How Deep Sleep May Help The Brain Clear Alzheimer’s Toxins

Jon Hamilton at NPR:

The brain waves generated during deep sleep appear to trigger a cleaning system in the brain that protects it against Alzheimer’s and other neurodegenerative diseases.

Electrical signals known as slow waves appear just before a pulse of fluid washes through the brain, presumably removing toxins associated with Alzheimer’s, researchers reported Thursday in the journal Science.

The finding could help explain a puzzling link between sleep and Alzheimer’s, says Laura Lewis, an author of the study and an assistant professor in the department of biomedical engineering at Boston University.

More here.

The Metaphysics of Horror

David Livingstone Smith in IAI News:

“What would your feelings be,” asks Ambrose in Arthur Machen’s novel The House of Souls, “… if your cat or your dog began to talk to you, and to dispute with you in human accents?” He goes on:

You would be overwhelmed with horror. I am sure of it. And if the roses in your garden sang a weird song, you would go mad. And suppose the stones in the road began to swell and grow before your eyes, and if the pebble that you noticed at night had shot out stony blossoms in the morning?

Machen’s examples are disturbing, but it’s not immediately obvious why. It’s not that they’re frightening, at least not in the ordinary sense of the word. Normally, we’re scared of things because we think they pose a physical danger to us, but singing roses don’t pose any such hazard, so why is the thought of them so nightmarish?

Notice that Machen said that if you encountered a singing rose you would be overwhelmed with horror rather than fear. Fear is a primitive emotional response—an instinctive reaction to perceived danger that we share with other mammals. But horror is a uniquely human state of mind that depends on sophisticated cognitive capacities of a sort that only human beings possess.

More here.

Friday Poem

Unpacking a Globe

I gaze at the Pacific and don’t expect
to ever see the heads on Easter Island,
though I guess at sunlight rippling
the yellow grasses sloping to shore;

yesterday a doe ate grass in the orchard:
it lifted its ears and stopped eating

when it sensed us watching from
a glass hallway—in his sleep, a veteran

sweats, defusing a land mine.
On the globe, I mark the Battle of

the Coral Sea—no one frets at that now.
A poem can never be too dark,

I nod and, staring at the Kenai, hear
ice breaking up along an inlet;

yesterday a coyote trotted across
my headlights and turned his head

but didn’t break stride; that’s how
I want to live on this planet:

alive to a rabbit at a glass door—
and flower where there is no flower

by Arthur Sze
from
Sight Lines
Copper Canyon Press, 2019

Secrets in the Brains of People Who Have Committed Murder

Nicoletta Lanese in The Scientist:

Kent Kiehl and his research team regularly park their long, white trailer just outside the doors of maximum-security prisons across the US. Inside the vehicle sits the bulky body of a mobile MRI machine. During each visit, people from the prison make their way to and from the vehicle in hourly shifts to have their brains scanned and help to answer an age-old question: What makes a murderer? “It’s not an uncommon thing for [incarcerated people], while they’re getting a scan, to be like, ‘I’ve always been different. Can you tell me why I’ve always been so different?’” says Kiehl, a neuroscientist at the University of New Mexico and the Albuquerque-based nonprofit Mind Research Network (MRN) who helped design the mobile MRI system back in the early 2000s.

The author of The Psychopath Whisperer: The Science of Those Without a Conscience, Kiehl has been fascinated by the criminal mind since he was an undergraduate at the University of California, Davis. Now, as director of mobile imaging at MRN, he oversees efforts to gather brain scans from thousands of people held in US prisons to learn what features, if any, might differ from scans of the general population. This massive dataset recently allowed Kiehl to examine the brain structures of more than 800 men held in state prisons in New Mexico and Wisconsin in an attempt to distinguish incarcerated people who have committed homicide from those who have committed other crimes. First, Kiehl and his colleagues laboriously sorted the pool of people who had volunteered for the study into three categories based on their crimes: homicide, violent offenses that were not homicide, or non-violent or minimally violent transgressions. The team relied on official convictions, self-reported homicides, and confidential interviews with participants to determine who attempted or committed murder—both offenses that got a “homicide” label in their dataset.

More here.

Implantable cancer traps could provide earlier diagnosis, help monitor treatment

Moore and Lynch in Michigan News:

ANN ARBOR—Invasive procedures to biopsy tissue from cancer-tainted organs could be replaced by simply taking samples from a tiny “decoy” implanted just beneath the skin, University of Michigan researchers have demonstrated in mice. These devices have a knack for attracting cancer cells traveling through the body. In fact, they can even pick up signs that cancer is preparing to spread, before cancer cells arrive. “Biopsying an organ like the lung is a risky procedure that’s done only sparingly,” said Lonnie Shea, the William and Valerie Hall Chair of biomedical engineering at U-M. “We place these scaffolds right under the skin, so they’re readily accessible.”

