Letters by Oliver Sacks – sex and motorcycles

Ralf Webb in The Guardian:

In 1960, Oliver Sacks, a 27-year-old University of Oxford graduate, arrived in San Francisco by Greyhound bus. Born in Cricklewood, London, Sacks spent the better part of his 20s training to be a doctor, but came to feel that English academic medicine was stifling and stratified. A “tight and tedious” professional ladder, he thought, was the only one available to aspiring neurologists like him.

A young queer man with a growing interest in motorcycle leather, Sacks had other reasons to leave. The revelation of his sexuality had caused a family rift: his mother felt it made him an “abomination”. And so he looked for escape across the Atlantic. America, for him, was the wide open west of Ansel Adams photographs; California was Steinbeck’s Cannery RowThe new world promised “space, freedom, interstices in which I could live and work”. This is how we meet Oliver Sacks in Letters: as an immigrant undertaking an internship at Mount Zion hospital, the first step in a career on US soil that would span another five decades.

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Do stem-cell transplants increase cancer risk?

Smriti Mallapaty in Nature:

Ever since the first blood-forming stem cells were successfully transplanted into people with blood cancers more than 50 years ago, researchers have wondered whether they developed cancer-causing mutations. A unique study1 on the longest-lived transplant recipients and their donors has revealed that people who receive donor stem cells don’t seem to have an increased risk of developing such mutations. The results are surprising but reassuring, says Michael Spencer Chapman, a haematologist at the Barts Cancer Institute in London.

“It’s fantastic news for people undergoing these therapies,” says Alejo Rodriguez-Fraticelli, a quantitative stem-cell biologist at the Institute for Research in Biomedicine in Barcelona, Spain. Blood-forming, or ‘haematopoietic’, stem cells are precursor cells that reside in the bone marrow and give rise to all types of blood cell. They have been used to treat hundreds of thousands of people with blood cancers and bone-marrow diseases. The transplants involve depleting a person’s entire blood stem-cell reserves and replacing them with cells from a healthy donor. But researchers have long worried that putting the cells under such pressure could increase the risk of cancer. In rare cases, about 1 in every 1,000 transplants, donor cells develop into a cancer in the recipients.

More here.

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The 18th Edition Of “The Chicago Manual of Style.”

Peter B. Kaufman at the LARB:

THE YEAR IS 1906. Theodore Roosevelt is in the White House. In New York, the newspapers are reporting on the political aspirations of William Randolph Hearst, unrest in Russia, and the latest dividends from US Steel. Scientific American is running articles about exploring the Sargasso Sea. In Boston, The New England Journal of Medicine is discussing new treatments for typhus and tuberculosis. Upton Sinclair’s new novel The Jungle, recently out from Doubleday, portrays the oppressive working conditions in Chicago’s meatpacking industry—Jack London calls it “the Uncle Tom’s Cabin of wage slavery”—and it’s taking the country by storm. In October, the Chicago White Sox play the Cubs in the country’s first intracity World Series, which the Sox go on to win (in a massive upset) four games to two.

That fall, the University of Chicago Press also publishes the first edition of The Chicago Manual of Style. For 15-plus years, from the days of the press’s founding in 1890, the editors had been circulating guidelines and style sheets of best practices for their own editorial and production staff. Over the summer, they decide to see if there might be more general interest in, and demand for, these rules outside of the press, so that members of the broader public can better communicate with each other through print.

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Pedro Almodóvar’s Conflict Of Interests

Leo Robson at The New Statesman:

In various ways, Pedro Almodóvar’s terrific new film represents a culmination or point of arrival. The Room Next Door, winner of the Golden Lion at the Venice Film Festival, marks the director’s first time working in English and telling a story set entirely outside Spain. It is also a clear admission – from a film-maker strongly associated with costume, production design and bodies – of an essential bookishness: his belief, expressed in his recently published collection of stories The Last Dream, that his vocation is “literary”, and it’s merely a quirk of fate that the bulk of his written output has been 22 screenplays, which he also directed. The film concerns two writers, Ingrid, a war reporter suffering from cancer (Tilda Swinton), and Martha (Julianne Moore), a novelist with whom Ingrid spends her final weeks. Though Almodóvar does away with many of the reference points in the source material, Sigrid Nunez’s novel What Are You Going Through, he introduces plenty of his own. The Room Next Door opens at a Manhattan bookshop, where Martha is doing a signing, and ends with a quotation from “The Dead” – and it isn’t the only bookshop, or mention of James Joyce.

