Dr. Benjamin Ebert is remarkable for his leadership in describing the genomic landscape of adult myelodysplastic syndrome (MDS), including identifying critical new roles for ribosomal dysfunction. His laboratory discovered the molecular basis of lenalidomide activity in MDS as well as multiple myeloma. Recent studies have identified clonal hematopoiesis and its contribution to both hematologic malignancies and cardiovascular disease. Along with human genetic studies, Dr. Ebert’s lab has made significant contributions to understanding the biological basis of the transformation of hematopoietic cells by somatic mutations. Currently, he is chair of the medical oncology department at Dana-Farber Cancer Institute and Professor of Medicine at Harvard Medical School.

Azra Raza, author of The First Cell: And the Human Costs of Pursuing Cancer to the Last, oncologist and professor of medicine at Columbia University, and 3QD editor, decided to speak to more than 20 leading cancer investigators and ask each of them the same five questions listed below. She videotaped the interviews and over the next months we will be posting them here one at a time each Monday. Please keep in mind that Azra and the rest of us at 3QD neither endorse nor oppose any of the answers given by the researchers as part of this project. Their views are their own. One can browse all previous interviews here.

1. We were treating acute myeloid leukemia (AML) with 7+3 (7 days of the drug cytosine arabinoside and 3 days of daunomycin) in 1977. We are still doing the same in 2019. What is the best way forward to change it by 2028?

2. There are 3.5 million papers on cancer, 135,000 in 2017 alone. There is a staggering disconnect between great scientific insights and translation to improved therapy. What are we doing wrong?

3. The fact that children respond to the same treatment better than adults seems to suggest that the cancer biology is different and also that the host is different. Since most cancers increase with age, even having good therapy may not matter as the host is decrepit. Solution?

4. You have great knowledge and experience in the field. If you were given limitless resources to plan a cure for cancer, what will you do?

5. Offering patients with advanced stage non-curable cancer, palliative but toxic treatments is a service or disservice in the current therapeutic landscape?

by Jeroen Bouterse

In a radio sketch by the British comedians David Mitchell and Robert Webb, David Mitchell plays an interviewer trying to get a cabinet minister to say what he really thinks about the government’s funding cuts. At first, Robert Webb, playing the minister, says there is no disagreement between him and the cabinet, but the interviewer presses on, continually repeating the same question: “OK …. but what do you really think?”

At one point, the minister unrealistically breaks under these faux-critical questions, and admits:

“It’s all lies. I hate it, I’m against it, all right? […] That’s it, my career is over.”

You’d think that was enough. But after a pause, the interviewer replies:

-“Yes, but what do you really think?”

“Look, it’s all futile. We’re all nothing but specks of flesh going through this obscene dance of death for nothing. Everything is nothing.”

-“….Thank you minister.”

I associate nihilism with existential honesty, a recognition of truths about our world and our lives that goes beyond personal, social or political honesty, that cuts through all webs of meaning that we have spun for ourselves and sees them for what they are: vanishingly thin threads in an infinite void.  As such, nihilism seems to me very much the final word on human existence. The only thing is that it is such a transcendental, ‘cosmic’ claim that it doesn’t really connect to any aspect of our own lives, petty or heroic as they are. Read more »

by Brooks Riley

Day 115 of the Kashmir Siege

halmas sheen

athann soor

dilas shishargaanth

—By Aliya Nazki

Snow furrows my phiran

Ashes: my hands

Icicle: my heart

Aliya Nazki, a Presenter at BBC Urdu, based in London, was born and raised in Kashmir.

Translated from the Kashmiri by Rafiq Kathwari /@brownpundit

Offices of the Brenner Base Tunnel project in Franzensfeste, South Tyrol. When completed, this will be the longest train tunnel in the world, stretching 64 kilometers (40 miles) between Innsbruck and Franzensfeste. It is more than 580 meters (1900 feet) below the surface as it passes underneath the border of Austria and Italy at the Brenner Pass in the Tyrolean Alps. Photo taken in November, 2019. Click here for more info.

by Emrys Westacott

In Homo Deus, the 2017 follow-up to his widely read Sapiens, Yuval Noah Harari dismisses the idea of free will in cavalier fashion. Contemporary science, he argues, has proved it to be a fiction. In support of this claim, he offers several arguments.

