Jonathan Meades in Literary Review:

Assassination signifies the taking of life. So, obviously, does murder. They are not, however, synonymous. Assassination is planned. It most probably involves an ambush or trap, and before that high-level debates and decisions made in meetings, which typically are not minuted. Murder doesn’t generally involve such things. Assassinations are intended. They are tactical instruments and tools – if not also proxies – of war. They are, equally, evasions of war and bulwarks against tyranny. Michael Burleigh is dubious about the beneficial effects of governmentally sanctioned killing. However, a perhaps unforeseen outcome of his relentlessly sanguinary book is the implication that the planet, far from being sullied by opérations ponctuelles, might be a happier place were a few more tyrants to be treated to well-aimed headshots. There can, for instance, be no doubt that had Benito Mussolini been shot and strung up in Piazzale Loreto a few years earlier than he was, he would not have bought a road map to catastrophe from Adolf Hitler.

More here.

Dayna Tortorici in Bookforum:

WHEN PEOPLE TALK ABOUT TRUTH OR DARE, the notorious 1991 documentary about Madonna’s Blond Ambition tour, they tend to mention the same handful of scenes. The gay kiss. Madonna deep-throating a bottle of Vichy Catalan (not Evian, as often misremembered). Kevin Costner calling the show “neat” and Madonna making a puking gesture. Are these the best scenes in the film? No, but they passed for scandal in 1991 and so they made an impression. In retrospect they feel a little try-hard, a little overhyped, but that’s because we’re watching from the world Madonna made. With the distance of thirty years, it’s easier to appreciate everything else. Her intense relationship with her dancers. The range of personality on display. Above all there’s the serendipity of timing and access. Few pop stars of Madonna’s magnitude would give a filmmaker the free hand she gave director Alek Keshishian in 1991, including the Madonna of 2021. Few documentarians would have as much as he did to show for it.

Truth or Dare caught Madonna at the height of her powers. She was thirty-two, divorced, and recently denounced by the Vatican for “Like a Prayer.” She was also in a new phase, marked by a blend of ambition and unguardedness that she would never quite experience again. When filming began, in 1990, she had just finished her performance in Warren Beatty’s Dick Tracy and recorded an album, I’m Breathless, tied to the film. Among the album’s tricky Sondheim numbers was a club track she cowrote with Shep Pettibone called “Vogue.” “Vogue” had little to do with Dick Tracy—it was inspired by the Harlem ballroom scene that Madonna had caught glimpses of in downtown clubs—but Beatty was now her boyfriend, and a single would give his movie a boost; the spoken-word interlude name-checking Hollywood icons (“Lauren, Katharine, Lana, too / Bette Davis we love you”) would suffice for thematic unity. One night at the Sound Factory, Madonna’s friend Debi Mazar introduced her to a young dancer from the House of Xtravaganza, Jose Gutierez, who was known to be a talented voguer. Madonna had him audition on the spot, persuading him to swap pants with her bodyguard so he could access his full range of motion. She then hired him and another young Xtrava, Luis Camacho, to choreograph and perform in the “Vogue” video and to join her as backup dancers on the Blond Ambition tour. At the time, Gutierez needed his mother’s written permission to go; he was still underage.

More here.

Chia and DeGregori in Nature:

Decades of research have revealed how mutations contribute to the evolution of malignant cells and to the ultimate characteristics of a given tumour. There is growing recognition that the surrounding tissue environment affects the natural selection of these mutation-driven characteristics. Less appreciated, however, have been the effects of interactions between malignant cells and their neighbouring wild-type cells — and how, through these interactions, malignant cells shape the surrounding environment to their advantage. Writing in Nature, Yum et al.¹, Van Neerven et al.² and Flanagan et al.³ provide crucial insights into the competitive dynamics of cancer cells and their neighbouring cells in the intestine.

To study interactions between cells with cancer-promoting mutations and neighbouring cells in their native environment, Yum et al.¹ developed a microscopy-based approach that uses a multicolour system to monitor cellular lineages (clones) in mice. This enabled the authors to track intestinal stem cells that express cancer-associated mutations in two key genes, Kras and Pik3ca, and also to assess their wild-type neighbouring cells. The authors report that the presence of intestinal stem cells harbouring these mutated genes increased the rate of differentiation of the surrounding wild-type cells. This outcome was driven by the mutant stem cells secreting specific factors — molecules that activate the BMP signalling pathway, and others that inhibit the WNT signalling pathway (Fig. 1).

More here.