The ease of access would also allow doctors to monitor the effectiveness of cancer treatments closer to real time.

The U-M team’s most recent work appears in Cancer Research, a publication of the American Association for Cancer Research. Biopsies of the scaffold allowed researchers to analyze 635 genes present in the captured cancer cells. From these genes, the team identified ten that could predict whether a mouse was healthy, if it had a cancer that had not begun to spread yet, or if a cancer was present and had begun to spread. They could do that all without the need for an invasive biopsy of an organ. The gene expression obtained at the scaffold had distinct patterns relative to cells from the blood, which are obtained through a technique known as liquid biopsy. These differences highlight that the tissue in these traps provides unique information that correlates with disease progression. The researchers have demonstrated that the synthetic scaffolds work with multiple types of cancers in mice, including pancreatic cancer. They work by luring immune cells, which, in turn, attract cancer cells.

More here.

Thursday, October 31, 2019

What John Rawls Missed

Jedediah Britton-Purdy in The New Republic:

John Rawls, who died in 2002, was the most influential American philosopher of the twentieth century. His great work, A Theory of Justice, appeared in 1971 and defined the field of political philosophy for generations. It set out standards for a just society in the form of two principles. First, a just society would protect the strongest set of civil liberties and personal rights compatible with everyone else having the same rights. Second, it would tolerate economic inequalities only if they improved the situation of the poorest and most marginalized (for example, by paying doctors well to encourage people to enter a socially necessary profession).

Taken seriously, Rawls’s principles would require a radical transformation: no hedge funds unless allowing them to operate will benefit the homeless? No Silicon Valley IPOs unless they make life better for farmworkers in the Central Valley? A just society would be very different from anything the United States has ever been. Rawls argued that justice would be compatible with either democratic socialism or a “property-owning democracy” of roughly equal smallholders. One thing was clear: America could not remain as it was, on pain of injustice.

It did not remain as it was, but Rawls’s vision did not triumph either. A Theory of Justice was published in 1971, just before economic inequality began its long ascent from its lowest level in history to today’s Second Gilded Age.

More here.

Perceptions of Musical Octaves Are Learned, Not Wired in the Brain

Elena Renken in Quanta:

In the lowlands of Bolivia, the most isolated of the Tsimané people live in communities without electricity; they don’t own televisions, computers or phones, and even battery-powered radios are rare. Their minimal exposure to Western culture happens mostly during occasional trips to nearby towns. To the researchers who make their way into Tsimané villages by truck and canoe each summer, that isolation makes the Tsimané an almost uniquely valuable source of insights into the human brain and its processing of music.

Most studies about music perception examine people accustomed to Western music, so only a few enclaves like these remote Tsimané villages allow scientists to make comparisons across cultures. There they can try to tease apart the effects of exposure to music from the brain’s innate comprehension of it — or at least start dissecting the relationship between the two. “We need to understand that interplay between our genes and our experience,” said Josh McDermott, an associate professor of brain and cognitive sciences at the Massachusetts Institute of Technology. He is the senior author of a recent paper involving the Tsimané in the journal Current Biology which suggests that a feature of music most of us might consider to be intrinsic — the perceived organization of musical pitches into octaves — is a cultural artifact.

More here.

The myth of Eurabia: how a far-right conspiracy theory went mainstream

Andrew Brown in The Guardian:

In July 2011, a quiet European capital was shaken by a terrorist car bomb, followed by confused reports suggesting many deaths. When the first news of the murders came through, one small group of online commentators reacted immediately, even though the media had cautiously declined to identify the attackers. They knew at once what had happened – and who was to blame.

“This was inevitable,” explained one of the anonymous commenters. And it was just the beginning: “Only a matter of time before other European nations get a taste of their multicultural tolerance that they’ve been cooking for decades.”

“Europe has been infested with venomous parasitic vermin,” explained another. “Anything and everything is fine as long as they rape the natives and destroy the country, which they do,” said a third.

As the news grew worse, the group became more joyful and confident. The car bomb had been followed by reports of a mass shooting at a nearby camp for teenagers. One commenter was “almost crying of happiness” to be proved right about the dangers of Islam. “The massacre at the children’s camp,” another noted, “is a sickening reminder of just how evil and satanic the cult of Islam is.”

More here.