1. Everything we do is fully determined by our “genes, hormones, and neurons,” and these “obey the same physical and chemical laws governing the rest of reality.” So from a scientific point of view, if we ask why a man performed any act, “answering ‘Because he chose to’ doesn’t cut the mustard. Instead, geneticists and brain scientists provide a much more detailed answer: ‘He did it due to such-and-such electro-chemical processes in the brain that were shaped by a particular genetic make-up, which in turn reflect evolutionary pressures coupled with random mutations.”[1]
2. The concept of free will is incompatible with the theory of evolution. According to Darwin’s theory, we came to be what we are by passing on genes that proved useful in the struggle to survive. If human actions (e.g. eating and mating) were freely chosen, then we couldn’t explain our evolution in terms of natural selection.
3. Recent laboratory research proves that our feeling that we make free choices is an illusion. Subjects whose brains are being monitored are told to press one of two switches. They think they are making a free choice; but a scientist watching a brain scanner can predict which switch they will press before the subject is even aware of having made a choice. This shows, says Harari, that “I don’t choose my desires. I only feel them, and act accordingly.”[2]
4. The idea of free will is bound up with the idea of an individual self that constitutes the inner essence of each human being. This modern notion of the self is really just a hangover from the religious concept of the soul. But all these notions–soul, self, essence–are outmoded; “so to ask, ‘How does the self choose its desires?’ …[is] like asking a bachelor, ‘How does your wife choose her clothes?’ In reality there is only a stream of consciousness, and desires arise and pass away within this stream, but there is no permanent self that owns the desires…”[3]

Harari advances these arguments with great confidence. Yet they are far from conclusive. Read more »

Andi. Untitled. Jokgakarta, Indonesia.

Batik art on fabric.

Digital photograph by Sughra Raza.

by Liam Heneghan

Once upon a time, in a beautiful but endangered forest far far away a prince and princess met, fell in love and married. They were blessed with a hundred children. “I wonder,” said the princess, somewhat exhausted from her exertions, “how best to raise our dear ones to care for each other and their beautiful forest home?” “I have heard,” replied her husband “that reading to children matters.”

Being of a scientific inclination, the royal couple assigned twenty children to each of five experimental groups. They prevented these children from mingling—for keeping the groups apart was deemed good experimental practice—and assessed if reading matters asking following questions. Should one read aloud to children, or narrate stories of a parent’s own devising, or read and discuss plot points at length as one proceeds through storytime, or should one perhaps, as early as possible, cultivate the youth to read on their own and abandon them to their own devices? One group of children—“our little controls” as the happy couple called them—were raised without the benefit of any stories at all.

The results of this longitudinal study were alas inconclusive. The prince haughtily accused his wife of surreptitiously reading to the control group; the princess icily retorted that her husband’s monotonic voice had lulled everyone asleep thus undermining the study. “I’d sooner stab myself in the ears than listen to another word from you.” Their scientific paper was rejected for publication; the couple lost their funding. And they all lived happily ever after. Read more »

Dr. Gary Schwartz is a recognized leader in the field of translational research and has been able to connect the basic and clinical science elements of drug development. His research focuses on the identification of new targeted agents for cancer therapy, especially in the treatment of sarcoma and melanoma. He earned NCI K24 and K12 Clinical Oncology Research Career Development Awards aimed at the mentoring of medical trainees in translational research. Moreover, he has authored about 200 papers and 17 book chapters in the field of basic and clinical cancer research. He currently serves as the Chief of the Division of Hematology and Oncology and Deputy Director of the Herbert Irving Comprehensive Cancer Center at Columbia University School of Medicine.