David Berlinski in Inference Review:

Mishra was moved to republish these essays in their hardcover coffin, he remarks in his introduction, as a response to Brexit, the election of Donald Trump, and the COVID-19 pandemic. The majority of these essays were written before Brexit, the election of Trump, or the advent of COVID-19. They lack the degree of prophetic force that Mishra might think appropriate. The title itself reprises a phrase due to Reinhold Niebuhr: “[A]mong the lesser culprits of history,” Niebuhr wrote in 1959, “are the bland fanatics of western civilization who regard the highly contingent achievements of our culture as the final form and norm of human existence.”⁵ Mishra’s bland fanatics, treating things alphabetically, run from Martin Amis, Ayaan Hirsi Ali, and Francis Fukuyama to Steven Pinker, Bari Weiss, and Leon Wieseltier, all of them bland, none of them fanatical. Robert Blackwill, Dick Cheney, Richard Perle, Condoleezza Rice, Paul Wolfowitz, and Robert Zoellick are unaccountably beyond the beam of Mishra’s indignation. I would have thought that Cheney, at least, had the beady eyes characteristic of the born bland fanatic.

Two of the sixteen essays in this collection are devoted to single combat: Mishra vs. Niall Ferguson and Jordan Peterson. Fluffy and forgettable, they did succeed in provoking their subjects to a display of petulance. Ferguson threatened to sue Mishra for libel, and Peterson proposed to slap him silly should they happen to meet.

What a pity they did not.

More here.

Sean Carroll in Preposterous Universe:

Any system in which politicians represent geographical districts with boundaries chosen by the politicians themselves is vulnerable to gerrymandering: carving up districts to increase the amount of seats that a given party is expected to win. But even fairly-drawn boundaries can end up quite complex, so how do we know that a given map is unfairly skewed? Math comes to the rescue. We can ask whether the likely outcome of a given map is very unusual within the set of all possible reasonable maps. That’s a hard math problem, however — the set of all possible maps is pretty big — so we have to be clever to solve it. I talk with geometer Jordan Ellenberg about how ideas like random walks and Markov chains help us judge the fairness of political boundaries.

More here.

William A. Haseltine in Project Syndicate:

At the start of the year, there was reason to hope that we were beginning to see the end of the COVID-19 pandemic. In the United States, the daily rate of new cases from the holiday surge began to drop precipitously, and the vaccine rollout accelerated soon thereafter. Although Europe lagged in the early months of 2021, there, too, the tide started to turn by April, as the pace of vaccination finally picked up.

But now that summer is almost upon us, the tide has turned once again, and not in our favor. New infections have been skyrocketing across South America, with countries like Argentina, Brazil, and Colombia approaching all-time highs of new infections in the past week. India crossed its own grim milestone last month with more than 400,000 new infections in a single day – a nearly unimaginable surge that overwhelmed hospitals and left families scrambling for any kind of care, oxygen, or medicines they could find. Even here in the US, states like Michigan and Oregon have struggled with recent spikes.

These resurgences should remind us that even with millions of vaccines being administered in some countries, the pandemic is far from over. We are certainly not back where we started, but nor can we ignore the challenges that await us.

More here.

Marco Roth at n+1:

But what does it mean when a building comes into existence as architecture only by accident—through contingency—under the erotic and transgressive conditions of an observer who was not supposed to be there seeing what was never supposed to be seen? There’s no usable lesson about “design” here, or urbanism, that the developer and his paid draughtsfolk might take away. No change to public policy or city codes. The experience of what we might think of as “the architectural,” in this instance, runs counter to every single intention behind the creation of this generic reflecting structure. It’s an experience born of incompleteness, of transience, like the spring itself.

I think sometimes that I live in the city in order to be able to experience nature more fully, in just these ways, at the moment when it takes fleeting vengeance against the buildings that have betrayed her. I no longer love the city for itself, as I once did, and all these stacked boxes meant to contain and mirror and project wealth, power, and property recall those sections of cemeteries where cremated remains are stored in stacked white drawers.

more here.

J. Hoberman at The Point:

Neel was, to use a much-abused word, a humanist—and not only because she was a figurative painter. Unlike ponderously performative portraitists like Francis Bacon and Lucian Freud, Neel did not objectify her subjects. She looked at them, and very often, they stared back at her. You might call her portraits a frank exchange of views. The gray-eyed woman who is the subject of “Elenka” (1936) could perform laser surgery with the intensity of her gaze. The expression on the face of Neel’s dying mother, bundled in a flannel robe, shrinking back and propped in a chair for “Last Sickness” (1953), is a lacerating blend of fear, reproach and shame. One of the two kids portrayed in “The Black Boys” (1967) is resigned, whereas the other, staring straight at the viewer, makes a challenge of his boredom.

Nearly four decades after her death, Neel reappears as an avatar of art-world diversity. If in 1974, she was hailed as a feminist (another term she uneasily accepted), she now is a woman who shucked off her white middle-class privilege.

more here.

