What Do I Get the Person Who Needs Nothing?

T Magazine in The New York Times:

“My friend is a late-in-life medical student with a graduate degree in art history. His hobbies include feeling sad on rainy nights, wearing expensive pajamas and reading the same John Cheever stories over and over again. He knows every smoking-allowed dive bar in Philadelphia. He sculls before class, plays tennis on the city courts and has an encyclopedic knowledge of Bill Evans recordings. His favorite things are small, impractical and impossible to find: a paperback edition of Lydia Davis’s “The Cows,” a pair of hand-painted Qajar dynasty equestrian tiles and a trompe l’oeil pen holder in the shape of a daikon radish.” — Michael, Philadelphia; budget: $75 to $100

If I hadn’t been hypnotized to quit smoking in 2019, I’d have sworn you were describing me. I, too, love being a sad little cozy snob. Just last night, as Smog played quietly in the background and my dog, whose name is Ennui, slept on my lap, I was reading Elif Batuman’s “The Idiot” in a waffle robe and Hästens slipper boots. At the risk of oversharing, I will admit that I was running the hair dryer, which I often use to warm my bare legs and feet. For lighting cigarettes or candles, I’d give your friend one of two lighter holders: a brightly colored plastic sheath from Resin at the Disco or a more opulent option by the New York-based jewelry brand Fry Powers, which comes in 14-karat gold, sterling silver or unlacquered brass and was inspired by the work of the Italian architect and designer Gio Ponti. (Your friend sounds a bit like a Bret Easton Ellis character — a compliment — so the second option might be your better bet.) When I’m indulging in the emptiness of adulthood, I like to rewatch the movies that formed me: earlier this year, the Criterion Collection released Gregg Araki’s “Teen Apocalypse” Trilogy — “Totally F***ed Up” (1993), “Doom Generation” (1995) and “Nowhere” (1997) — as a box set. It’s the perfect eye roll to everyone and everything. (If he doesn’t have a DVD or Blu-ray player, how about a one-year subscription to the Criterion Channel?) For an alternative to a novel, I suggest “Cat Full of Spiders,” a guidebook and tarot deck by the actress Christina Ricci. Each of the 78 cards is illustrated with one of her many mordant characters. Finally, since your friend likes trompe l’oeil, I think he might enjoy this 3-D-printed plastic wallet, which the artist Stefan Gougherty has hand-detailed to look like a cuneiform tablet. If that won’t impress him, try a hair dryer. (For my money, there’s none better than the Dyson Supersonic in Prussian blue.) — Nick Haramis

More here.

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Alex Ross at The New Yorker:

Dmitri Shostakovich’s Fifth Symphony, one of the mainstays of the twentieth-century orchestral repertory, ends with an unapologetic display of musical bombast. The coda consists of thirty-five triple-forte bars in the key of D major, anchored on grandiloquent, fanfare-like gestures in the brass. The strings saw away at the note A, playing it no fewer than two hundred and fifty-two times, the winds piping along with them. The timpani pound relentlessly on D and A, the final notes accentuated by elephantine bass-drum thwacks. It is the pum-pum-pum-pum of “Also Sprach Zarathustra” run amok. The audience invariably springs to its feet.

If Shostakovich had written the Fifth under ordinary circumstances, the coda would present few problems. A bravura, over-the-top finish; end of story. The work arose, however, in 1937, at the time of Stalin’s Terror, and its meanings are profoundly fraught. The previous year, Stalin had conspicuously walked out of a performance of Shostakovich’s “Lady Macbeth of Mtsensk,” and the composer had been castigated in Pravda for practicing decadent formalism. While Shostakovich was at work on the Fifth, one of his highest-ranking supporters, the Soviet general Mikhail Tukhachevsky, had been executed. Not only the composer’s career but also, possibly, his life depended on what he did next.

more here.

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Thursday Poem

Surely We Can

Surely we can talk again,
without using cloven tongues
that lisp and hiss
cleft meanings,
disguising our true intent.

Surely we can smile again,
with teeth washed clean
of each other’s blood,
mould lips into the forgiving kiss
Jesus gave to Judas Iscariot.

Surely we can touch palms again
without losing caste,
hold fast in an embrace
that will keep us face to face
as future friends, not yester-foes.

Surely we can age together,
teach your youth and mine,
what they need to know,
about how close we came
to committing joint infanticide.

