Your diet can change your immune system — here’s how

Nic Fleming in Nature:

Reboot your immune system with intermittent fasting. Help your ‘good’ bacteria to thrive with a plant-based diet. Move over morning coffee: mushroom tea could bolster your anticancer defences. Claims such as these, linking health, diet and immunity, bombard supermarket shoppers and pervade the news. Beyond the headlines and product labels, the scientific foundations of many such claims are often based on limited evidence. That’s partly because conducting rigorous studies to track what people eat and the impact of diet is a huge challenge. In addition, the relevance to human health of results from studies of animals and cells isn’t clear and has sometimes been exaggerated for commercial gain, feeding scepticism in nutrition science.

In the past five or so years, however, researchers have developed innovative approaches to nutrition immunology that are helping to close this credibility gap. Whereas nutrition scientists have conventionally studied the long-term impacts of loosely defined Mediterranean or Western diets, for example, today they have access to tools that allow them to zoom in on the short-term effects — both helpful and harmful — of narrower food groups and specific dietary components, and to probe the molecular mechanisms underpinning the effects of foods on immunity.

More here.

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Tuesday, October 15, 2024

How Nazi Germany Created the Volkswagen Beetle

Witold Rybczynski at Literary Hub:

The car I bought in Hamburg had distinctive oval German export license plates, and an international registration sticker marked with a D, for Deutschland. As I drove through Holland on my way to Paris, more than once when asking for directions I received dirty looks, especially from older persons for whom the wartime German occupation was a living memory.

And, after all, my car’s godfather was Adolf Hitler himself. Opening the 1933 Berlin Motor Show as the newly appointed reich chancellor, he had announced a national policy to motorize Germany, which despite having invented the automobile a half century earlier, lagged other European countries in car ownership. Hitler called on the auto industry to produce an affordable people’s car, a volkswagen.

The automotive engineer who would realize Hitler’s vision was not a German native. Ferdinand Porsche (1875–­1951) was born in the small Bohemian market town of Maffersdorf in the Austro-­Hungarian Empire; after the First World War, he would become a citizen of the newly created Czechoslovak Republic.

More here.

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‘The Genetic Book of the Dead’: A Dawkinsian Medley

Daniel James Sharp at The Freethinker:

In The Oxford Book of Modern Science Writing (2008), Richard Dawkins writes:

Our ability to understand the universe and our position in it is one of the glories of the human species. Our ability to link mind to mind by language, and especially to transmit our thoughts across the centuries is another. Science and literature, then, are the two achievements of Homo sapiens that most convincingly justify the specific name.

And I think I am justified in saying that Dawkins himself is one of the few who have really managed to combine these two greatest achievements of humanity. In a corpus of work written over half a century, Dawkins has innovated and explained, and he has done so with the ear and eye of a poet. It is appropriate, then, that his new book, The Genetic Book of the Dead: A Darwinian Reverie, is a medley and a melody: a revisiting and extension of his previous ideas about evolution written with elegance and beauty. The very word ‘reverie’ suggests a pleasant and roaming meditation, which is exactly what The Genetic Book of the Dead is. Come to think of it, the quintessentially Dawkinsian phrase ‘a Darwinian reverie’ might just sum up Dawkins’s entire career. Call this book a Dawkinsian medley, or a Dawkinsian melody, then.

More here.

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Economics Nobel awarded for study of inequality

Helena Kudiabor & Mark Buchanan in Nature:

Why are some countries richer than others? The 2024 Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel has been awarded to three researchers who have helped shed light on this fundamental question.

The income gap between the richest and the poorest nations has been widely documented. However, Daron Acemoglu and Simon Johnson, both from the Massachusetts Institute of Technology in Cambridge, and James A. Robinson from the University of Chicago in Illinois, have studied the evidence for why these inequalities persist.

The three economists, who will share the 11 million Swedish Kronor (US $1 million) prize for their findings, researched the impact of European colonization on various countries’ economies.

More here.

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Jeremy Strong on Taking a Risk With a New Film About Trump

Eliana Dockterman in Time Magazine:

Jeremy Strong is not known for his sense of humor. When getting dressed, he favors brown for its “monastic” connotation. He famously thought that Succession, the HBO show that shot him to stardom, was a straight drama when his co-stars believed it to be a comedy. When he sits down for our Zoom conversation in September—in a brown shirt, of course—he recites poetry and quotes Stella Adler, the godmother of Method acting. He describes Succession as reflecting “the Emersonian notion of the institution as the shadow of a man.”

