by Anitra Pavlico

There is only one healing force, and that is nature. —Arthur Schopenhauer

The Biophilia Effect: A Scientific and Spiritual Exploration of the Healing Bond Between Humans and Nature, by Austrian biologist Clemens G. Arvay, is a mind-expanding read. It is part of the relatively recent resurgence of interest in incorporating exposure to nature into physical and psychological healing regimens. Until recently, the notion of “taking the cure” by relaxing at a Swiss resort in a natural setting was seen as archaic, thought to have been prescribed only because medicine had not advanced to a point where a “real” treatment could be used. Not that everyone had abandoned the idea: Erich Fromm used the term “biophilia” in his 1973 work The Anatomy of Human Destructiveness to describe “the passionate love of life and of all that is alive.” American biologist Edward O. Wilson published Biophilia in 1984, positing genetic bases for humans’ tendency to gravitate to nature. Now scientists en masse are studying nature’s extraordinary healing effects. In Japan, shinrin-yoku–“taking in the forest atmosphere,” or as it is more often translated in the West, “forest bathing”– is officially recognized as a method of preventing disease as well as a supplement to treatment. In 2012, Japanese universities created an independent medical research department called Forest Medicine. Scientists around the world have begun to participate in this research.

Arvay writes that “Plants, like insects, communicate using chemical substances. They send out molecules . . . [that] can definitely be compared with a human language because, just like our words, they carry certain meaning in the world of plants and, therefore, information — a ‘plant vocabulary.’” Plants emit substances called terpenes, secondary plant compounds with almost forty thousand representatives that fulfill numerous functions. For example, plants emit terpenes as a sunscreen (you may be able to see terpenes forming a blue haze above a forest on a hot day). Plants also use terpenes to attract insects or other animals when they need their services, or to warn other plants about pests so that they can mobilize their immune systems. Plants also produce terpenes as a toxin to kill pests or deter predators. Read more »

Renata Pasqualini, is the Chief, Division of Cancer Biology, Department of Radiation Oncology at Rutgers Cancer Institute and Rutgers New Jersey Medical School having previously served as Associate Director for Translational Research and Chief of the Division of Molecular Medicine at the University of New Mexico Comprehensive Cancer Center. She has published more than 200 joint peer-reviewed research manuscripts and have more than 100 patents filed worldwide. Dr. Pasqualini’s lab discovered Prohibitin-TP01 which specifically targets the vasculature that nourishes white fat, a critical contributing factor in poor prostate cancer outcome. Preclinical studies in mouse models showed that TP01 treatment reduced white fat and resulted in ~30% weight reduction. Her goal is to successfully translate Prohibitin-TP01 into the clinic as a new agent for obese men with advanced prostate cancer.

Azra Raza, author of the forthcoming book The First Cell: And the Human Costs of Pursuing Cancer to the Last, oncologist and professor of medicine at Columbia University, and 3QD editor, decided to speak to more than 20 leading cancer investigators and ask each of them the same five questions listed below. She videotaped the interviews and over the next months we will be posting them here one at a time each Monday. Please keep in mind that Azra and the rest of us at 3QD neither endorse nor oppose any of the answers given by the researchers as part of this project. Their views are their own. One can browse all previous interviews here.

1. We were treating acute myeloid leukemia (AML) with 7+3 (7 days of the drug cytosine arabinoside and 3 days of daunomycin) in 1977. We are still doing the same in 2019. What is the best way forward to change it by 2028?

2. There are 3.5 million papers on cancer, 135,000 in 2017 alone. There is a staggering disconnect between great scientific insights and translation to improved therapy. What are we doing wrong?

3. The fact that children respond to the same treatment better than adults seems to suggest that the cancer biology is different and also that the host is different. Since most cancers increase with age, even having good therapy may not matter as the host is decrepit. Solution?

4. You have great knowledge and experience in the field. If you were given limitless resources to plan a cure for cancer, what will you do?