Elizabeth Bruenig in The Atlantic:

By the time Republicans and centrist Democrats had united late last week to scold Representative Ilhan Omar for a tweet—one of the few pastimes that still draw the two parties together, and something those selfsame chiders would doubtlessly decry, under different circumstances, as cancel culture or censorship—it no longer mattered what, exactly, Omar had said. They had already managed to make a news cycle out of it: mission accomplished. Now, following Democratic outrage and Republican calls for a floor vote to strip Omar of her committee assignments, let me record the following for posterity: Omar demonstrably did not say what she’s been accused of having said; what she did say was true; and every politico using this opportunity to take a swing at her likely knows those two things—they just think you don’t.

What did Omar say? Context is key. In 2020, the Trump administration imposed sanctions on International Criminal Court prosecutors who moved to investigate potential U.S. war crimes in Afghanistan as well as potential Israeli crimes in the West Bank, East Jerusalem, and Gaza, arguing that because the U.S. and Israel aren’t members of the ICC, the court has no right to adjudicate such matters. (The ICC recognizes the State of Palestine as a party to its governing statute, a decision that the U.S. insists the ICC lacks the power to make.) Omar vocally opposed the sanctions—as did the European Union, the president of the ICC’s Assembly of States Parties, Senator Patrick Leahy, and, presumably, anyone skeptical of America’s willingness to look into its own savagery abroad.

During a June 7 budget hearing, Omar asked Secretary of State Antony Blinken a series of questions based on the ICC incident. First, Omar praised Blinken for lifting the Trump-era sanctions. Then she pointed out that he nevertheless still opposed an ICC investigation into war crimes in Afghanistan and Palestine—including, in the first case, offenses allegedly perpetrated by the U.S., the Afghan national government, and the Taliban; and, in the second, Israeli security forces and Hamas. Omar asked, “Where do we think victims are supposed to go for justice? And what justice mechanisms do you support?”

To which Blinken replied, more or less, that the U.S. and Israel are competent to adjudicate all of the above. This raised the obvious question Then why haven’t they?, but Omar’s time was up, and she politely yielded to the next representative. Later that day, Omar’s official Twitter account shared a video and tweeted a paraphrase of the exchange. The tweet read, in its entirety: “We must have the same level of accountability and justice for all victims of crimes against humanity. We have seen unthinkable atrocities committed by the U.S., Hamas, Israel, Afghanistan, and the Taliban. I asked @SecBlinken where people are supposed to go for justice.”

More here.

Amy Maxmen in Nautilus:

Every time he bent over a freshly dead body, pathologist George Martin pondered the diversity before him. Although his cadavers almost always belonged to the elderly, they varied dramatically. One would have intestines pocked by polyps. Another’s arteries were plugged with plaque. Variety even existed within the same types of disease. For instance, the location of beta amyloid deposits in the brain of people who’d suffered from Alzheimer’s differed significantly. If each type of malady shared the identical underlying cause, bodies ravaged by that cause should look similar in death. But they didn’t. “I never saw two people who had aged in the same way,” Martin says.

Martin read everything he could on aging. He took particular interest in observations showing how organisms ranging from clonal yeast to human twins had wildly different lifespans. One of the more dramatic examples were reports of tiny worms, Caenorhabditis elegans, that varied in lifespan by up to five-fold even when the worms were genetically identical and lived in identical laboratory surroundings.

Biologists know how chance events in the environment (such as getting hit by a bus) impact lifespan. And they understand the role of chance in genetics (such as inheriting genes for Huntington’s disease and certain cancers). But it now seems a third realm of uncertainty emerges as animals grow older, causing them to age in different ways. Researchers are only beginning to figure out the basis of biological fluctuations that build up over time. Some result from mutations that slip into the genomes within cells as they replicate. Others occur because of changes in molecules that either shut off or activate genes.

More here.

Untitled

If the cosmos
loves repetition
and variety, why
struggle? All
things carry the
weight of
creation, so
why judge? We
are a never ending
dream of matter
diving in and
out of existence,
our turgid well of
consciousness
enduring our
dismissals, evading
our immortality—
what becomes
an empty vessel
drifting through
space, trying
to piece us together
again.

by Robert Darlington
from Poetry Feast

Hello Readers and Writers,

We received a large number of submissions of sample essays in our search for new columnists. Most of them were excellent and it was very hard deciding whom to accept and whom not to. If you did not get selected, it does not at all mean that we didn’t like what you sent; we just have a limited number of slots and also sometimes we have too many people who want to write about the same subject. Today we welcome to 3QD the following persons, in alphabetical order by last name:

1. Omar Baig
2. Dick Edelstein
3. Deanna K. Kreisel
4. David J. Lobina
5. Derek Neal
6. Nicola Sayers
7. Ethan Seavey
8. Danielle Spencer

I will be in touch with all of you in the next days to schedule a start date. The “Monday Magazine” page will be updated with short bios and photographs of the new writers on the day they start.

Thanks to all of the people who sent samples of writing to us. It was a pleasure to read them all. Congratulations to the new writers!

Best wishes,

Abbas