Is ‘friendly fire’ in the brain provoking Alzheimer’s disease?

Alison Abbot in Nature:

Neuroscientist Michael Heneka knows that radical ideas require convincing data. In 2010, very few colleagues shared his belief that the brain’s immune system has a crucial role in dementia. So in May of that year, when a batch of new results provided the strongest evidence he had yet seen for his theory, he wanted to be excited, but instead felt nervous. He and his team had eliminated a key inflammation gene from a strain of mouse that usually develops symptoms of Alzheimer’s disease. The modified mice seemed perfectly healthy. They sailed through memory tests and showed barely a sign of the sticky protein plaques that are a hallmark of the disease. Yet Heneka knew that his colleagues would consider the results too good to be true.

Even he was surprised how well the mice fared; he had expected that removal of the gene, known as Nlpr3, would protect their brains a little, but not that it would come close to preventing dementia symptoms. “I thought something must have gone wrong with the experiments,” says Heneka, from the German Center for Neurodegenerative Diseases in Bonn. He reanalysed the results again and again. It was past midnight when he finally conceded that they might actually be true. Over the next couple of years, he confirmed that nothing had gone wrong with the experiments. Together with his colleagues, he replicated and elaborated on the results1. Since then, numerous studies have bolstered the link between dementia and the brain’s immune system, highlighting the cells and signals involved2. But none has managed to fully pin it down — the link seems to be slippery and dynamic, changing as the disease progresses.

More here.

Is ‘friendly fire’ in the brain provoking Alzheimer’s disease?

Alison Abbot in Nature:

BrainNeuroscientist Michael Heneka knows that radical ideas require convincing data. In 2010, very few colleagues shared his belief that the brain’s immune system has a crucial role in dementia. So in May of that year, when a batch of new results provided the strongest evidence he had yet seen for his theory, he wanted to be excited, but instead felt nervous. He and his team had eliminated a key inflammation gene from a strain of mouse that usually develops symptoms of Alzheimer’s disease. The modified mice seemed perfectly healthy. They sailed through memory tests and showed barely a sign of the sticky protein plaques that are a hallmark of the disease. Yet Heneka knew that his colleagues would consider the results too good to be true.

Even he was surprised how well the mice fared; he had expected that removal of the gene, known as Nlpr3, would protect their brains a little, but not that it would come close to preventing dementia symptoms. “I thought something must have gone wrong with the experiments,” says Heneka, from the German Center for Neurodegenerative Diseases in Bonn. He reanalysed the results again and again. It was past midnight when he finally conceded that they might actually be true. Over the next couple of years, he confirmed that nothing had gone wrong with the experiments. Together with his colleagues, he replicated and elaborated on the results1. Since then, numerous studies have bolstered the link between dementia and the brain’s immune system, highlighting the cells and signals involved2. But none has managed to fully pin it down — the link seems to be slippery and dynamic, changing as the disease progresses.

More here.

IN PRAISE OF THE POETRY OF ELIZABETH JENNINGS

02Jennings02Dana Gioia at First Things:

The English poet Elizabeth Jennings had the peculiar fate of being in the right place at the right time in the wrong way. Her career began splendidly. Her verse appeared in prominent journals, championed by Oxford’s new generation of tastemakers. Her first publication, Poems (1953), launched the acclaimed Fantasy Poets pamphlet series, which would soon present the early work of Philip Larkin, Kingsley Amis, Thom Gunn, and Geoffrey Hill. Her first full-length collection, A Way of Looking (1955), won the Somerset Maugham Award and became the Poetry Book Society recommendation. She was the youngest poet featured in the first Penguin Modern Poets volume (1962). Meanwhile Jennings achieved enduring notoriety as the only female member of “The Movement,” the irreverent and contrarian group that dominated mid-century British poetry. By age thirty, Jennings was a celebrated writer.