5. Offering patients with advanced stage non-curable cancer, palliative but toxic treatments is a service or disservice in the current therapeutic landscape?

by Elizabeth S. Bernstein

If we find that society values the traits and skills that are associated with being male and devalues the traits and skills that are associated with being female, then it is time to rethink societal values instead of denying the existence of biologically based male-female differences. —Diane F. Halpern, Sex Differences in Cognitive Abilities (2012)

Two months ago I wrote about the gender wage gap in the United States, and the fact that the careers of women vary from men’s in ways which align with the values which women express. Compared with men, women rank helping people higher and maximizing earnings lower. They express less willingness to commit actions which may harm others for the sake of profit. Their tendency to emphasize interpersonal relationships is reflected not only in the paid work they engage in, but also in the greater likelihood that they will reduce or exit employment to care for children or other family members.

While writing the piece I read a great deal of online commentary. There was the occasional nod towards the possibility that biology had something to do with the different inclinations on which men and women were acting. Far more common, though, were the explanations which pointed to women’s actions being steered by extrinsic forces – “social norms and expectations” that women will care for family members, “multitude of messages that women get from society about what sorts of jobs they should pick,” “the way that society views the bond between mothers and their children,” “unique socialization histories which instill more negative reactions to ethical compromises,” “persistence of stereotypes that drive women toward service labor.”

The emphasis on expectations and socialization over biology is hardly surprising. As the sociologists Shannon Davis and Barbara Risman write in their article “Feminists wrestle with testosterone: Hormones, socialization and cultural interactionism as predictors of women’s gendered selves,” feminists “worry that any nod of the head to biology will backfire.” Still, the conclusion of Davis and Risman’s own study was that both culture and biology (specifically exposure to prenatal hormones) influenced the degree to which women’s personalities evidenced “masculinity” or “femininity” (the latter of which the researchers suggest might better be called “nurturance and empathy”). There is no logical reason, Davis and Risman write, that feminists should deny that biology “shapes some part of our personality structure,” but neither should that justify “providing differential opportunities, constraints, and privileges to women and men.” Read more »

by Adele A Wilby

Many feminists, and indeed scholars more generally, frequently, and rightly, decry the writing of women out of history. Books such as Cathy Newman’s Bloody Brilliant Women, attempt to redress the historical omission and accord recognition to women who have made major contributions to the progress of humanity. However, while these developments are to be welcomed, it has to be acknowledged that women’s history has its darker side also: women have been complicit in the perpetration of historical wrongs. Sarah Helm’s If This Is A Woman documents the dehumanisation of female prisoners by female guards at the notorious all woman concentration camp at Ravensbrück during World War II; Laura Sjoberg and Caron E. Gentry’s Mothers, Monsters, Whores: Women’s Violence in Global Politics points out the potential of women to support and participate in acts of genocide. And, as Stephanie E. Jones-Rogers’s They Were Her Property: White Women as Slave Owners in the American South informs us, women were deeply involved in another historical wrong: slavery in the United States. Women were, as Jones-Rogers’ says, ‘co-conspirators’ in the institution of slavery in the US, and their involvement constitutes an aspect of the wider history of white supremacist organisations in the US.

Jones-Rogers lays to rest any assumption that the trading and ownership of enslaved human beings in the US was primarily the domain of white men. Indeed, the objective of Jones-Roberts’ book is ‘to focus on women who owned enslaved people in their own right and, in particular, on the experiences of married slave-owning women…the pecuniary ties formed one of slave-owning women’s primary relations to African American bondage’. Thus, women as slave owners challenges our understanding of the gender identity of women, gender power relations and indeed property rights during this period in US history. She reveals just how far the ownership of enslaved people was a source of economic independence and hence power and status for many white women in the family and society, and the creation of such conditions for women frequently began in early childhood. Read more »

by Brooks Riley

by Scott F. Aikin and Robert B. Talisse

In ordinary contexts, one is said to be civil when one maintains a soft tone and calm manner in the face of opposition. It is consequently seen as uncivil to be uncompromising, trenchant, and exercised in debate. Civility, it seems, is the requirement that disputants adopt a stance towards one another that minimizes the escalation of hostility. The thought is that disagreement tends to be most productive when enacted in cooler temperatures.

