by Vivek Menezes

Our first glimpse of Lou Majaw comes just outside the Guwahati airport – his face is building-sized, emblazoned high above the multi-lane expressway to Meghalaya, on an advertisement for Star Cement. These billboards turn out to be ubiquitous along our route. By the time we’ve wound our way up from the Brahmaputra floodplains into the cloud-wreathed Khasi hills, the legendary rocker of the North-East seems a reassuringly familiar fixture of the landscape, even the toddler in our midst chortling with glee every time his flowing silver hair looms up ahead, instantly recognizable even in the fading light that slowly obliterates the thick pine forests that line the steep, curving road to Shillong.

But when we set out to find him the very next morning, the man seems as elusive as the fast-rising mists that are a permanent fixture of life in his hometown. We knew that Lou Majaw doesn’t go on the Internet, but now we learn that he doesn’t have a permanent contact number, or even a particularly fixed address. Then we discover that you can’t buy a copy of any of his albums in any of the music stores in Shillong either.

Read more »

by Namit Arora

On English in India and the linguistic hierarchies of colonized minds

(NB: an updated version of this essay is here.)

The modern era of European colonialism began in the Americas with bands of adventurers seeking El Dorado. Their early intrusions evolved into predatory monopolies like the East India Company and European states exerting direct control over the economic and political life of the colonies. The natives tended to not welcome and cooperate with the intruders, so alongside came great developments in the art of subjugating the natives, through military, political, and cultural means. In this essay, I’ll look at some cultural means of controlling the natives, particularly through language, and its effect on the psyche of the colonized, using examples from Africa and India.

When it comes to colonial quests, military might is what breaches the metaphorical Gates of Damascus. Regime change follows. Thereafter, the most efficient and durable means of colonial control happens via culture. Culture holds the keys to how a group sees itself and knows its place in the world. As Ngugi wa Thiong’o—Kenyan novelist, professor, and author of Decolonizing the Mind—has pointed out, ‘Economic and political control can never be complete or effective without mental control. To control a people’s culture is to control their tools of self-definition in relationship to others.’ [1]

When done right, the native comes to elevate and mimic his master’s ways, to see his own culture as inferior, and to look down on his past as ‘a wasteland of non-achievement’. He begins to defer to the colonizer’s ideas on fundamental things like beauty, art, and politics. In time, writes Ngugi, he begins to understand himself and his culture through the eyes of the colonizer—using the latter’s concepts, categories, and judgments. Before too long, he turns into a proxy for his master: colonialism with a native face.

How does the colonizer gain such control? The easiest method, explains Ngugi, is to actively spread his language among the natives, and to simultaneously denigrate the language of the natives as crude and unfit for proper education. It is amazing how much mileage this delivers. Simply make the colonizer’s language the lingua franca of imperial administration, accord prestige and upward mobility to those who learn it in colonial schools, and before too long, there is a feeding frenzy among a native minority. This has been the way of the great colonialists of history, such as the Arabs in the 7-8th centuries, the British and the French in the 19th, and the Russians with the Baltic States in the 20th. Ngugi writes,

Read more »

by Michael Blim

With each stone thrown, each Molotov cocktail hurled from one side of Cairo’s Liberation Square to another, an Egyptian revolution appears being thrown further away. The Square is a symbolic space, first occupied by people envisioning revolutionary change, and now made a marker in a game of competition among elites for governance. The state is secure. No one has yet set upon storming Cairo’s Winter Palace. No one in the popular movements against the state has set upon taking the state.

It is puzzling. What are the immediate reasons? Perhaps all of the candidate revolutionary state-takers are dead or among the 17,000 political prisoners of the regime. Not to be under-estimated is the 59-year military rule and two generations of stop and go mixes of cooptation and repression. The figure of Omar Suleiman, the torturer, the renditioner, the Israel interlocutor, says much about the center of things in Egypt today. The sheer corruption of Egyptian state power scars his face. He is no Kerensky; he is evil incarnate.

Perhaps Egypt is better off without a Lenin. In any event, it does not have one. Must it forego revolution as well?

Read more »

by Rishidev Chaudhury

Five years ago I spent six months working on a farm about an hour outside Bangalore. To get to it I took a city bus thirty miles along the highway to a dusty crossing where it turned onto dirt roads and bounced along them for about twenty minutes before ending in the centre of a small village called Mukodlu. As we left the city behind, the occupants of the bus changed from office staff to farm workers, and eventually included goats and chickens. I once witnessed a heated altercation between the bus conductor and the owner of a goat that was soiling the bus floor. It was eventually resolved when the owner held the goat’s bottom out of the window for the rest of the journey.

