Love in Plague Time

Clair Wills at the NYRB:

‘Joy’; from the Lombardy edition of the Taqwim as-Sihha, an eleventh-century medical treatise by Ibn Butlan of Baghdad, circa 1390

“Ordinary time” is that part of the liturgical calendar, between Easter and Advent, when nothing much happens. But ordinariness also stands for life lived under temporal constraints, for the commonplace experience of being human. Questions of free will and the shape given to private thoughts and desires hover at the margins of both of these novels. And it cannot be a coincidence that in both novels those questions are posed by a clerk who takes on the role of a priest, without having the authority to administer the sacraments or to shrive sins. In The Corner That Held Them, the false priest is Ralph Kello, a clerk who turns up at the convent gate in 1349, claiming to be a priest because he is hungry, and who becomes trapped by his lie for thirty years. In To Calais, it is Thomas, a religious scholar but not an ordained priest, who is forced by circumstance to hear the last confessions of dying victims of the plague. In the act of confessing to the living, rather than to God, whose pardon is required? In the absence of the sacrament, the confessions are nothing but stories—nothing more or less than a means for people to ask forgiveness of one another, and to give it. In this scenario confessing is like talking, or thinking, and the basis of enlightenment measured on a human, and ordinary, scale.

more here.

Wednesday Poem

To a Friend Who Likes Transcendence

Here’s a brook in all its April energy.
.
Up its steep and many-bouldered bank
a profusion of nasturtiums scatter –
“like bright syllables”
a transcendentalist poet might say.
.
Her eye would read that poem.
She’d hear harmonies of rock and water,
feel the soft touch of sun,
the warm taste of spring,
and think of what it meant.
.
Yet, air is full
of a blue confidence in itself.
The world is full of fullness.
.
Nothing to transcend here.

.
by Nils Peterson

from All the Marvelous Stuff

Do We Share DNA with ET?

Daniel Oberhaus in Nautilus:

The primary difficulty of interstellar communication is finding common ground between ourselves and other intelligent entities about which we can know nothing with absolute certainty. This common ground would be the basis for a universal language that could be understood by any intelligence, whether in the Milky Way, Andromeda, or beyond the cosmic horizon. To the best of our knowledge, the laws of physics are the same throughout the universe, which suggests that the facts of science may serve as a basis for mutual understanding between humans and an extraterrestrial intelligence. One key set of scientific facts presents an intriguing question. If aliens were to visit Earth and learn about its inhabitants, would they be surprised that such a wide variety of species all share a common genetic code? Or would this be all too familiar? There is probable cause to assume that the structure of genetic material is the same throughout the universe and that, while this is liable to give rise to life forms not found on Earth, the variety of species is fundamentally limited by the constraints built into the genetic mechanism.

On Earth we have only sequenced the genomes of a small percentage of living organisms and have only recently completed the human genome. We have successfully cloned several animals, but technical and ethical roadblocks prevent scientists from doing the same with humans. If an extraterrestrial civilization isn’t burdened with ethical dilemmas about cloning, however, sending the genetic code for humans and other species may be the most effective way to teach them about our biology.

More here.

The Philosopher King: Tommie Shelby on MLK

Julian Lucas and Tommie Shelby at The Point:

Julian Lucas: Your introductory essay suggests that when it comes to King, contemporary thought is held “captive by a picture.” Do you think that there can be a coexistence between King the political icon and King the serious philosophical thinker?

Tommie Shelby: Well, I suppose there’s not a lot we can do about his iconic status. But it’s possible to show a world-historical figure like him due respect without treating him like an infallible oracle. In philosophy as a field, we revere a small canon of figures. We also disagree with them, point out their limits, and take them down new avenues which might be more productive. One way of re-engaging King is to read him in the way we would thinkers like Immanuel Kant, John Stuart Mill, John Dewey—as interested in fundamental moral principles, what aspects of society deserve our allegiance and which do not.

