Mathematics, and the excellence of the life it brings

by Ashutosh Jogalekar

Shing-Tung Yau and Eugenio Calabi

Mathematics and music have a pristine, otherworldly beauty that is very unlike that found in other human endeavors. Both of them seem to exhibit an internal structure, a unique concatenation of qualities that lives in a world of their own, independent of their creators. But mathematics might be so completely unique in this regard that its practitioners have seriously questioned whether mathematical facts, axioms and theorems may not simply exist on their own, simply waiting to be discovered rather than invented. Arthur Rubinstein and Andre Previn’s performance of Chopin’s second piano concerto sends unadulterated jolts of pleasure through my mind every time I listen to it, but I don’t for a moment doubt that those notes would not exist were it not for the existence of Chopin, Rubinstein and Previn. I am not sure I could say the same about Euler’s beautiful identity connecting three of the most fundamental constants in math and nature – e, pi and i. That succinct arrangement of symbols seems to simply be, waiting for Euler to chance upon it, the way a constellation of stars has waited for billions of years for an astronomer to find it.

The beauty of music and mathematics is that anyone can catch a glimpse of this timelessness of ideas, and even someone untrained in these fields can appreciate the basics. The most shattering intellectual moment of my life was when, in my last year of high school, I read in George Gamow’s “One, Two, Three, Infinity” about the fact that different infinities can actually be compared. Until then the whole concept of infinity had been a single concept to me, like the color red. The question of whether one infinity could be “larger” than another sounded as preposterous to me as whether one kind of red was better than another. But here was the story of an entire superstructure of infinities which could be compared, studied and taken apart, and whose very existence raised one of the most famous, and still unsolved, problems in math – the Continuum Hypothesis. The day I read about this fact in Gamow’s book, something changed in my mind; I got the feeling that some small combination of neuronal gears permanently shifted, altering forever a part of my perspective on the world. Read more »

On Not Knowing: Amateur Hour

by Emily Ogden

Fans are the people who know the quotes, the dates of publication, the batting averages, the bassist on this album, the team that general manager coached before. I am not a fan. Don’t get me wrong. I’m full of enthusiasms. But I can’t match you statistic for statistic. I haven’t read the major author’s minor novel. I don’t care who the bassist was. You win. I’m an amateur.

Amateur gets opposed to professional sometimes: the amateur isn’t making money from her skill or her knowledge. Other times, amateurism gets opposed to expertise: amateurs screw it up, experts fix it. These are not the meanings I intend. In French, an amateur is a lover; fan, a nineteenth-century US coinage, comes from fanatic. The amateur leaves some space for ignorance, letting the relationship to the beloved thing—the sports team, the artwork—retain the quality of an affair. The fan, in the particular sense I mean, gets lumbered under facts. There is something of the jealous monogamist about fandom, something of the checker for digital traces of the beloved’s secret life. Who hasn’t been there? But wouldn’t it be better if we hadn’t? When I say I am not a fan, I mean I aspire not to follow out that particular impulse. I aspire not to compete, at the cocktail party, for possession of Herman Melville, as measured in knowledge of his vital statistics.

Ownership of the beloved object is tempting but it’s not the shiniest prize that fandom holds out to you. The greatest temptation is a credential, a badge: you know all these things, so you must not be dumb. I’ve flashed that badge plenty, even if it would have been better not to. Read more »

The Cancer Questions Project, Part 1: Guido Marcucci

Azra Raza, author of the forthcoming book The First Cell: And the Human Costs of Pursuing Cancer to the Last, oncologist and professor of medicine at Columbia University, and 3QD editor, decided to speak to 26 leading cancer investigators and ask each of them the same five questions listed below. She videotaped the interviews and over the next months we will be posting them here one at a time each Monday. Please keep in mind that Azra and the rest of us at 3QD neither endorse nor oppose any of the answers given by the researchers as part of this project. Their views are their own.

1. We were treating acute myeloid leukemia (AML) with 7+3 (7 days of the drug cytosine arabinoside and 3 days of daunomycin) in 1977. We are still doing the same in 2019. What is the best way forward to change it by 2028?

2. There are 3.5 million papers on cancer, 135,000 in 2017 alone. There is a staggering disconnect between great scientific insights and translation to improved therapy. What are we doing wrong?

3. The fact that children respond to the same treatment better than adults seems to suggest that the cancer biology is different and also that the host is different. Since most cancers increase with age, even having good therapy may not matter as the host is decrepit. Solution?

4. You have great knowledge and experience in the field. If you were given limitless resources to plan a cure for cancer, what will you do?

