‘Reprogrammed’ stem cells implanted into patient with Parkinson’s disease

David Cyranoski in Nature:

Japanese neurosurgeons have implanted ‘reprogrammed’ stem cells into the brain of a patient with Parkinson’s disease for the first time. The condition is only the second for which a therapy has been trialled using induced pluripotent stem (iPS) cells, which are developed by reprogramming the cells of body tissues such as skin so that they revert to an embryonic-like state, from which they can morph into other cell types. Scientists at Kyoto University use the technique to transform iPS cells into precursors to the neurons that produce the neurotransmitter dopamine. A shortage of neurons producing dopamine in people with Parkinson’s disease can lead to tremors and difficulty walking.

In October, neurosurgeon Takayuki Kikuchi at Kyoto University Hospital implanted 2.4 million dopamine precursor cells into the brain of a patient in his 50s. In the three-hour procedure, Kikuchi’s team deposited the cells into 12 sites, known to be centres of dopamine activity. Dopamine precursor cells have been shown to improve symptoms of Parkinson’s disease in monkeys. Stem-cell scientist Jun Takahashi and colleagues at Kyoto University derived the dopamine precursor cells from a stock of IPS cells stored at the university. These were developed by reprogramming skin cells taken from an anonymous donor. “The patient is doing well and there have been no major adverse reactions so far,” says Takahashi. The team will observe him for six months and, if no complications arise, will implant another 2.4 million dopamine precursor cells into his brain. The team plans to treat six more patients with Parkinson’s disease to test the technique’s safety and efficacy by the end of 2020.

More here.

Tuesday, November 13, 2018

The Rivalry That Shaped Modern Egypt

Shadi Hamid in Foreign Affairs:

Seven years since the heady days of early 2011, when massive, electrifying protests brought down the Egyptian dictator Hosni Mubarak, the political atmosphere in Egypt has turned somber. In 2013, General Abdel Fattah el-Sisi overthrew President Mohamed Morsi, a leader of the Muslim Brotherhood who had narrowly won Egypt’s first free presidential election the prior year. Since seizing power, Sisi has emptied the country of any real politics. His crackdown against the Muslim Brotherhood has been particularly brutal: he has jailed tens of thousands of Brothers, and designated the group a terrorist organization. On the regional stage, Egypt has found itself relegated to second-tier status. What was once the center of the Arab world today feels like a ghost of its former self.

In this environment, it is easy to forget that for much of the twentieth century, Egypt was the most consequential battleground in the struggle for the soul of the new Arab state. Following the formal dissolution of the Ottoman caliphate, in 1924, new ideologies and approaches to governing competed to fill the vacuum. In the 1930s and 1940s, during Egypt’s so-called liberal era, secularists, socialists, and Islamists vied for legitimacy in a chaotic but relatively free political atmosphere. The freedom did not last. In 1952, a clandestine cohort of young military officers led by a man named Gamal Abdel Nasser overthrew the Egyptian monarchy and eventually ended what little was left of Egypt’s liberal age.

More here.

The origins of Earth’s water are a big mystery—but we may have one more piece of the puzzle

Neel V. Patel in Popular Science:

In a new paper published in the Journal of Geophysical Research: Planets, Arizona State University researchers suggest that water on Earth originated from material brought by asteroids, assisted by some leftover gas strewn about after the sun’s formation.

This is certainly far from the first time people have suggested water as we know it (and drink) it has an extraterrestrial origin. Historically, the easiest explanation has been that all of Earth’s water came from asteroids that impacted the Earth during the early days of its 4.6 billion year life. Why? Water from Earth shares the same chemical signatures as water found in asteroids—specifically, the ratio of deuterium (a heavy hydrogen isotope) to normal hydrogen. And previous experiments have shown that, in spite of all the heat and energy created by these massively powerful collisions, that water could have been preserved as it found itself on the yet-to-be-blue planet.

Still, those theories have never been quite enough to fill in some of the other blind spots we have about water’s origin. The hydrogen found in Earth’s oceans isn’t necessarily the same sort of hydrogen present throughout the rest of the planet—samples collected closer to the Earth’s core possess exceedingly low amounts of deuterium, which seems to suggest this hydrogen didn’t come from asteroid impacts.