He’s also engaged in a public discussion. No great thinker is just sitting in their study coming up with everything on their own. Everybody builds on what came before, and King is no different.

More here.

Sean Carroll’s Mindscape Podcast: Jenann Ismael on Connecting Physics to the World of Experience

Sean Carroll in Preposterous Universe:

Physics is simple; people are complicated. But even people are ultimately physical systems, made of particles and forces that follow the rules of the Core Theory. How do we bridge the gap from one kind of description to another, explaining how someone we know and care about can also be “just” a set of quantum fields obeying impersonal laws? This is a hard question that comes up in a variety of forms — What is the “self”? Do we have free will, the ability to make choices? What are the moral and ethical ramifications of these considerations? Jenann Ismael is a philosopher at the leading edge of connecting human life to the fundamental laws of nature, for example in her recent book How Physics Makes Us Free. We talk about free will, consciousness, values, and other topics about which I’m sure everyone will simply agree.

More here.

Joseph Stiglitz: Trump’s economy is an absolute disaster

Joseph Stiglitz at AlterNet:

As the world’s business elites trek to Davos for their annual gathering, people should be asking a simple question: Have they overcome their infatuation with US President Donald Trump?

Two years ago, a few rare corporate leaders were concerned about climate change, or upset at Trump’s misogyny and bigotry. Most, however, were celebrating the president’s tax cuts for billionaires and corporations and looking forward to his efforts to deregulate the economy. That would allow businesses to pollute the air more, get more Americans hooked on opioids, entice more children to eat their diabetes-inducing foods, and engage in the sort of financial shenanigans that brought on the 2008 crisis.

Today, many corporate bosses are still talking about the continued GDP growth and record stock prices. But neither GDP nor the Dow is a good measure of economic performance. Neither tells us what’s happening to ordinary citizens’ living standards or anything about sustainability. In fact, US economic performance over the past four years is Exhibit A in the indictment against relying on these indicators.

More here.

Is Professor Bhaer Jewish, and Other Mysteries

Sadie Stein at The Paris Review:

Last week, my parents saw Little Women. My mother immediately phoned me. “I think Professor Bhaer is Jewish,” she said, her voice vibrating with barely suppressed excitement. I said I didn’t think the facts supported this theory. But several days later, I got an email from her with the subject line “FYI!!!” When I clicked on the link, I saw it was Forward piece by Eve LaPlante headed, “Discovering Louisa May Alcott’s Jewish History on Portuguese Tour.”

I knew her game: my mom regarded this as proof that Alcott, apparently proud of her Sephardic ancestry—which, I read, the family credited with some of its dark coloring—had, indeed, written in a sympathetic Jewish foil for Jo. I couldn’t help but suspect that my mother was projecting; just because she had married a Jewish guy didn’t necessarily mean her favorite childhood literary figure had. “I just don’t see the evidence,” I wrote back, not without regret. “Bhaer is pretty Christian in the later books. He’s probably a 48er. And fwiw, the actor Louis Garrel isn’t Jewish, I don’t think.”

more here.

March 1917: ‘The Red Wheel, Node III, Book 2’ by Aleksandr Solzhenitsyn

Gary Saul Morson at The American Scholar:

Aleksandr Solzhenitsyn’s multivolume historical novel about the Russian Revolution, The Red Wheel, is divided into four “nodes,” each a lengthy account of a short span of time. March 1917, the third node, is in turn divided into four volumes, the second of which is the book under review, translated into English for the first time. Combining nonfictional historical argument with novelistic accounts of the principal historical actors and a few fictional characters, March 1917 covers a mere three days of unrest and revolution, March 13–15, 1917, at the end of which Tsar Nicholas II abdicates, ending the Romanov dynasty in Russia. Marian Schwartz’s splendid translation captures the prose’s powerful pace and conveys, as few translators could, the author’s subtle use of tone.

