What Does an Ant Smell Like?

James Barron in The New York Times:

The office where Daniel Ksepka was working was overrun with ants. On the wall above the desk were army ants, bull ants, leaf-cutter ants and turtle ants. On a shelf were two honeypot ants that looked as if they had yellow balloons where their stomachs should have been. Kspeka, the curator of science at the Bruce Museum in Greenwich, Conn., did not call an exterminator. There was no need to: None of the ants in the office were real. The ones on the wall were drawings. The honeypot ants were plastic models made on the museum’s 3-D printer in preparation for an exhibition called “Ants: Tiny Creatures, Big Lives” that will open on Nov. 13.

“I love ants,” Ksepka said. “They keep the world running.” Let him count the ways. “They are architects,” he said. “They are farmers.” They construct elaborate nests, stockpile food and tend fungal gardens. Some harvester ants in East Africa even collect bones — the remains of birds, lizards and pygmy mice. Some can snap their jaws shut in one-tenth of a millisecond.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

What Are Senescent Cells?

Laura Tran in The Scientist:

As time marches on, aging is inevitable. Naturally, a person can accumulate wrinkles, laugh lines, stress, and cellular damage. Of these, damaged cells can take multiple paths: they can undergo programmed death; they can proliferate uncontrollably and become cancer; or they can become senescent cells. They don’t claw their way out of graves, but senescent cells are the body’s biological zombies—damaged, unable to divide, but very much metabolically alive. Instead of dying like normal cells, these “undead” entities can avoid immune system clearance and linger in the brain and other parts of the body. “They are no longer the original cell that they once were,” explained Miranda Orr, a translational neuroscientist at Washington University School of Medicine (WashU Medicine). Orr added that senescent cells not only differ from their initial form but also vary by the cell type within the tissue they came from, the stress triggers, and whether the aging process is healthy or pathological.

Cellular senescence has a complex relationship with the body.1 These cells have beneficial roles in development, tissue regeneration, and wound healing.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

Goethe: A Life in Ideas

Ritchie Robertson at Literary Review:

Goethe’s philosophical coordinates came initially from Rousseau and Spinoza, two thinkers who appealed to and fortified his own disposition. Rousseau’s concept of amour de soi, the urge for self–preservation, appears in Goethe as the need for individual authenticity. The opposing force, Rousseau’s amour propre, becomes the dead weight of social conventions suppressing whatever is distinctive, original and creative. Hence Goethe’s protagonists are powerful, charismatic personalities who experience society as a ‘prison’, the metaphor used by Werther and Faust. For some, such as Werther, the only way out is death. Others, such as Faust, preserve their essential character, but the struggle to do so leaves victims in its wake. Werther himself, unable to conquer his love for the married Lotte, leaves her and her husband devastated by his suicide. Faust’s egotism inflicts tragedy on his lover Gretchen. Goethe is honest about the cost to others of preserving one’s own authenticity.

Disliking the arid Lutheranism of his upbringing, Goethe found a more congenial religious outlook in the Dutch-Jewish philosopher Spinoza, who was often unjustly reviled as an atheist. Spinoza offered him a God who was identical with the world.

more here.

Enjoying the content on 3QD? Help keep us going by donating now.

Sunday, October 19, 2025

Neo-Schumpeterian

Cédric Durand in Sidecar:

The neo-Schumpeterian approach of Philippe Aghion – co-author of The Power of Creative Destruction (2021), among many other books – has had a significant influence on European economic policy since the turn of the century. Earlier this week, he was one of three economists to receive the Sveriges Riksbank Prize in memory of Alfred Nobel, the most prestigious award in the discipline, with the committee praising his account of how innovation provides the impetus for growth. What is the nature of this account, and what are its implications? It is perhaps an auspicious moment to reflect on Aghion’s thinking, as France undergoes a political crisis whose origins can be traced to the unpopular economic policies he championed as an adviser to President Macron.

The governing thesis of Aghion’s work, which draws inspiration from Schumpeter who in turn inherited the theme from Marx and Rosa Luxemberg, is that innovation is the engine of capitalism, and that the source of growth is creative destruction. ‘The new replaces the old’, as Aghion puts it. What has set him apart is his attempt to model and measure this phenomenon. According to his findings, this process has two key conditions. The first is flexibility. Markets should be liberalized so that innovations lead to an effective reorganization of the productive forces, resulting in increased economic activity. The second, however, is a limit on competition, too much of which inhibits innovators, who must be encouraged with low capital taxation and strong intellectual property rights. If this generates inequality, it’s a necessary evil. ‘I’ll take it’, Aghion says.

But he has a problem. There may have been growth in patents in recent decades – Aghion’s preferred indicator for measuring innovation – but economic growth as a whole is declining. And so he wonders: why is this acceleration in innovation not reflected in growth and productivity trends?