5. Offering patients with advanced stage non-curable cancer, palliative but toxic treatments is a service or disservice in the current therapeutic landscape?

A nationally-recognized authority on leukemia, Dr. Guido Marcucci has lectured around the world and authored more than 270 scholarly papers on the subject. His ultimate goal is to make leukemia a thing of the past. He has received numerous competitive NCI grants for his clinical and research work focused on the pathogenesis, treatment and prognostic assessment of patients with acute myeloid leukemia. Dr. Marcucci currently serves on the editorial board of three journals, including Blood and the Journal of Clinical Oncology.

Apollo 11 Then And Now

by Mary Hrovat

Image of the near side of the full moon.When I watched the 2019 documentary on Apollo 11, it carried me back not to the summer of 1969, when it happened, but to the mid-1980s, when I was an undergrad. I was eight when Apollo 11 launched; of course I was aware of the space program and the moon landings, but I don’t have any memories of everyone gathering around to watch those first steps on another world. My parents weren’t particularly interested, and I don’t remember being caught by the spirit of the times myself.

It wasn’t until shortly before I began an undergraduate program in astrophysics, in the mid-1980s, that I started to take a serious interest in space exploration. I read everything I could find on the Mercury, Gemini, and Apollo programs; I was particularly interested in first-hand accounts by the astronauts themselves. Carrying the Fire, by Michael Collins, still stands out in my mind as the very best of these.

I was gripped by the idea of being out in space and seeing Earth from space or the moon from orbit. Sometimes when I was out at night under a dark starry sky, I thought about Collins’s descriptions of his solo passes behind the moon, during which he was out of contact with Earth. I imagined seeing the blackness of space and untwinkling stars out one window of the spacecraft and the impenetrable darkness of the moon in shadow out the other. Read more »

Is “Yesterday” the Future of British Asian Film?

by Claire Chambers

Today I ask to what extent it is a positive development that there are no discussions of race and religion in Danny Boyle’s and Richard Curtis’s film Yesterday, whose protagonist Jack Malik is from a South Asian, possibly Muslim, background.

In his essay ‘Airports and Auditions’ for Nikesh Shukla’s The Good Immigrant, the actor Riz Ahmed outlined three stages of cinematic representations of Muslims. Stage One features stereotyped figures (the taxi driver, terrorist, cornershop owner, or oppressed woman). Stage Two involves a portrayal that subverts and challenges those stereotypes. Finally, Stage Three is ‘the Promised Land, where you play a character whose story is not intrinsically linked to his race’. Does Yesterday reach that Promised Land or fall short? I examine the film’s depiction of Jack Malik, whose race and religion are irrelevant to this story about love, fame, the music industry, and the Beatles.

Building on Riz Ahmed’s work, in 2017 two researchers, Sadia Habib and Shaf Choudry, developed the Riz Test for Muslims’ depictions in film and television. Inspired by Ahmed’s speech to the House of Commons about the power and harm of media representations, Habib and Choudry created their own version of the famous Bechdel Test for cinematic portrayals of women. They asked some key questions about the cinematic portrayals of Muslims: 

If the Film/ TV Show stars at least one character who is identifiably Muslim (by ethnicity, language or clothing) – is the character:

  • Talking about, the victim of, or the perpetrator of terrorism?
  • Presented as irrationally angry?
  • Presented as superstitious, culturally backwards or anti-modern?
  • Presented as a threat to a Western way of life?
  • If the character is male, is he presented as misogynistic? Or if female, is she presented as oppressed by her male counterparts?

If the answer for any of the above is Yes, then the Film/ TV Show fails the test.

This test has already been hugely influential in the world of television, with Channel 4’s new Head of Drama Caroline Hollick (herself of Trinidadian descent, pictured) arguing at 2019’s Bradford Literature Festival that it should be uppermost in the mind of anyone commissioning programmes about Muslims. Read more »

The Return of the Repressed: Freud Sneaks Back into Neuroscience

by Joan Harvey

Our expectations sculpt neural activity, causing our brains to represent the outcomes of our actions as we expect them to unfold. This is consistent with a growing psychological literature suggesting that our experience of our actions is biased towards what we expect. —Daniel Yon

Because consciousness is something common to all of us, it is also interesting to many of us, though we may lack both philosophical and scientific backgrounds. And while many regular people are interested to some degree in the workings of their mind, those who have experimented with drugs and meditation may be even more curious about the latest research. From a fairly young age I’ve had a fair amount of experience with both psychedelics and meditation, though certainly not consistently through my life. And, for a while, I had separate conversations with two different persons—one heavily into psychedelics and one a longtime Zen practitioner—about some of the general books on consciousness.