“To be lucky in the beginning is everything,” claimed Cervantes, but Jennings’s luck did not hold. In the great expansion of universities and literary publishing following World War II, her Movement peers gained academic appointments, lucrative book deals, and critical esteem. Jennings’s career stalled. Her fame as a Movement poet proved a dead end. She never belonged in that Oxbridge boys’ club. She shared The Movement’s commitment to clarity and traditional form, but her politics were to the left of their mostly conservative stance.

more here.

The Political Economy of Anti-Racism

Walter Benn Michaels at nonsite:

Again, the point is not to highlight the discrepancy between the egalitarian ideals of these students and their class position since, if the equality you’re committed to is between groups, there is no discrepancy. And just as no hypocrisy is required at the elite college where you fight hard against racism, none will be required at the NGO or the job as a consultant or in finance (“Why Goldman Sachs? Diversity!”15) where you start making enough money (average salary of a Princeton grad at 34: $90,70016) to enable your kids to carry on the struggle. Actually, the need for a little hypocrisy—for virtue to pay its symbolic tribute to vice—would be an upgrade. The problem here is the literal tribute virtue’s paying to virtue—the complete identity of idealism and careerism. In other words, it’s not ethical but political.

And the demand for a working-class politics cannot be met by adding class to race and gender. This is in part because most actually existing intersectionalists are not very interested in class, but even if they were, the great attraction of intersectionality is precisely that it can absorb class too into the logic of discrimination, which is to say, into the neoliberal theory of inequality. On this theory, the fact of being born poor is a problem in the way that the fact of being born Black or Latino or a woman can be—if it keeps you from having an equal opportunity to succeed. In other words, we should treat class difference like race and gender by understanding poverty not as something we should get rid of but as something we should help people overcome.

more here.

The Political Economy of Anti-Racism

Income-Distribution-of-Households-600x264Walter Benn Michaels at nonsite:

Again, the point is not to highlight the discrepancy between the egalitarian ideals of these students and their class position since, if the equality you’re committed to is between groups, there is no discrepancy. And just as no hypocrisy is required at the elite college where you fight hard against racism, none will be required at the NGO or the job as a consultant or in finance (“Why Goldman Sachs? Diversity!”15) where you start making enough money (average salary of a Princeton grad at 34: $90,70016) to enable your kids to carry on the struggle. Actually, the need for a little hypocrisy—for virtue to pay its symbolic tribute to vice—would be an upgrade. The problem here is the literal tribute virtue’s paying to virtue—the complete identity of idealism and careerism. In other words, it’s not ethical but political.

And the demand for a working-class politics cannot be met by adding class to race and gender. This is in part because most actually existing intersectionalists are not very interested in class, but even if they were, the great attraction of intersectionality is precisely that it can absorb class too into the logic of discrimination, which is to say, into the neoliberal theory of inequality. On this theory, the fact of being born poor is a problem in the way that the fact of being born Black or Latino or a woman can be—if it keeps you from having an equal opportunity to succeed. In other words, we should treat class difference like race and gender by understanding poverty not as something we should get rid of but as something we should help people overcome.

more here.

Rappers’ Tales of Brotherhood and Betrayal

Burhan Wazir at The New Statesman:

Hawkins grew up in a single parent family in Brooklyn and Park Hill on Staten Island. Whenever he inquired about the family patriarch, his mother would reply, “God is your father!” Unlike Mane, who describes being orbited by grandparents, aunts and uncles, Hawkins’s childhood was blighted by black-on-black crime and drugs-related violence. He describes witnessing his first death when he was four years old and watched a woman leap or fall from the roof of an apartment building. “Lovin’ You” by Minnie Riperton was playing on a radio in the street. Hawkins was a member of gangs called Baby Cash Crew, Dick ’Em Down and Wreck Posse. He carried a gun from the ages of 14 to 21 and recalls watching one of his babysitters shooting up heroin on the couch. Years later, Staten Island’s rappers would describe Park Hill as “Killa Hill” in their music. “Dudes would shoot dogs and leave their carcasses behind our building all the time,” writes Hawkins. “It was like a concentration camp for poor black people.”