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

The Great Reckoning

Kaiser Kuo in The Ideas Letter:

The world feels unsettled, as if history itself were changing tempo. The familiar landmarks of the modern age are blurring, slipping away, and the stories we once told ourselves about progress and power no longer map cleanly onto the terrain before us. What we are living through seems, with each new day, less like a passing rearrangement of power, less like a momentary realignment of nations. We sense something deeper and more enduring: a transformation whose outlines we are only beginning to discern. History no longer feels like something unfolding behind us but something rushing toward us, urgent and impossible to ignore.

The economic historian Adam Tooze, reflecting on his recent, intense engagement with China, put it to me in July with characteristic directness: “China isn’t just an analytical problem,” he said. It is “the master key to understanding modernity.” Tooze called China “the biggest laboratory of organized modernizations there has ever been or ever will be at this level [of] organization.” It is a place where the industrial histories of the West now read like prefaces to something larger.

His observation cuts to the heart of what makes this moment so difficult to process. We have witnessed not merely the rise of another great power, but a fundamental challenge to assumptions long embedded in Western thought—about development, political systems, and civilizational achievement itself. We simply haven’t yet found the intellectual courage to face it.

This reckoning touches all of humanity, but it falls especially hard on the developed world and hardest on the United States, where assumptions about exceptionalism and hierarchy are most exposed and most fiercely denied. The familiar framing of China as “rising” or “catching up” no longer holds. China is now shaping the trajectory of development, setting the pace economically, technologically, and institutionally. For Americans especially, the deeper psychic shock lies in the recognition that modernity is no longer something they authored and others merely inherit. That story has outlived its usefulness.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

Great Power Antinomies

Brian J. Chen in Phenomenal World:

In late July, the Trump administration released “America’s AI Action Plan,” its executive strategy to fast-track domestic AI infrastructure and achieve technological supremacy. Like other US policies of any serious ambition, it bears an obvious insistence on bolstering the nation’s security against China. The Plan’s coverpage tagline is bold, if uninspired: “Winning the Race.”

Even so, Washington’s national security experts aren’t entirely satisfied with Donald Trump’s technology policy. Of late, their ire has been directed at the administration’s decision to resume the sale of certain Nvidia chips to China. The chips in question, H20 graphics processing units, were designed to comply with Biden-era export restrictions; Trump’s Commerce Department rescinded those rules but later blocked H20 sales, anyway. They are not class-leading, but their technological edge at the stage of AI inference makes them extremely valuable. Accordingly, their sale to foreign adversaries, especially to the Chinese, has been the centerpiece of recent US geopolitical strategy. It took personal lobbying by Nvidia chief executive Jensen Huang to convince the President to drop the ban, arguing that it is better for America’s interests for China to depend on US-designed chips than to not have them at all.

For those that have spent the last half decade or more engaged in sophisticated supply-chain wargaming, the reversal of US semiconductor controls has been received as anathema.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

Sunday Poem

Winter’s hubris

The winter killed the sun’s macho glares
drubbed leaves, imposed shades, nascent
but mocking and as time passed, they snarled
through barks, naked, gnarled, swaggering
monarchical asides, later the wind pummeled
birds’ feathers, flaunted its plans plucked
their migratory secrets, under the dark lust
of an evening freaked cars parked like a
defeated army rattled electric poles, shook
pages with a smidgen of woes yet to be
written, while the dew crowned the benches
there a vacancy that stumbled on memory,

what else but a faded bush like an antagonist.

by Rizwan Akhtar
of the Institute of English Studies
Punjab University

Enjoying the content on 3QD? Help keep us going by donating now.

Why AI Companies Are Racing to Build a Virtual Human Cell

Veronique Greenwood in Time Magazine:

A human cell is a Rube Goldberg machine like no other, full of biological chain reactions that make the difference between life and death. Understanding these delicate relationships and how they go wrong in disease is one of the central fascinations of biology. A single mistake in a gene can bend the protein it makes into the wrong shape. A misshapen protein can’t do its job. And for want of that protein, the organism–you–may start to fall apart.

Cells are so complex, however, that getting a sense of how one protein’s failure spreads through the system is tough. Graham Johnson, a computational biologist and scientific illustrator at the Allen Institute for Cell Science, recalls fantasizing at a lunch table, more than 15 years ago, about a computer model of a cell so detailed, so complete, that scientists could watch such processes happening. At that time, “everyone just snickered,” he says. “It was just too unrealistic.” But now some researchers are using AI to take new steps towards the goal of a “virtual cell.” Google’s DeepMind is working on such a project, and the Chan Zuckerberg Initiative (CZI) has made virtual cells a major focus in their Biohub research network, says Theo Karaletsos, senior director of AI at CZI. There is even a new prize, set up by the Arc Institute, for virtual-cell-style models.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

How the Brain Moves From Waking Life to Sleep (and Back Again)

Yasemin Saplakoglu in Quanta Magazine:

The pillow is cold against your cheek. Your upstairs neighbor creaks across the ceiling. You close your eyes; shadows and light dance across your vision. A cat sniffs at a piece of cheese. Dots fall into a lake. All this feels very normal and fine, even though you don’t own a cat and you’re nowhere near a lake. You’ve started your journey into sleep, the cryptic state that you and most other animals need in some form to survive. Sleep refreshes the brain and body in ways we don’t fully understand: repairing tissuesclearing out toxins and solidifying memories. But as anyone who has experienced insomnia can attest, entering that state isn’t physiologically or psychologically simple.