Civility in this ordinary sense of the term is something to be commended. When disputes become needlessly heated, they fly off the rails. And when disputes escalate in this way, the problems and questions over which people divide go unaddressed. Incivility leads either to standstills or to circumstances where one side simply imposes its will on the other. Neither makes for healthy relations.

However, when it comes to political disagreements among democratic citizens, ordinary civility presents a puzzle. Although democracy is commonly associated with its most familiar institutional mechanisms such as elections, voting, campaigns, representative offices, and so on, these draw their justification from the deeper moral ideal that democracy serves. This ideal is self-government among social equals. In other words, democracy is the moral proposal that a relatively stable and just political order is possible in the absence of rulers, lords, and bosses. To be sure, all politics involves the exercise of coercive power; however, in sharing political power as equals, democratic citizens are never simply subjected to force. In a democracy, political power is both constrained by constitutional provisions that protect individual rights and accountable to those over whom it is exercised.

At any rate, that’s the ideal of democracy. It goes without saying that real democracies fall far short. Hence the question arises of whether any existing political order is truly democratic. Read more »

Pakistani tailor repairing my US Navy winter peacoat in his shop in Brixen, South Tyrol, in November of 2016.

by Brooks Riley

Now that the Emmys are over and we Americans have patted ourselves and a few Brits on the back for outstanding work, it’s time to consider one of the grandest achievements of the past year, a Netflix series from South Korea called Mr. Sunshine, which has, inexplicably, been ignored by media critics in the West.

Masterpiece Theater meets Gone with the Wind seems a sorry way to try to pigeonhole this epic series and there are those who might want to relegate it to the level of soap opera in costume. Mr. Sunshine is operatic, yes, but there’s not a soap bubble in sight in this multi-faceted, extravagant, scrupulously constructed tale of Korea at the turn of the last century.

I had planned a different essay this time, a critical examination of Nietzsche’s writings on Richard Wagner and was deep into reading and researching for that post when I started Mr. Sunshine. At first, I was able to divide my days between the loquacious, bellicose Mr. N in the morning, and the reticent finesse of a sprawling word-spare historical drama from the Far East at night. As time went on, however, I was lured away from Nietzsche’s late-19^th-century twitterstorm, moving deeper into a subtly structured saga set in the Korea of a few years later–its rich, intricate dramaturgy, its attention to detail, its sprawling story, its inspired screenplay. Nietzsche’s infantile trolling of Wagner and counterpunch extolling of Bizet paled against the quiet retributions, political intrigues and slowly unfurling love quadrangle within a roiling cultural and social upheaval on the other side of the globe. Read more »

by Shadab Zeest Hashmi

Oversized photography equipment. Tangled wires.

In a corner, a dusky, crooked mirror.

Ami takes us to the studio for our first passport photos. I am wearing a dress that reminds me of beets for its color and glassy smooth texture. The passport is for a visit to India.

From her purse, ami takes out cash, maybe forty-five rupees for three passport photos and a formal portrait of all three children together.

The rupee coin in India had had Empress Victoria engraved on it for decades by the time my grandparents were born. And around the time my parents were born, the earlier struggle for independence from the British Empire was already becoming the struggle to settle the new nation of Pakistan— the crescent and star newly engraved on the currency. By the year of my own birth, gone was that currency of my parents’ generation, those banknotes with the Bengali script; only Urdu remained— East Pakistan had been split from West Pakistan.

When India was partitioned from Pakistan, my young married aunts had stayed in India while my grandparents migrated with the rest of their children to Dhaka, East Pakistan. It was there my father had attended the American school and prepared for college in the UK, my mother had attended Dhaka University as an exchange student from Lahore, and it was there my parents were engaged.

When another partition was on the horizon, the one between East and West Pakistan, the entire family moved to West Pakistan. In the late sixties, my father returned from London and married my mother in Lahore.