While Raw is full of the despairing tales that inform the Wu-Tang’s music, it is also fuelled by the gallows humour that runs through albums staffed by fictionalised gangsters called Tony Starks or Lex Diamonds. Hawkins describes watching thieves steal his mother’s handbag on five separate occasions. One day, as she walked him home from school, a young man pulled the jewellery off her ears. Years later, she saw a man on TV who she swore was her attacker – it was Mike Tyson.

more here.

rappers’ tales of brotherhood and betrayal

Download (32)Burhan Wazir at The New Statesman:

Hawkins grew up in a single parent family in Brooklyn and Park Hill on Staten Island. Whenever he inquired about the family patriarch, his mother would reply, “God is your father!” Unlike Mane, who describes being orbited by grandparents, aunts and uncles, Hawkins’s childhood was blighted by black-on-black crime and drugs-related violence. He describes witnessing his first death when he was four years old and watched a woman leap or fall from the roof of an apartment building. “Lovin’ You” by Minnie Riperton was playing on a radio in the street. Hawkins was a member of gangs called Baby Cash Crew, Dick ’Em Down and Wreck Posse. He carried a gun from the ages of 14 to 21 and recalls watching one of his babysitters shooting up heroin on the couch. Years later, Staten Island’s rappers would describe Park Hill as “Killa Hill” in their music. “Dudes would shoot dogs and leave their carcasses behind our building all the time,” writes Hawkins. “It was like a concentration camp for poor black people.”

While Raw is full of the despairing tales that inform the Wu-Tang’s music, it is also fuelled by the gallows humour that runs through albums staffed by fictionalised gangsters called Tony Starks or Lex Diamonds. Hawkins describes watching thieves steal his mother’s handbag on five separate occasions. One day, as she walked him home from school, a young man pulled the jewellery off her ears. Years later, she saw a man on TV who she swore was her attacker – it was Mike Tyson.

more here.

Tuesday, April 24, 2018

On the occasion of the four-hundredth anniversary of William Shakespeare’s death, New Yorker writers share their experiences of reading, watching, studying, performing, memorizing, and falling in love with the work of the Bard

From The New Yorker:

TNY-Enounters-With-ShakespearElif Batuman: One of my most memorable encounters with Shakespeare took place in the Taurus Mountains, in 2012, where I was reporting a story about the Arslanköy Women’s Theatre Group, a rural Turkish theatre company, founded in 2000 by Ümmiye Koçak, a forty-four-year-old farmworker with a primary-school education. Koçak wrote most of the group’s plays herself—they were about village life—but she was also really proud of having once played the title role in her own adaptation of “Hamlet,” titled “Hamit,” in 2009. Hugely popular in the village of Arslanköy, “Hamit” went on to tour several Turkish cities. They staged the graveyard scene using pumpkins for skulls. The women still talked about “Hamlet” all the time—about what Hamlet’s problem had been.

Anyway, one night, after I had been hanging out with Koçak and the village women, who were shooting their first feature-length movie (based on a script by Koçak), I drove back to the hotel where I was staying, in the nearby city of Mersin. It was a weirdly fancy hotel, with a glass globe on the ceiling that could light up in all different colors—you controlled it with a remote control. It could change to something like thirty-six different colors, and there was a strobe function. I remember lying on the bed under pulsing disco lights, eating a fruit basket that someone had sent to my room by mistake, and buying “Hamlet” on my Kindle, just to see what in there had been so captivating to the village women.

To be honest, a tiny part of me had worried that they were only (“only”) excited about “Hamlet” because it was famous, and Western, and the very opposite of what people in their village thought that they, Turkish peasant women, were capable of. But when I reread “Hamlet” after spending a few days with the women, and read some of the other plays that Koçak had written, it was immediately clear what had resonated for them.