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Thursday, October 24, 2024

Notes From The Progress Studies Conference

Scott Alexander at Astral Codex Ten:

Tyler Cowen is an economics professor and blogger at Marginal Revolution. Patrick Collison is the billionaire founder of the online payments company Stripe. In 2019, they wrote an article calling for a discipline of Progress Studies, which would figure out what progress was and how to increase it. Later that year, tech entrepreneur Jason Crawford stepped up to spearhead the effort.

The immediate reaction was mostly negative. There were the usual gripes that “progress” was problematic because it could imply that some cultures/times/places/ideas were better than others. But there were also more specific objections: weren’t historians already studying progress? Wasn’t business academia already studying innovation? Are you really allowed to just invent a new field every time you think of something it would be cool to study?

It seems like you are. Five years later, Progress Studies has grown enough to hold its first conference. I got to attend, and it was great.

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Realistically, how much damage could Trump do to the U.S. economy?

Noah Smith at Noahpinion:

Twenty-three Nobel-winning economists just signed a letter saying that Trump’s economic policies would be bad for the country. Some excerpts:

While each of us has different views on the particulars of various economic policies, we believe that, overall, Harris’s economic agenda will improve our nation’s health, investment, sustainability, resilience, employment opportunities, and fairness and be vastly superior to the counterproductive economic agenda of Donald Trump.

His policies, including high tariffs even on goods from our friends and allies and regressive tax cuts for corporations and individuals, will lead to higher prices, larger deficits, and greater inequality…By contrast, Harris has emphasized policies that strengthen the middle class, enhance competition, and promote entrepreneurship. On issue after issue, Harris’s economic agenda will do far more than Donald Trump’s to increase the economic strength and well-being of our nation and its people.

Simply put, Harris’s policies will result in a stronger economic performance, with economic growth that is more robust, more sustainable, and more equitable.

I don’t have quite as much confidence in Harris’ economic policy program as these top economists do — I’m worried about the amount of debt it would incur — but she definitely does want to promote entrepreneurship and enhance competition. And I would expect her to continue Biden’s industrial policies, which (as regular readers all know) I am a huge fan of.

When it comes to the dangers of Trump’s policy program, I’m pretty much in complete agreement with what the economists say here. But I think it’s useful to lay out what I think the risks of these policies are, and which ones we should be especially worried about.

More here.

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Animals’ Understanding of Death Can Teach Us About Our Own

Susana Monso in Time Magazine:

In 2018, field researchers in Uganda came across an unusual sight: a female chimpanzee carried an infant that she had recently given birth to, and which was affected by albinism, an extremely uncommon condition in this species that gives their fur a striking white color. Chimpanzee mothers often remove themselves from the group to give birth, which protects their babies from the infanticides that are sadly frequent in this species. The researchers seemed to have caught this mother on her return to the group. Sure enough, they were soon able to document the reactions of her mates when they first encountered the infant and his distinctive look.

The behaviors they saw were far removed from the curiosity and care that newborns tend to elicit: instead, the chimpanzees reacted with what looked like extreme fear, with their fur on end and emitting the kinds of calls that signal potentially dangerous animals, such as snakes or unknown humans. Shortly after, violence ensued, and the alpha male together with a few of his allies killed and dismembered the little one. Upon his death, the behavior of the chimpanzees radically changed, and the apes, overtaken by curiosity, began to investigate the corpse: sniffing it, poking it, tugging at its fur and comparing it to their own, entranced by this being who smelled like a chimp but looked so different.

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Thursday Poem

Traffic Stop

The officer asked, Do you know why
I pulled you over? So I tried to explain about the correlation
between an unhappy childhood and the need

to pull, about how Elon Musk invented Teslas
because we’re all characters
in Grand Theft Auto, about needing to outrun

my future, but he wanted to see my license and registration
so I pointed at his chest with my gold finger (in the shape of a gun)
showed him the Valentine’s cards stuffed in my glovebox

handed him a snapshot of my border collie at the beach
because a badge needs a quota like a chew toy
needs a puppy, but he asked me to step

out of the car, put the world in a backwards spell,
touch my eyes with my nose
closed, so I put on my blue

shoes, walked heel to toe,
cartwheeled for the crowd, asked
if he could share his body-

cam video on my wall, which is to say I promised
to donate a kidney for the Policeman’s Ball, which is to say I signed
his autograph book

and as he rolled away, the radio played,
there will be an answer, let it be, let it be.

by Pankaj Khemka
from Tribute to Indian Poets
Rattle Magazine #73, Fall 2021

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The Ontology of Social Norms

Kevin Richardson at Notre Dame Philosophical Reviews:

It is incredibly difficult to say something new about social norms. The question “What is a social norm?” has been given many detailed answers by philosophers and social scientists. Social norms are often theorized as rules of some kind; most of the ensuing literature concerns the nature of such rules and how they are established or maintained. Despite the mountain of literature on social norms, Charlotte Witt’s Social Goodness not only makes an original contribution to the literature, but it also does so in a way that points toward important, underexplored regions of conceptual space.