Among the three of us, our biases sometimes came to the fore. Andy Clark’s book on predictive processing has a very sexy title—Surfing Uncertainty–and some very difficult, academic text—my Zen friend found it unreadable, and attributed this to the fact that Clark is not a meditator. My friend, in turn, had me read some recent books on consciousness with a Buddhist bias, which I disliked for their slanted view (though I have had a regular meditation practice at times). Of course the psychedelic expert liked Michael Pollen’s book How to Change your Mind, as did we all. And we all particularly liked Thomas Metzinger’s The Ego Tunnel. Though not much discussed in the book, perhaps Metzinger’s background in both meditation and psychedelics unconsciously played into our appreciation. We could relate to his ideas of conscious experience as a process and a tunnel through reality, as well as his discussion of transparency, the name he gives for the way we are unaware of the medium through which information reaches us. All of us were (the Zen practitioner has since died) atheist materialists (though also all familiar with plenty of ecstatic, mystical, and irrational states which we felt had a purely physical basis), and intuitively Metzinger’s position made sense to us. The “ego tunnel,” as Metzinger says, is a complex property of the neural correlates of consciousness, the “neurofunctional properties in your brain sufficient to bring about a conscious experience.” He also locates out-of-body experiences and other related phenomena squarely in the physical, as opposed to metaphysical, world.

But my beloved grandmother was a Freudian psychoanalyst, and due to her (and alone in my family, and among most of my friends) I became interested in Freud. Read more »

The White Deer: Reflections in Nature

by Marie Gaglione

  1. Into the Woods

 Most college students would readily submit that there are any number of external forces that inhibit their ability to perform or engage meaningfully with their academic endeavors, even when there is a genuine motivation and desire to do so, although such drives are often compromised by more compelling opportunities (see: survivor hour and other fun! college! activities!). There’s life outside of the university to contend with; relationships end, grandparents die, dads go to jail (the last one is particularly case-specific, but statistics on students with parents in prison would be an interesting metric to have). The necessary reaction to all of these things, for those students who have the means to carry on, is to carry on. These events can be managed, more or less, with the passage of time and the support of the community, in whatever sense of the word. There are Things One Can Do to move on from Hard Times.

I am no stranger to these external forces. Since I’ve been an undergrad, I’ve had partners become exes, I’ve lost my grandmas, I’ve been told over text of far too serious things. It’s an eerie dimension of the modern era that one can read of a friend’s suicide or a father’s prison time via instant message. We bounce from one screen to another in our waking hours and we pretend like Alexa isn’t recording our every word. Every day we let Google know our thoughts, our questions, our hopes, our fears; every day we feed into the ultimate hive mind, an unlimited data collective. We’re living in Bradbury’s fever dream with a heightened dose of Orwellian anxiety. And it’s the world today (in conjunction with certain childhood traumas and genetic predispositions) that contributes to what I’ve found far more difficult to overcome than the Hard Times: the internal forces. 

The two ages I oscillate between when considering how long I’ve been depressed are seven and fifteen. At 22, that just means I’ve been depressed for either amount of time. I think about what qualifies as the true beginning – was it the cookie-cutter childhood I missed? Or the chemical dependency that’s kept me prisoner since high school? Was it when I first contemplated the unsustainable and toxic nature of capitalism, and does it get worse the more I study the climate patterns? Whatever the answer may be, the fact remains that a lot of the time I am sad (or worse – sad and panicked). And this isn’t said in an attempt to garner pity or gain sympathy because I’m being vulnerable – it’s the reality of my experience. And it’s relevant here, in a nature essay, because it’s what brought me to the white deer; it’s what made me abandon my car and belongings and head, without intention or explanation, into the woods. Read more »

Appreciating Art

by Thomas O’Dwyer

LesParapluies by Auguste Renoir
Les Parapluies by Auguste Renoir

The first real work of art I ever saw was Auguste Renoir’s Les Parapluies. I was a teenager, and the painting had arrived in Dublin following a 1959 agreement between the governments of Ireland and Britain. This they had signed to solve an arts wrangle as tortuous as the Greek Elgin Marbles saga. The Renoir was part of a collection bequeathed to Ireland by Sir Hugh Lane. A Cork-born art collector, Lane died on board the Lusitania, which a German torpedo sank off the coast of Ireland in 1915. His collection of 39 paintings include works by Manet, Monet, Pissarro, Renoir, Morisot, and Degas. He had first left his collection to London’s National Gallery, but it was later found that he had attached a codicil to the will. It stated that he had changed his mind and wanted his paintings to stay in Dublin. The addendum was signed but not witnessed, and the London gallery declared legal ownership.