More here.

Why An Agnostic Philosopher Says We’re All ‘Religious’

Cathy Lynn Grossman in Publishers Weekly:

53534-v1-600xStephen Asma, a philosophy professor at Columbia College in Chicago, was a childhood Catholic altar boy who grew up to become a “cultural Buddhist” and religion-skewering writer for Skeptic magazine. Now, at 51, he's finds himself agnostic about God, but is asserting Why We Need Religion in his new book due out from Oxford in June.

You write in Why We Need Religion that “… the irrationality of religion does not render it unacceptable or valueless.” Will your unbelieving friends think you’ve lost your mind?

Maybe! But there are a number of people like me who are skeptical about the belief claims of religions yet nonetheless respect it. They haven’t had the voice for what they are thinking. I say religion is actually very good therapy for our emotional lives. It resonates. There are levels of suffering that art and science can’t do much with and religion is very good at. People think of religion as a system of beliefs but it is fundamentally an emotional management system, one that science and any other kind of “cultural technology” cannot offer.

Are we all – including you — inherently “religious” but some of us don’t ‘name it and claim it’?

Yes. We are mammals. Our brains evolved to seek help. Sometimes there is no help to be found with other human beings so your brain and emotions reach out to the universe. Bill Nye and Neil deGrasse Tyson don’t need to tell a grieving mother that the religion that gives her solace and the strength to get up and keep going is all fictive. We evolved things such as prayer to manage our spontaneous yearning to survive and flourish. I’m not embarrassed and I don’t think it is intellectually cowardly. Religiosity is in human nature. I don’t kneel down and pray as I did in my childhood. But I allow myself to have spontaneous conversations with the universe.

More here.

Rooting for Elon

Musk1

Andrew Elrod in the Boston Review:

For the past fifty years, after all, among the easiest and most widely accepted formulas for people to work together to change their futures has been through patterns of personal consumption. We invest our savings, purchase private equipment, place our bets in the enthralling spectator sport that is the clash of powerful personalities and organizations—and then we wait.

It is this sleek, efficient temple of opportunity and security that Musk has cultivated and we have bought in to that justifies the massive government spending behind his projects. Indeed, the most potent collective action behind Musk’s success has come from the state. In today’s political climate, projects such as his, which promise a return on investment and private-management practices, are the only ones deemed worthy of public investment. The states of California, Nevada, New York, and Oregon, have all joined the federal government in offering direct grants and loans to Musk’s companies, and hundreds of millions of dollars in consumer rebates are ultimately paid into Tesla through consumers (the federal government, for example, pays a $7,500 tax credit to purchasers of electric cars; California pays a further $2,500). As early as 2015, the Los Angeles Times attempted to sum the total public aid to Musk’s operations and arrived at $4.9 billion.

Yet Musk’s profitability—his success by the conventional standard—still hasn’t materialized. Tesla was run at a $671 million loss in the third quarter of 2017—$117 million paid in interest on the company’s debts alone. In fiscal year 2017, losses summed to $2.2 billion, about three times what the company lost in 2016.

Moreover, Tesla has repeatedly missed every deadline promised to its customers and is currently under investigation by the National Labor Relations Board for denying employees the right to collective bargaining. The company faces numerous shareholder lawsuits alleging managerial violations of fiduciary duty, with a raft of class-action suits following a recent investigation by the Securities and Exchange Commission.

Musk’s career thus illustrates the central challenge of U.S. industrial planning. Because of taboos against government ownership and income-tax financed public services, the public must find ways of persuading businessmen to manage private property to meet public objectives.

More here.

Life Inside China’s Social Credit Laboratory

Img_2029-1

Simina Mistreanu in Foreign Policy:

Rongcheng was built for the future. Its broad streets and suburban communities were constructed with an eye to future expansion, as the city sprawls on the eastern tip of China’s Shandong province overlooking the Yellow Sea. Colorful billboards depicting swans bank on the birds — one of the city’s tourist attractions — returning there every winter to escape the Siberian cold.