The farm was only a few miles off the highway but was also only a few miles away from a game sanctuary. Twenty years ago, when Bangalore was just starting to grow, the area was entirely rural. Now it was an odd hybrid of small villages, smaller farms, urban overflow, the game sanctuary and numerous granite quarries (many of them illegal). Perhaps it was once good for farming, but now the soil was thin, stony and eroded. We grew rice, vegetables and herbs, and had a small shed for breeding silkworms. The farm also hosted an NGO that ran workshops on governance for women from village-level self-governance bodies (Panchayats) and workshops on low-cost herbal medicine for midwives and other community healers.

Read more »

by Steven Poole

Please tear your eyes away from this elegant and curiously seductive prose for a few seconds and look at what surrounds this webpage on your display. Unless you are browsing in full-screen “kiosk” mode or kicking it old-school with Lynx, chances are your browser program is designed to look like some sort of machine. It will have been crafted to resemble aluminium or translucent plastic of varying textures, with square or round or rhomboid buttons and widgets in delicate pseudo-3D gradients, so they look solid, and animate with a shadowed depth illusion when you click them. Me, I hate this stuff. I think it's not only useless but pernicious and sometimes actively misleading. Won't you please join me in declaring a War on Chrome?

By “chrome” I don't mean Google's browser of that name, but all the pseudo-solid, pseudo-3D visual cruft that infests user interfaces in modern computing. For an example of Chrome Gone Wild I need only turn to Apple, who have somehow acquired a reputation for elegant and minimalist user-interface design while perpetrating monstrosities like this:

Can you tell what that does, and how to work it? Me neither, and I've been using it for years. (It is the Ultrabeat drum machine in Logic.)

Read more »

Ben Walters (BW) and J. M. Tyree (JMT) write about movies. Together, they wrote a critical appreciation of The Big Lebowski for The British Film Institute’s Film Classics series, and they also have co-written reviews of No Country for Old Men and Burn After Reading for Sight & Sound. They discussed this year’s crop of Oscar-nominated films on a transatlantic chat between Rotterdam and Lake Erie, and they agreed on a film to recommend: Exit Through the Gift Shop. Also discussed: Inception, Winter’s Bone, The Fighter, Somewhere, The King’s Speech, Shutter Island, True Grit, Catfish, and The Social Network.

JMT: Have you noticed how many of this year’s Oscar-nominated films are about family businesses of one kind or another?
10:08 AM It’s odd…
10:09 AM From Inception and Winter’s Bone to Black Swan, The Fighter, and The King’s Speech. “We’re not a family, we’re a firm,” Colin Firth says in The King’s Speech. And several of these films feature rotten families trying to push the kids into their firms…
10:10 AM BW: interesting. true grit and the kids are all right are about a determination toward family loyalty too
but the business side is something else, i guess
10:11 AM JMT: Yeah, on the other end of the spectrum, True Grit, like The Social Network, deliberately presents a total absence of family life. In another sense maybe True Grit presents a business venture that winds up becoming a sort of ad hoc American family. In The Social Network the business relationship is really more of a romance.
10:13 AM But for me it’s still the year of The Bad Family.

Read more »

by Hartosh Singh Bal

Over the past month there have been two separate reasons to return to the story of Srinivasa Ramanujan. The first was the result of an astounding piece of mathematics by Ken Ono and his colleagues on the theory of partitions, bringing to a conclusion some of Ramanujan’s most interesting work in number theory. The second was thanks to Patrick French’s recent book – India, a portrait – which ends with a short two page biography of Ramanujan. The first Ramanujan is of course the Ramanujan who should matter, the mathematician, the second is unfortunately the Ramanujan who has come to occupy public memory, the metaphor.

It is not clear what French’s Ramanujan stands for in a chapter that seeks to explain the specifics of individual, social and organizational behavior on the basis of particular Indian traits such as religion or caste, but given the title of the chapter – Only in India – it does seem that French believes there was something particularly Indian about Ramanujan’s story.

This belief is not unique to French and has only been compounded by Ramanujan’s own description of the Goddess of Namagiri as the source of his inspiration. The result is that Ramanujan has come to embody certain romantic notion of eastern or more specifically Indian thought. Even those who want to allude to Ramanujan the mathematician do so in such terms. Paul Hoffman, in an otherwise entertaining book on the Hungarian mathematician Paul Erdos – The Man who Loved Only Numbers – writes, “While Hardy and Ramanujan’s partnership lasted, the two men stood the world of pure mathematics on its head. It was East meets West, mysticism meets formality, and the combination was unstoppable.”

