gone to see Dora, oder die sexuellen Neurosen unserer Eltern (“Dora, or The Sexual Neuroses of Our Parents”). This was the pomegranate that had afforded her so much pleasure in Asia Minor, and which is reputed to have been the snake’s gift to Eve, and thus hers to Adam, in the Garden of Eden. This particular pomegranate, however, was part of a story of natural origins from a different cultural tradition, but was to prove no less my fruit of knowledge that evening as I began to decipher Stina Werenfels’ retelling of a myth central to western culture. A myth about fertility, and death, and love, and sex. And food. Read more »

by Eric J. Weiner

There are two ways to be fooled. One is to believe what isn’t true; the other is to refuse to believe what is true. ― Soren Kierkegaard

A lot has changed since 1967, the year Noam Chomsky published “The Responsibility of Intellectuals.” His essay threw damning shade at the intelligentsia—particularly those in the social and political sciences—as well as those that supported what he called the “cult of expertise,” an ideological formation of professors, philosophers, scientists, military strategists, economists, technocrats, and foreign policy wonks, some of who believed the general public was ill-equipped (i.e., too stupid) to make decisions about the Vietnam war without experts to make it for them. For others in this cult, the public represented a real threat to established power and its operations in Vietnam, not because they were too stupid to understand foreign policy, but because they would understand it all too well. They had a sense that the public, if they learned the facts, wouldn’t support their foreign policy. Of course, in retrospect, we know that this is exactly what happened. Once the facts of the operation leaked out or were exposed by Chomsky and others like him, the majority of people disagreed with the “experts.” Soon there were new experts to provide rationalizations for why and how the old experts got it wrong, but not before a groundswell of popular protest and resistance turned the political tide and gave a glimpse at the power of everyday people—the “excesses of democracy”—to control the fate of the nation and the world.

Chomsky has consistently been confident that people who were not considered experts in foreign affairs were as capable if not more so to decide what was right and wrong without the expert as a guide. This is one of the things that continues to make Chomsky such a threat to the established order. He has faith in the public’s ability to think critically (i.e., reasonably, morally, and logically) about foreign affairs and other governmental actions at the local and national levels. For Chomsky, the promise of democracy begins and ends with the people. He does not have the same confidence that those in positions of power will give the public the facts so that they can make good and reasonable decisions. But this does not mean that Chomsky uncritically embraces the public simply because it is the public. He does not support, nor has he ever, the cult of willful ignorance; that is, those members of the public—experts, intellectuals or laypeople—who, as Kierkegaard wrote, “refuse to believe what is true.” Read more »

Dr. Mark Heaney is a hematologist and an active principal investigator of several clinical trials that have aimed at developing novel treatments for leukemia. His research has focused on metabolic differences between leukemia cells and normal cells that can provide understanding into how leukemias behave in the individual patient and how they respond to treatment. He chiefly focussed on the new treatments of the myeloproliferative neoplasms, primary myelofibrosis, polycythemia vera and essential thrombocythemia, however, has also studied new treatments for chronic myeloid leukemia, mastocytosis and Langerhans cell histiocytosis in keeping with his clinical expertise in rare blood cancers. He currently serves as Professor of Medicine and Director of Hematology and Medical Oncology Fellowship Program at Columbia University Medical Center.

Azra Raza, author of The First Cell: And the Human Costs of Pursuing Cancer to the Last, oncologist and professor of medicine at Columbia University, and 3QD editor, decided to speak to more than 20 leading cancer investigators and ask each of them the same five questions listed below. She videotaped the interviews and over the next months we will be posting them here one at a time each Monday. Please keep in mind that Azra and the rest of us at 3QD neither endorse nor oppose any of the answers given by the researchers as part of this project. Their views are their own. One can browse all previous interviews here.

1. We were treating acute myeloid leukemia (AML) with 7+3 (7 days of the drug cytosine arabinoside and 3 days of daunomycin) in 1977. We are still doing the same in 2019. What is the best way forward to change it by 2028?

2. There are 3.5 million papers on cancer, 135,000 in 2017 alone. There is a staggering disconnect between great scientific insights and translation to improved therapy. What are we doing wrong?

3. The fact that children respond to the same treatment better than adults seems to suggest that the cancer biology is different and also that the host is different. Since most cancers increase with age, even having good therapy may not matter as the host is decrepit. Solution?

4. You have great knowledge and experience in the field. If you were given limitless resources to plan a cure for cancer, what will you do?

5. Offering patients with advanced stage non-curable cancer, palliative but toxic treatments is a service or disservice in the current therapeutic landscape?

by Michael Liss

How do you feel about an Imperial Presidency?  

Attorney General William Barr has been on a bit of a bender recently. He’s suggested that communities that are critical of law enforcement will lose police protection, disagreed with the Inspector General’s report about the FBI and the Russia investigation, and warmed the hearts of the faithful at Notre Dame in decrying a “war on religion.”

While Mr. Barr rarely fails to make news, his most consequential opinions came in a speech he gave to the Federalist Society on November 15, 2019, in which he went on, at some length, as to why he supports the broadest possible interpretation of Presidential powers. 

If you have read reports about Mr. Barr’s remarks, you probably already know they have been criticized for their ferocious partisanship. There is unquestionably a considerable amount of energy devoted to critiquing those who get in President Trump’s way (Congress, the federal courts, Progressives, and private citizens who exercise their right of free speech). But Mr. Barr is not only a man of intensity, he is also one of words (over 6000 here), and, when moved to talk about substance, he has a lot to say. You can find the text on the Department of Justice website. Read more »

by Dave Maier

Here we have either a) a holiday gift guide; b) just another ordinary book roundup; or c) a bunch of mini-reviews each of which just didn’t have the oomph to deserve its own post. Answer provided below!

