Alison Abbot in Nature:
Neuroscientist Michael Heneka knows that radical ideas require convincing data. In 2010, very few colleagues shared his belief that the brain’s immune system has a crucial role in dementia. So in May of that year, when a batch of new results provided the strongest evidence he had yet seen for his theory, he wanted to be excited, but instead felt nervous. He and his team had eliminated a key inflammation gene from a strain of mouse that usually develops symptoms of Alzheimer’s disease. The modified mice seemed perfectly healthy. They sailed through memory tests and showed barely a sign of the sticky protein plaques that are a hallmark of the disease. Yet Heneka knew that his colleagues would consider the results too good to be true.
Even he was surprised how well the mice fared; he had expected that removal of the gene, known as Nlpr3, would protect their brains a little, but not that it would come close to preventing dementia symptoms. “I thought something must have gone wrong with the experiments,” says Heneka, from the German Center for Neurodegenerative Diseases in Bonn. He reanalysed the results again and again. It was past midnight when he finally conceded that they might actually be true. Over the next couple of years, he confirmed that nothing had gone wrong with the experiments. Together with his colleagues, he replicated and elaborated on the results1. Since then, numerous studies have bolstered the link between dementia and the brain’s immune system, highlighting the cells and signals involved2. But none has managed to fully pin it down — the link seems to be slippery and dynamic, changing as the disease progresses.
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Again, the point is not to highlight the discrepancy between the egalitarian ideals of these students and their class position since, if the equality you’re committed to is between groups, there is no discrepancy. And just as no hypocrisy is required at the elite college where you fight hard against racism, none will be required at the NGO or the job as a consultant or in finance (“Why Goldman Sachs? Diversity!”
Hawkins grew up in a single parent family in Brooklyn and Park Hill on Staten Island. Whenever he inquired about the family patriarch, his mother would reply, “God is your father!” Unlike Mane, who describes being orbited by grandparents, aunts and uncles, Hawkins’s childhood was blighted by black-on-black crime and drugs-related violence. He describes witnessing his first death when he was four years old and watched a woman leap or fall from the roof of an apartment building. “Lovin’ You” by Minnie Riperton was playing on a radio in the street. Hawkins was a member of gangs called Baby Cash Crew, Dick ’Em Down and Wreck Posse. He carried a gun from the ages of 14 to 21 and recalls watching one of his babysitters shooting up heroin on the couch. Years later, Staten Island’s rappers would describe Park Hill as “Killa Hill” in their music. “Dudes would shoot dogs and leave their carcasses behind our building all the time,” writes Hawkins. “It was like a concentration camp for poor black people.”
Outside the kitchen door at the Kuala Belalong Field Studies Center in Brunei, on a number of trees near the balcony, there is a nest of very special ants. They explode.