I am negotiating wires and tripods, making my way to the mirror. Read more »

Ellin Berman is a board-certified medical oncologist and hematologist with a clinical and research focus on new drug development in acute and chronic leukemias, including acute myelogenous leukemia (AML) and chronic myelogenous leukemia (CML). As a member of the multidisciplinary Leukemia Disease Management Team at Memorial Sloan Kettering Cancer Center (MSKCC), she works closely with the many individuals who make up the clinical and research programs there. Along with other members of the Leukemia Service, she is involved in clinical trials of new drugs that hopefully will lead to new treatment approaches for these diseases. She has also worked closely with the Food and Drug Administration in this regard, and for the last 20 years have helped review new drug applications for the treatment of leukemia. She is a member of KSKCC’s Institutional Review Board (IRB), the committee that approves, monitors, and reviews research studies at the Center. She is an Associate Editor for the journal Leukemia Research, and reviews articles for a number of other journals including Blood, the Journal of Clinical Oncology, Cancer Research, The Lancet, and the New England Journal of Medicine.

Azra Raza, author of the forthcoming book The First Cell: And the Human Costs of Pursuing Cancer to the Last, oncologist and professor of medicine at Columbia University, and 3QD editor, decided to speak to more than 20 leading cancer investigators and ask each of them the same five questions listed below. She videotaped the interviews and over the next months we will be posting them here one at a time each Monday. Please keep in mind that Azra and the rest of us at 3QD neither endorse nor oppose any of the answers given by the researchers as part of this project. Their views are their own. One can browse all previous interviews here.

1. We were treating acute myeloid leukemia (AML) with 7+3 (7 days of the drug cytosine arabinoside and 3 days of daunomycin) in 1977. We are still doing the same in 2019. What is the best way forward to change it by 2028?

2. There are 3.5 million papers on cancer, 135,000 in 2017 alone. There is a staggering disconnect between great scientific insights and translation to improved therapy. What are we doing wrong?

3. The fact that children respond to the same treatment better than adults seems to suggest that the cancer biology is different and also that the host is different. Since most cancers increase with age, even having good therapy may not matter as the host is decrepit. Solution?

4. You have great knowledge and experience in the field. If you were given limitless resources to plan a cure for cancer, what will you do?

5. Offering patients with advanced stage non-curable cancer, palliative but toxic treatments is a service or disservice in the current therapeutic landscape?

by Ali Minai

Sometimes, history moves faster than thought. Something like that is happening in the United States in these early days of fall. Though the season is taking longer than normal to turn, the political season has changed more quickly than anyone expected. The opinions of last week – such as the long article I had written for 3QD on the prospects of Donald Trump and the Democrats in 2020 – have suddenly become irrelevant, and I find myself writing this wholly surprising piece on the possible impeachment of Donald Trump. As these lines are being written, 223 Democrats and one Independent in the US House of Representatives – a clear majority – have announced on the record that they support opening an impeachment process against the President. That number was 120 at the beginning of September, and below hundred just a couple of months ago. We are at a hinge moment in the Trump presidency and in American history.

In critical situations with severely limited options, timing is almost always critical. If a fearsome beast is charging to attack you and you have a single bullet in your gun, when you fire that bullet is as important as whether you aim right. If you fire too soon, the bullet falls to the ground ineffectually and you are at the mercy of the beast, and if you hold your fire too long, the beast will already be upon you.  Nancy Pelosi, expert huntress that she is, seems to have got her timing on impeachment exactly right.

The Democratic base has wanted to impeach Donald Trump virtually since the minute he was elected. That fervor persisted as the so-called “Resistance” grew in the wake of the Muslim Ban and other inhumane, ill-advised, and outright cruel Trump Administration policies. However, while the intensity of this fire grew every day, it did not spread beyond the base, and all those who wished to check Trump’s reckless administration came to see winning back the House of Representatives for the Democrats in 2018 as the primary goal. Fed by this passion, the Democrats duly captured the House, decimating the Republicans in cities and suburbs from Wisconsin to Texas. After eight years in the minority, the Democrats were back in charge. Read more »

by Joan Harvey

a skilled
Vigilant, flexible,
Unemphasised, enthralled
Catching of happiness

from Born Yesterday by Philip Larkin, quoted in Adam Phillips, One Way and Another

But the fear’s so strong it leaves you gasping
No way to last out here like this for long
‘Cause everywhere I go, I know
Everywhere I go, I know
All my happiness is gone
All my happiness is gone
It’s all gone somewhere beyond
All my happiness is gone