In an attempt to ease bureaucracy, the city hall, a glass building that resembles a flying saucer, has been fashioned as a one-stop shop for most permits. Instead of driving from one office to another to get their paperwork in order, residents simply cross the gleaming corridors to talk to officials seated at desks in the open-space area.

At one of these stations, Rongcheng residents can pick up their social credit score.

In what it calls an attempt to promote “trustworthiness” in its economy and society, China is experimenting with a social credit system that mixes familiar Western-style credit scores with more expansive — and intrusive — measures. It includes everything from rankings calculated by online payment providers to scores doled out by neighborhoods or companies. High-flyers receive perks such as discounts on heating bills and favorable bank loans, while bad debtors cannot buy high-speed train or plane tickets.

By 2020, the government has promised to roll out a national social credit system. According to the system’s founding document, released by the State Council in 2014, the scheme should “allow the trustworthy to roam everywhere under heaven while making it hard for the discredited to take a single step.” But at a time when the Chinese Communist Party is aggressively advancing its presence across town hall offices and company boardrooms, this move has sparked fears that it is another step in the tightening of China’s already scant freedoms.

But it has been hard to distinguish future promises — or threats — from the realities of how social credit is being implemented. Rongcheng is one place where that future is visible.

More here.

Women Intellectuals and the Art of the Withering Quip

Sharp_michelle-dean-1024x750Dustin Illingworth at the Paris Review:

“If one is a woman writer there are certain things one must do,” the British writer and journalist Rebecca West wrote to a friend in 1952. “First, not be too good; second, die young, what an edge Katherine Mansfield has on all of us; third, commit suicide like Virginia Woolf. To go on writing and writing well just can’t be forgiven.” West, ignoring her own advice, neither died prematurely nor blunted the fineness of her writing. As a young woman, she made her name with witty, digressive book reviews that were often wonderfully cutting. (On Henry James: “He splits hairs until there are no longer any hairs to split, and the mental gesture becomes merely the making of agitated passes over a complete and disconcerting baldness.”) She also wrote several novels and covered world events for prestigious magazines, including the trial of the English fascist William Joyce and the 1947 lynching of Willie Earle. Her final book, an idiosyncratic history of the year 1900, was published just before her death at the age of ninety. It was the capstone to a career that spanned almost seven decades. West’s true audacity was not merely “to go on writing,” as she put it, but to flourish in an insular, nepotistic intellectual culture that was largely hostile to women. She was ambitious, unafraid, and prodigiously gifted—in a word, sharp.

The literary critic Michelle Dean’s new book of the same name, a cultural-history-cum-group-biography, examines the lives and careers of ten sharp women, among them Susan Sontag, Joan Didion, Dorothy Parker, Renata Adler, Hannah Arendt, and Zora Neale Hurston. What unites this disparate group, Dean claims, is the ability “to write unforgettably.”

more here.

Cardi B’s “Invasion of Privacy” Is as Studious as It Is Bombastic

180423_r31922Carrie Battan at The New Yorker:

If you need more proof that reality television and social media are this era’s greatest cultural incubators, look no further than Cardi B (born Belcalis Almanzar), the twenty-five-year-old Bronx native who has taken an unprecedented but well-documented path to pop-world domination. In 2014, while working as a stripper, she launched a grassroots campaign for her personality on Instagram and Vine, posting bawdy, unflinching videos in which she monologued about whatever was on her mind—unfaithful boyfriends, the indignity of backhanded compliments, the relative merits of ihop and Philippe Chow—in a thick New York Spanish accent. She sometimes wore nothing but a shower cap. “I ain’t gon’ lie to y’all, these terrorist attacks got my mental a li’l finicky. That’s why I been in the Bronx,” she said in one video, from 2015. “Keep me away from downtown. Ain’t nobody tryna blow up the hood. ”

These little gems of street wisdom got her cast in Mona Scott-Young’s VH1 reality series “Love & Hip Hop.” A chatterbox with a refreshingly unvarnished self-presentation, Cardi, in perhaps her greatest accomplishment, inverts the uses of the platforms she first called home: in her universe, social media and television serve as megaphones for candor and exuberance rather than for deception or artifice.

more here.