But when I suggest that he could have capitalized on that show’s success by earning a hefty paycheck from a superhero movie—as many in his position have done—he cracks a self-aware smile. The notion that he, an actor who insists on disposing of his own personality in order to fully inhabit a character, would implement that extreme approach to play a spandex-wearing hero is, indeed, funny.

More here.

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Nanoparticles Breathe New Life into Lungs

Sneha Khedkar in The Scientist:

In 2019, the Food and Drug Administration approved Trikafta for patients with cystic fibrosis (CF) who have the most common disease-causing mutation. Trikafta targets the defective protein—a misfolded form of cystic fibrosis transmembrane conductance regulator (CFTR)—produced as a result of this mutation.However, people with other mutations in the CFTR gene, including those with variants that result in no proteins being made at all, cannot benefit from the drug. “Therefore, interest is being placed on genetic therapies,” said Daniel Siegwart, a chemist at the University of Texas Southwestern Medical Center.

Current gene therapy methods involve delivering mutation-correcting gene-editing tools directly to lung cells. However, such tools are often administered through inhalation and struggle to cross the thick, sticky mucus on their way to the cells.Now, in a paper published in Science, Siegwart and his team showed that lipid nanoparticles (LNPs) delivered intravenously successfully delivered gene-editing tools to all lung cell types, including stem cells.3 This approach enabled long-lasting gene correction in a mouse model of CF and in patient cells. The LNP-based system offers new therapeutic avenues for delivering gene-editing tools to specific tissues.

More here.

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Constant Confession

Aaron Neiman at Aeon Magazine:

Foucault was greatly disturbed by modern psychiatry’s ability to draw definitive lines between the ‘reasonable’ and the ‘unreasonable’. He came to see it as another way for society to punish and marginalise its most troublesome subjects. Deploying the metaphor of a circulatory system, he conceived of psychiatrists as figures of ‘capillary’ power – unlike the conspicuous, beating heart of the state, these authorities functioned as more subtle, distal agents of the status quo. Writing in the 1960s and ’70s, Foucault saw the psychoanalytic therapists of his day as the latest technicians managing ‘one of the West’s most highly valued techniques for producing truth of one kind or another’ – the confession. This is the idea that disclosing one’s inner darkness leads to salvation, truth, self-actualisation. There is an important similarity between how this dynamic plays out in the church and the clinic: ‘bravely confront and share the ugly things inside you’ equally describes the task of the confessional booth as it does the therapist’s couch. In both cases, there is more at play here than simple unburdening: it is not just that ‘shared sorrow is half sorrow’, as in the case of confiding in a friend, but also that having an adversarial encounter with yourself can be fruitful in some way.

This uneasy brush with the self, mediated through a person with social authority, is an essential feature of these confessional practices, and distinguishes them from other kinds of dialogue. Therapy is based on this same model: it is carefully choreographed around a highly skilled worker, one with the practical knowledge and symbolic authority to endow this interaction with the gravity it deserves.

more here.

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Revisiting ‘Citizen,’ 10 Years Later

Maria Siciliano at The Millions:

Representing suffering—how to do it, when we should do it at all—has long been a subject of debate. At the center of that debate is the role of the audience: how do we, as readers and viewers, witness depictions of violence in images, films, plays, or literature?

In On PhotographySusan Sontag suggests that the act of looking, from a distance, is self-regarding. For writer and photographer Teju Cole, this visual and affective act is limited in what it can connote. Joining Sontag in conversation, Cole argues in Black Paper that the visual illustrates without condemning, becoming a collection of violence for consumption. But he ultimately concludes that in many ways, bearing witness to the existence of this suffering is better than ignoring its reality. Claudia Rankine’s Citizen: An American Lyric—a hybrid work of poetry, prose, and visual art—boldly considered these questions, and many others, through its use of language and form. Recounting a series of mounting racial slights and aggressions, endured in daily life and in the media, the book has proven both prescient and timeless.

more here.

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Tuesday Poem

So Live Your Life

So live your life that the fear of death
can never enter your heart. Trouble
no one about their religion; respect
others in their view, and demand
that they respect yours.