More here.

A Hundred Years After the Armistice

Adam Hochschild in The New Yorker:

For millions of soldiers, the First World War meant unimaginable horror: artillery shells that could pulverize a human body into a thousand fragments; immense underground mine explosions that could do the same to hundreds of bodies; attacks by poison gas, tanks, flamethrowers. Shortly after 8 p.m. on November 7, 1918, however, French troops near the town of La Capelle saw something different. From the north, three large automobiles, with the black eagle of Imperial Germany on their sides, approached the front lines with their headlights on. Two German soldiers were perched on the running boards of the lead car, one waving a white flag, the other, with an unusually long silver bugle, blowing the call for ceasefire—a single high tone repeated in rapid succession four times, then four times again, with the last note lingering.

By prior agreement, the three German cars slowly made their way across the scarred and cratered no man’s land between the opposing armies. When they reached the French lines, they halted, the German bugler was replaced by a French one (his bugle is in a Paris museum today), and the German peace envoys continued their journey. At La Capelle, flashes lit up the night as the envoys were photographed by waiting press and newsreel cameramen, then transferred to French cars. Their route took them past houses, factories, barns, and churches reduced to charred rubble, fruit trees cut down and wells poisoned by retreating German troops.

More here.

Art and The Rectangle

Amy Knight Powell at Cabinet Magazine:

Scholars have built a tight historical and corresponding conceptual link between the advent of the rectangular, Renaissance frame and the advent of linear perspective. It’s true that the renovation of Fra Angelico’s San Domenico altarpiece entailed both, but this was usually not the case. In 1480, about a century and a half after it was made, Giotto’s altarpiece for the Baroncelli Chapel in Santa Croce was renovated. Its original frame was removed and discarded, along with God the Father, who had occupied the gable above the heads of the Virgin and Christ. Spandrels decorated with vermilion cherubim were added, along with a new, rectangular frame that slices right through the curves of the cusped arches.

No new background in perspective was needed. To bring the painting up to date, it sufficed to change its shape—into a rectangle. This shape became so prevalent in Italy by the end of the fifteenth century that paintings came to be called quadri, even when they were round.

more here.

The Dragon: Fear and Power

Tom Shippey at Literary Review:

‘A dragon is no idle fancy,’ wrote Tolkien in 1936, but ‘a potent creation of men’s imagination, richer in significance than his barrow is in gold’. The potency has only increased over the last eighty years. Dragons crowd the pages of modern fantasy; no one needs telling that Daenerys, the Mother of Dragons, holds a crucial place in George R R Martin’s Game of Thrones universe.

Tolkien nevertheless also declared that ‘dragons, real dragons … are actually rare’, counting ‘only two that are significant’. One has to say that even back in 1936 his vision was far too narrow. Dragons, as is proved to the hilt by Martin Arnold’s exceptionally wide-ranging and multicultural survey, are in fact ‘a global phenomenon’ and a cross-temporal one as well. They go as far back in time as the Babylonian Epic of Gilgamesh, and they turn up across Eurasia, from Ireland all the way to Japan. But how consistent is the dragon phenomenon? And what on earth can it mean about us?

more here.

The Drawings of Klimt and Schiele

Michael Prodger at The New Statesman:

Although it was Klimt’s paintings that first impressed Schiele, especially a solo show in 1908, the two men didn’t meet until the following year when they established a strong rapport and exchanged drawings. The role of drawings occupied a different place in the art of each man. The majority of Klimt’s were composed with paintings in mind but he also made private works, often quickly executed, that deviated from the ideal of heady beauty that permeated his paintings. Sketches of his elderly mother or a nude pregnant woman past the first flush of youth shed stylisation for an unflinching intimacy. Sometimes he didn’t bother with limbs, while figures fill the sheet like columns, cropped at the head and feet. Schiele, though, took it all in.

The closeness of the two men lasted until death. Both died in 1918, Klimt at the beginning of the year from pneumonia following a stroke, Schiele at the end of the year, three days after the death of his wife Edith, then six months pregnant, both victims of the global flu pandemic.

more here.