First up:

Theodore M. Bernstein – Miss Thistlebottom’s Hobgoblins: The Careful Writer’s Guide to the Taboos, Bugbears, and Outmoded Rules of English Usage (1971)

Rodney Huddleston and Geoffrey K. Pullum – A Student’s Introduction to English Grammar (2005)

I rarely read Columbia’s alumni magazine, but I did happen to see an interesting exchange (“Verbal Dispute”) in the Feedback section of the Fall 2019 issue. Apparently the cover of the previous issue had read “About 8 million tons of plastic ends up in the ocean every year,” and, perhaps not surprisingly, numerous quasi-literate chuckleheads had conveyed their righteous outrage at the offense to grammar so publicly displayed. Two are quoted; one explains to us that “‘Tons’ is a plural subject that takes the plural verb ‘end up,” continuing witheringly, “Are you a native English speaker? From California? [ooh, snap!] Are you intent on sabotaging Columbia or unqualified and irresponsible?” and so on.

The editor’s response is at once coolly civil and delectably devastating.

While it is certainly true that “end up” is the standard plural form, a singular verb is often used instead when the subject is a phrase that can be viewed as a single unit. This is particularly common when the subject is an expression of quantity or measure, as in “eight million tons.”

He then provides supporting examples from the above authors. I’ve listed the Huddleston and Pullum book I own; the actual quote is from their previous work, The Cambridge Grammar of the English Language (2002), on which the former is based. Their examples are simply brutal. (Try to say these sentences out loud with the plural form of the verb; you won’t even be able to.)

Twenty dollars seems a ridiculous amount to pay to go to the movies. Five miles is rather more than I want to walk this afternoon. Three eggs is plenty. [Yow.]

From Bernstein’s book (which I immediately ordered upon reading this):

You would not [or, you know, maybe you would, if you were a quasi-literate chucklehead] write “Three inches of snow have fallen,” because you are not thinking of individual inches; you are thinking of a quantity of snow that accumulates to that depth. Likewise you would not write “About $10,000 were added to the cost of the project,” because again you are thinking of a sum of money, not of individual dollars.

I’m tempted to quote as well what Huddleston and Pullum say about singular uses of “they,” because it also combines definitive analysis with deliciously polite snark, but let’s move on. Read more »

by Brooks Riley

by Bill Murray

Godfrey points the Land Rover toward Ngorongoro Crater. The road is fine to lull the unwary, but before you know it there is one lane, then no tarmac, then mud and potholes and empty hills.

Close cropped with a natty little mustache, Godfrey is kempt, forties, paunch-softened,  with an easy smile. A veteran guide, he has been here before. Says it will take five hours to do the 250 kilometers to the crater and so it does.

No package tour jets preceded us when we flew into Kilimanjaro International Airport aboard a small plane from Nairobi, so the airport bank wasn’t open. Consequently, we have no Tanzanian Shillings.

Oxen pull plows across the fields. Buses are occasional and private cars are rarer than cows. At the time of this visit (several years ago), the road is primarily for foot traffic, human and animal. No matter how far from a village, people are everywhere walking on the roads, always. They only move to the verge, reluctantly, when a Land Rover thunders by.

The few vehicles you do pass are either chock full of ride-sharing local folks, or they’re hauling two or three white Europeans on safari, or maybe they’re jeeps that read something like, “Africa Wildlife Research Project, funded by Belgian government.”

What do you know, way out here Godfrey knows where to buy a few beers. Two hot Tuskers from Kenya, two hot Safari beers from Tanzania, a roadside bodega, no power, no refrigeration, just a handful of dusty beers on a shelf for four for five dollars at an anonymous shack, friendly enough, opaque to a stranger. Godfrey’s got this round. Read more »

by Bill Benzon

I’ve been thinking about it a lot recently, how we regulate our minds. It can be simply things, like listening to some music, taking a walk, taking a few deep breaths, a time-out, maybe we take in a movie, or have some coffee, wine or liquor? perhaps smoke some weed – it’s legal now in America, at least in some states. Maybe one meditates, perhaps every now and then, perhaps daily; perhaps you go on a retreat for a week, a month, two or three. One can see a shrink, get a prescription or two. Read a good novel? Take an evening class at the local community college. For that matter, isn’t education about training the mind?

It’s what we do, one of the things. Regulating the mind. The list could grow and grow.

But I’ve got something more specific in mind. I’m interested in those various moments either when: one’s mind impresses itself on you as a stranger, as something perhaps a little perhaps a lot foreign, or you take a leap to see whether or not your mind will catch you. Welcome to your mind. And welcome to the world.

Herewith I offer a collection of experiences. I’m embarrassed to say that they’re my own. I don’t regard them as particularly special. They’re just the experiences I know about. They span my life from about age four to perhaps thirty.

We all have such liminal experiences, each in our own way.

Fiddle-De-Dee

That’s the earliest more or less distinct memory I’ve got, Burl Ives singing that song. I’m told I played the record over and over, on one occasion driving my visiting Uncle Harry to distraction. As I note in the preface to Beethoven’s Anvil, “It is my mind’s tether to history, my umbilical to the world.“

Since that particular experience happened at the house on Cherry Lane, I would have to have been four years old or so at the time. Though, come to think of it, there is an exceedingly vague impression of the house in Ellsworth, where we’d lived before moving to Cherry Lane in Johnstown, Pa. Read more »

Fane Alm, South Tyrol, in October of 2013.