Heavily indebted to Tolstoy’s War and Peace, Solzhenitsyn (1918–2008) borrows a central insight of his great predecessor: war is far more chaotic, random, and contingent than its representation in historical narratives. Tolstoy described battle as no one had ever done before, showing soldiers moving blindly in fog with no idea what is going on and generals, unable to keep up with ever-changing situations, issuing orders that are impossible to execute.

more here.

Bombay Bicycle Club

Ellen Peirson-Haggar at The New Statesman:

The last time we heard from Bombay Bicycle Club, they’d gone out on a high. 2014’s So Long, See You Tomorrow, their fourth album, was their first to reach number one. Their final show before they announced a hiatus in January 2016 was also the last ever gig at London’s 19,000-capacity Earl’s Court – a historic, confetti-fuelled moment before the bulldozers came in to flatten 40 years of rock history.

The thrill of being a teenage Bombay fan lay in their unwillingness to sit still within any one genre. With each new album, their sound evolved, from the dancefloor indie of 2008’s I Had the Blues But I Shook Them Loose, through the pared-back folk of Flaws, to the eclectic pop-ready A Different Kind of Fix and the international eclecticism of So Long, See You Tomorrow, which featured Bollywood samples and enthusiastic percussion.

more here.

Back to the Land

George Scialabba in The Baffler:

AN ANTIMODERNIST is someone who stands in the path of progress and yells “Stop!” Of course different antimodernists want to stop different things. The first antimodernists, the Luddites of early nineteenth-century England, wanted to stop power looms from replacing (and thereby starving) weavers, to the considerable profit of textile industrialists. John Ruskin and William Morris in late nineteenth-century England wanted to stop the comely landscapes and buildings of the English countryside from being razed to make way for cheap and ugly but profitable new construction, both commercial and residential. William F. Buckley Jr., who coined the phrase about standing “athwart history, yelling Stop,” wanted to stop democracy, racial and sexual equality, and pretty much everything else humane and good, but above all, progressive taxation. (He was rich.) Ivan Illich wanted to stop expertise, which he thought had trapped modern men and women in universal dependence. Christopher Lasch wanted to stop mass society, which he showed, with a wide-ranging critique spanning history, sociology, and psychoanalysis, produces people who are less able to resist authority than those who grow up in a human-scale, largely face-to-face society.

Wendell Berry is probably the best-known and most influential antimodernist alive today, at least in the English-speaking world. Besides being a prolific essayist, novelist, story writer, and poet, Berry is a farmer in the Kentucky River Valley, an experience that has provided him with his material, his message, and his pulpit. He did not come to farming in midlife, as a novelty or a pastoral retreat. He grew up where he now farms, and his family has been farming in the area for many generations.

More here.

Our best weapons against cancer are not magic bullets

Vinay Prasad in Nature:

Earlier this month, the American Cancer Society announced its latest figures on cancer incidence and mortality1. These included the largest drop ever observed in national cancer statistics, which several media outlets seized on. Cancer death rates in the United States peaked in 1990, and in 2008–17 fell by about 1.5% per year. Between 2016 and 2017, the drop was slightly larger: 2.2%. This is undeniably good news.

But our optimism must be tempered by other measures of population health — particularly declining life expectancy.

The reason behind the large drop is a decrease in mortality for lung cancer — without lung cancer, the rate is still about 1.5%. Several reactions to the Cancer Society’s news heralded advances in precision treatments. Yet much of the continued reduction in mortality is due to the lower incidence of lung cancer, or a reduction in new cases per year. And new drugs cannot cause that. The two major therapeutic advances for treating this cancer — genome-targeted therapies and immunotherapy — are currently approved for the worst-off individuals: those with advanced or metastatic disease. Exciting technologies that uncover genetic drivers of cancer and unleash the immune system against it make headlines, but I think we must be careful not to give customized treatments too much credit, and I have been outspoken about my work to pin down the impact of these therapies. We would do better to focus on public-health strategies that are less glamorous.

More here.

