Dr. Mustafa Çetiner is well-known for his research in Hematology and has published numerous articles in different national and international journals and three books on Hematological Malignancies. He was the chairman of the Turkish Hematology Society Bone Marrow Deficiency Scientific Subcommittee during 2014-2018. He is a member of many national and international associations, including Turkish Hematology Association, American Society of Hematology, European Bone Marrow Transplantation Registry. He is one of the founders of the Cancer Fighters Association and is currently a board member and vice president. Dr. Çetiner is currently working as Professor of Hematology at Acibadem Maslak Hospital in Turkey, Istanbul.

Azra Raza, author of The First Cell: And the Human Costs of Pursuing Cancer to the Last, oncologist and professor of medicine at Columbia University, and 3QD editor, decided to speak to more than 20 leading cancer investigators and ask each of them the same five questions listed below. She videotaped the interviews and over the next months we will be posting them here one at a time each Monday. Please keep in mind that Azra and the rest of us at 3QD neither endorse nor oppose any of the answers given by the researchers as part of this project. Their views are their own. One can browse all previous interviews here.

1. We were treating acute myeloid leukemia (AML) with 7+3 (7 days of the drug cytosine arabinoside and 3 days of daunomycin) in 1977. We are still doing the same in 2019. What is the best way forward to change it by 2028?

2. There are 3.5 million papers on cancer, 135,000 in 2017 alone. There is a staggering disconnect between great scientific insights and translation to improved therapy. What are we doing wrong?

3. The fact that children respond to the same treatment better than adults seems to suggest that the cancer biology is different and also that the host is different. Since most cancers increase with age, even having good therapy may not matter as the host is decrepit. Solution?

4. You have great knowledge and experience in the field. If you were given limitless resources to plan a cure for cancer, what will you do?

5. Offering patients with advanced stage non-curable cancer, palliative but toxic treatments is a service or disservice in the current therapeutic landscape?

by Charlie Huenemann

GENIE: AT LAST! Esteemed Master, you have released me from the ancient lamp! Out of my boundless gratitude, I shall grant you three wishes!

TRAVELER: No thanks, I’m good.

GENIE: Wait, what?

TRAVELER: I’m good. No granting of wishes needed. Have a nice day.

GENIE: But, Master, you must understand that you can wish for anything it is in my power to grant – and let me tell you, that power is enormous!

TRAVELER: I’m sure it is. But I’ve heard all the stories about you genies and the way you grant wishes, and I’d like no part of it.

GENIE: What do you mean, Honored Master?

TRAVELER: Well, you genies are tricky. I might wish to play the piano, but you’ll grant it and then stick me out on a desert island, or you’ll make me deaf so I can’t hear my own playing. Or I’ll wish for a pile of money, but then I’ll go to jail for tax fraud, or the money will be in some outdated currency. Or I’ll ask for a great army to command, and you’ll give me an army of frogs. So no thanks, I’ll have no part of it. Too risky!

GENIE: Well … true, that sort of thing has happened from time to time. But only when there is a lesson to be learned. And let me say that sometimes it is the wisher’s own fault for not being more specific! Like the man who wished to be a great opera singer – how was I supposed to know he didn’t want to be a soprano? Read more »

by Brooks Riley

by Mary Hrovat

The indicators that people use to track and understand their moods include exercise, diet, sleep, and many others. I’ve been thinking recently that my library activity surely must be correlated with my mood. I’m a frequent user of two libraries, and my checkouts and returns have a fairly small and regular ebb and flow. Overlying these minor fluctuations are larger and more diffuse patterns that I think offer clues to my inner state.

Reading the clues can be complicated. If there’s a connection between mood and library activity or reading, it’s not clear-cut. But that’s true of various other markers that people track. For example, sometimes I get a lot of exercise because I’m filled with energy and relish the physical pleasure of walking and observing. At other times, a high step count reflects the fact that I’m restless and anxious; part of me is hoping that if I walk far enough, I can out-walk my problems or maybe even myself. Sometimes I push myself to get out a lot even if I feel exhausted and sick at heart, because I hope the exercise will lighten my mood or help me sleep. And sometimes, of course, I walk a lot because there are many errands to run, and I don’t drive.

The depression questionnaire they use at my doctor’s office asks about seemingly contradictory things; one question asks whether you’ve either lost your appetite or been overeating, for example, and another asks if you’re sleeping more or less. I don’t know if that means that depression can either enhance or suppress appetite, or whether people respond to depression by shunning food or seeking comfort from it, or (most likely) a little of both. It can be very hard to tell symptoms from attempts to treat symptoms. Read more »

by Rafiq Kathwari

A Jewish grandfather and a Muslim man walk into a New York delicatessen….and 55 years later the Muslim man writes a trailblazing autobiography.