The Life of Alexander von Humboldt

Download (31)Peter Moore at Literary Review:

That Alexander von Humboldt was not dead by the age of thirty-five was a minor miracle. In 1794 he nearly suffocated while testing his miner’s lamp in a subterranean tunnel. The next year he subjected his body to such an extreme series of galvanic experiments that his doctor felt compelled to intervene. In 1800, among the ceiba trees beside the Apure River in Venezuela, he disturbed a resting jaguar (‘never had a tiger appeared to me so enormous’). On that occasion, Humboldt tiptoed to safety, but weeks later he almost paralysed himself while pulling on a sock contaminated with curare, the lethal arrow poison.

Humboldt’s narrowest escape of all, perhaps, came in 1802, during one of his series of high-altitude ascents in the mountains of Ecuador. Nearing a summit, he glanced down to see a bluish light glowing through the snow. He smelled sulphur. ‘He realised with a shudder,’ writes Maren Meinhardt in this evocative and perceptive biography, that he and his companion ‘were on top of the crater itself’. The only thing separating them from the volcano was a ‘thin bridge of compacted snow’.

more here.

Tuesday Poem

. . . life which does not give the preference to any other life,
of any previous period, which therefore prefers its own existence . . .
………………………………………………………… — Ortega y Gasset

Walt Whitman at Bear Mountain

Neither on horseback nor seated,
But like himself, squarely on two feet,
The poet of death and lilacs
Loafs by the footpath. Even the bronze looks alive
Where it is folded like cloth. And he seems friendly.
“Where is the Mississippi panorama
And the girl who played the piano?
Where are you, Walt?
The Open Road goes to the used-car lot.
“Where is the nation you promised?
These houses built of wood sustain
Colossal snows,
And the light above the street is sick to death.
“As for the people—see how they neglect you!
Only a poet pauses to read the inscription.”
“I am here,” he answered.
“It seems you have found me out.
Yet did I not warn you that it was Myself
I advertised? Were my words not sufficiently plain?
I gave no prescriptions,
And those who have taken my moods for prophecies
Mistake the matter.”
Then, vastly amused—“Why do you reproach me?
I freely confess I am wholly disreputable.
Yet I am happy, because you found me out.”
A crocodile in wrinkled metal loafing . . .
Then all the realtors,
Pickpockets, salesmen and the actors performing
Official scenarios,
Turned a deaf ear, for they had contracted
American dreams.
But the man who keeps a store on a lonely road,
And the housewife who knows she’s dumb,
And the earth, are relieved.
All that grave weight of America
Cancelled! Like Greece and Rome.
The future in ruins!
The castles, the prisons, the cathedrals
Unbuilding, and roses
Blossoming from the stones that are not there . . .
The clouds are lifting from the high Sierras,
The Bay mists clearing,
And the angel in the gate, the flowering plum,
Dances like Italy, imagining red.

by Louis Simpson
from The Owner of the House: New Collected Poems, 1940-2001
BOA Editions, Ltd. .

These Ants Explode, but Their Nests Live to See Another Day

Veronique Greenwood in The New York Times:

Outside the kitchen door at the Kuala Belalong Field Studies Center in Brunei, on a number of trees near the balcony, there is a nest of very special ants. They explode.

