Elana Gotkine in Medical X Press:
For women with breast cancer, stressors are associated with deleterious alterations to the systemic and tumor immune environment, according to a study published online Feb. 14 in JAMA Network Open.
…More favorable immune-stimulatory changes were seen in association with greater perceived social support (e.g., increased serum interleukin-5 and activated natural killer cells in noncancerous breast tissue of Black women). Associations were seen for higher levels of perceived stress, exposure to discrimination, and neighborhood deprivation with systemic inflammation, deleterious immune cell profiles, and aggressive tumor biologic characteristics. Distinct immunologic features associated with stressors were identified in Black women, including chemotaxis with stress and immune suppression with stress at the systemic level and increased tumor-associated myeloid cells at the tissue level. An association was seen for perceived stress with elevated tumor mutational burden.
More here.
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“Now he is scattered among a hundred cities,” W.H. Auden wrote in 1939, “And wholly given over to unfamiliar affections.” Auden was ruminating on the recent death of the Irish poet W.B. Yeats, but the words could serve as an epitaph for any great author. Poets like to imagine that their creations confer afterlives—for themselves and their subjects—impervious to the assaults of “wasteful war” and “sluttish time” so ruinous to monuments of marble or metal (see Horace’s Ode 3.30 and Shakespeare’s Sonnet 55). But as Auden recognized, the moment an author dies, his or her legacy is on the loose. Any chance those poems have of a future depends on what readers make of them: “The words of a dead man,” Auden continues, “Are modified in the guts of the living.”
The modern concept of GDP was developed in the 1930s and became firmly established during World War II, as it served a national purpose. While Germany was working on its own methods for gauging economic capacity, the United States and the United Kingdom gained a decisive strategic edge by being the first to define total output and compile reliable statistics. This enabled the Allies to maximize production and manage the sacrifices required of their citizens more effectively.
How will AI affect American workers? There are two major narratives floating around. The “
On Wednesday
The visible effects of ageing on our body are in part linked to invisible changes in gene activity. The epigenetic process of DNA methylation — the addition or removal of tags called methyl groups — becomes less precise as we age. The result is changes to gene expression that are linked to reduced organ function and increased susceptibility to disease as people age. Now, a meta-analysis of epigenetic changes in 17 types of human tissue throughout the entire adult lifespan provides the most comprehensive picture to date of how ageing modifies our genes.
Few American authors of the past century churned out as many words. Even peers who matched or exceeded Updike’s productivity when it came to novels, such as Philip Roth, could not keep pace when factoring in the numerous other modes in which he regularly put pen to paper: short stories, poems, book reviews, essays, a play, a memoir, and even five books for children. Multiple books appeared after his death, including a final volume of short stories, My Father’s Tears.
In 1974, five years before he wrote his Pulitzer Prize–winning book Gödel, Escher, Bach: An Eternal Golden Braid, 
A postwar plan for Gaza circulating within the Trump administration, modeled on President Donald Trump’s vow to “take over” the enclave, would turn it into a trusteeship administered by the United States for at least 10 years while it is transformed into a gleaming tourism resort and high-tech manufacturing and technology hub.
Rosalind Fox Solomon has almost never worked on assignment. When she first started taking photographs with an idea of making art, no one would have expected her to turn that into a career; she was heading into her 40s with two children, a woman learning to communicate as she hadn’t been able to before. She started out shooting close to her home in Chattanooga, Tennessee. Even after she started gaining recognition and traveling farther afield, she didn’t exactly have a long-term plan: She would, she says, just decide to go somewhere — occasionally because of a disruptive event, like an earthquake or a flood, but usually just because, hiring a guide and a translator if she needed one. In India, Guatemala, Brazil, or Missouri, she’d move around and look at people, engaging them but not saying much, and come back with pictures. That’s it.
Christopher Marlowe is having a moment. In London’s West End, the Royal Shakespeare Company is staging Born with Teeth, a new play by Liz Duffy Adams that imagines the erotic tension crackling between Marlowe and Shakespeare as they collaborate on Henry VI. And right on cue comes the first major biography of Marlowe in two decades, written by the unquestioned eminence of Shakespearean new historicism. This is in some ways a counterpoint to Will in the World, Stephen Greenblatt’s gloriously rich evocation of the early modern culture that nourished Shakespeare’s creative genius. It was Greenblatt more than anyone else who taught us to understand the writer by examining the society in which he or she lived, but in Dark Renaissance the Greenblattian method is turned on its head. He shows us an Elizabethan England altogether too small, bigoted and fearful to account for the emergence of a shooting star like Marlowe.
There’s a certain flavor of advice that is dominating the self-help best-seller list. These books have titles like “The Courage to Be Disliked” and “Set Boundaries, Find Peace.” They tell readers not to worry so much about letting people down, not to answer those calls from aggravating friends, not to be afraid of being the villain.