Drug-Resistant Malaria Is Emerging in Africa. Is the World Ready?

Pratik Pawar in Undark:

In June 2017, Betty Balikagala traveled to a hospital in Gulu District, in northern Uganda. It was the rainy season: a peak time for malaria transmission. Balikagala, a researcher at Juntendo University in Japan, was back in her home country to hunt for mutations in the parasite that causes the disease.

For about four weeks, Balikagala and her colleagues collected blood from infected patients as they were treated with a powerful cocktail of antimalarial drugs. After initial analysis, the team then shipped their samples — glass slides smeared with blood, and filter papers with blood spots — back to Japan.

In their lab at Juntendo University, they looked for traces of malaria in the blood slides, which they had prepared by drawing blood from patients every few hours. In previous years, Balikagala and her colleagues had observed the drugs efficiently clearing the infection. This time, though, the parasite lingered in some patients. “We were very surprised when we first did the parasite reading for 2017, and we noticed that there were some patients who had delayed clearance,” recalled Balikagala. “For me, it was a shock.”

More here.



Russia Has Been Warning About Ukraine for Decades, The West Should Have Listened

Anatol Lieven in Time:

When I was a journalist for The Times (London) in Moscow in December 1992, I saw a print-out of a speech by the then Russian foreign minister, Andrei Kozyrev, warning that if the West continued to attack vital Russian interests and ignore Russian protests, there would one day be a dangerous backlash. A British journalist had scrawled on it a note to an American colleague, “Here are more of Kozyrev’s ravings.”

Andrei Kozyrev was the most liberal and pro-Western foreign minister Russia has ever had. As he stated in his speech, his anxiety about Western behavior was rooted in fear that the resulting backlash would destroy liberalism in Russia and Russian co-operation with the West. He was proved right as we see today. Yet when he expressed this fear, in entirely moderate and rational terms, he was instinctively dismissed by western observers as virtually insane.

The point about this history is that the existing crisis with Russia has origins that go far beyond Putin.

More here.

Tuesday, February 1, 2022

Huw Price reviews Cheryl Misak’s biography of Frank Ramsey

Huw Price at the Springer website:

Cheryl Misak’s new book is the first intellectual biography of Frank Plumpton Ramsey, a brilliant but tragically short-lived scholar who illuminated Cambridge in the 1920s. The biography has been eagerly awaited by many of us, in several fields, who’ve built chunks of our own careers from fragments of Ramsey’s astonishing meteorite.

In my case, eagerness came with a few nerves. Ramsey has been a huge figure in my philosophical life. Might my image of him get bruised in some way? I also had a grandfatherly concern about the book itself. By happy accident, I’d helped to steer Misak’s intellectual trajectory towards this project. Like any grandfather, I was anxious for the child to shine.

More on the fate of those anxieties below. I first heard about Ramsey from the Cambridge philosopher, D. H. (Hugh) Mellor (1938–2020). In another happy accident, Mellor was once a huge influence on my intellectual trajectory. In 1975 I was an undergraduate at Australian National University (ANU), Canberra, studying philosophy as a sideline to mathematics. Mellor was visiting ANU, and sat in on some of our teaching seminars. His kind interest in my future plans helped to steer me towards a PhD in philosophy, and to Cambridge to do it (under his supervision).

More here.

Memory involves the whole body; It’s how the self defies amnesia

Ben Platts-Mills in Psyche:

When you wake up in the morning, how do you know who you are? You might say something like: ‘Because I remember.’ A perfectly good answer, and one with a venerable history. The English philosopher John Locke, for example, considered memory to be the foundation of identity. ‘Consciousness always accompanies thinking,’ he wrote in 1694. ‘And as far as this consciousness can be extended backwards to any past Action or Thought, so far reaches the Identity of that Person.’

For most of us, the question of where identity comes from doesn’t have much bearing on day-to-day life. We don’t have to try to remember who we are; it just happens. But for the growing number of people who survive brain injury every year, it can be a different story. If you survive an accident or an illness that limits your ability to form new memories, leaving you with what’s called ‘anterograde amnesia’, you might be forced to look elsewhere for your sense of self.

More here.

A Whiff of Munich

Harold James in Project Syndicate:

The Cold War ended 30 years ago. But since the 2007-08 financial crisis, it has not only returned but mutated into a hybrid lukewarm war. And with the United States and its European allies now struggling to manage the threat of a Russian attack on Ukraine, the specter of a hot war is looming. The 1938 appeasement of Nazi Germany has become an attractive historical analogy, since that was the moment when the post-World War I cold war mutated decisively, supposedly making a hot conflict inevitable.

Munich will forever be associated with that moment, because that is where Britain, France, and Italy ceded to Germany substantial territory in Czechoslovakia without consulting either the Czechs or the Soviet Union. This episode has been revisited repeatedly, most recently in Christian Schwochow’s brilliant new film Munich: The Edge of War, based on the novelist Robert Harris’s interesting attempt to rehabilitate British Prime Minister Neville Chamberlain’s reputation.