Love your life, perfect your life,
beautify all things in your life.
Seek to make your life long
and its purpose in the service
of your people.

Prepare a noble death song for the day
when you go over the great divide.

Always give a word or a sign of salute
when meeting or passing a friend, even
a stranger, when in a lonely place.

Show respect to all people
and grovel to none.

When you arise in the morning
give thanks for the food and for
the joy of living.

If you see no reason for giving thanks,
the fault lies only in yourself. Abuse
no one and no thing, for abuse turns
the wise ones to fools and robs
the spirit of its vision.

When it comes your time to die,
be not like those whose hearts
are filled with the fear of death,
so that when their time comes
they weep and pray for a little
more time to live their lives
over again in a
different way.

Sing your death song and die
like a hero going home.

Chief Tecumseh
from Poetic Outlaws

 

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Monday, October 14, 2024

What Good Is Great Literature?

A.O. Scott in the New York Times:

The Swedish Academy is not here to tell you what writers you might like. Greatness is not the same as popularity. It may even be the opposite of popularity. Great books are by definition not the books you read for pleasure — even if some of them turn out to be, and may even have been intended to be, fun — and great writers, being mostly dead, don’t care if they’re your favorites. The great books are the ones you’re supposed to feel bad about not having read. Great writers are the ones who matter whether you read them or not.

How strange. And yet, how normal. “It is natural to believe in great men,” Ralph Waldo Emerson wrote. “We call our children and our lands by their names. Their names are wrought into the verbs of language, their works and effigies are in our houses, and every circumstance of the day recalls an anecdote of them.” That’s from the beginning of “Representative Men,” an 1850 collection of essays, influenced by Thomas Carlyle’s “On Heroes, Hero-Worship, and the Heroic in History,” that pursues the principle of greatness through time, locating it in a half-dozen exemplary individuals.

Given Emerson’s title and his times, it’s not surprising that all his exemplars are male. But it is notable that most are writers and thinkers, including Plato, Montaigne, Shakespeare and Goethe and Emerson’s favorite, the theologian Emanuel Swedenborg. Napoleon is the only political leader in the group, perhaps in keeping with a mid-19th-century New Englander’s temperamental mistrust of monarchic or imperial power.

More here.

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How Learning Can Guide Evolution

An interesting 1987 paper by this year’s physics Nobel laureate Geoffrey E. Hinton, and Steven J. Nowlan:

Geoffrey Hinton

Many organisms learn useful adaptations during their lifetime. These adaptations are often the result of an exploratory search which tries out many possibilities in order to discover good solutions. It seems very wasteful not to make use of the exploration performed by the phenotype to facilitate the evolutionary search for good genotypes. The obvious way to achieve this is to transfer information about the acquired characteristics back to the genotype. Most biologists now accept that the Lamarckian hypothesis is not substantiated; some then infer that learning cannot guide the evolutionary search. We use a simple combinatorial argument to show that this inference is incorrect and that learning can be very effective in guiding the search, even when the specific adaptations that are learned are not communicated to the genotype. In difficult evolutionary searches which require many possibilities to be tested in order to discover a complex co-adaptation, we demonstrate that each learning trial can be almost as helpful to the evolutionary search as the production and evaluation of a whole new organism. This greatly increases the efficiency of evolution because a learning trial is much faster and requires much less expenditure of energy than the production of a whole organism.

More here.

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The U.S. Election Abroad: Twelve writers tell us what the race between Donald Trump and Kamala Harris looks like where they live

From The Dial:

The U.S. presidential election is decided by American citizens in a handful of states, but its outcome reverberates internationally: the new president will have the power to shape trade, migration, security and rising authoritarianism across the world, as well as the wars in Gaza and Ukraine. The race is therefore a global event, the subject of countless newspaper articles, debates and calculations. We asked 12 writers, each from a different country, to share what the conversation sounds like where they live: What are politicians saying, and how is the press covering the race? What are the hopes for a Kamala Harris presidency, or a Donald Trump one — and what are the fears? Our writers describe widely divergent attitudes toward the election and its unknown conclusion, from apathy and disillusionment to anxiety, hope and glee.

More here.