Tuesday Poem

Morning, Jamaica Plain

The swan is a white star drifting
across the onyx pond,
the phosphorescent neck
curving between the black altitudes of trees,
in the held silence of balance:
bird in the shroud and bunting of water.
On the roadway, drivers stare from their bright wild cars,
glassed inside their confused galaxies,
as this one white piece
falls into place, so silently,
this swan
gathering no speed at all,
in the low firmament of the pond.

by Suzanne E. Berger
from Smith College Poetry Center

The politics of forgiveness

Peter Salmon in New Humanist:

On 24 July 1967, the poet Paul Celan gave a reading in Freiburg im Brisgau. At the time he was on a leave of absence from Saint-Anne psychiatric hospital, where he had been interned after suffering a nervous breakdown, in the midst of which he attempted suicide. At the reading was the philosopher Martin Heidegger. The day after the reading Celan was invited to a meeting with Heidegger at the philosopher’s hut. On arrival Celan signed the guestbook, then the two men went for a walk, which was curtailed by rain, and were driven back to the hut. After their brief meeting Celan returned to Saint-Anne’s. One week later, on 1 August, Celan wrote a poem about the encounter in the form of a single, oblique sentence named after the place where Heidegger’s hut stood, “Todtnauberg”. The title contained two words crucial to both the the poetry of Celan and the philosophy of Heidegger – berg meaning mountain, and todt, death.

What was discussed on their walk is not known – some have speculated they discussed their shared interest in botany, while other accounts suggest that Heidegger talked about his recent interview with the magazine Der Spiegel. But it is what was not discussed, between a Jewish poet who survived the Holocaust and a philosopher who was one of the highest-profile sympathisers of Nazism, that has continued to resonate for more than 50 years.

Paul Celan was born Paul Antschel (Celan is a reversal of the two syllables) in 1920, into a German-speaking Jewish family in Bukovina in Romania. His father, Leo, was a Zionist, who insisted his son learn Hebrew, while his mother, Fritzl, insisted, as a devotee of German literature, that German be the language spoken at home. After briefly studying medicine in Tours, France – a Jewish quota made it impossible for him to study in Romania – he returned to Bukovina in 1939. His journey to France had taken him through Berlin, where, from the train, he saw plumes of smoke rising the day after Kristallnacht. Under German occupation in Bukovina, Celan was interned in a ghetto, writing poetry and translating Shakespeare’s sonnets while being forced to gather and destroy Russian books. In a life shot through with historical symbolism, the significance of these simultaneous acts seems terrifyingly apt.

More here.

Do gut bacteria make a second home in our brains?

Kelly Servick in Science:

We know the menagerie of microbes in the gut has powerful effects on our health. Could some of these same bacteria be making a home in our brains? A poster presented here this week at the annual meeting of the Society for Neuroscience drew attention with high-resolution microscope images of bacteria apparently penetrating and inhabiting the cells of healthy human brains. The work is preliminary, and its authors are careful to note that their tissue samples, collected from cadavers, could have been contaminated. But to many passersby in the exhibit hall, the possibility that bacteria could directly influence processes in the brain—including, perhaps, the course of neurological disease—was exhilarating. “This is the hit of the week,” said neuroscientist Ronald McGregor of the University of California, Los Angeles, who was not involved in the work. “It’s like a whole new molecular factory [in the brain] with its own needs. … This is mind-blowing.”

The brain is a protected environment, partially walled off from the contents of the bloodstream by a network of cells that surround its blood vessels. Bacteria and viruses that manage to penetrate this blood-brain barrier can cause life-threatening inflammation. Some research has suggested distant microbes—those living in our gut—might affect mood and behavior and even the risk of neurological disease, but by indirect means. For example, a disruption in the balance of gut microbiomes could increase the production of a rogue protein that may cause Parkinson’s disease if it travels up the nerve connecting the gut to the brain. Talking hoarsely above the din of the exhibit hall on Tuesday evening, neuroanatomist Rosalinda Roberts of The University of Alabama in Birmingham (UAB), told attendees about a tentative finding that, if true, suggests an unexpectedly intimate relationship between microbes and the brain.

More here.