He’s scrawny when he leaves his native home in the Vale of Kashmir, a disputed land in the Himalayan foothills between India and Pakistan. He dodges an impending war. He has no formal passport, just an official residency permit which expired many years ago.

Yet, he takes a chance and, amazingly, boards the last flight from Delhi to Lahore before war breaks out.…it’s an electrifying moment among many, some heartbreaking, some joyful, others human, all too human.

Those moments lead one to believe that the young man was destined for the future of his adopted home, America, where his grit and pluck, his trysts with good luck, his innate belief in common sense all combined to feed his fire within before the fire could feed on him.

Read, how many years ago the Jewish grandfather saw the hunger in the eyes of the Muslim man and sent him on a Mission Impossible to Washington D.C.

Muslim man made the impossible possible, earning the trust of his Jewish mentor who, soon after, handed over the captaincy of his quintessentially Yankee company— Ethan Allen (named after a hero of the American Revolution) — that he had founded during the Great Depression to the young Muslim man named Farooq — which in Islamic tradition means “The Redeemer” or “the one who distinguishes between right and wrong.”

Read how Farooq brought his only previous role as captain (of his college cricket team in his native Kashmir) to bear upon his new captaincy of Ethan Allen in Danbury, Connecticut, its headquarters. Read more »

by Joseph Shieber

This semester I’ve been teaching a first year seminar entitled “Propaganda”. It is, unfortunately, a very timely topic.

The course draws first year students from across the spectrum of majors — some up-and-coming humanities majors, but also economists, natural scientists and engineers. Because of that mix, and because of the fact that I can’t really expect that many of the students have been exposed to philosophical thinking in their pre-college careers, I try to use the course as an opportunity to introduce the students to a little bit of how philosophy is done.

Having taught the course over a few iterations now, I’ve had an opportunity to observe a few different reactions on the part of my students to the bit of philosophy that we engage in in the course. There’s some dismissiveness, of course, on the part of some of the students, but I’ve also noted surprise on the part of some of the students in response to my own stance about how modest the fruits of philosophy often are.

I think that many of the students expect me to claim more for philosophy and what it can achieve. Perhaps they expect me to declaim dramatically that there is no such thing as truth. Instead, I’m more than happy to assert a variety of truths: that human-caused global warming is a genuine phenomenon, for example, or that vaccines don’t cause autism, or that human beings are the result of evolution by natural selection. But I also take pains to try to expose the assumptions on which those assertions of mine rely. And I also try to trace how different assumptions — including about what counts as good evidence — might lead someone to have different beliefs.

What I hope to achieve with the way that I deploy philosophy in the course is to get students to appreciate the value of intellectual humility. I want them to recognize how rigorous and exacting intellectual humility can be. It involves excavating the hidden premises that underlie our beliefs. It is also compatible with maintaining our belief in the truth of those premises, while at the same time acknowledging that those who accept different, incompatible premises, will arrive at different beliefs. Read more »

by Abigail Akavia

When you opened the door to the apartment where I grew up, you could see all the way to the end of the living room and the large window that spanned its width, an entryway-less structure typical of apartment buildings in Tel Aviv. Our living room was particularly long, though, so that my father’s desk, which sat close to the window but facing the middle of the room, felt far enough away to be considered its own space, set apart from the bustle of a three-kids household that was also my mother’s in-home clinic. Add to the physical distance my father’s ability to immerse himself in whatever he was reading, ignoring anything that was not a direct address to him (one of those universal dad superpowers, my mothering self now knows), and he was almost completely cordoned off from the rest of us when he was sitting at his desk, as if behind a door ajar.

Even when his reading lamp was the only light on in the big room, it was possible to consider his almost immobile figure as not quite there. When my first boyfriend stepped into the apartment for the first time, however, he most definitely recognized my father’s dimly-lit, looming professor-like presence at the edge of the room. He was what you would call “a good kid”—I, in hindsight, have taken to defining him, even at 19, as a mensch—and he took the prospective meeting with my dad seriously. My father, for his part, preferred to act as if nothing out of the ordinary was happening. He put down his glasses, looked up to say a short hello, and then resumed his reading, a combination of simply holding on to his business-as-usual seat at his desk, deliberately extending the gift of privacy to his late-bloomer daughter, and a possibly unconscious urge to avoid the awkwardness of the encounter.