Ramanujan’s otherwise excellent biographer Robert Kanigel devotes the entire first chapter of the book – The Man who Knew Infinity – to Ramanujan’s religious and social upbringing. However important this may have been to Ramanujan the man, the claim that it is central to Ramanujan the mathematician does not stand up to scrutiny. Ramanujan did not learn his mathematics in a temple. By the time he went to school only a few of the traditional Vedic schools still functioned. They had been largely replaced by schools teaching a curriculum based on European science.

Read more »

Justin E. H. Smith

O Isaac? Isaac! Come forthwith! The clamp 'round my gouty ankle must needs be tighten'd. That's right, Isaac. The left ankle. Yes, my loyal Clampsman. Just like that.

Do you know what I've been doing, Isaac? I've been reading about comic sections. Do you know what those are? They are the Curves produced by the Intersection of a Conus by a Plane. Now look here, Isaac. There are not only Circles and Ellipses so form'd, but e'en edifying Parabolae and whimsical Hyperbolae. Some are most comical indeed!

What's that, Isaac? You say it's 'conic' sections about which the immortal Euclid held forth, and not 'comic' sections?

Now, Isaac, did you see a Signe hanging o'er the Door of my den, warning “Let no one enter here who is ignorant of Mathematics?” You didn't? Well that's why you're allowed in, you Orang-Outang! You are here to tighten my ankle-Clamp, not to out-do the great Roberval.

Now, to our Quaeries.

Firstly, for some period, o'er a decade of Years ago now, we repeatedly heard that jubilant Declaration: Whoomp, there it is! What was discover'd at that time, precisely? A great Treasure of Portuguese Bullion? El Dorado? Verulam's Fountain of Youth? In what barbaric Tongue, furthermore, does whoomp translate the wise Archimede's elegant exclamation, εὕρηκα? Wherefore, finally, did the Jubilation cease so suddenly? Was this Discovery at length only a Fata Morgana?

Whence, moreover, all this talk of 'Wikileaks'? Wiki, we suppose, is of the same Lingua Hottentotica as whoomp, but what is leaking 'round here besides my woe-ridden joints? Information, you say? First of all, Isaac, you know not to interrupt me once I've begun. But more importantly how could 'Information' be a-leaking and a-flowing when we are unable to receive so much as a single sensible Reply to our Quaeries?

Read more »

Historians are generally quick and correct to insist that we jump to easy political analogies at our peril. One of the first lessons of historiography is that grand generalizations are more apt to flatter an author’s own sympathies than to capture a disinterested abstraction of events. Did Tunisia, Wikileaks, Facebook, or Twitter contribute to the Egyptian uprising? Possibly, but who would have the hubris to argue that any of these mattered more than local conditions: the rigged elections in December that gave the ruling National Democratic Party 93 percent of parliamentary seats, the bombings in Alexandria that left twenty-one Coptic Christians dead, the thirty years of daily personalized humiliation at the hands of a brutal police state.

And yet it seems possible to respect the importance of historical specificity while also acknowledging that popular energies can, and do, spread. Not for nothing is the rhetoric of revolution and counter-revolution shot through with the metaphors of fever, contagion, and conflagration. When yesterday’s unthinkable prospect becomes today’s historical fact, we are reminded that possibility can be more than a speculative concept. The events in Tunisia or Egypt make us feel political possibility, they make us experience it as an emotion, a passion no less infectious than anger or joy.

That feeling of possibility has already raised new questions for Uganda’s president Yoweri Museveni, who celebrated 25 years of continuous rule last Wednesday and is widely expected to claim victory in the presidential elections scheduled for February 18. When the question of Tunisia’s relevance for Uganda was put to him directly, Museveni shocked no one by arguing that Uganda’s situation is entirely different than the one that led to the ouster of Zine El Abidine Ben Ali: “I would not want you to confuse longevity with performance…social conditions in Tunisia are different to those in Uganda which are improving.”

Read more »

On Sundays, Sylvia and I go to the Shire. As anyone with even a cursory knowledge of Tolkien’s world will tell you, the Shire is a happy place. It is a place of beginnings, homecomings, nostalgia and merrymaking. I loved the Shire, and I loved going there with Sylvia. There was a train station very close to our boarding school in South Wales, conveniently located for our Shire excursions. Every Sunday at noon we met at the train station to go to the Shire.