—David Berman, All My Happiness is Gone

It’s tied to that word we were talking about this morning—ebbrezza. There is a sort of wondrous fever that can go on, and that is very near a feeling of happiness. The Sanskrit word tapas, “ardor,” is deeply connected with this. —Roberto Calasso

In Microhabitat, a film by Korean Jeon Go-woon, a young woman who cleans houses for a living goes to an elegant bar after work each day where she sits alone and contemplatively drinks a glass of good whiskey and smokes a cigarette. When her rent goes up, rather than give up this daily bit of relief she gives up her apartment, and moves nomadically around the city, staying with friends when she can. Some of her friends in the film are morally outraged at her choice, especially as neither cigarettes nor whiskey are considered healthy. I found the film striking in showing a woman taking care of herself, in a way not socially acceptable, knowing what she needed to get through the day. Men are often filmed in bars, but we rarely see women just pausing, not unhappy, not looking for anything but time alone for themselves, in a place where, for a change, they are waited upon. I saw in this a woman’s way of allowing herself some daily respite, an achievement of a space of happiness. Read more »

by Emily Ogden

When Donald Trump was elected, I was pregnant with twins. My sons were born after the 2017 inauguration, under what I cannot help but feel is an ill star—though in themselves they are privileged and want for nothing. Nothing, that is, except a planet whose future is secure and a nation that does not “reign without a rival” for “revolting barbarity and shameless hypocrisy”—words of Frederick Douglass’s whose restless sound wave has kept propagating itself. My sons were learning to crawl when white supremacists marched in downtown Charlottesville, a mile from our house. They started walking at about the time that NPR played recordings of children wailing in detention centers. No crisis that has come, has passed. Another election is approaching; talk of impeachment grows serious. And my sons, oblivious to all of this, are asking for stories.

“Story bout that,” they say, when some event, or more commonly some non-event, captures their attention. In the dark, Beckettian world of their fictions, little happens except for a persistent breaching of bodily integrity. Here are some of the stories; judge for yourself (L. and N. are my sons, and Zeke is one of our dogs):

When L. got stung by a bee

When N. got stung by an ant

When N. got a splinter in his foot

When a wheel fell off the neighbor’s pickup truck

When Zeke broke [killed] the snake

When Zeke broke the lizard

When the weather broke

When a bowl broke

When L. had broken skin

When the red balloon went up to the ceiling and we couldn’t reach

When Zeke got out the front door

When N. was coughing so hard he gagged

When the red baby cried

Things break and people break and we, the tellers of stories, survive. That is the common burden of these monotonous, unstructured downers, each of which I have been ordered to tell at least fifty times. My sons listen, calm as sucklings. Why such an appetite for damage? It reflects their reality, I suppose. Toddlers fall and they destroy things. I understand the appeal of Humpty Dumpty without the need to search for royalist intimations. An egg, who is at once a fragile person and a fragile object, shatters beyond repair. Welcome to my household. My sons have had several great falls each, and they have broken literally dozens of literal eggs. Read more »

by Jeroen Bouterse

I remember the first time I thought I might be able to get on board with Stoicism. I read a passage in Aulus Gellius’ Attic Nights, about a distinguished Stoic philosopher on a ship crossing the Ionian sea. The ship finds itself in a violent storm, and seems to be on the verge of being overpowered by the elements. The narrator describes how everybody is working to keep the vessel afloat, all the while lamenting their situation.

In the midst of all the chaos, he looks for the Stoic – perhaps to anchor his own courage in the idea that the truly wise are unperturbed even by this seemingly dire situation. “And then”, he remembers later, “I beheld the man frightened and ghastly pale, not indeed uttering any lamentations, as all the rest were doing, nor any outcries of that kind, but in his loss of colour and distracted expression not differing much from the others.” Whether the philosopher at least manages to make himself useful at the pumps remains unclear.

To add evident insult to apparent injury, a rich man then heckles the Stoic, remarking that he himself showed no fear whatsoever. The philosopher’s retort is something to the effect that apparently the man doesn’t have as much to lose by his death as has the philosopher. We can hardly expect that witticism, expressed in a convoluted way and apparently after some hesitation, to have saved his face.