Azra Raza, author of The First Cell: And the Human Costs of Pursuing Cancer to the Last, oncologist and professor of medicine at Columbia University, and 3QD editor, decided to speak to more than 20 leading cancer investigators and ask each of them the same five questions listed below. She videotaped the interviews and over the next months we will be posting them here one at a time each Monday. Please keep in mind that Azra and the rest of us at 3QD neither endorse nor oppose any of the answers given by the researchers as part of this project. Their views are their own. One can browse all previous interviews here.

1. We were treating acute myeloid leukemia (AML) with 7+3 (7 days of the drug cytosine arabinoside and 3 days of daunomycin) in 1977. We are still doing the same in 2019. What is the best way forward to change it by 2028?

2. There are 3.5 million papers on cancer, 135,000 in 2017 alone. There is a staggering disconnect between great scientific insights and translation to improved therapy. What are we doing wrong?

3. The fact that children respond to the same treatment better than adults seems to suggest that the cancer biology is different and also that the host is different. Since most cancers increase with age, even having good therapy may not matter as the host is decrepit. Solution?

4. You have great knowledge and experience in the field. If you were given limitless resources to plan a cure for cancer, what will you do?

5. Offering patients with advanced stage non-curable cancer, palliative but toxic treatments is a service or disservice in the current therapeutic landscape?

by Samia Altaf

Baiji, my grandmother, was the custodian of  standards of behavior of  young women in the family. How to comport oneself — sit, stand, speak, eat—were strictly prescribed according to her rules of what was “proper” practice for girls. These rules did not apply to young men and boys.

Although I found most of Baiji’s rules onerous, it was especially difficult to adhere to one related to  what the girls should eat and how much. First on Baiji’s list was meat –of all kinds. Mutton, beef and fish were strictly  forbidden. Organ meat could not be mentioned in the same sentence that had the word girls in it. Neither were eggs, or butter or cream or rich edible oils. Nuts—walnuts, cashews and specially almonds—were also prohibited.

Once in a while, on special occasions such as Eid or at family weddings, girls could eat meat–in moderation. In winter they could have almonds —but no more than five a day. Peanuts were allowed but just a fistful, no more, at a time. Basic dry cereals, bread without butter, vegetables and fruits—these too in moderation—were best for girls. These foods kept them calm and of a clear mind, she said. Meat and such were “hot” and prone to causing agitation in women. Pregnant women and lactating mothers had special privileges. Even then, though calorie rich foods such as butter were fine, as were eggs — meat was still considered too extravagant for them. Read more »

by Joseph Shieber

There’s a well-established notion in film theory referred to as the “male gaze”. Here’s its description according to the theorist Laura Mulvey, who first introduced the concept in her 1975 essay, “Visual Pleasure and Narrative Cinema”. Mulvey suggests that, in Hollywood films, “the determining male gaze projects its phantasy on to the female form which is styled accordingly” (my emphasis).

According to Mulvey, the (heterosexual) male gaze reduces female figures in films to mere objects, devoid of agency and incapable of advancing the cinematic narrative. As she analyzes it, mainstream cinema makes the viewer complicit in this gaze. It places the viewer in the position of identifying with the male actors, who advance the plot, and to treat the female characters in films as scenery. Women in films, on Mulvey’s analysis, can serves as objects and frames for the action, but men are the sole actors.

I was reminded of the notion of the “male gaze” when reading an essay by L.D. Burnett on the occasion of Harold Bloom’s death, in a piece at the Society for US Intellectual History blog. Burnett’s essay reminded me that, without detracting from the incisiveness of Mulvey’s analysis, it is important to recognize there are other roles to which men can seek to consign women.