The dispute roused Irish nationalist passions, already at fever point in the fight for independence. Hugh Lane’s aunt was Lady Gregory, a patron of W.B. Yeats. They led Ireland’s cultural elites in a campaign to honour Lane’s last wishes. The governments renegotiated the 1959 agreement in 1993, and it comes up for renewal again this year. The new accord divided the paintings into two groups. London restored 31 of the pictures to Dublin, and every six years the cities trade the remaining eight, Les Parapluies among them. Read more »

Punctuation: What Is It Good for?

by Gabrielle C. Durham

My friend does not use punctuation when he texts, so there is a stream-of-consciousness quality to much of his communications. According to the fine folks at Buzzfeed, you would likely infer that he is a millennial, but that is not true. He conveys his points while eschewing syntactic finality fairly clearly, so when he does use punctuation, he makes a big deal of it, as in “Look. At. The. Punctuation. I’m. Using.”

According to this article, using ending punctuation (specifically a period) in a text can convey insincerity (by way of gratuitous formality) or anger due to code-switching. That sounds a little forced to me, but I’m a Gen Xer, so I do not fit in the classification of folks who are deemed to be responsible for killing half the industries your parents relied on utterly.

Punctuation, which comes from the Latin root punctatio for making a point from the verb pungere, which means to pierce (circa 1539), is the set of standardized symbols in every language, and the marks do vary, that clarify meaning by separating phrases, clauses, and sentences as well as by adding breathing cues. Pablo Picasso described punctuation marks as “the fig leaves that hide the private parts of literature.” The standard punctuation marks in English are period, question mark, exclamation point, comma, colon, and semicolon. Read more »

Alan Dershowitz, Devil’s Advocate

Connie Bruck in The New Yorker:

“A lie is a lie is a lie,” Whoopi Goldberg said. It was May 2nd, and she was on the set of “The View,” the daytime talk show that she co-hosts. The subject was Attorney General William Barr, who had argued that the special counsel Robert Mueller’s report was not as alarming as it seemed—endorsing Donald Trump’s claim that there had been “no collusion, no obstruction” in the Russia case. Goldberg was incredulous. “Our parents taught us, if you lie, there are consequences,” she said. “When are consequences coming back?”

Her guest, the attorney Alan Dershowitz, offered an answer that combined legal analysis and political handicapping. “They come back in November of 2020, when we all go to the polls and we vote against people that we think lied,” he said. “But it would be a terrible thing”—he held up a finger for emphasis—“to criminalize lies.”

Dershowitz is a frequent guest on shows like “The View”; for decades, he has been a frequent guest just about everywhere. If you are a television producer putting together a segment about a celebrated criminal case, Dershowitz is an ideal booking. Intellectually nimble and supremely confident, he is an emeritus professor at Harvard Law School but also an occasional reader (and subject) of the tabloids.

More here.

The three horsemen of the machine learning apocalypse

Ashutosh Jogalekar in The Curious Wavefunction:

My colleague Patrick Riley from Google has a good piece in Nature in which he describes three very common errors in applying machine learning to real world problems. The errors are general enough to apply to all uses of machine learning irrespective of field, so they certainly apply to a lot of machine learning work that has been going on in drug discovery and chemistry.

The first kind of error is an incomplete split between training and test sets. People who do ML in drug discovery have encountered this problem often; the test set can be very similar to the training set, or – as Patrick mentions here – the training and test sets aren’t really picked at random. There should be a clear separation between the two sets, and the impressive algorithms are the ones which extrapolate non-trivially from the former to the latter. Only careful examination of the training and test sets can ensure that the differences are real.

Another more serious problem with training data is of course the many human biases that have been exposed over the last few years, biases arising in fields ranging from hiring to facial recognition. The problem is that it’s almost impossible to find training data that doesn’t have some sort of human bias (in that context, general image data usually works pretty well because of the sheer number of random images human beings capture), and it’s very likely that this hidden bias is what your model will then capture.

More here.

Absent Opposition, Modi Makes India His Hindu Nation

Sonia Faleiro in the New York Review of Books:

One night in May, a strange and seemingly inexplicable thing happened in India. A divisive and ineffectual prime minister returned to power with a historic mandate.