Maybe he also knew, in a parental sixth-sense which I used to think only my mother had but of which I can now also imagine a paternal version, that this very nice guy wasn’t the love of my life—that he was not going to sweep me away, there was really nothing to worry about. So there was no menacing handshake, no steely look into the young man’s eyes to force him to own up to his mythically filthy intentions and metaphorical abduction of my father’s youngest, no once-over to assess his prospective ability to provide for me. In short, no forced and embarrassing macho face-off.  Read more »

Martin Roth. “from may to june 2012 i grew grass on rugs in a castle”.

” …This state of in-between is central to his Persian rugs on which grass grows “on the ‘dust of history’.” They were inspired by philosopher Michel Foucault’s examination of “heterotopias,” spaces that both exist and do not exist. Since the designs of carpets were first patterned after gardens, Foucault wrote that “the garden is a rug onto which the whole world comes to enact its symbolic perfection, and the rug is a sort of garden that can move across space.”

More here and here.

Dr. Burhan Ferhanoglu is specialized in areas of lymphoma, Hematological Malignancies and multiple myeloma. He is a member of many national and international scientific societies, including the Turkish Hematology Association, American Society of Hematology, European Bone Marrow Transplantation Society and International Society of hematology. In 1998, he became the chief of the Hematology Department of V.K.V American Hospital in Istanbul. Currently, he serves as head of the Department of Internal Medicine at Koç Üniversitesi School of Medicine in Turkey, Istanbul.

Azra Raza, author of The First Cell: And the Human Costs of Pursuing Cancer to the Last, oncologist and professor of medicine at Columbia University, and 3QD editor, decided to speak to more than 20 leading cancer investigators and ask each of them the same five questions listed below. She videotaped the interviews and over the next months we will be posting them here one at a time each Monday. Please keep in mind that Azra and the rest of us at 3QD neither endorse nor oppose any of the answers given by the researchers as part of this project. Their views are their own. One can browse all previous interviews here.

1. We were treating acute myeloid leukemia (AML) with 7+3 (7 days of the drug cytosine arabinoside and 3 days of daunomycin) in 1977. We are still doing the same in 2019. What is the best way forward to change it by 2028?

2. There are 3.5 million papers on cancer, 135,000 in 2017 alone. There is a staggering disconnect between great scientific insights and translation to improved therapy. What are we doing wrong?

3. The fact that children respond to the same treatment better than adults seems to suggest that the cancer biology is different and also that the host is different. Since most cancers increase with age, even having good therapy may not matter as the host is decrepit. Solution?

4. You have great knowledge and experience in the field. If you were given limitless resources to plan a cure for cancer, what will you do?

5. Offering patients with advanced stage non-curable cancer, palliative but toxic treatments is a service or disservice in the current therapeutic landscape?

by Tamuira Reid

Mom, why are we always at the doctor? Every week we come here. Are you dying?

No, baby.

Why are we always here then?

If you grow-up in NYC with a single mom at the helm, then you grow-up in waiting rooms. And every kid knows what waiting rooms really are: babysitters. And they all pretty much look the same. Books with pages missing. Cartoons on a television jutting out of the wall. And if you’re lucky, an entire vat of dum-dums in every flavor known to man.

This is a special kind of doctor. A doctor that takes care of my brain.

Your brain is sick?

Yeah, a little. I guess you could say that.

Like my dad’s?

Not that sick.

I’ve become very good at self-editing. Hiding what needs to be hidden, saying what needs to be said. The fact that there is a rhino-sized pit in my stomach is my business. No one needs to peer into the bowels of my brokenness.

Ollie looks at me through his coke-rimmed glasses, so dirty I can barely see his big green eyes. He’s waiting for more information. I can feel him processing. Read more »

by Mindy Clegg

In issue 85 of The Big Takeover, regular contributor Tim Sommer declared in his editorial that we continue to get punk wrong. Rather than a singular historical event, split between NYC and London, he argued for two different events with a shared name happening in each place.¹ He advocates for something like a polygenist theory of punk, which he argues only stabilized in definition in the early 1990s with the popularity of Green Day and the like. There is much to like about his argument, most notably the acknowledgment that people often attempt to shoehorn a neat and tidy narrative onto the past in a way that does little justice to history. Without meaning to perhaps, he mostly points out the divergence between histories written by music critics (often, but not always, in service to the mainstream of the recording industry) and those written by historians seeking to better understand change over time.