The Contemporary essay as Self-Reflection

Katherine Lucky at Commonweal:

A pair of recent essay collections—Jia Tolentino’s Trick Mirror and Leslie Jamison’s Make It Scream, Make It Burn—invite easy comparisons. They were released within a month of each other. The current professional status of their authors is superficially similar: two established women writers in their thirties both living in Brooklyn. Each writes about weddings, travel, and the sensations of drugs and alcohol; each takes up overtly feminist topics, from defeated heroines and female rage to “difficult women” and women in pain. Even the two books’ bold text-only covers are similar: multicolored lettering in ochre, hot pink, and orange (Tolentino) and fuschia, peach, and sky blue (Jamison). But to my mind what really connects them is how Tolentino and Jamison reason. What’s objective, they demonstrate, is often subjective, or hypocritical, or at the very least, complicated.

more here.

Edith Wharton’s Ghosts

J. Nicole Jones at The Paris Review:

In a preface to her ghost stories, Wharton writes, “I do not believe in ghosts, but I am afraid of them.” Following an attack of typhoid as a child, Wharton writes in her autobiography, A Backward Glance, that she returned from the brink of death with “chronic fear” that felt like a “choking agony of terror.” Well into young adulthood, she would not sleep without a light and a maid present in her room. “It was like some dark, indefinable menace, forever dogging my steps, lurking, and threatening,” she writes, and I could not help but think of Hilary Mantel’s childhood encounter with an indescribable evil in her family’s garden. Must all women be visited by terror so consistently and from such a young age? The rumors of paranormal activity at the Mount began after the house become an all-girls school in the forties, and intensified when the theater troupe Shakespeare and Company took residence there in the seventies. The performers were kicked out more than a decade ago in a landlord-tenant dispute that seemed, publicly, not related to the supernatural. Even so, nothing attracts the devil more than a group of adolescent girls, except for maybe a group of actors.

more here.

Philosophers Debate Democracy

John Tasioulas and Jonathan Wolf at the TLS:

Does the ferocity of the Brexit debate reveal different conceptions of the nature and value of democracy? Brexiteers proudly talk as if the 2016 vote was a rare paradigm of real democracy – “the largest democratic exercise in our history” – while Remainers respond that majority voting by the electorate is only a small part of our democratic system. In a representative democracy, our elected representatives can and should scrutinize the result of an “advisory” referendum as they scrutinize anything else. So why should a referendum result be “respected” if the democratically elected politicians were to decide that, all things considered, it is not in the country’s best interests? On the other hand, Brexiteers will respond that if parliament can overturn the result, what was the point of the referendum in the first place?

It might seem, then, that the Brexit debate is a debate about democracy itself: what it is, why it is valuable, and how it should work.

more here.

Thursday Poem

We Sinfull Women

It is we sinful women
who are not awed by the grandeur of those who wear gowns

who don’t sell our lives
who don’t bow our heads
who don’t fold our hands together.

It is we sinful women
while those who sell the harvests of our bodies
become exalted
become distinguished
become the just princes of the material world.

It is we sinful women
who come out raising the banner of truth
up against barricades of lies on the highways
who find stories of persecution piled on each threshold
who find that tongues which could speak have been severed.

It is we sinful women.
Now, even if the night gives chase
these eyes shall not be put out.
For the wall which has been razed
don’t insist now on raising it again.

It is we sinful women
who are not awed by the grandeur of those who wear gowns

who don’t sell our bodies
who don’t bow our heads
who don’t fold our hands together.
.
by Rukhsana Ahmad
from:
We Sinful Women: Contemporary Urdu Feminist Poetry (with original Urdu poems)
The Women’s Press Ltd, London, 1991, ISBN 0—7043—4262-6

Never Underestimate the Intelligence of Trees

Brandon Keim in Nautilus:

Consider a forest: One notices the trunks, of course, and the canopy. If a few roots project artfully above the soil and fallen leaves, one notices those too, but with little thought for a matrix that may spread as deep and wide as the branches above. Fungi don’t register at all except for a sprinkling of mushrooms; those are regarded in isolation, rather than as the fruiting tips of a vast underground lattice intertwined with those roots. The world beneath the earth is as rich as the one above. For the past two decades, Suzanne Simard, a professor in the Department of Forest & Conservation at the University of British Columbia, has studied that unappreciated underworld. Her specialty is mycorrhizae: the symbiotic unions of fungi and root long known to help plants absorb nutrients from soil. Beginning with landmark experiments describing how carbon flowed between paper birch and Douglas fir trees, Simard found that mycorrhizae didn’t just connect trees to the earth, but to each other as well.

Simard went on to show how mycorrhizae-linked trees form networks, with individuals she dubbed Mother Trees at the center of communities that are in turn linked to one another, exchanging nutrients and water in a literally pulsing web that includes not only trees but all of a forest’s life. These insights had profound implications for our understanding of forest ecology—but that was just the start.