Now that’s my kind of Stoic – the kind of hero who still jumps at loud noises, and who still gets bullied by obnoxious social superiors. Read more »

by Brooks Riley

by Claire Chambers

I’m just back from a short trip to Lahore and, while the colours, tastes, and sounds are still vibrant in my mind, I want to write it all down.

On my way to Pakistan I got talking to someone at Manchester Airport. We were both eager to charge our phones before the long flight and ended up taking turns with our plugs at the socket as we engaged in desultory chat. This young woman hailed from London and, like me, was unusual in travelling alone. She told me she was on a visit to her Pakistani husband. They had met on their degree courses at the University of Nottingham, and while they waited for his UK spousal visa to come through she was making regular trips to Lahore to see him. A British Indian Sikh, she still hadn’t told her family, even though the couple had been married for almost two years. His family in Lahore also had no knowledge of their nuptials, for the couple believed that their relatives on either side would never accept this marriage across borders and faith groups

Indeed, this is a tense time for Indo-Pak relations. In Lahore, friends would from time to time reveal their heightened awareness of how long it had been since Narendra Modi’s abrogation of Kashmir’s semi-autonomous status. At the time of writing it is fifty days since this decision was passed by the Rajya Sabha. Aghast as I am at Modi’s lockdown of the valley, before this trip I would not have thought of counting days (like a prisoner, aptly enough). Read more »

by Gabrielle C. Durham

Do you remember when the Irish playwright and critic George Bernard Shaw suggested significant changes to English spelling so that it would make more sense? Probably not, because it was more than 70 years ago. According to him and, likely, some predecessors, English spelling was so goofy that ghoti could be manipulated to sound like fish. (Gh as in “enough,” o as in “women,” ti as in “action.”) He had an admittedly excellent point about the, um, esoteric spelling rules of English.

Often alphabets reform during times of great social and political upheaval as an issue of nationalism. For instance, many of the languages and alphabets in Europe underwent serious changes to uphold and distinguish themselves from other similar languages in the second half of the 19th century, amidst all sorts of revolutions.

For example, one Serbian hero is Vuk Karadžić, who updated the Serbian Cyrillic alphabet in 1818, which was officially adopted in 1868 in Serbia, Bosnia, and Herzegovina. He removed many letters from the old alphabet and added a few new letters to better match how people actually spoke. If you have ever heard of Saints Cyril and Methodius, you may be familiar with the two brothers creating the alphabet that led to modern Cyrillic in or around 900 (Cyrillic being named for St. Cyril). The alphabet they created was actually Glagolitic, which in its original form has been found in parts of modern Croatia. The alphabet that the brothers created was intended to for transcribing the liturgical language Old Church Slavonic. Its strongest predecessor was ancient Greek, with elements of Old Bulgarian and Old Macedonian. Read more »

Crescent moon with vapor trails at twilight in Brixen, South Tyrol, in December, 2016.

by Marie Gaglione

Things are changing. Always, everywhere, immensely and minutely, the history of mankind unfolds as we rotate around a grand burning star (also, everything everywhere else changes; the history of mankind may be of the least consequence on a cosmic scale, but I digress). I digress too early; I include parentheticals too soon; I stall with flowery descriptions of the sun. Because – ugh – I’m going to talk about “how divided we are as a nation.” It’s such a tired phrase; I don’t want to write about it. It’s stale because it’s static, and anyway, the declaration is often accompanied by divisive rhetoric. Wherever one may fall on the political spectrum (and here I’m being gracious; how often do we now identify with a “side”), they likely have established opinions of those who lie elsewhere. It does seem increasingly difficult to imagine a sweeping reconciliation when we continue to pour our definitions in concrete and defend our positions by reason of consistency. Inflexibility begets inability to listen, and thus to understand, which is why we find our differences so baffling and allow our prejudices to influence our opinions. So, finally, here it is: my own personal take on how we can get people to stop saying how divided we are. Bear with me, because I’m going to try and sell contradictions as potential energy for unity. Read more »