The original anti-vaxxers

Gareth Williams in MIL:

In September 1798 a self-published book with an outlandish premise was about to change the world. At first sight, “An Inquiry into the Cowpox” looked more like a piece of vanity publishing than one of the greatest landmarks in the history of medicine. Its author, a doctor called Edward Jenner, was largely unknown outside rural Gloucestershire. In a 75-page illustrated manual, Jenner explained how people could protect themselves from smallpox – a horrific brute of a disease that killed one person in 12 and left many survivors scarred for life – by inoculating themselves with cowpox, an obscure disease that affected cattle. This extraordinary process was to be known as vaccination, from the Latin for cow.

The “Inquiry” was an instant sensation. Within a few years, vaccination became mainstream medical practice in Britain, Europe and North America, while the King of Spain sent it as a “divine gift” to all the Spanish colonies. By the time Jenner died in 1823, millions had come to regard him as a hero. His admirers included Native Americans, the Empress of Russia (who sent him a diamond ring out of gratitude), and Napoleon, who “could refuse this man nothing” even though France and England were at war. In 1881 Louis Pasteur proposed that the term “vaccination” should be used for any kind of inoculation.

But not everyone thought Jenner was a saint. In 1858 Prince Albert unveiled a statue to Jenner in Trafalgar Square, amid much pomp and circumstance. There was such an outcry that two years later the statue was carted away to a lower-key resting place in Kensington Gardens. Jenner’s earliest and most vocal opponents had been men of the church, who reasoned that smallpox was a God-given fact of life and death. If the Almighty had decided that someone would be smitten by smallpox, then any attempt to subvert this divine intention was blasphemy.

More here.

Woman is first to receive cornea made from ‘reprogrammed’ stem cells

David Cyranoski in Nature:

A Japanese woman in her forties has become the first person in the world to have her cornea repaired using reprogrammed stem cells. At a press conference on 29 August, ophthalmologist Kohji Nishida from Osaka University, Japan, said the woman has a disease in which the stem cells that repair the cornea, a transparent layer that covers and protects the eye, are lost. The condition makes vision blurry and can lead to blindness.

To treat the woman, Nishida says his team created sheets of corneal cells from induced pluripotent stem (iPS) cells. These are made by reprogramming adult skin cells from a donor into an embryonic-like state from which they can transform into other cell types, such as corneal cells. Nishida said that the woman’s cornea remained clear and her vision had improved since the transplant a month ago. Currently people with damaged or diseased corneas are generally treated using tissue from donors who have died, but there is a long waiting list for such tissue in Japan.

More here.

Tuesday Poem

Andromeda

Already the countdown has begun:
four billion years before Andromeda
collides with the Milky Way, rupturing
forever that footpath through the forest

of dreamers’ jewels. I would scoff,
if I did not recall the tracery of fine hairs
swirled across an infant’s skull
like the softest of inbound galaxies.

Andromeda, all your starry wonders
cannot salve the ache of baby teeth
chanced upon, this 2 A.M.,
at the bottom of a bedside drawer.
.

by Campbell McGrath
from
Nouns & Verbs
Harper Collins, 2019

If Mass Poverty is Declining, Why should We Worry about High Inequality?

by Pranab Bardhan

There is widespread concern about increasing or high economic inequality in many countries, both rich and poor. At a global level, according to the World Inequality Report 2018, the richest 1% in the world reaped 27% of the growth in world income between 1980 and 2016, while bottom 50% of the population got only 12%. Over roughly the same period, however, absolute poverty by standard measures has generally been on the decline in most countries. By the widely-used World Bank estimates, in 2015 only about 10 per cent of the world population lived below its common, admittedly rather austere, poverty line of $1.90 per capita per day (at 2011 purchasing power parity), compared to 36 per cent in 1990. This decline is by and large valid even if one uses broader measures of poverty that take into account some non-income indicators (like deprivations in health and education) for the countries for which such data are available.