Tuesday Poem

Gravelly Run

I don’t know somehow it seems sufficient
to see and hear whatever coming and going is,
losing the self to the victory
..of stones and trees,
of bending sandpit lakes, crescent
round groves of dwarf pine:

for it is not so much to know the self
as to know it as it is known
..by galaxy and cedar cone,
as if birth had never found it
and death could never end it:

the swamp’s slow water comes
down Gravelly Run fanning the long
..stone-held algal
hair and narrowing roils between
the shoulders of the highway bridge:

holly grows on the banks in the woods there,
and the cedars’ gothic-clustered
..spires could make
green religion in winter bones:

so I look and reflect, but the air’s glass
jail seals each thing in its entity:

no use to make any philosophies here:
..I see no
god in the holly, hear no song from
the snowbroken weeds: Hegel is not the winter
yellow in the pines: the sunlight has never
heard of trees: surrendered self among
..unwelcoming forms: stranger,
hoist your burdens, get on down the road.

by A. R. Ammons
from
The Selected Poems, Expanded Edition
W. W. Norton & Company, Inc.

Courting the Deplorables

by Ali Minai

For the last three years, I have struggled with a dilemma: As a reasonable, quite liberal person, what should I think of my 60 million fellow Americans who voted for Donald Trump in 2016, and the vast majority of whom continue to support him today? Normally, a personal dilemma is a private thing, not a topic for public airing, but I feel that this particular problem is one the vexes many others – perhaps even a majority of Americans, as more of us voted for Hillary Clinton and many did not vote at all. Since that bleak day in November 2016, an unspoken – and sometimes loudly spoken – question hangs in the air: What kind of “deplorable” person would vote for Donald Trump?

By now, it is clear to any reasonably sentient person that Donald Trump is a venal, corrupt, narcissistic individual with no shred of human decency or moral principle. From his first announcement where he called Mexicans rapists and criminals, to the Access Hollywood tape exposing his habit of groping women, the mocking of a disabled journalist, the xenophobic Muslim ban, calling white supremacists “very fine people”, the abduction and caging of innocent children, the destruction of environmental protections, the denial of the climate threat, the shredding of all ethical norms, the open defiance of laws, the appointment of racists and thugs to high office, the pardoning of war criminals, the decimation of government institutions and policies, the betrayal of allies, the subversion of American democracy, the celebration of despots, and blind obedience to Vladimir Putin – and much, much more – everything Trump has done has established him as a person of truly monumental vice. And yet, something like 40% of American voters still support him reliably, including many who have been grievously hurt by his policies and know that they have been hurt. Why? And how should those who cannot stand Trump relate to them? Read more »

The Fermi-Pasta-Ulam-Tsingou problem: A foray into the beautifully simple and the simply beautiful

by Ashutosh Jogalekar

In November 1918, a 17-year-student from Rome sat for the entrance examination of the Scuola Normale Superiore in Pisa, Italy’s most prestigious science institution. Students applying to the institute had to write an essay on a topic that the examiners picked. The topics were usually quite general, so the students had considerable leeway. Most students wrote about well-known subjects that they had already learnt about in high school. But this student was different. The title of the topic he had been given was “Characteristics of Sound”, and instead of stating basic facts about sound, he “set forth the partial differential equation of a vibrating rod and solved it using Fourier analysis, finding the eigenvalues and eigenfrequencies. The entire essay continued on this level which would have been creditable for a doctoral examination.” The man writing these words was the 17-year-old’s future student, friend and Nobel laureate, Emilio Segre. The student was Enrico Fermi. The examiner was so startled by the originality and sophistication of Fermi’s analysis that he broke precedent and invited the boy to meet him in his office, partly to make sure that the essay had not been plagiarized. After convincing himself that Enrico had done the work himself, the examiner congratulated him and predicted that he would become an important scientist.