Monday, November 12, 2018

Monday Poem

“In erratic times one cannot be too attentive, too
ready to stand or duck.”
—A. Skutočné

Politics

what’s real depends upon where a thing lands—
how far along it is from ultraviolet to infrared
(from invisible to invisible), but on the
spectrum of real, it might be said

if it’s a matter of life-or-death I’m inclined to think
whatever’s coming at me now is most real,
so I move, I snap to

but if, instead, I’m lost in the contours
of the coming bumper that will ice me,
lost in chiaroscuro,
lost in its seductive curves,
lost in the way fenders sleek and silver slice air,
lost in the hood’s patina,
in the way its lacquered finish
creates a bright steel mood,
if I’m gone in its pricey logo
cast in chrome
……………. …… — if at that moment
my real is just beauty, then realities collide,
aesthetics gives way to physics (the most
essential real of the moment) and the
reality of beauty dies

then too, but late, the meaning of distraction
would’ve suddenly been real, suggesting a deeper take
on the meaning of lies

joy and sorrow
are both real

some say money is real
and it is, the way it wrenches things—

anything with that much clout,
anything that so shapes the mind of the world,
anything that so pummels and rips the fabric of love
is surely real

but what’s real is ephemeral as mist:
thin       thick       opaque      divine
depending upon where and when it lands
on the spectrum of real

real is different
at different times

Jim Culleny
11/6/18

An American Tries To Understand Armistice Day

by Michael Liss

This past Sunday, November 11, marked the Centennial of Armistice Day, the European commemoration of the agreement to end World War I. Representatives from more than 60 countries attended carefully choreographed ceremonies to honor the sacrifice of those who fought.

The Europeans take the Great War seriously. Americans really don’t. It just doesn’t feel like our war. To us, it’s an old chest filled with musty, tattered maps and the remains of broken monarchies and shattered ambitions. Even the early film footage, jerky and grainy in black and white, looks more like a silent movie than something real. We know we participated, and naturally we were heroic. Our boys saved the Allied powers from the Huns, all the while singing “Over There” and wooing the local pulchritude. It’s what we broad-shouldered, brave, optimistic, can-do Americans do.

But, if you want to contextualize our actual contribution, consider the following:

The United States committed 2.8 million servicemen to the war, and suffered 53,402 killed in action, 63,114 deaths from disease and other causes, and about 205,000 wounded. On an absolute level, that’s a lot of lives. But, by contrast, in just one extended, insane battle, the Europeans fought the Somme Offensive, with more than 3 million men engaged and 1 million casualties. Then there was Gallipoli, the infamous, disastrous push by then-First Lord of the Admiralty Winston Churchill in the Dardanelles, which provided the Ottoman Empire with its last meaningful military victory, and included a horrific sacrifice by ANZAC (Australian and New Zealand combined forces) and half a million casualties. And Verdun (between the French and the Germans), which lasted close to 11 months in 1916, and yielded nearly 700,000 casualties and more than 300,000 dead. And Passchendaele (3rd Battle of Ypres, Flanders Fields), between Great Britain, France, Belgium and Germany, in July to November 1917, in which the dead and wounded may have been as high as 700,000. And Operation Michael, the last major German offensive in the West (Germany, the UK, France, and, finally, the United States), which had almost 500,000 casualties. That, of course, skips every battle between the Germans and the Russians. Read more »

America’s Great Sadness & The End for Robert Lowell

by Robert Fay

Robert Lowell

I get sad whenever I think of Robert Lowell. He is the poet of a lost America, an America that likely never was, but one that is gone nonetheless. I get sad when I think of Robert Lowell because of my own inadequacy to love poetry the way he did, the way I once did, when I was more vulnerable, when I was more courageous. I get sad for Robert Lowell because he is unfashionable and his legacy may soon disappear, if not from our university curriculums, than certainly from our hearts.

The optics, as they now say, don’t look good.

Lowell was the patrician poet with a trust fund; the privileged, white-male literary figure who wore a corduroy sport jacket and sloppily-knotted tie—the casual wear of the “bummy rich,” as they were once known on Boston’s North Shore. He was the old Brahmin from Yankee Beacon Hill, whose full name was Robert Traill Spence Lowell IV, and whose ancestors were a “who’s who,” of American history, including William Samuel Johnson, a signer of the U.S. Constitution, and Jonathan Edwards, the Calvinist theologian whose sermon “Sinners in the Hands of an Angry God,” is a foundational American literary text.