Now that the Biden administration has offered to hold another summit with Russian President Vladimir Putin, following weeks of abortive negotiations, are we witnessing a replay of Chamberlain’s efforts in Munich?

More here.

Tuesday Poem

A Calling

Over my desk Georgia O’Keefe says
I have no theories to offer and then
takes refuge in the disembodied
third person singular: One works
I suppose because it is the most
interesting thing one knows to do.

O Georgia! Sashaying between
first base and shortstop as it were
drawing a list of all the things
one imagines one has to do . . .
you get the garden planted. You
take the dog to the vet. You
certainly have to do the shopping.

Syntax, like sex, is intimate.
One doesn’t lightly leap from person
to person. The painting, you said,
is like a thread that runs
through all the reasons for all the other
things that make one’s life.

O awkward invisible third person,
come out, stand up, be heard!
Poetry is like farming. It’s
a calling, it needs constancy,
the deep woods drumming of the grouse,
and long life, Like Georgia’s, who
is talking to one, talking to me,
talking to you.

by Maxine Kumin
from
Nuture, Poems by Maxine Kumin
Penguin Book, Ltd, 1989

Translating Olga Tokarczuk

Jennifer Croft at Lit Hub:

Olga Tokarczuk’s twelfth book, the novel The Books of Jacob, first published in Poland in 2014 to great acclaim and considerable controversy, kicks off in 1752 in Rohatyn, in what is now western Ukraine, and winds up in a cave near Korolówka, now eastern Poland, where a family of local Jews has hidden from the Holocaust. Between mid-18th-century Rohatyn and mid-20th-century Korolówka, Olga traverses the Habsburg and Ottoman Empires and the Polish-Lithuanian Commonwealth in search of the manifold secrets of Jacob Frank, a highly charismatic real historical figure, beloved and despised by his contemporaries, the leader of a wildly heretical Jewish sect that converted in different moments to both Catholicism and Islam.

more here.

Céline Sciamma’s Quest for a New, Feminist Grammar of Cinema

Elif Batuman at The New Yorker:

For most of November, 2020, the director Céline Sciamma didn’t have any lamps in her apartment. They were all on the set of her fifth film, “Petite Maman.” Each day, she got ready before sunrise, leaving her Paris apartment in the dark. One morning when she was running late, she rushed into her room and hit something with her foot. It hurt, a lot, but she put on her shoes and hurried to the set, where she sat around for three hours, waiting for everyone else to be ready. Suddenly, she heard a familiar, uneven step behind her: that of her maternal grandmother, Marie-Paule Chiron, who walked with a limp and who had been dead for six years. Sciamma jumped from her chair, remembering too late her injured foot. Instinctively, she reached for the closest support: a silver-topped walking stick that had belonged to Marie-Paule.

The limping woman toward whom Sciamma was limping was, in fact, the actor Margot Abascal, playing a character based on Marie-Paule and wearing the same kind of corrective shoes that she had worn.

more here.

12 Black American Health and Wellness Pioneers

Timothy Frie in AFPA:

February is Black History Month in the US, a month dedicated to paying tribute to Black American history. It is also a month dedicated to raising awareness about the deeply inequitable treatment that Black communities have endured in the US, as well as the incredible contributions Black individuals and communities have made to the wellbeing of all people, despite the disadvantages that exist to this day. This article names twelve of the many Black Americans in history who have had, and continue to have, a profound impact on the health and wellness of people in the US and worldwide.

Dr. Rebecca Lee Crumpler (1831–1895)

Dr. Rebecca Lee Crumpler was the first Black American physician in the United States. She was born in Delaware but raised in Pennsylvania by her aunt, who cared for the sick using knowledge passed down to her by her ancestors. Rebecca attended the West-Newton English and Classical School, a prestigious private school in Massachusetts. Shortly after her graduation, she moved to Charlestown in Massachusetts, where she worked as a nurse by vocation from 1852 to 1860. She had a passion for caring for the ill and boldly applied to the New England Female Medical College in 1860, only ten years after it was founded.

More here. (Note: At least one post throughout the month of February will be devoted to Black History Month. The theme for 2022 is Black Health and Wellness)

We Still Can’t See American Slavery for What It Was

Jamelle Bouie in The New York Times:

The historian Marcus Rediker opens “The Slave Ship: A Human History” with a harrowing reconstruction of the journey, for a captive, from shore to ship:

The ship grew larger and more terrifying with every vigorous stroke of the paddles. The smells grew stronger and the sounds louder — crying and wailing from one quarter and low, plaintive singing from another; the anarchic noise of children given an underbeat by hands drumming on wood; the odd comprehensible word or two wafting through: someone asking for menney, water, another laying a curse, appealing to myabecca, spirits.

An estimated 12.5 million people endured some version of this journey, captured and shipped mainly from the western coast of Africa to the Western Hemisphere during the four centuries of the trans-Atlantic slave trade. Of that number, about 10.7 million survived to reach the shores of the so-called New World.

It is thanks to decades of painstaking, difficult work that we know a great deal about the scale of human trafficking across the Atlantic Ocean and about the people aboard each ship. Much of that research is available to the public in the form of the SlaveVoyages database. A detailed repository of information on individual ships, individual voyages and even individual people, it is a groundbreaking tool for scholars of slavery, the slave trade and the Atlantic world. And it continues to grow.