The corporate-driven narratives some more mainstream critics produce represents the kind of bad history he’s rebelling against here, histories that assume and anticipate outcomes and progress. In these sorts of historical accounts, the end is already established and all roads lead to the Rock & Roll Hall of Fame. Sommer hovers around that, while not precisely coming out and saying it. After all, he very well knows the problems with the mainstream music industry dominating the narrative. I wish to springboard off Sommer’s insights to highlight a more nuanced view of the history of punk rock, one of the two most important musical movements in the last quarter of the twentieth century (the other being hip hop). Read more »

by Brooks Riley

by Samia Altaf

When we were young and living in Sialkot, we went frequently, almost once a week, to Lahore, the grand and hip city just a two-hour drive away. The trips were ostensibly for some real work—father, a district court lawyer, was appearing in a case being heard in the High Court or, his tuxedo in the trunk, was heading to a meeting of the Freemasons. Or it was for mother, who had critical shopping at Haji Karim Buksh, for crystal fruit bowls or the latest coffee cups, things not to be found in Sialkot, or was going to Hanif’s for a hair trim. Mother in the early 1960s sported a Jackie Kennedy cut that needed serious maintenance and only Hanif’s could manage that. For the children it might be to see doctors or dentists at Sir Ganga Ram Hospital—deflected septum (one of the boys was an avid boxer), enlarged tonsils, persistent skin rash, and such. And of course the routine checkups for father’s hypertension. Sialkot at the time did not have specialist doctors or reliable surgical facilities. (Interestingly enough it still does not, despite being a manufacturer and exporter of surgical goods.)

SGRH and Fatima Jinnah Medical College for Women were where mother’s sister worked as a young doctor, and where the best doctors were, as far as we were concerned. It was there that we sat on high stools in the college canteen and sipped Coca-Cola on the rocks. Rocks! At a time when ice cubes had barely made their way into our lives. Coca-Cola in tall glasses through paper straws—even the paper straw a novelty, what to say of the nose-tingling fizzy drink. Thrown in would be a visit to grandma for a rest and wash and maybe a sleepover. Grandma lived on Waris Road and in addition to encouraging comments on how one had grown—since last week!—we got to eat oodles of delicious food, homemade mango ice cream in summer and piping hot gajar halwa in winter, and to flirt with the curly-haired shy cousins on holiday from Karachi. Usually an evening trip to the zoo in Lawrence Gardens, named after John Lawrence, one of the viceroys, was a bonus. (Lawrence Gardens has now morphed into Bagh-e-Jinnah.)

But in reality all of these were just excuses to go to Lahore, that grand and glorious city full of throbbing and thrilling life, of sin and splendor, of glamorous women in sleeveless, waistless blouses worn with chiffon saris and men with Brylcreemed hair in bow ties congregating at the Gymkhana Club or Services Club, or the Saturday night jam session at Falleti’s Hotel. Read more »

by Katie Poore

A few weeks ago, one of my closest friends finished a thru-hike of the Pacific Crest Trail, the 2,650-mile footpath that snakes its way from Campo, California on the Mexican border to Mansfield Park, a few miles into Canada. It follows—as the name suggests—the crests of some of the West’s grandest mountain ranges: the Cascades in the Pacific Northwest, the Sierra Nevadas further south. It meanders through the Mojave Desert in southern California.

Ever since I read Cheryl Strayed’s 2012 memoir Wild: From Lost to Found on the Pacific Crest Trail as a fourteen-year-old, this footpath has occupied something of a sacred space in my imagination. And I am, evidently, not the only one. The trail granted 4,000 long-distance permits in 2016, the majority given to those intending to thru-hike—or walk the entire length of—the trail. Outside Magazine reports that the release of Wild’s 2014 film adaptation resulted in a 300% increase in web traffic on the official PCT website. If you’ve watched Netflix’s new installment of Gilmore Girls, you might recall a few scenes where Lorelai decides to remake her over-complicated life by following in Strayed’s footsteps. As she staggers to the PCT trailhead, however, she is greeted by a hoard of middle-aged divorcées and otherwise unsatisfied women with precisely the same idea. “Book or movie?” they ask each other. Gilmore Girls paints this journey as a kitschy one, the modern woman’s cliché strategy for shrugging off a mid-life crisis and walking off crappy ex-husbands. But here’s what’s true about those women, and the real people who hike this trail: most of them are there to remake themselves, to realize something, even if they don’t know what that something is just yet.

One can believe or not believe in this kind of spiritual journey, but it’s nonetheless an idea whose roots run deep in American soil. Think of Henry David Thoreau and Ralph Waldo Emerson and John Muir, of Robert Frost and Emily Dickinson and Walt Whitman. Consider Annie Dillard. Wendell Berry. Mary Oliver, whom the New York Times calls “one of the best-selling poets in the country.” Narratives of a redemptive natural world are everywhere. American wilderness, it seems, is nothing if not a spiritual and intellectual treasure trove. Where the flora and fauna run wild, these writers suggest, so may our souls. Read more »