The traditional philosophical question about social norms is: what is a social norm? In Social Goodness, Witt asks a different question: what is the source of social normativity? Alternatively put: what makes social norms binding on us? Witt specifically investigates what she calls social role norms. Teachers ought to teach. Students ought to do their homework. Parents ought to take care of their children. In each case, we have a norm that follows from a social role (teacher, student, parent).

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Wednesday, October 23, 2024

Fear And Loathing In Faulkner Country

Jennie Lightweis-Goff at The Point:

College towns are a little like Vegas. They’re fallen capitals, scourged by development and game-day apartments. The boomer professors got there and built the Museum of the American Rebel; soon after, they withered into Cadaver Bohemias. The Godfather, the department chair who hired me in 2016, was nonetheless confident that I’d assimilate to the sprawling “family” he had helped build there. “Faculty regard Oxford as a suburb of New Orleans,” he told me, referring to the city where I’d lived for more than a decade. “So it won’t be too much of a change.” It was an amiable conversation, in which he assured me he’d hired his first choices for the two posts they’d needed: me as an instructor, and the Superstar writer-in-residence, a bestselling novelist and infamous Twitter provocateur.

On the first day of my visit, I heard someone call Oxford “the Little Easy”; no one has said it to me since. To be fair, I’ve never heard its referent—the Big Easy—used in conversation down South in New Orleans, and I don’t think anyone calls Oxford “the Velvet Ditch,” its alleged nickname, without well-earned embarrassment.

more here.

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Why is academic writing so boring?

Samantha Laine Perfas interviews Leonard Cassuto in The Harvard Gazette:

You start your book by pointing out that all academic writers begin their careers writing for one person: their teacher. Why does that create problems?

This is the primal scene of academic writing: some student writing some paper for some teacher someplace. It happens again and again and is the process by which we are socialized into the community of academic writers.

The distinguishing feature of that primal scene is one that I think gets very little attention, namely that the reader (in this case the teacher) is being paid. You grow up as a writer where your audience is one who can never be bored or discouraged because they’re being paid to read to the end of it. You’re learning in some sense that the reader doesn’t matter that much and that they’re going to be with you no matter what.

This is inevitably the root of many potential bad habits, which can burst into flower as writers become more and more advanced.

More here.

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Pull-Up Diary

Mitchell Morgan Johnson at The Paris Review:

Went back to the gym after ten days out of town. On vacation in Oregon, with my family, I didn’t work out a single time. On the plane home, I watched an episode of Succession with Alexander Skarsgård in it and thought, I’d like to look like him. He probably works out even when he’s on vacation. But he’s rich, of course, and likely does other extreme things like steroids and blending chicken into smoothies. Still I would like to look more like Alexander Skarsgård than I currently do. I’m 6’3, almost his height, but far skinnier.

Today I felt weaker than before the trip, but maybe that was in my head. I set the assisted pull-up machine to sixty pounds and could complete only four before my arms gave out. I moved on, humbled, to the leg press. I’ve googled “how to do a pull-up” a few times, which has inspired Instagram to start showing me Reels about it. One man with shoulders like cantaloupes explains proper technique. Arms no narrower than shoulder width, he says. You don’t want your body just dangling loosely in space.

more here.

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Sean Carroll’s Mindscape Podcast: Doyne Farmer on Chaos, Crashes, and Economic Complexity

Sean Carroll at Preposterous Universe:

A large economy is one of the best examples we have of complex dynamics. There are multiple components arranged in complicated overlapping hierarchies, out-of-equilibrium dynamics, nonlinear coupling and feedback between different levels, and ubiquitous unpredictable and chaotic behavior. Nevertheless, many economic models are based on relatively simple equilibrium principles. Doyne Farmer is among a group who think that economists need to start taking the tools of complexity theory seriously, as he argues in his recent book Making Sense of Chaos: A Better Economics for a Better World.

More here.

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