There’s a particular one of these roles that I have in mind, one that I haven’t seen discussed before in quite the way that Burnett’s discussion sparked for me. I’ll call it the “imagined female gaze”. Read more »

by Brooks Riley

by Katie Poore

A few weeks ago, I journeyed up to Chamonix-Mont-Blanc during a work vacation. I went with a few friends of mine, embarking from our homes in Chambéry, France, taking a train to Annecy, and a bus to our final destination. I was outrageously tired, having stayed up until some ungodly hour of the morning playing, of all things, Just Dance.

After shuffling around Annecy for a few hours, laden down with luggage and waiting for the arrival of our bus, we were on our way into the so-called heart of the French Alps. As badly as I wanted to sleep, I couldn’t tear my eyes away from the changing landscape, framed through immense bus windows. I pressed my forehead against the glass and turned on some music, hoping to block out any sounds of more mundane humanity for just a moment. Views like this always felt too sacred for human chatter, for the faint rumble of an engine. I couldn’t do much about the vibrating of the bus, or the fact that I was on a bus at all, but this I needed: a world composed of only those things which have taken great thought and time.

For me, this was those mountains and Gregory Alan Isakov, a singer-songwriter and farmer based near Boulder, Colorado, who writes his songs in a barn-studio plastered with giant pieces of paper scrawled with potential song lyrics. He calls songwriting “laborious” in an interview with Atwood Magazine, but this labor gives way to music that is something else entirely: quietly transcendent, aching, longing, at once fragile and formidable. It feels clear that these songs are constructed slowly, scrupulously, mined from the depths of feeling. Anyone familiar with that so-often agonizing creative process might feel the erasures and changes, the takes and retakes, the immense and fatiguing degree of ceaseless thought and emotion that slowly amalgamates to form each of his compositions.

It felt like the only proper music to which I might listen: carefully composed and somehow soaring, a perfect sonic accompaniment to the mountains whose formations might well be described the same way. Read more »

A closeup of the very sharp horizontal snow line on the mountain Riol in Franzensfeste, South Tyrol, with winter creeping down from above while autumn lingers below. Photo taken in the golden light of the early morning sun in November of 2019.

by Mindy Clegg

Welcome to the future, which is now the past. As James Gleick argued (in his thoughtful and entertaining book, Time Travel: A History) the concept of the future is now fodder for historical understanding. As Gleick notes in his book, popular culture provides a key insight into how ideas about the future shaped the past, present, and the actual future.¹

Pop culture during the twentieth century has long imagined the near and far future. Such imaginings became a running gag for talk show host Conan O’Brien. Back in the late 1990s, he started a new segment on his show, called “In the Year 2000.” It started first with him and his co-host Andy Richter (and later guests he was interviewing) donning collars and lighting up their faces with flashlights, while the band played futuristic sounding music in the background. Then, a round of predictions based on current events, ridiculous and silly predictions, all set to happen in the far off future of the year 2000. This bit continued well into the new millennium. Only during O’Brien’s all too-short stint hosting the famed Tonight Show did the format change to predict events in the year 3000 (with Captain Kirk himself, William Shatner providing a regular voice over—although once it was Lt. Sulu instead, George Takei).

The joke revolved around the idea that the future was already here, but the year “2000” still sounds pretty futuristic. Plus, it plays on how we viewed the future across the breadth of the twentieth century, as culminating in a utopia of technological progress, inevitably leading to social progress. Think Disney’s Epcot Center or Gene Roddenberry’s hopeful, post-scarcity, racially unified vision of the future in Star Trek. But O’Brien also pointed to a new phenomenon, when dates from popular culture in what was once the future recede into the past. I argue in this essay that the future we imagined in the past both shaped the present and contradicts it. This becomes clearest when we examine how some science fiction films or TV shows imagined a future date in our recent past. I’ll take three examples, the first being the classic anime, Neon Genesis Evangelion (set in 2015). The second is Ridley Scott’s classic adaptation of Phillip K. Dick’s novel Do Androids Dream of Electric Sheep, Blade Runner (set in 2019). Last will be two events in the Star Trek universe: one set in our recent past (the Eugenics Wars) and one in the near future (the Bell riots). Read more »