More here.

Wednesday, October 30, 2019

Off the Wave: A conversation with Justin E. H. Smith

Jon Baskin in The Point:

Justin E. H. Smith is a professor of history and philosophy of science at the University of Paris. In addition to his recent book, Irrationality: A History of the Dark Side of Reason, Smith is the author of the blog post “It’s All Over,” republished by The Point in January, which sparked weeks of debate across the internet and remains the magazine’s most popular article of 2019. He is currently in New York on a Cullman Fellowship, researching a book on Leibniz, the St. Petersburg Academy of Sciences, and the Second Kamchatka Expedition of 1731-41. In September, we met at Bryant Park for a casual conversation about postmodernism, comedy in the age of the algorithm, and what it means to be an aging cultural critic during a period of accelerated generational upheaval. What follows is an edited transcript of that discussion.

More here.

Using Quantum Computers to Test the Fundamentals of Physics

Andrew Sornborger and Andreas Albrecht in Scientific American:

If you could look closely enough at the objects that surround you, zooming in at magnifications far beyond those you could ever see with most microscopes, you would eventually get to a point where the familiar rules of your everyday experiences break down. At scales where blood cells and viruses seem enormous and molecules come into view, things are no longer subject to the simple laws of physics that we learn in high school.

Atoms—and the electrons, protons and neutrons they are made of—don’t exist in the same way a marble does. Instead they are smeared in clouds that are difficult to understand and impossible to describe without the complex mathematics of quantum mechanics.

And yet atoms make up molecules, which, in turn, are the building blocks of marbles and everything else we touch and see each day. Nature has clearly found some way of suppressing quantum behavior when quantum objects are assembled into the familiar ones all around us.

How can things that obey the classical laws of physics—such as a pitched baseball or a bumblebee in flight—be composed of parts that are subject to quantum rules at minute levels? That is one of the deepest questions in modern physics. In pursuit of an answer, recent research—with funding from the High Energy Physics program at the Department of Energy’s Office of Science—should help shed light on how the classical world emerges from the underlying quantum one.

More here.

In U.S., Decline of Christianity Continues at Rapid Pace

From the Pew Research Center:

The religious landscape of the United States continues to change at a rapid clip. In Pew Research Center telephone surveys conducted in 2018 and 2019, 65% of American adults describe themselves as Christians when asked about their religion, down 12 percentage points over the past decade. Meanwhile, the religiously unaffiliated share of the population, consisting of people who describe their religious identity as atheist, agnostic or “nothing in particular,” now stands at 26%, up from 17% in 2009.

Both Protestantism and Catholicism are experiencing losses of population share. Currently, 43% of U.S. adults identify with Protestantism, down from 51% in 2009. And one-in-five adults (20%) are Catholic, down from 23% in 2009. Meanwhile, all subsets of the religiously unaffiliated population – a group also known as religious “nones” – have seen their numbers swell.

More here.

‘The Peanuts Papers’: How a comic strip shaped the lives of writers and artists

Bob Blaisdell in The Christian Science Monitor:

The best thing about this excellent and pleasing anthology of 33 tributes to “Peanuts” is that it will probably evoke your own memories of newspaper comic-strip reading and reawaken your appreciation of Charles M. Schulz’s round-headed, adult-sounding children and the imaginative dog Snoopy. “An isolated four-panel comic strip of Charlie Brown and Linus debating a philosophical point can be appreciated just as it is, humorous, insightful, compact, and perfect; one strip a day documenting one man’s thoughts for half a century has the weight of a full life,” writes the cartoonist Ivan Brunetti. As a collective eulogy to a cultural phenomenon, “The Peanuts Papers: Writers and Cartoonists on Charlie Brown, Snoopy & the Gang, and the Meaning of Life” testifies to the inspiration and importance of Schulz’s work at critical times in the authors’ (usually) younger lives. Satirist and critic Joe Queenan reflects: “Unlike so many other venerated objects in U.S. pop culture, it was sweet without being stupid, reassuring without being infantile.”

…That daily dose of taking in Schulz’s “not arty” work allowed us to identify with hopefulness despite all the evidence in the newspaper and in our lives that hopelessness is more reasonable. Discussing the annual depiction of Lucy yanking the football away from Charlie Brown as he runs up to kick it, the psychiatrist Peter D. Kramer explains, “Charlie Brown is trusting to a fault – or a virtue. He prefers to trust, however often his faith is betrayed. Giving fellow humans the benefit of the doubt is a fine if painful way to live. ‘Don’t! Don’t!’ we cry to Charlie Brown, and then we’re glad he does.”

More here.