If absolute poverty is declining, while measures of relative inequality (of income or wealth) show a significant rise (or remain very high), this implies that the conditions of the poor may be improving, but those for the rich may be improving much more. But if people are less poor than before, should we be concerned about high or rising inequality, about how much better-off the rich are, and, if so, why? This is an important question on which more clarity is needed, as quite often when people tell you why they dislike inequality many of the examples they cite are really about their aversion to the stark poverty around them. Read more »

Spooky factions at a distance

by Ashutosh Jogalekar

For me, a highlight of an otherwise ill-spent youth was reading mathematician John Casti’s fantastic book “Paradigms Lost“. The book came out in the late 1980s and was gifted to my father who was a professor of economics by an adoring student. Its sheer range and humor had me gripped from the first page. Its format is very unique – Casti presents six “big questions” of science in the form of a courtroom trial, advocating arguments for the prosecution and the defense. He then steps in as jury to come down on one side or another. The big questions Casti examines are multidisciplinary and range from the origin of life to the nature/nurture controversy to extraterrestrial intelligence to, finally, the meaning of reality as seen through the lens of the foundations of quantum theory. Surprisingly, Casti himself comes down on the side of the so-called many worlds interpretation (MWI) of quantum theory, and ever since I read “Paradigms Lost” I have been fascinated by this analysis.

So it was with pleasure and interest that I came across Sean Carroll’s book that also comes down on the side of the many worlds interpretation. The MWI goes back to the very invention of quantum theory by pioneering physicists like Niels Bohr, Werner Heisenberg and Erwin Schrödinger. As exemplified by Heisenberg’s famous uncertainty principle, quantum theory signaled a striking break with reality by demonstrating that one can only talk about the world only probabilistically. Contrary to common belief, this does not mean that there is no precision in the predictions of quantum mechanics – it’s in fact the most accurate scientific framework known to science, with theory and experiment agreeing to several decimal places – but rather that there is a natural limit and fuzziness in how accurately we can describe reality. As Bohr put it, “physics does not describe reality; it describes reality as subjected to our measuring instruments and observations.” This is actually a reasonable view – what we see through a microscope and telescope obviously depends on the features of that particular microscope or telescope – but quantum theory went further, showing that the uncertainty in the behavior of the subatomic world is an inherent feature of the natural world, one that doesn’t simply come about because of uncertainty in experimental observations or instrument error. Read more »

The Cancer Questions Project, Part 5: Mohandas Narla

Mohandas Narla, D.Sc. is Vice President for Research of New York Blood Center and has authored 340 peer-reviewed publications and 100 review articles and book chapters. His research focuses on red cell physiology and pathology; helping improve understanding of the molecular and structural basis for red cell membrane disorders, developing mechanistic insights into pathophysiology of thalassemias and sickle cell anemia, characterizing structural and functional changes induced in red cells by the malarial parasite, plasmodium falciparum and understanding of erythropoiesis particularly on disordered erythropoiesis in Diamond-Blackfan Anemia and Myelodysplasia. Dr. Narla has been a member of numerous NIH review and advisory panels for the last 30 years and is currently on the editorial boards of numerous journals including Journal of Biological Chemistry, Biochemistry, and Current Opinion in Hematology.

Azra Raza, author of the forthcoming book The First Cell: And the Human Costs of Pursuing Cancer to the Last, oncologist and professor of medicine at Columbia University, and 3QD editor, decided to speak to more than 20 leading cancer investigators and ask each of them the same five questions listed below. She videotaped the interviews and over the next months we will be posting them here one at a time each Monday. Please keep in mind that Azra and the rest of us at 3QD neither endorse nor oppose any of the answers given by the researchers as part of this project. Their views are their own. One can browse all previous interviews here.

1. We were treating acute myeloid leukemia (AML) with 7+3 (7 days of the drug cytosine arabinoside and 3 days of daunomycin) in 1977. We are still doing the same in 2019. What is the best way forward to change it by 2028?