Twenty five years later Fermi was indeed an important scientist, so important in fact that J. Robert Oppenheimer had created an entire division called F-Division under his name at Los Alamos, New Mexico to harness his unique talents for the Manhattan Project. By that time the Italian emigre was the world’s foremost nuclear physicist as well as perhaps the only universalist in physics – in the words of a recent admiring biographer, “the last man who knew everything”. He had led the creation of the world’s first nuclear reactor in a squash court at the University of Chicago in 1942 and had won a Nobel Prize in 1938 for his work on using neutrons to breed new elements, laying the foundations of the atomic age. Read more »

No Such Lies: The Novels of Charles Wright

by Joan Harvey

The radio music is smooth now, sentimental, semi-classic in the popular vein…music something like a golden bell, promising that tomorrow will be better. Jazz, good jazz, tells no such lies.  —Charles Wright, The Messenger

Recently, in an independent bookstore in a city I was visiting, one of the books I randomly scooped up to weigh down my luggage on the way home was The Collected Novels of Charles Wright, with an introduction by Ishmael Reed. The confusing thing was, had I heard of him? It seemed to me that of course I had, but there is a famous American poet named Charles Wright and this is not that man. There was also of course Richard Wright; the first novel in this collection is dedicated in part to him. There’s Charles White, the artist, whose work I happened to see on this same trip. But the Charles Wright of these novels is Charles Stevenson Wright (1932-2008). I later looked this collection up on Amazon. There are zero reader reviews of this edition. The last copyright before this was 1993. And yet he’s back in print, or still in print; there are editions of the novels separately. Very little has been written about him. Yet Wright’s writing felt familiar, as if he were an old friend.

The collection contains Wright’s three novels. The first, The Messenger, is from 1963, The Wig from 1966, and Absolutely Nothing to Get Alarmed About from 1973. The Wig is satirical and fictional; Reed cites it as an influence. Some think it is a better book than the other two, which are mostly made of vignettes of Wright’s direct experience. I prefer the more autobiographical books that bookend the satire. In Absolutely Nothing Wright mentions having a drink with Langston Hughes in the Cedar Tavern just before Hughes died. Wright remembers Hughes saying, “The Wig disturbed me, and it’s a pity you can’t write another one like it. But don’t. Write another little book like The Messenger” (278). Although The Wig is a scathing and often brilliant satire, I think Hughes was right. Read more »

Why I’ll change how I talk to my students about proof

by Jeroen Bouterse

I have some very simple New Year’s resolutions, and some that require an entire column to spell out. One example of the latter is that I want to make a subtle but meaningful change in how I talk to my (middle and high school) math students about proofs.

First, I need to be open about the fact that talking about proof in mathematics comes with an especially strong impostor syndrome: as a secondary school teacher, who am I to talk about the nature and limits of deductive reasoning in a discipline of which I have barely scratched the surface? I know high school proofs of high school mathematical concepts; I am vaguely aware that people much cleverer than I have tried to reduce all mathematical claims to analytical (logical) truths, or at least to a limited set of axioms; and I believe that after having mentioned this, I have to name-drop Gödel as the person who has supposedly put a stop to these projects, even though I have never studied his incompleteness theorem and doubt I would be able accurately to judge its relevance and meaning. That’s about it.

Usually, doubts like these are something to keep hidden in a light-hearted column like this, because they waste space and look self-absorbed. In this case, however, I think they are relevant, because I suspect I will not be the only one who (1) is by no means an expert on mathematical logic, and (2) still has some intuitive convictions about the special relation between mathematics and provability. Most of us, when we think about mathematics and proof, think of high school or undergraduate mathematics. I think it is fair to say that this is the most culturally prominent face of mathematics: the concepts almost all of us have been taught, or at least heard about, and the discourses surrounding the teaching of those concepts.