This colony was studied in depth by scientists who, last week in the journal ZooKeys, published an in-depth description of the newly named species, called Colobopsis explodens, including a portion of their genome sequence. Workers of C. explodens have a distinctive, rather foul talent. When their nest is invaded, they rupture their own abdomens, releasing a sticky, bright yellow fluid laced with toxins on their attackers. Similar to honey bees that die after stinging, the exploded ants do not survive, but their sacrifice can help save the colony. Exploding ants have been known to science for more than 200 years, and the special ability for which they are named was first documented in 1916. But since 1935, no new species from the group had been officially named and described. To do this, ideally one needs to collect members of all the different castes in the colony, from worker to queen, write a detailed description of their appearance, and give the species a Latin name, among other things, said Alice Laciny, a graduate student at the Natural History Museum Vienna who is an author of the new paper.

“We knew they existed, and we did experiments on them,” she said, “but it wasn’t described as an official species yet.”

More here.

These Ants Explode, but Their Nests Live to See Another Day

Veronique Greenwood in The New York Times:

AntiesOutside the kitchen door at the Kuala Belalong Field Studies Center in Brunei, on a number of trees near the balcony, there is a nest of very special ants. They explode.

This colony was studied in depth by scientists who, last week in the journal ZooKeys, published an in-depth description of the newly named species, called Colobopsis explodens, including a portion of their genome sequence. Workers of C. explodens have a distinctive, rather foul talent. When their nest is invaded, they rupture their own abdomens, releasing a sticky, bright yellow fluid laced with toxins on their attackers. Similar to honey bees that die after stinging, the exploded ants do not survive, but their sacrifice can help save the colony. Exploding ants have been known to science for more than 200 years, and the special ability for which they are named was first documented in 1916. But since 1935, no new species from the group had been officially named and described. To do this, ideally one needs to collect members of all the different castes in the colony, from worker to queen, write a detailed description of their appearance, and give the species a Latin name, among other things, said Alice Laciny, a graduate student at the Natural History Museum Vienna who is an author of the new paper.

“We knew they existed, and we did experiments on them,” she said, “but it wasn’t described as an official species yet.”

More here.

Monday, April 23, 2018

Intellectual Blame

Scott F. Aikin and Robert B. Talisse Tarot Fool

1.

Here's a philosophical heuristic about normative assessment: Domains and grounds for assessing responsibility will track domains and grounds for holding ourselves and others to be praise-worthy and blame-worthy. So, if there are unique ways to be blameworthy, there are coordinate ways in which one can be irresponsible. That's the rough heuristic, and we think it helps to elucidate intellectual responsibility.

One particular locus of intellectual irresponsibility is the exercise of our argumentative skills. On analogy with practical skills, there are situations where things go badly due to one's failure to exercise one's skill appropriately. Take the professional soccer player who shanks a shot over an easy goal, or the bartender who over pours a drink, or the teacher who mishandles a simple question in class. In these cases, it is appropriate for these people to blame themselves for their poor performances – it was their fault for failing to live up to a standard set by the skills they have. It's not because of the overwhelming difficulty of the situation, but rather it was because the requisite skills were not engaged effectively. Hence a modestly negative assessment of their performance is appropriate. Each may kick themselves for squandering a shot on goal, wasting whiskey, or a missed pedagogical opportunity. And so, too, may others. The sports writers may speak of the soccer player's ‘whiff,' and the barfly may mock the bartender's ‘party foul,' and a student may resent a question badly answered. Finally, notice that the degree of negative reaction of fault-finding is proportionate to the skills we assess these agents to have – the more skilled the soccer player, for example, the more blameworthy the shank. There's little, we think, unusual about these mundane practical failures of skill, and so it goes for intellectual skills, too.

Consider the skill of simply exploring a range of deductive entailments from a few pieces of information. The following task, Republican Friends, is illuminating. Assume these facts:

A is a Republican

A and B are friends

B and C are friends

C is not a Republican

Now the question: does it follow from these facts that there is at least one Republican with a non-Republican friend? Give yourself a second.

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