2. There are 3.5 million papers on cancer, 135,000 in 2017 alone. There is a staggering disconnect between great scientific insights and translation to improved therapy. What are we doing wrong?

3. The fact that children respond to the same treatment better than adults seems to suggest that the cancer biology is different and also that the host is different. Since most cancers increase with age, even having good therapy may not matter as the host is decrepit. Solution?

4. You have great knowledge and experience in the field. If you were given limitless resources to plan a cure for cancer, what will you do?

5. Offering patients with advanced stage non-curable cancer, palliative but toxic treatments is a service or disservice in the current therapeutic landscape?

River-Crossing Riddles Through the Ages

by Jeroen Bouterse

Have you ever been in this situation where you had to get a group of 3 men and their sisters across a river, but the boat only held two and you had to take precautions to ensure the women got across without being assaulted?

This problem is one of 53 puzzles in the oldest extant puzzle book in the Western (Latin) tradition: the Propositiones ad acuendos iuventes or problems to sharpen the young. Its authorship is uncertain but it is often and plausibly attributed to Alcuin, who possibly sent them to the Frankish ruler Charlemagne in 800 AD.[1] I hope you will allow me a brief introduction of these puzzles, before I go on to do what I hope will by then be redundant, namely spelling out why I think you should be thrilled by their existence.

Slugs and Pigeons

Alcuin’s puzzles are diverse, but puzzles of the same type often show up more than once. For example, some have us figure out a number based on a multiple of it, provided in a somewhat convoluted manner: a man seeing a certain number of horses and wishing that he possessed that number, and then that number again, and then a quarter more than that, for then he would possess a hundred horses (puzzle 4). There are questions that effectively ask how often a given area fits into another given area, how items can be distributed in discrete quantities given certain conditions, or how long it will take for one animal to overtake another or to cover a given distance. The first puzzle, for instance, has a leech invite a slug over for lunch, only to have us realize that it will take the poor creature centuries to get to its destination. Read more »

Deranged

by Joan Harvey

If you can get the old voting against state-subsidized healthcare, and the poor voting in favor of cuts to inheritance tax, then democratic capitalism really is workable after all. —Malcolm Bull

As the objective view of the world recedes, it is replaced by intuition as to which way things are heading now. —William Davies

Life is short, and I’ve shortened mine /in a thousand delicious, ill-advised ways,/a thousand deliciously ill-advised ways  —Maggie Smith “Good Bones”

Photo by Cristofer Jeschke on Unsplash

Mark Twain, in his wonderful Letters from the Earth, nails the essence of human unreason. It’s not just the creation story with a talking snake, but how man has conceived of heaven, at least in Christianity.

[H]e has imagined a heaven, and has left entirely out of it the supremest of all his delights, the one ecstasy that stands first and foremost in the heart of every individual of his race—and of ours—sexual intercourse!

It is as if a lost and perishing person in a roasting desert should be told by a rescuer he might choose and have all longed-for things but one, and he should elect to leave out water!

A singing, harp-playing heaven is, as Twain points out, like the most boring church service ever, and for eternity. Yet this was the creative fantasy the main religion of the West landed on, and people for years somehow bought it. (The Islamic version is perhaps closer to what Twain had in mind, but still an extraordinarily shabby version of the imagined possible). If people are going to imagine an afterlife, not only could they be having sexual intercourse as much as they want with whoever they want with no negative consequences, but they could easily take it farther, giving themselves many more sex organs and erogenous zones and pleasures that put orgasms to shame. (I’m sure science fiction writers have gone there with no problem). Throw in some great powder skiing for me between bouts in the sack, and no knee pain. And for those who don’t like sex or don’t want it all the time, let heaven be whatever they like, endless gourmet meals with no weight gain, fantastic chess matches in Turkish baths, conversation with their philosopher heroes, horseback riding on perfect steeds. Read more »

“One-Week Man” Ponders the Climate Crisis

by Joshua Wilbur 

This month I’m submitting a guest post written by an acquaintance of mine.