Surely we can offer a common prayer
in our separate dialects
to our separate, equal Gods.
Have we not proof enough
that my God is not stronger than yours,
nor yours any stronger than mine?

by Fakir Aijazuddin

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Wednesday, November 27, 2024

“Dietetics”—the relationship between diet, health, and identity

Benjamin Aldes Wurgaft in the Los Angeles Review of Books:

Throughout his career as a historian of science, Shapin has shown that scientific authority rests not simply on established fact but also on what people consider truth—and truth has a fundamentally social character. He has done this in books such as Leviathan and the Air-Pump: Hobbes, Boyle, and the Experimental Life (co-written with Simon Schaffer, 1985), A Social History of Truth: Civility and Science in Seventeenth-Century England (1994), The Scientific Life: A Moral History of a Late Modern Vocation (2008), and the admirably subtitled collection Never Pure: Historical Studies of Science as If It Was Produced by People with Bodies, Situated in Time, Space, Culture, and Society, and Struggling for Credibility and Authority (2010). These works have made him a leading scholar of the Scientific Revolution, which supplies many of his case studies (see Shapin’s The Scientific Revolution, 1996). How do scientists (or “natural philosophers”) earn each other’s trust and the public’s trust? How do they establish what counts as scientific truth, and why do we believe them? These questions go far beyond the institutional settings of the sciences. They extend, Shapin argues in Eating and Being, into our kitchens and dining rooms.

More here.

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Ozempic Could Crush the Junk Food Industry

Tomas Weber in the New York Times:

For decades, Big Food has been marketing products to people who can’t stop eating, and now, suddenly, they can. The active ingredient in Ozempic, as in Wegovy, Zepbound and several other similar new drugs, mimics a natural hormone, called glucagon-like peptide-1 (GLP-1), that slows digestion and signals fullness to the brain. Around seven million Americans now take a GLP-1 drug, and Morgan Stanley estimates that by 2035 the number of U.S. users could expand to 24 million. That’s more than double the number of vegetarians and vegans in America, with ample room to balloon from there. More than 100 million American adults are obese, and the drugs may eventually be rolled out to people without diabetes or obesity, as they seem to tame addictions beyond food — appearing to make cocaine, alcohol and cigarettes more resistible. Research is at an early stage, but they may also cut the risk of everything from stroke and heart and kidney disease to Alzheimer’s and Parkinson’s.

The prospect of tens of millions of people cutting their caloric intake down to roughly 1,000 per day, which is half the minimum amount recommended for men, is unsettling the industry.

More here.

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RFK Jr. should not be at the helm of Health and Human Services, writes former Harvard Medical School dean Jeffrey S. Flier

Jeffrey S. Flier at The Free Press:

The Secretary of Health and Human Services oversees an enormous federal agency in charge of Medicare, Medicaid, federally funded biomedical research, public health, and drug approval. In other words, it’s a very important job—and the health of the American people is in that person’s hands.

In choosing Robert F. Kennedy Jr. for the role, president-elect Donald Trump has made a profound mistake.

That is not because I believe the status quo must be defended.

Those who point out that America is startlingly unhealthy, with outcomes worse than many other developed countries, are right. Look no further than the sorry state of U.S. life expectancy. We have problems—perhaps most of all when it comes to the health of our children—and those problems require solutions.

But the problem with RFK Jr. is not that he wants to change things. It’s that he is uniquely ill-suited to deliver the change that is needed.

More here.

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Did People Ever Stop Believing In The Greek Gods?

Ed Simon at The Hedgehog Review:

By 1140, when the Italian monk Gratian compiled the first collection of ecclesiastical laws, the Corpus Juris Canonici, the last Olympic Games were 747 years in the past, held in the same year that the Oracle of Delphi delivered its last prophecy, a little more than a century before the Byzantine emperor Justinian I closed Plato’s Academy, in 529 CE. Ever since Rome became Christian, starting with its legalization by Constantine I in 313 and then its establishment as the religion of the empire by Theodosius 380, Europe had existed in the long dusk of its classical past, the ancient rites discarded or suppressed, the oracles made mute, the gods gone silent. Yet within Gratian’s compendium, with its stipulations for restitution and penitence, there is a curious section that mandates a “penance for forty days on bread and water” for those who have “observed Thursday in honor of Jupiter.” In another section, there is discussion of the punishment warranted for those caught worshipping Diana, the Roman goddess of the hunt. If these penitentials reflect a reality in the twelfth century, are we then to imagine that in the age of Peter Abelard and Hildegard von Bingen and of the Cathedrals at Notre Dame and Westminster Abbey, that there were people still genuflecting before Jupiter?

more here.