Now that I think about it, I met Sylvia because she introduced me to the Shire. At first, I thought it was a stupid euphemism but we grew into it. Gradually, it became a habit. I was new to the boarding school and she was a senior, two years older than me. Sixteen and Eighteen, we were struck with an underdeveloped pessimism unique to growing up. Sylvia was a girl of decadent tastes: cheap white wine, unfiltered cigarettes and fishing. The only times she tried to avoid these topics was when she was in the mood to impress boys with her feminine side but these little efforts were always doomed to fail. She could not stop talking about wine, cigarettes and fishing. How a Catalan girl had developed the habits of a truant Scot, I never found out. She never talked about herself. How I ended up being friends with her was something I knew even less about: something to do with Dostoevsky, the atman, salvia and short hair. It happened in a serenely fast rush like a tide coming in to cover my feet.

One Sunday, I was early. I recognized her coming from a distance. As she approached, she planted a noisy kiss on my cheek and flashed a wide smile. The two of us, foreigners in this vast countryside of Wales, trudged along the empty tracks and made our way to a forgotten bench, around fifteen minutes away from the station, hidden in unkempt bushes and facing the tracks. There she took out the ticket to the Shire from the front pocket of her fur coat. After warming it with her red lighter she sparked the tip and, hypnotized, watched it catch fire. We each took two puffs and kept passing. It wasn’t long before we were smiling stupidly as the cannabis set in. We were in the Shire and it was a very happy place.

Read more »

The spark that lit the tinder was a series of what began as peaceful protests followed by disproportionate – and uneven – countermeasures by the Tunisian government. Protests began after the public self-immolation of Mohamed Bouazizi, a street vendor left destitute after harassment by local authorities. Early media coverage was stifled and word of the protests leaked out through social networks and satellite television. Tunisian authorities reacted violently, then backpedaled and granted elaborate concessions (for example Pres. Ben Ali visited Bouazizi in his hospital bed shortly before the latter died and former fled.) The government seemed weak, arbitrary and cruel. People quickly lost confidence.

The United States might seem immune to the miseries roiling Egypt and Tunisia, yet the lack of opportunities and bleak outlook among Arabian youth is hardly unique, particularly to a young American. Unemployment as measured by the number of Americans out of work for over 15 weeks and still looking is at a historically high 9.1 percent according to the Bureau of Labor Statistics, yet that number belies deeper pools of unemployment and underemployment among segments of the population. Last month’s tally of job seekers and those “marginally attached and working part-time for economic reasons” was 16.7 percent. Among recent college graduates and minorities the numbers are higher still.

Repression in the United States is not just economic but systematic, according to N+1’s “Intellectual Situation.” By challenging the peculiar American phenomenon of the pejorative use of the word “elite” being directed against “cultural” as opposed to “power” elites (i.e. readers of N+1 as opposed to readers of The Wall Street Journal), N+1’s editors reveal a menacing strain of anti-intellectualism that the “resentful right, under the banner—hoisted by the likes of Beck, Huckabee, and Palin—of common sense, flatters deprivation as wisdom by implying to the uneducated that an education isn’t worth having;” doing “incalculable, unforgivable” violence to the talents and capacities of millions of people.”

The root of this astringent claim is that the Right “not only brands higher education as an instrument of class domination, but… ensures the educational system increasingly functioned in such a way as to make the accusation stick.” The Right achieved this by appropriating (perhaps unwittingly) sociologist Pierre Bourdieu’s argument that educated taste is a marker of “cultural capital,” and that taste functions as an index of social status, thereby enforcing class distinctions. N+1 argues that a “truly Democratic America” would instead hew closer to Ortega y Gasset’s argument that there are two classes of creature, “those who demand much of themselves and assume a burden of tasks and difficulties, and those who require nothing special of themselves, but rather for whom to live is to be every instant only what they already are.” Thus empowered the unwashed masses would admire rather than sneer at the achievements of cultural elites, and aspire for greater achievement.

A laudable goal, certainly, and one shared by both sides of the political equation, at least their more sensible members. Crudely put the Left would prefer to marshal the resources of the state to nudge people along in their self-improvement, while the Right would rather let them do it on their own, pulling themselves up by the bootstraps and presumably succeeding in a more business-like fashion. Perhaps the “cultural elite” gives themselves too much credit. Suspicion toward cultural elitism might not stem from culture itself, but rather its self-appointed stewards, the bastions of power and wealth sitting on the boards of elite universities and august cultural institutions.

