Carl Zimmer in The New York Times:’
Scientists have created a living organism whose DNA is entirely human-made — perhaps a new form of life, experts said, and a milestone in the field of synthetic biology. Researchers at the Medical Research Council Laboratory of Molecular Biology in Britain reported on Wednesday that they had rewritten the DNA of the bacteria Escherichia coli, fashioning a synthetic genome four times larger and far more complex than any previously created. The bacteria are alive, though unusually shaped and reproducing slowly. But their cells operate according to a new set of biological rules, producing familiar proteins with a reconstructed genetic code. The achievement one day may lead to organisms that produce novel medicines or other valuable molecules, as living factories. These synthetic bacteria also may offer clues as to how the genetic code arose in the early history of life.
Each gene in a living genome is detailed in an alphabet of four bases, molecules called adenine, thymine, guanine and cytosine (often described only by their first letters: A, T, G, C). A gene may be made of thousands of bases. Genes direct cells to choose among 20 amino acids, the building blocks of proteins, the workhorses of every cell. Proteins carry out a vast number of jobs in the body, from ferrying oxygen in the blood to generating force in our muscles. Nine years ago, researchers built a synthetic genome that was one million base pairs long. The new E. coli genome, reported in the journal Nature, is four million base pairs long and had to be constructed with entirely new methods.
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The wars in Afghanistan and Iraq have gone on so long that the Middle East war novel has itself become a crusty genre — a familiar set of echoes coming back to us from ravaged lands. Many of these books are stirring on the level of detail but an equal number thoughtlessly valorize the American soldier or wallow in the morally vacuous conclusion that war is hell and that’s that. Where is the ferocious “Catch-22” of these benighted conflicts? Who will have the temerity to make these wars the subject of bracing comedy?
Jared Diamond’s new book,
On a recent afternoon in Helsinki, a group of students gathered to hear a lecture on a subject that is far from a staple in most community college curriculums.
This January, Hussein Fancy, an American academic of Pakistani origin, received the Herbert Baxter Adams Prize, awarded annually by the American Historical Association “to honor a distinguished book published in English in the field of European history,” for his groundbreaking work The Mercenary Mediterranean: Sovereignty, Religion, and Violence in the Medieval Crown of Aragon. This isn’t the first prize awarded to this book: it had earlier been the recipient of the Jans F. Verbruggen Prize from De Re Militari for the best book in medieval military history and the L. Carl Brown AIMS Book Prize in North African Studies. These three very different prizes, each with different parameters, indicate the range and importance of Fancy’s research.
Audrey Hepburn was one of the most celebrated actresses of the 20th century and a winner of Academy, Tony, Grammy, and Emmy awards. She was a style icon and, in later life, a tireless humanitarian who worked to improve conditions for children in some of the poorest communities in Africa and Asia as an ambassador for UNICEF. But this extraordinary individual was the product of an extremely difficult childhood. Her father was a British subject and something of a rake and her mother was a minor Dutch noblewoman. Both of her parents flirted with the Nazis in the 1930s. Her mother met Adolf Hitler and wrote favorable articles about him for the British Union of Fascists. After abandoning the family in 1935, her father moved to England and became so active with Oswald Mosley’s fascists that he was interned during World War II. As a child, Hepburn rarely saw him.
It’s a well-known saying that women lost us the empire,” the film director David Lean said in 1985. “It’s true.” He’d just released his acclaimed adaptation of A Passage to India, EM Forster’s novel in which a British woman’s accusation of sexual assault compromises a friendship between British and Indian men. Misogyny may not be the first prejudice associated with British imperialists, but it has proved as enduring as it was powerful. As Katie Hickman discovered when she started writing about British women in India, Lean’s view (if not Forster’s) “remains stubbornly embedded in our consciousness”. “Everyone” she talked to “knew that if it were not for the snobbery and racial prejudice of the memsahibs there would, somehow, have been far greater harmony and accord between the races”. Her book, vivaciously written and richly descriptive, offers a rebuke to such stereotypes. She animates a cast of British women who travelled to India before the 1857 rebellion. They included “bakers, dressmakers, actresses, portrait painters, maids, shopkeepers, governesses, teachers, boarding house proprietors … missionaries, doctors, geologists, plant-collectors, writers … even traders” – and some of them might not have been out of place in a Lean epic of their own.
Emily Wilson in The New Statesman:
Jan-Werner Müller in The Nation:
Over at The Hedgehog & the Fox, an interview with Rachel Sherman:
Brian Resnick in Vox:
“Lent” opens with a beautifully rendered retelling of the life of Savonarola: his visions of demons, his prophecy, his political meddling and his role in vast historical forces tearing apart Italy and France. We meet a cast of characters, each with the ringing verisimilitude of well-researched, real historical personages from the heretical Count Giovanni Pico della Mirandola to the statesman Lorenzo de’ Medici and various clergy, peasants, nuns and friars of feuding orders. Finally, we come to the martyrdom of Savonarola, hanged over a roaring flame, then cut down to fall into the blaze …
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