His name, strange as it may sound, is One-Week Man.  He suffers from an unusual quirk: he can only remember the most recent week of his past, and he can only imagine one week into his future. He is forever stuck in this ever-shifting window of time.

One-Week Man is a bizarre, parochial soul, and I’m skeptical of his capacity to hold a well-informed opinion on anything of consequence. Nevertheless, he insisted on sharing his thoughts, which I present below, unedited.

It’s true.  I can only recall one week of the past and think ahead one week into the future. (Maybe “Two-Week Man” would be a more fitting name, but I didn’t have much of a choice in the matter.)

Some explanation might be helpful. I’m writing this on a Sunday, September 1st. Exactly one week ago, I spent the day on the beach. What happened in my life prior to that sunny afternoon, I couldn’t tell you: it’s all a haze. Looking forward to next Sunday, I’m planning to do some work around the house, a one-bedroom cottage that I don’t remember moving into. Beyond that, I literally cannot imagine what the future holds. August 25th and September 8th represent the limits of my mental universe. 

As it turns out, I’m very busy this week. My calendar—who would I be without it?—is filled with work meetings, doctors’ appointments, even an out-of-state conference from Wednesday to Friday. I work in the life insurance industry; I always have as far as I can tell.

For the most part, I’m content with things, despite my temporal malady. The doctors can’t explain my condition, which they consider untreatable and “psychosomatic” (whatever that means, I’ve forgotten), so there’s nothing I can do but live one week at a time. Most people, apparently, are terrible at thinking about the future. For me, it’s an absolute black hole. It’s difficult because I really do care about the fate of, well, everything: myself, my country, my planet. But I can’t see beyond the week, cursed as I am with a short-sighted brain and countless things-to-do. This is my dilemma. Read more »

Wildlife: Not (Too Much) In My Back Yard

by Mary Hrovat

Photograph of a bat on a stone wallLast weekend, a bat got into my house somehow. I first heard it in the small hours of Friday night as it scratched around somewhere near the furnace flue. I didn’t know if it was an animal settling into a new home in my attic, or if perhaps it was going out periodically to get food and bringing it back to feed babies in an established nest. All became clear very late the next night, when the bat managed to get out of the enclosure around the flue and then exit the closet where the furnace is. After some drama that I need not recount here, it flew out the front door, and I stopped gibbering on my front walk and went back inside.

The thing is, I don’t dislike bats. I enjoy seeing them in the evening sky. I worry about white-nose syndrome. I want there to be bats in the world, and now that I’ve had time to calm down, I’m glad the bat in my house got safely away. I can see that the experience was more stressful and life-threatening for the bat than for me. But I don’t really want bats anywhere near my house.

I was upset in large part simply because wild animals don’t belong in the house, period. But after a conversation with a friend about the bat situation at my house, I began to think about the fact that my love for and appreciation of nature is selective. I know that humans are having an appalling effect on the lives of other animals, and there’s no possible justification for our destructiveness. Yet, although I’m grateful for the presence of a fair amount of the urban wildlife around me, I wish some of it weren’t there. On some level, I’m not sure I’d mind if it were gone. Read more »

Poetry in Translation

Day 28: India’s Siege on the Vale of Kashmir

by Ayaz Rasool Nazki

Trapped
in a tomb
you yearn
for a voice:

a family kin
a friend
a stranger

even an enemy would do
a nightingale sings (of joy?)
a crow caws caws caws

Your santoor
in the corner
its strings
concertina

Dumb
for notes
you sing

only of blood
to sculpt
wounds

* * *

Ayaz Rasool Nazki, Kashmiri poet, painter, novelist lives in Srinagar. His recent poetry collection is ‘Songs of Light’ (Writers Workshop 2018). Translated from the original Kashmiri by Rafiq Kathwari / @brownpundit #StandWithKashmir

Not so fast, Johnny Bravo

by Thomas O’Dwyer

I, Johnny Bravo, Jair Bolsonaro, won,"
“I won. I, Johnny Bravo, Jair Bolsonaro, won,” Brazil’s president told a news conference.