Prime Minister Narendra Modi’s triumph on May 23 was conclusive. His Hindu nationalist Bharatiya Janata Party (BJP) won more than 300 of the 543 seats in the lower house of Parliament. But Modi had spent the last five years letting India down. Very little he had said on the 2014 campaign trail turned out to be true and virtually nothing he promised was delivered.

The prime minister had pledged to create 10 million jobs each year, but under him the country has experienced its highest rate of unemployment in forty-five years, with more younger and better-educated people than ever before stranded helplessly. His hasty decision to void the largest currency bills, in 2016, removing more than 80 percent of the money in circulation was supposed to curb corruption, but it cost more than a million jobs and did nothing to prevent graft in India or make business more transparent.

More here.

A History Of Women In Quentin Tarantino Movies

Alison Willmore in BuzzFeedNews:

The Cannes Film Festival has been an adoring showcase for Quentin Tarantino ever since he was anointed with the big prize, the Palme d’Or, for Pulp Fiction in 1994. That only made the discomfort of his tense exchange with New York Times reporter Farah Nayeri at this year’s event more telling. Tarantino’s latest film, Once Upon a Time in Hollywood, made its world premiere at the festival in May, where it received a six-minute standing ovation. The filmmaker and his cast were holding court at the subsequent press conference when Nayeri pressed Tarantino about why the movie’s woman lead, Margot Robbie (playing real-life Manson family murder victim Sharon Tate), had so little dialogue in the shaggy 1960s-set showbiz comedy.

“This is a person with great acting talent, and yet you haven’t given her many lines in the movie,” Nayeri said, citing Robbie’s roles in I, Tonya and The Wolf of Wall Street. “I guess that was a deliberate choice on your part. And I just wanted to know why that was that we don’t hear her speak that much.” Tarantino didn’t reply to Nayeri so much as refuted her whole line of questioning. “Well, I just reject your hypotheses,” he said, leaving Robbie to smooth over the awkward moment by speaking about the challenge of playing a character who’s mostly by herself in her biggest scenes.

It was, to be fair, an oddly phrased question. Tarantino didn’t write the script around the cast; Once Upon a Time features a range of famous faces in much smaller roles than Robbie’s; and even with a writer as verbose as Tarantino, counting lines is not a surefire way to measure the quality of a part. But his curtness in dismissing the concerns of a woman journalist (dredging up memories of his painfully testy exchange with critic Jan Wahl in 2003) made the exchange explode across the internet. And it reignited a conversation that’s dogged the director for years and that has, post-#MeToo, risen in volume: As a filmmaker, is Tarantino bad to — or for — women?

More here.

Here’s to you, Mrs. Dalloway!

Noah Knopf in Harvard Political Review:

It took me three tries to understand even a little of Mrs. Dalloway, Virginia Woolf’s famous 1925 modernist novel set on a single day in London. Even now, when I try to explain the book, I tend to sound like a stereotypical rambling undergraduate literary analyst, parroting lecture slides and pontificating on the meaning of life — if Good Will Hunting saw me at a bar, he’d take me outside. But confusing as it is, this is a book that makes me walk around differently. Here’s why:

“Fear no more the heat o’ the sun
Nor the furious winter’s rages.”

Fear no more the heat of the sun ⎯ it’s a line from Shakespeare’s Cymbeline, from a funeral song about embracing death and escaping the torments of life. Clarissa Dalloway, Mrs. Dalloway’s title character, happens to catch a glimpse of the lyric through the glass of a shop window as she putters about London making arrangements for her party that night. Clarissa really wants this party to be good, but she is mocked, derided; everyone thinks it’s frivolous to care so much about throwing a party for society elites.

It takes the suicide of a man she has never met for Clarissa to understand that her doubters are dead wrong. The news arrives during the party, and, stunned, she retires upstairs. But after the shock melts away, Clarissa actually feels “glad that he had done it; thrown it away. He made her feel the beauty; made her feel the fun.” Death is not to be feared, that’s true, and it’s a theme repeated enough that the concept likely doesn’t shock anyone. But the suicide helps Clarissa realize that life isn’t to be feared either: the energies, passions, and flames of human interaction are the best things we have in this world, particularly in the face of London’s constantly ticking clocks, which serve as a reminder of the thrilling knowledge that death might strike at any minute. Clarissa’s party is not frivolous. It’s actually the most important thing. Her guests await: “Fear no more the heat of the sun. She must go back to them.”

More here. (Note: The review from last year is a reminder to re-read Mrs. Dalloway yet again this summer. I just did. You should too. Magnificent.)