by Jalees Rehman
How can we toggle the immune system’s “off switch”? How do we deactivate the cells and molecules which form an essential line of defense for our body and protect us against invading pathogens once their job is done? Persistent inflammation after pathogens are eliminated can be very harmful to the body because oxidants and other injurious molecules produced by immune cells end up attacking the body’s own tissues and organs instead of the pathogens.
During an infection, immune cells become activated and mount an inflammatory response against harmful bacteria and viruses. Inflammation in a tissue or organ entails an increase in the number of immune cells which is achieved by the release of chemokines – molecules which beckon fellow immune cells to the sites of infection and inflammation – as well as the upregulation of molecules such as oxidants which help eliminate pathogens as well as important protein molecules. Some of the molecules released by immune cells – such as the protein interleukin 1β (IL-1β) – amplify inflammation and also cause fever, which is thought to improve the ability of our immune system to fight. In the case of bacterial infections, our immune system may be overwhelmed by the invading bacteria and thus needs the help of antibiotics which directly kill bacteria. Appropriate antibiotic treatments combined with the valiant efforts of a healthy immune system are usually sufficient to get rid of most pathogens. Once they are eliminated, the inflammation then subsides. The immune system switches into a cooling off mode, at which point immune cell numbers decrease and their attack activity diminishes.
Unfortunately, the immune system does not always stand down from an inflammation mode. Instead, immune cells remain hyper-activated in some patients and continue to engage in a fight even after the pathogens have been eradicated. Read more »

For someone who spent most of his life trying to get on Page Six, (the New York Post’s iconic gossip column), hitting Page One was pay dirt for Donald Trump. Now that he’s there, he means to stay there, devouring our attention for the foreseeable future. One could even argue that all his lies and deplorable actions are motivated by a single, sorry ambition, to be the center of attention at all times and in all places. Outrage sells.



It turns out you learn a lot when you write a book. This may seem counterintuitive. Perhaps you think, “Well, that’s dumb. If you write a book about something you should already be an expert on it.” 


Why do people care about sport? With hundreds of millions of human beings (myself included) obsessively following the world cup that is being played out in Russia, it’s a good time to reflect once again on this perennially interesting question.



The ability to control electricity so that it arrives in measured doses where and when needed combined with simple steps to improve public sanitation, such as running water, indoor toilets and the removal of the uncountable tons of horse manure that marked major cities before the advent of the internal combustion engine that spurred roads and transportation networks that enabled frozen food to be enjoyed from coast to coast, wrought a step change in living standards unlikely to be repeated.