Read more »

I have trouble with old pics
their sweet bitterness
their cutting edge
their tricks

—a daughter’s mittens
hung from cuffs
laid out in kodachrome
a taunt of time. Enough.

I’d rather mine old nuggets
upturn what’s scattered
in my skull —the gold

stick with what
my head will hold

I do not take nostalgic risks
The photobox stays
beneath the bed
with jewel cases of bygones
in code on disks

When my memory goes
it will not matter
I may not even know the aliens
who peer from three by fours
or are splashed on screens
in pixel splatters

Love is best as it occurs
life too;

Now is breath’s agency
Love and life are only inside time

not frozen
not shot with poignancy
not both a blur

(Wherein we dump the obsolete Adam and Eve tale of the Advent of Consciousness for a more radical and contemporary one based on evolutionary psychology and cognitive neuroscience)

by Fred Zackel

“Something fell out of the mirror.”
“Did you hold it upside down?”
“Yes.”
“Did you shake it?”
“Yes.”
“After I told you not to?”
“I got curious.”

We must congratulate ourselves. Name another animal capable of creating its own meaning for its existence and then imposing it on the universe. We might even be the ones who most delay their own extinction.

We may not be alone on this evolutionary journey. The journey itself may not be exclusive to any one species but open to any species that ruminates over its reflection in the waterhole. Other species may be in the process of following in our footsteps. (Don’t look back. They might be closing in.) Other species have seen themselves in the mirror. Well, individuals within those species have. Have they told the others yet? Have they brought them to the mirror? As they tell the others of their Herd … could they too have their epiphany? Even more ominously to some of us, once they see themselves in the mirror, can reading (and writing) be far behind?

We human beings saw our reflections, had that epiphany, and got aimed in a different evolutionary trajectory. We survive the Crucible of the Veldt. The Crucible of the Savannah. We went looking for greener grasses elsewhere and we went everywhere on this planet. Being desperate to survive, we adapted ourselves to almost every geography and climate. Over the multitudinous millennia, we have been tempered like swords or plowshares. We survived and thrived.

Mirrors and reading – now we are capable of symbolic thought and we can pass that information on to anyone in Our Herd. We can pass the Good News onto the Next Generation. And the one after. And the one …

(That’s why libraries are so very dangerous to the religious, by the way. As the pulpit bullies always say, Quick, let’s burn the books. All we need is my Holy Scriptures. No, not yours but my Holy Scriptures. Yours are alternatives to mine, options to my agenda, and therefore these “choices” must be heresies. You and your ideas, your visions and priorities, must be destroyed and eradicated.)

I do not know how many epiphanies we as a species have had and learned from. But a dangerous few knocked us for a loop. They have threatened us as few others have done since the inaugural Epiphany at the waterhole.

Let’s start with Galileo’s telescope. Let’s go back 400 years almost to the month. In 1610, Galileo published his “Sidereus Nuncius” (aka “The Starry Messenger”), describing the surprising observations that he had made with the new telescope. That epiphany changed how we looked at our place in the Cosmos, our position in the Great Scheme of Things.

Read more »

The proper basis for a marriage is mutual misunderstanding. —Oscar Wilde

People necessarily make use of assumptions in speaking to one another, choosing their words to convey necessary information succinctly and effectively. The assumption process creates a theory of mind regarding the audience, including their culture, motivations, previous experiences, etc. While communicating with a stranger or an unfamiliar audience, the speaker will seek to include extra detail or background to be certain that the message is understood. But old acquaintances share more history and might require less information to understand the speaker’s intent (and may regard excessive detail as condescension). This habit promotes quick and effortless communication. Reciprocal theories of mind between long-time friends will grow into a shared ecosystem, with experiences, inside jokes and deep comprehension.

Or not. In the case of long-married couples, spouses sometimes communicate ambiguous information no better than strangers would. Two psychologists, Boaz Keysar and Kenneth Savitzky, have been studying how people interpret and misinterpret ambiguous communications. They devised an experiment in which participants sat in a circle with their backs to one other and tried to discern the meaning of spoken ambiguous phrases chosen from everyday conversations. The “speaker” was given a list of ambiguous phrases, and instructed to read each one aloud to communicate which of four meanings was intended. For example, “it’s getting hot in here” might be a flirtatious overture, a comment about tempers rising, a warning that the cops are closing in, or a hint to open the window. The listeners in the experiment chose from among the four possible meanings based on the speaker’s verbal delivery, and the speaker would rate the likelihood that each listener got the correct message.