To fall asleep, “everything has to change,” said Adam Horowitz(opens a new tab), a research affiliate in sleep science at the Massachusetts Institute of Technology. The flow of blood to the brain slows down, and the circulation of cerebrospinal fluid speeds up. Neurons release neurotransmitters that shift the brain’s chemistry, and they start to behave differently, firing more in sync with one another. Mental images float in and out. Thoughts begin to warp. “Our brains can really rapidly transform us from being aware of our environments to being unconscious, or even experiencing things that aren’t there,” said Laura Lewis(opens a new tab), a sleep researcher at MIT. “This raises deeply fascinating questions about our human experience.”

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

Friday, October 17, 2025

Why Sports Journalism Is Boring and Cruel

Jeannette Cooperman at The Common Reader:

Sports writing can be brilliant; it is one of the most exciting forms, full of suspense and rich with lore. Yet most sports reporting winds up formulaic and pedestrian. This is an arena of high drama and individual challenge, but for the performer, the interest is in the training and the doing, not the words the rest of us try to surround it with. Reporters lean hard on interviews with athletes, yet they only turn chatty when they retire from their sport. While competing, they are intense and focused, utterly uninterested in coming up with quotable sound bites. They are not running for public office. They are running for speed, or swimming, or doing floor routines.

“The reporters talk to them right afterward, and sometimes all my son wants to do is go vomit into a trashcan!” exclaims the mother of a star collegiate athlete. So much adrenaline has pumped through his system, and right after a race, he is reeling with either triumph or disappointment.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

The first non-opioid painkiller

Michelle Ma at Works in Progress:

In the nineteenth century, the invention of anesthesia was considered a gift from God. But post-operative pain relief has continued to rely on opioids, derivatives of opium, the addictive substance employed since ancient times. Although no other drug has managed to match the rapid, potent, and broadly effective relief delivered by opioids, their side effects have led to decades of addiction and overdose, leaving researchers keen to find a better solution.

This all changed in January 2025, when the FDA approved Vertex Pharmaceuticals’s Journavx (suzetrigine): the first non-opioid pain reliever suitable for treating post-surgery pain. Clinical trials found no signs of the problematic side effects associated with opioids: no drug abuse, tolerance, or withdrawal. But this was not an easy win: Vertex and other pharma companies spent decades searching for drugs like this to no avail.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

Three competing narratives of the second Trump administration

Jedediah Britton-Purdy and David Pozen in the Boston Review:

Political judgment takes place within political time. And political time is less a matter of chronology than of genre. What kind of moment are we living through? Is our system of government undergoing a cyclical swing, an existential transformation, or something in between? Nine months into the second Trump administration, Americans confront three very different answers to these questions.

One view, dominant at this point among mainstream liberals and centrists, is that the United States has entered a dangerous new era of authoritarian crisisFollowing a playbook used in Viktor Orbán’s Hungary, Recep Tayyip Erdoğan’s Turkey, and other illiberal regimes, the Trump administration is attacking independent institutions such as the media and universities, turning the Justice Department and other government agencies into instruments of extortion and retaliation, manipulating official data, pardoning violent allies, dehumanizing marginalized communities, declaring endless emergencies, and preparing the military to suppress “the enemy from within.”

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

Oscar Wilde’s library card reissued 130 years after being revoked over gay conviction

Paul Glynn in BBC:

The British Library has honoured late Irish writer Oscar Wilde by reissuing a reader’s card in his name, 130 years after his original was revoked following his conviction for “gross indecency”.

The celebrated novelist, poet and playwright was excluded from the library’s reading room in 1895 over his charge for having had homosexual relationships, which was a criminal offence at the time.

The new card, which will be collected by his grandson, author Merlin Holland, on Thursday, is intended to “acknowledge the injustices and immense suffering” Wilde faced, the library said.

Mr Holland said the new card is a “lovely gesture of forgiveness and I’m sure his spirit will be touched and delighted”.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

Friday Poem

Ungently

My mother passed at forty-one
nearly half of a century ago—
a typical thought a son might have
|turning sixty-eight, the way a date
can trigger any number of thoughts
to cross your mind: her laugh
letting you know it was a good night,
how silent she put on a brave face
in front of the canaries she raised,
sunlight shaking through the window
like the nervous whistle of not having
long, and though she did sing along
to the Four Seasons and Neil Diamond
on days with reasons to get lost
|in a chorus, all I remember is her
buying the first album by Aerosmith
but only listening to “Dream On,”
the quiet way it opened to let her in,
how she set the volume loud
enough for the living room to fill
with the part where she and the singer
started screaming at the end.

by Charles Carr
from Rattle #89, Fall 2025

Enjoying the content on 3QD? Help keep us going by donating now.