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Wednesday Poem

Journey to the End of the Mind

There in the park where I played as a kid
I saw them painting the brown grass green.
Just us early risers and the unfolding of the nascent day—
the clustered clarity of it all impinging trenchantly
on my slowly developing take of things
so early in the morning—
Entering into commerce I saw those who were unable
doing the best they could—
compromised by issues which they’ll never overcome
but loved nonetheless by someone somewhere—
and there was a twang in the rusty heartstrings.

Later in the darkness I saw something altogether
different—it looked like a searing flame but it was just
the flickering glow of a huge TV—the actualities
dawning, yawning; colored as they were with their
unsettling palette of tempered uncertainty.
Recollecting the future while anticipating the past
I set out to reconcile the paradoxes
only to arrive somewhere else entirely
and undergo the heavyweight realization that the
paradoxes have long since—maybe even always—
been wholly reconciled.

by Mark Terrill
from Empty Mirror

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How Some Cancer Cells Survive Chemotherapy

Sahana Sitaraman in The Scientist:

Glucose is the fuel to the cellular engine. It powers the cell’s functions and serves as the raw material for synthesizing various essential biomolecules, including the sugar backbone of DNA and RNA. It is crucial for the growth and proliferation of all cells in the body, including cancer cells. Yet, cancer cells thrive despite the fact that their surrounding environment—the tumor microenvironment—is severely depleted of glucose.1  In a new study published today (November 26) in Nature Metabolism, researchers at New York University Grossman School of Medicine reported that in the presence of certain chemotherapy drugs, cancer cells rewire their metabolisms to use a glucose-depleted tumor microenvironment to their advantage and escape death.2 “Our study shows how cancer cells manage to offset the impact of low-glucose tumor microenvironments, and how these changes in cancer cell metabolism minimize chemotherapy’s effectiveness,” said Richard Possemato, a cancer biologist and coauthor of the paper, in a press release.

The improved understanding of the tumor microenvironment’s impact on the growth and survival of cancer cells will help guide the development of targeted treatments and predict responses to drugs under specific conditions.

More here.

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Who Can Claim Aristotle?

Edith Hall at Aeon Magazine:

I’m an Aristotle scholar but also an enthusiast for his ideas. I’ve studied his work in the original Greek, and even made a pilgrimage to his birthplace and the various places he lived. He was the most brilliant philosopher ever to have lived. I believe that his Nicomachean Ethics offers us a guide for how to live good lives and flourish. Oddly, though, for a writer whose thinking was so clear and, in many ways, modern, people with radically different stances have tried to claim him for their own.

He often features as a darling of Right-wing ideologues: his Politics is the first text in Benjamin Wiker’s 10 Books Every Conservative Must Read (2010); his authority is invoked on the Breitbart News website. Yet he is celebrated by Marxists for identifying the importance of economic factors in political history, having been heroised in Hugo Gellert’s Karl Marx’ ‘Capital’ in Lithographs (1934). Over the past decade, Aristotle’s face has appeared in Greek wall-art protesting against austerity along with his statement that poverty engenders revolution and crime. On the other hand, his (misinterpreted) views on elites, women and slavery in his Politics are often censured, especially since the advent of ‘cancel’ culture. Yet he has a significant record and potential as a radical and reforming force. This has been overlooked because his views on constitutional issues, the equality of women and even slavery have often been misrepresented, distorted and downright falsified.

more here.

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Tuesday, November 26, 2024

Against The Generalized Anti-Caution Argument

Scott Alexander at Astral Codex Ten:

Suppose something important will happen at a certain unknown point. As someone approaches that point, you might be tempted to warn that the thing will happen. If you’re being appropriately cautious, you’ll warn about it before it happens. Then your warning will be wrong. As things continue to progress, you may continue your warnings, and you’ll be wrong each time. Then people will laugh at you and dismiss your predictions, since you were always wrong before. Then the thing will happen and they’ll be unprepared.