Even with a lot of contextual information stripped away, all listeners were able to guess the speaker’s intent at well above chance levels, which is a testament to the utility of the social assumptions the researchers are investigating. However, the speakers in this experiment consistently overestimated their own ability to communicate the appropriate meaning, and they overestimated their ability more so toward their partners than toward the strangers. They thought their spouses “got it” for 6 out of 10 phrases, when in fact the spouses averaged the same as strangers, at around 4 out of 10.

The scientists who designed this study chose the conditions to illustrate the flip side of a developed intimacy. The habits of ellipsis and allusion can become counterproductive when the topic falls outside of the shared sphere, or, as in this experiment, context is removed to the point of real ambiguity (in real life, think of emails or text messages; or, speaking near a running faucet). Speakers presume that they’re being clear; and a listener, may use their own take on the shared relationship to mistakenly believe they don’t need clarification. Preventing this sort of miscue is the basis for an entire cottage industry of counselors and marriage therapists.

Reference:The closeness-communication bias: Increased egocentrism among friends versus strangers. Kenneth Savitsky, Boaz Keysar, Nicholas Epley, Travis Carter, and Ashley Swanson. J. Exp. Soc. Psychology 47:269-273, 2011.

Cartoon © Randy Glasbergen from www.glasbergen.com <http://www.glasbergen.com>, used with permission.

by Jenny White

I’m a faithful reader of the New York Times Science Section, cover to cover, because I want to know about things, not be caught flatfooted. Somehow it seems necessary for survival to know about quarks and bosons, the social structure of ants, scientific explanations of the smile, and the sexual life of grapes. I had a fling with books explaining how to endure being stranded in snow (make an igloo) and identify edible weeds in the park. What does this say about me? I never kept any extra food in the house beyond what was fresh in the fridge until after 9/11 when I laid in some canned beets and tomato sauce and a gallon jug of water. The tomato sauce exploded and the water leaked, so clearly I am batting zero as a survivalist. Perhaps knowing things about the world lets me feel that nothing can surprise me, jump out of the dark corners beyond my peripheral vision. Illness is like that. Two months ago I saw spots and flashes in my right eye and was told I had a partially detached retina. Why? No reason. Out of the blue. Once I was allowed to read again after the repair, I read a lot about retinas. But what do we really learn about how illnesses and the body work from reading popular science? Recently, I had a long conversation with a prominent scientist at Harvard, the molecular biologist Michael R. Freeman, who explained to me what cancer was. It wasn’t anything I expected, even after years of reading science stories. It was as if he had opened a door into an alternate universe. Below is a transcript of part of our conversation.

Jenny White: Tell me what we should know about cancer?

Michael Freeman: Cancer is an uncontrolled proliferation of cells, so a tumor is actually is a swelling or a cyst, something that isn’t necessarily life-threatening, but a malignancy is something that has the potential to grow and spread in the body and its the spreading in the body as well as the growth that is lethal. We’re still trying to understand fundamental processes that are part of cancer. A recently recognized process involved in cancer, for instance, is autophagy, which means “self-eating.” This is a normal way that cells use to conserve energy and nutrients, and it’s a process that can be used by cancer cells to progress to malignant states. Tumor cells generally are in a very stressful environment, so there’s a Darwinian pressure to select for variants that can overcome various stresses. So if you’re a tumor cell and your descendants have the ability to take in nutrients from this process of autophagy, then you have a selective advantage over other cells that might be killed in the stressful environment.

JW: So basically the Pac-Man cells survive because they eat the cells surrounding them.

MF: They actually eat themselves.

JW: Are there any other cool concepts that are out there? Autophagy, self-eating Pac-Man cells. What else is going on?

MF: There’s another concept that was very new when I was a postdoctoral fellow, but is now very much understood to be a fundamental process in tumor biology, which is apoptosis or programmed cell death. This is a program that cells initiate that causes them to die. It’s basically cell-suicide. There are signaling molecules that can initiate the suicide program that’s built into the cell. This is a normal process that takes place during development. The fingers on your hand were created in part through an apoptopic mechanism, where the webbing between the digits was formed by cells killing themselves. In development, in the formation of the body plan, there’s growth as well as loss of structure. It even happens during normal life as an adult. It’s like what a sculptor does, right? A sculptor creates form by removing things.

Read more »