Natalia Mesa in The Scientist:
Without the trillions of bacteria in the gut, muscles might not be able to knit themselves back together after an injury. According to a study published February 22 in Immunity, T cells that normally reside in the mouse colon play a crucial role in tissue regeneration—and rely on gut microbes to do so. Without these helpful microbes, the study suggests, inflammation could get out of control, preventing healing and causing fibrosis. “The main message of the paper is that the microbiota is influencing your immune system and your general health in a way larger way than we appreciated before,” says Bola Hanna, an immunologist at Harvard Medical School. Hanna studies regulatory T cells, a class of immune cells found in tissues throughout the body. He describes regulatory T cells as the “peacekeepers” of the immune system because they rein in other immune cells, ensuring inflammation doesn’t get out of control.
“To find that immune cell populations that are modified [in the gut] . . . have systemic effects and influence physiological and pathophysiological processes that occur elsewhere is obviously of major interest,” says Alexander Rudensky, an immunologist at Memorial Sloan Kettering Cancer Center who was not involved in the study. “It sets the stage to explore further other aspects of physiology that can be affected by the cells generated in the intestine.”
More here.
The specter of being trapped in a world of illusions has haunted humankind much longer than the specter of A.I. Soon we will finally come face to face with Descartes’s demon, with Plato’s cave, with the Buddhist Maya. A curtain of illusions could descend over the whole of humanity, and we might never again be able to tear that curtain away — or even realize it is there.
Between 1910 and 1940, thousands of Chinese immigrants were detained—sometimes for months—in facilities on Angel Island, off the coast of San Francisco.
A record outbreak of 
The very deepest worries center around the question of AGI, Artificial General Intelligence, and the question of the Singularity. AGI is a form of artificial intelligence so advanced that it could understand the world at least as well as a human being in every way that a human being can. It is not too far a step from such a possibility to the idea of AGIs that can produce AGIs and improve both upon themselves and further generations of AGI. This leads to the Singularity, a point at which this production of super-intelligence goes so far beyond that which humans are capable of imagining that, in essence, all bets are off. We can’t know what such beings would be like, nor what they would do. Which sets up the alignment problem. How do you possibly align the interests of super intelligent AGIs with those of puny humans? And as many have suggested, wouldn’t a super intelligent self-interested AGI be rather incentivized to get rid of us, since we are its most direct threat and/or inconvenience? And even if super AGIs did not want to exterminate humans, what is to ensure that they would care much what happens to us either way?
There are certain sweet-smelling, sugarcoated lies current in the world which all politic men have apparently tacitly conspired together to support and perpetuate. One of these is that there is such a thing in the world as independence: independence of thought, independence of opinion, independence of action.
Scientists who study happiness know that being kind to others 
It’s all wrong. The wrongness is pervasive; you could not, if asked, identify the it or the its that went wrong. Wrongness leaches into everything, like the microplastics you read about, which may or may not be reducing sperm count in men, which may or may not be good, in the long run—it’s something to do with the environment. Someone wanted you to feel one way or the other about it, but you can’t remember who or why or whether you agreed with him. Everyone speaks so authoritatively, whether it’s on the evening news or a podcast, in an Internet video or a book, or even in one of those Twitter threads that begins (irksomely, you once felt, but now you don’t notice) with the little picture of a spool. Authority makes them all sound the same; it crosses all their faces and leaves many of the same furrows. Only afterward, trying to add it all up, do you half-remember that none of them agreed with each other. But the wrongness you can be sure of. It is like God, undergirding all things.
The creators have used a combination of both Supervised Learning and Reinforcement Learning to fine-tune ChatGPT, but it is the Reinforcement Learning component specifically that makes ChatGPT unique. The creators use a particular technique called Reinforcement Learning from Human Feedback (RLHF), which uses human feedback in the training loop to minimize harmful, untruthful, and/or biased outputs.
For years, philanthropists have poured money into progressive climate groups, while 
After I’d wandered the grounds, I spent the weekend in Oxford, a heady experience for a Northern fetishist of things Southern. I ate catfish and grits, drank whiskey in a bar on the outskirts of town where old men in hats played guitars. I visited Faulkner’s grave and his birthplace, drove around the Mississippi hill country, and ate okra with congenial strangers. I tried to understand why I felt drawn to this part of the world. To that end, I drank whiskey in a second bar, this one downtown, overlooking the statue of the Confederate soldier who gazed “with empty eyes,” in Faulkner’s phrase, at the square. I decided the reason was this. I grew up in Amherst, a mile down the road from Dickinson’s house, and Massachusetts is the Mississippi of the North, Mississippi the Massachusetts of the South. They’re on opposite sides of the American political spectrum, but they’re both places where the present is dwarfed and chastened by the past. In Massachusetts, a given location is known as the spot where the minutemen faced the redcoats on the green, or where Jonathan Edwards delivered his sermon “Sinners in the Hands of an Angry God,” or where the Mayflower landed, or where the whalers set sail, or where the tea was dumped in the harbor. In Mississippi, it’s the same: here’s where Grant’s army bivouacked; here’s where the formerly enslaved Union soldiers drove the Texans from the field; here’s where Elvis grew up; here’s where Emmett Till was murdered; here’s where the earliest blues music was performed. I’ve heard both Massachusetts and Mississippi maligned as boring, and I’ve tried to explain to the maligners: You need to stop living so much in the present.