Brazil’s president Jair Bolsonaro fired the head of the agency which monitors Amazon deforestation. “Fired” is an unfortunate word here – flames sweep across the country and down into Bolivia. Scientists and environmentalists have been alarmed by how quickly their predictions, that Bolsonaro’s aggressive anti-conservation agenda would boost deforestation, have come to pass. Brazil’s National Institute for Space Research (Inpe), publishes monthly deforestation alerts and has reported around 80,000 wildfires in Brazil since January, 40,000 of them in the Amazon rain-forest.

Bolsonaro was incensed as first the local, and then international media started picking up what are publicly-available statistics. “Most of the foreign press has a completely distorted image of who I am and what I intend to do here with our policies and for the future of our Brazil,” he said. “I perfectly understand the level of the poisoning that is done to Brazil by the foreign press.” He declared that the data from the Inpe space research institute was a pack of lies and set off down the well-trodden right-wing Conspiracy Road. Read more »

Seeing is Believing: The Crop Circle Controversy

by Carol A Westbrook

Metal and silver UFO invasion on planet earth landscape 3D rendering

It’s summer’s end. The fields are golden with ripe grain, bringing thoughts of harvest festivals, hayrides, apple cider… and crop circles. Yes, I can’t drive past a field full of golden grain without keeping my eyes peeled for crop circles.

Scanning for crop circles is a habit I picked up 25 years ago during a trip to Wiltshire County, England. 1994 was the height of the alien frenzy. There were bestseller books, magazines, and TV shows about crop circles, flying saucers and alien abductions. A 1990 Gallup poll found that almost half of all Americans believed we had alien visitors. The highly popular “X-Files” weekly show had a large viewership who tuned in every Sunday evening to watch Special Agents Scully and Mulder investigate paranormal phenomenon, focusing on alien abductions; their slogan was “the truth is out there.” Sensational alien stories swept the nation in these pre-social media days, as people relied on news media and best-seller books for their information. And there were plenty of books and TV specials to stoke your imagination.

A 1994 best-seller,  Abduction: Human Encounters With Aliens, by Harvard psychiatrist John Mack, discussed interviews with people who claimed they were abducted by aliens. Oprah and other talk show hosts interviewed abductees. There were books about dead aliens from a flying saucer crash hidden by the government at the top-secret Area 51 in Nevada. The first book about crop circles was published in 1989. The book, Circular Evidence: a Detailed Investigation of the Flattened Swirled Crops Phenomenon was jointly written by Colin Andrews, an electrical engineer from England, and Pat Delgado, a former NASA engineer, concluded that these circles were not a man-made hoax, but remained an unexplained phenomenon. These authors inaugurated the new “science” of crop circles, or cereology. Other self-styled experts from around the world quickly came forward to examine the circles and advance their own theories. More books were written, and organization and institutes devoted to cereology sprang up like, well, crop circles. Read more »

Fairy Tales and Sound Change

by Gabrielle C. Durham

Jacob Grimm

If you grew up in the Western Hemisphere, chances are good that you heard or read several fairytales by the Brothers Grimm as a child. Examples include “Cinderella,” “Rapunzel,” “Little Red Riding Hood,” “Hansel and Gretel,” and “The Emperor’s New Clothes.” Less well known, and for good reason, are stories of retribution, such as “St. Joseph in the Forest” or “King Thrushbeard,” or gratuitous violence, such as “The Louse and the Flea.”

These German purveyors of macabre moralism were not just busy horrifying children and their parents for countless generations; one of the brothers, Jacob Grimm (1785–1863), was also a linguist, or philologist, as the profession was known in the 19th century. Grimm’s concern was how the branches of the Indo-European languages tree led to the altered Germanic languages. (The original nine Indo-European language families are Indo-European, Armenian, Hellenic, Albanian, Italic/Romance, Balto-Slavic, Celtic, and Germanic, which includes English.)