Toy example: suppose you’re a doctor. Your patient wants to try a new experimental drug, 100 mg. You say “Don’t do it, we don’t know if it’s safe”. They do it anyway and it’s fine. You say “I guess 100 mg was safe, but don’t go above that.” They try 250 mg and it’s fine. You say “I guess 250 mg was safe, but don’t go above that.” They try 500 mg and it’s fine. You say “I guess 500 mg was safe, but don’t go above that.”

They say “Haha, as if I would listen to you! First you said it might not be safe at all, but you were wrong. Then you said it might not be safe at 250 mg, but you were wrong. Then you said it might not be safe at 500 mg, but you were wrong. At this point I know you’re a fraud! Stop lecturing me!” Then they try 1000 mg and they die.

The lesson is: “maybe this thing that will happen eventually will happen now” doesn’t count as a failed prediction.

I’ve noticed this in a few places recently.

More here.

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You’re Thinking About Hurricanes All Wrong

Quico Toro at Persuasion:

Are hurricanes getting more intense due to climate change? This is one of those questions that seems straightforward—almost banal—but gets weirder the closer you look into it. The discussion atmospheric scientists are having about the drivers of the trend towards stronger hurricanes has shockingly little in common with the simplified story you get in the press.

The standard media narrative begins by comparing hurricane trends so far this century with the three preceding decades. They stress that sea surface temperatures have risen substantially since the late 20th century, and warm oceans are hurricane fuel: the hotter the ocean, the stronger the storm.

“Warm Air and Warm Oceans Power Storms Like Debby,” ran a New York Times headline this summer. Last week, Axios reported that “Due to warming ocean waters and air temperatures from human emissions of greenhouse gasses, tropical storms and hurricanes are now delivering heavier precipitation than just a few decades ago.”

The message is that there’s a nice, neat, clean relationship: more greenhouse gas emissions means a hotter planet, which means warmer oceans, which means stronger hurricanes.

The end.

But this story isn’t quite right.

More here.

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A firsthand account of homelessness in America

Patrick Fealey in Esquire:

3:00 a.m., parked in a public lot across the street from the town beach in Westerly, Rhode Island. Just woke up, sleep evasive. It’s my first week out here. I pour an iced coffee from my cooler. I’m walking around the front of the Toyota I’m now living in when a car pulls into the lot, comes toward me. I see only headlights illuminating my fatigue and the red plastic party cup in my hand. Must be a cop. Someone gets out and approaches. It is a cop, young. I’m not afraid, exactly, but I’m also not yet used to being homeless.

“How you doing?” he says.

“Good.”

“Just hanging out?”

“Yes.”

“Are you okay?”

“Yes.”

“Do you need anything?”

“No.”

“Okay. Just checking. Have a good night.”

In the morning, I awake with back pain. Sleeping in the driver’s seat will be an acquired skill.

More here.

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Tuesday Poem

Green Midnight

Green midnight at the nightingale’s northernmost border. The heavy leaves
hang entranced deafening the automobiles’ rush towards some neon line.
The path of the nightingale’s voice is not beside the point. It is like a break-through,
like a rooster’s madness, but beautiful and without vanity. I was in prison
and it visited me. I was sick and it attended me. Then I did not heed it,
but I do now. Time’s stream flows down from the sun and moon through
the tick-tock, tick-tockings of all clocks.  But just here, no time exists – only
the nightingale’s voice.  It has the power to ring notes as polished as
the night sky’s scythe of light.

by Tomas Transtromer
“Translation” by Nils Peterson

 

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Where to start with: Hanif Kureishi

Ruvani Ranasinha in The Guardian:

Two years ago, on Boxing Day 2022, novelist and screenwriter Hanif Kureishi suffered a fall in Rome that left him paralysed. Since then, with the help of family members, he has been recounting his devastating experience of “becoming divorced from [himself]” on Substack and in a memoir, Shattered, published earlier this year.

The author, who turns 70 next month, has had to adjust just about everything in his life. But that hasn’t stemmed his creative output: as well as the memoir, this year Kureishi adapted his acclaimed novel The Buddha of Surburbia for stage with the theatre director Emma Rice, which has just finished a second run at the Barbican in London. For those wanting to dive deeper into the author’s work, there’s plenty to explore: from his early essays and screenplays to his novels, memoirs and short stories, Kureishi’s biographer Ruvani Ranasinha suggests some good ways in.

More here.

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