These discourses will depend in part on the teachers you have encountered, but I’ll go out on a limb here and speculate that most mathematics teachers will have told most of their classes, at some point, that “in mathematics we believe things because we can prove them”. I know I have made comments in that spirit. I have also come to feel a bit uncomfortable about them. Let me tell you why. Read more »

The Cancer Questions Project, Part 25: Stavroula Kousteni

Stavroula Kousteni, is the Associate Professor of Medicine in Physiology and Cellular Biophysics at Columbia University Medical Center. The goal of her research is to understand the influence of the skeleton on various physiological processes, to uncover the pathogenesis of degenerative diseases and to suggest therapies for them. She is currently examining the role of osteoblasts in hematopoiesis with particular emphasis in myelodysplasia (MDS) and acute myeloid leukemia (AML). Her lab has discovered the skeletons role as an inducer of leukemogenesis, identifying a mutation in osteoblasts that disrupts hematopoiesis leading to leukemogenic transformation of hematopoietic stem cells (HSCs) and establishment of MDS progressing to AML. Additionally, she has helped establish the role of osteoblasts in the engraftment of leukemia blasts. She is currently characterizing the signaling pathway that mediates these actions to manipulate osteoblasts to make the hematopoietic niche hostile to residual leukemia cells.

Azra Raza, author of The First Cell: And the Human Costs of Pursuing Cancer to the Last, oncologist and professor of medicine at Columbia University, and 3QD editor, decided to speak to more than 20 leading cancer investigators and ask each of them the same five questions listed below. She videotaped the interviews and over the next months we will be posting them here one at a time each Monday. Please keep in mind that Azra and the rest of us at 3QD neither endorse nor oppose any of the answers given by the researchers as part of this project. Their views are their own. One can browse all previous interviews here.

1. We were treating acute myeloid leukemia (AML) with 7+3 (7 days of the drug cytosine arabinoside and 3 days of daunomycin) in 1977. We are still doing the same in 2019. What is the best way forward to change it by 2028?

2. There are 3.5 million papers on cancer, 135,000 in 2017 alone. There is a staggering disconnect between great scientific insights and translation to improved therapy. What are we doing wrong?

3. The fact that children respond to the same treatment better than adults seems to suggest that the cancer biology is different and also that the host is different. Since most cancers increase with age, even having good therapy may not matter as the host is decrepit. Solution?

4. You have great knowledge and experience in the field. If you were given limitless resources to plan a cure for cancer, what will you do?

5. Offering patients with advanced stage non-curable cancer, palliative but toxic treatments is a service or disservice in the current therapeutic landscape?

All Those Yesterdays That Built Today

by Thomas O’Dwyer

An 1820 print celebrating the execution of the English Cato conspirators.
An 1820 print celebrating the execution of the English Cato conspirators.

We still recall the 1920s as the Roaring Twenties or the Jazz Age. Not many will know that the decade which began 200 years ago with U.S. President James Monroe in office was the Era of Good Feelings, a name coined by a Boston newspaper. In 1820, a presidential election year, Monroe ran for his second term — he was unopposed, so there was really no campaign. He won all the electoral college votes except one, narrowly leaving George Washington to remain as the only president ever to score a unanimous victory.

In the flood of commentary, prophecy, gloom, and nostalgia that has greeted the start of a new decade, many of the comparisons with the past have fixed on the 1920s. That age is almost within living memory, maybe not personal, but at least familial, through the reminiscences and records of parents or grandparents. And for the first time in human history, we have extensive evidence in sound, film, and photography from the fascinating 1920s.

But is also interesting to look even further back, another 100 years, to the 1820s. For here, most people can agree, lie the true roots of the science-driven modernity that was more spectacularly obvious in the 1920s and beyond. Full documentary records in the 1820s were sparse but growing. Nicephore Niepce developed the first photograph in 1826 but sound reproduction would have to wait another 50 years for Thomas Edison. The first moving-picture sequence was made by Frenchman Louis le Prince in 1888. The new inventions and discoveries of the 1820s were physically primitive, but loaded with hidden significance and promise that no one could have guessed. Read more »