Specifically, Grimm wanted to explain how consonants changed from Indo-European roots, recognized throughout those languages from Farsi to French, into Germanic languages. We’re going to get a little linguistic here, so bear with me. Read more »

Working Title

by Marie Gaglione

I don’t know where exactly the blame lies for the United States’ relationship with work. Early disciples of capitalism, probably, or the first few factory owners of the industrial revolution. I could (and readily would) fill this essay pointing fingers at monopolists and wall-streeters and Reagan-era plutomaniacs, but it wouldn’t stop inquiring minds from demanding twenty-year plans from children. Every kid gets asked, and everyone asks it, but we don’t talk about what we’re really communicating. What do you want to be when you grow up? The language of it carries its own implication. Adults with even the very best intentions are telling the youth of this country that what you do is who you are. Your work will define you; it’s what you will be

When I was very little, I wanted to be an astronaut, a firefighter, or a hairdresser. They were the most glamorous jobs I could fathom with what I imagined to be comparable levels of danger involved (here I spare the reader a lengthy digression on the psychology of fearing blowdryers).  It wasn’t about the work of the position; I don’t remember ever contemplating the daily lives of these people. It was an idea of the kind of person I wanted to be. Bold and powerful and exciting. But because what we do and who we are get braided together from such a young age, I floundered around with my answers as I grew up. And it’s weird because you get to college and they reinforce what you’ve heard forever: choose wisely, this will define you. Your major will determine what you do and who you become for the rest of your life. It’s no wonder so many undergrads are in a state of perpetual panic. Read more »

Idleness as Flourishing

Kieran Setiya in Public Books:

It is hard work to write a book, so there is unavoidable irony in fashioning a volume on the value of being idle. There is a paradox, too: to praise idleness is to suggest that there is some point to it, that wasting time is not a waste of time. Paradox infuses the experience of being idle. Rapturous relaxation can be difficult to distinguish from melancholy. When the academic year comes to an end, I find myself sprawled on the couch, re-watching old episodes of British comedy panel shows on a loop. I cannot tell if I am depressed or taking an indulgent break. As Samuel Johnson wrote: “Every man is, or hopes to be, an Idler.” As he also wrote: “There are … miseries in idleness, which the Idler only can conceive.”

This year brings three new books in praise of wasting time: a manifesto by MIT professor Alan Lightman; a critical history by philosopher Brian O’Connor; and a memoir by essayist Patricia Hampl. Each author finds a way to write in the spirit of idleness. Yet none of them quite resolves our double vision. Even as they bring its value into focus, they never shake a shadow image of the shame in being idle.

Why idleness now? Because we are too busy, too frantic; because of the felt acceleration of time. Lightman supplies a measure. “Throughout history,” he writes, “the pace of life has always been fueled by the speed of communication.”

More here.

The truth about the female brain

Saloni Dattani in UnHerd:

“The so-called ‘female’ brain,” says Rippon, “has suffered centuries of being described as undersized, underdeveloped, evolutionarily inferior, poorly organised and generally defective.” Such assertions were, and still are, so widespread that Rippon admits feeling as though she’s playing “Whac-a-Mole”. She has barely disproved the newest study professing to demonstrate how men and women’s brains differ, when another is published.

Rippon’s opponents, whom she calls biological determinists, argue that we know sex differences in the brain are innate because they are evident even in young infants, before socialisation has had the opportunity to exert its influence. But according to Rippon, “the general consensus appears to be that, once variables such as birth weight and head size have been taken into account, there are very few, if any, structural sex differences in the brain at birth”.

She claims that the emergence of sex differences between boys and girls’ brains as they age is evidence for the role of brain plasticity and socialisation in shaping these differences – that is, if and when sex differences exist at all.

More here.