More here. (Note: At least one post throughout the month of February will be devoted to Black History Month. The theme for 2022 is Black Health and Wellness)

Sunday, January 30, 2022

Rebecca Solnit Is Not Giving Up Hope

John Nichols in The Nation:

Rebecca Solnit, the great essayist of this time, gave us a fresh understanding of George Orwell with her brilliant 2021 book Orwell’s Roses (Viking). But as with all things Solnit, Orwell’s Roses is about a good deal more than its nominal subject: the flowers that the author of Animal Farm and 1984 planted in the garden of a rented cottage in the English village of Wallington. I spoke with Solnit about the need for bread and roses—especially in perilous times. —John Nichols

JN: Why Orwell? Why now?

RS: The book kind of ambushed me. Although I’d known the essay where he described planting those roses well, I’d never thought about what it meant that our great prophet of totalitarianism, the man famous for facing unpleasant facts, was planting roses. It let me talk about all these things that I wanted to talk about—essentially about the left, about how we lead our lives, about what it looks like to lead a sustainable life.

It was only after I met the rose bushes and started reading Orwell’s domestic diaries and letters that I realized that I, like most people, had a misapprehension of him as this grim, pessimistic figure, and that he took immense pleasure in a lot of everyday things, and that’s what kept him going.

More here.

How mRNA and DNA vaccines could soon treat cancers, HIV, autoimmune disorders and genetic diseases

Deborah Fuller in The Conversation:

How can a vaccine treat cancers or chronic infectious diseases?

T cell responses are very important for identifying cells infected with chronic diseases and aberrant cancer cells. They also play a big role in eliminating these cells from the body.

When a cell becomes cancerous, it starts producing neoantigens. In normal cases, the immune system detects these neoantigens, recognizes that something’s wrong with the cell and eliminates it. The reason some people get tumors is that their immune system isn’t quite capable of eliminating the tumor cells, so the cells propagate.

With an mRNA or DNA vaccine, the goal is to make your body better able to recognize the very specific neoantigens the cancer cell has produced. If your immune system can recognize and see those better, it will attack the cancer cells and eliminate them from the body.

More here.

The Science Behind Aesop’s Menagerie

Dan Falk in Undark:

Several chapters into “Aesop’s Animals: The Science Behind the Fables,” zoologist and science writer Jo Wimpenny explains that, as a very young girl, she sometimes wanted to be a dog. (In a footnote she credits growing up in Wales for encouraging her “to think outside the box.”) This childhood fantasy, as the reader can readily imagine, involved crawling along the ground on all fours. But that only gets one part-way toward doghood, as the grown-up Wimpenny would come to realize.

For starters, we humans rely primarily on our senses of sight and hearing, but for dogs, it’s smell that reigns supreme; as she explains, a dog’s sense of smell is somewhere between 10,000 and 100,000 times better than our own. Dogs “can also wiggle their nostrils independently, helping them to pinpoint the direction of a smell,” and there’s some evidence that the left and right nostrils serve slightly different purposes, with the right tuned to “novel and potentially threatening smells,” and the left responding to “familiar, non-aversive smells (such as food) and scent from other species (such as human sweat for tracking purposes).” Who knew?

More here.

Across the Muslim World, Islamism is Going out of Vogue

Imran Said in Quillette:

Though the Taliban has once again taken power in Afghanistan, they have come back at a rather inopportune time. Across the Muslim world, many seem to be souring on Islamists, defined as those who derive legitimacy from Islam and advocate for modern states to be governed along Islamic precepts, both economically and judicially. Over the last few years, Islamist governments have fallen out of power across the Middle East and Africa, haemorrhaged support in Turkey, and failed to make headway in Southeast Asia.

Islamism was once seen as an unstoppable force throughout most of the Muslim world, its proponents representing the most organized and influential voices in opposition to the often corrupt and incompetent secular leadership of Muslim countries. In more authoritarian states, mosques regularly served as one of the few “safe spaces” for citizens to vent their disenchantment about the state of society, ensuring the institutions of Islam a prominent place in the larger anti-statist opposition. Many Islamist groups further amass popular support by filling the gap left behind by woefully inadequate welfare systems and, in turn, providing their own social services, including schools and hospitals.

More here.

Sunday Poem

Repent

A visual delight,
the killer whale.
Two-tone black and white
from snout to tail.
Worth hunting deep at sea.

And when we’ve captured two or three
we pen them in a little jail
and teach them tricks
to do for fishy snacks
for paying multitudes who fill

the stands and scream to see
these mammals leap in synchrony,
who cruise a hundred miles a day
when free
beneath the bounding main.

Occasionally from the strain
they turn upon the rubber-suited crew
who labor so to train
them to cavort on cue,
and even maim a few.

Stu-
pidity, said
Immanuel Kant
is caused by a wicked
heart. Repent

by Maxine Kumin
from
Nurture; Poems by Maxine Kumin
Viking Penguin Inc., 1989