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Don’t Waste Your Wildness

Maria Popova at The Marginalian:

Jay Griffiths offers a mighty antidote in her 2006 masterpiece Wild: An Elemental Journey (public library) — the product of “many years’ yearning” pulling her “toward unfetteredness, toward the sheer and vivid world,” learning to think with the mind of a mountain and feel with the heart of a forest, searching for “something shy, naked and elemental — the soul.” What emerges is both an act of revolt (against the erasure of the wild, against the domestication of the soul) and an act of reverence (for the irrepressible in nature, for landscape as a form of knowledge, for life on Earth, as improbable and staggering as love.)

A century and a half after Thoreau “went to the woods to live deliberately” (omitting from his famed chronicle of spartan solitude the fresh-baked doughnuts and pies his mother and sister brought him every Sunday), Griffiths spent seven years slaking her soul on the world’s wildness, from the Amazon to the Arctic, trying “to touch life with the quick of the spirit,” impelled by “the same ancient telluric vigor that flung the Himalayas up to applaud the sky.”

more here.

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Commit Lit: In search of higher education

Joseph Keegin in The Point:

In 2012, at the age of 25, I quit my part-time jobs cooking and cleaning houses and, having dropped out during my first semester seven years earlier, went back to school. To help pay for the modest tuition at Indiana University Southeast in New Albany, Indiana, I took a work-study gig at the university library. The campus of IUS is small, and most students are commuters; the library was accordingly quiet, the work languid. So in the many slow periods between tasks, I read. Essays, stories, poems—whatever I could get my hands on. My reading was omnivorous and unstructured: like the critics in the first part of Roberto Bolaño’s 2666, I pursued knowledge like sleuths in a roman noir, or like the poet Juan García Madero from his Savage Detectives, for whom “every book in the world is out there waiting to be read by me.” I followed a friend onto Twitter—the early 140-character years, with few journalists and politicians and no blue checkmarks—and there I came into contact for the first time with the world of magazines, small and large, that constituted the internal chatter of the educated American upper-middle class.

Amid this cacophony of culture-talk—heard from a remove, like music from a distant room—I began to discern a theme. I listened, equally interested and perplexed. It concerned the state of American higher education: plummeting enrollment in English, philosophy, history and other bookish, scholarly disciplines leading to the annulment of programs and the shuttering of departments; skyrocketing tuition and ballooning student debt; a pervasive sense of panic and despair.

More here.

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A Palestinian Photographer Reflects on One Year of Life and Death in Gaza

Yasmeen Serhan in Time Magazine:

A year later, the 28-year-old is still documenting the lived experience of Palestinians in a place with scars visible from space. But for all of the images of physical destruction, Alghorra’s most profound photographs are of the human impact. In one, he found a Palestinian child crying in the rain as she and others wait for food to be distributed outside a refugee camp in the southernmost city of Rafah. Insufficient humanitarian aid reaching the Strip means that for most people, one meal a day is the most they can hope for. Dozens of children have died of starvation.

In another photo, a Palestinian family sits in the living room of their dilapidated home in Khan Yunis. The walls are scorched black and the infrastructure is crumbling, but it’s preferable to the alternative—the crowded tents where the vast majority of people in Gaza, including Alghorra, are now living. Since being forced to leave his home in Gaza City in the early days of the war, he now shares a tent with colleagues next to the Nasser Medical Complex, one of Gaza’s last remaining hospitals.

More here.

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The Elements of Marie Curie

Wendy Moore at Literary Review:

Marie Curie’s life was defined by professional triumph and personal tragedy. Ninety years after her death, she remains history’s most famous woman scientist. Curie was the first woman to receive a Nobel Prize – in 1903, she and her husband, Pierre, received the award for physics. In 1911, she was awarded a second Nobel Prize, this time for chemistry. She is still the only Nobel laureate to be garlanded in two scientific fields.

Yet after her husband’s death in a freak traffic accident in 1906, just eleven years into their marriage, she led a sorrowful and often lonely existence dedicated to continuing the work they had begun together. Meeting Curie in 1920, an American journalist described her as ‘a pale, timid little woman in a black cotton dress, with the saddest face I had ever looked upon’. She was selfless and self-effacing too. When asked to write an autobiography, Curie dictated a single paragraph: ‘I was born in Warsaw of a family of teachers. I married Pierre Curie and had two children. I have done my work in France.’

more here.

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