And then there was his relationships with women. Read more »

Amazon is disrupting the publishing world….again

by Sarah Firisen

Books have always mattered to me. When I was single in my 20s, I mentioned to my then boss that whenever I first visited a date’s apartment I would look at his bookshelves. He didn’t get it. Why did it matter what books a person read? I tried to explain that for starters, it mattered to me that someone actually read at all. Soon after this, I met my now ex-husband. The circumstances of our meeting had a tangential connection to his love of the Thomas Pynchon novel, Gravity’s Rainbow (long story short, we connected over the Internet in its early days and his persona was Tyrone Slothrop). I’d never read it. For our second date, he brought me a copy of the book. To this day, that was the single most romantic gift a man has ever given me. When we moved into together a mere 6 weeks later, the merging of our books was a major undertaking – interestingly, while there were a lot of authors we didn’t share a love of, like Pynchon, we had a lot of books which completed each other’s sets of various authors. We gave away a fair number of duplicates. When we divorced 18 years later, the process of remembering whose books were whose was challenging. I actually left some behind by accident. He kindly returned them to me, or let me take them off his bookcase, when one, or both us realized. Books have always mattered to me. Read more »

The Evolution Of Music

by Anitra Pavlico

In a recent study, data scientists based in Japan found that classical music over the past several centuries has followed laws of evolution. How can non-living cultural expression adhere to these rules?

Evolution is an “algorithmic process applied to populations of individuals.” [1] Individuals vary, and certain individuals’ traits are passed on while others are culled. These steps are repeated many times. In biology, scientists can study the gene as a “unit of inheritance,” but an analogous unit of inheritance has to be selected in a study of a cultural practice. Eita Nakamura at Kyoto University and Kunihiko Kaneko at the University of Tokyo decided to look at unique musical features such as the tritone–a dissonant interval of three whole notes–and measure the number of occurrences in Western musical compositions over the centuries.

According to Nakamura and Kaneko, “The mean and standard deviation of the frequency (probability) of tritones steadily increased during the years 1500-1900.” Because this might have been just a function of individual composers’ preferences or “social communities” and not necessarily governed by statistical evolutionary laws, they developed a mathematical model of evolution to tell the difference. The tritone is a relatively rare musical event, but its use has spread over the centuries in a way that the study’s authors say follow precise statistical rules. [2] Read more »

“How Do You Feel about Being an American?” A Conversation with Patricia Thornley

by Andrea Scrima

Indian Scout

From November 17, Patricia Thornley’s work The Western, part of her series THIS IS US, is on view as part of the group exhibition “Empathy” at Smack Mellon Gallery in Brooklyn, New York. The project is the latest in a seven-year series of installation and single-channel video works consisting of interviews and performances. Previous videos of the series are An American in Bavaria (2011), Don’t Cry for Me (2013), and Sang Real (2015). As a whole, THIS IS US  formulates multiple parallel inquiries into the collaborative fantasies Americans enact through popular media. In the current political climate, as the escalation of social and economic forces impacting millions of lives is cast into increasingly sharp relief, these fantasies take on new urgency and, in many cases, a new absurdity.

The Western’s cast of characters consists of these Civil War-era archetypes: Indian Scout, Beast of Burden, Frontiersman, Savage, Deserter, Justice, and Drifter. The work is conceived as a two-part installation in which the cinematic trope of the Western is used as a framework for inquiring into the American psyche. In the exhibition space, a projected “movie” is installed opposite a wall of screens playing a series of interviews with the seven participating characters.

Beast of Burden

Andrea Scrima: Patricia, a few years ago I conducted an interview with you about a previous work of yours, Sang Real (2015), for the online poetry magazine Lute & Drum. Now, with The Western, the overall structure of THIS IS US is coming more and more clearly into focus. The last time we spoke at length about your series was a year and a half before the last presidential election. How have recent changes on the political landscape affected your approach to the themes in your work?

Patricia Thornley: From the beginning in the THIS IS US series, one of the questions I asked in my interviews with the people who featured in the individual videos was “how do you feel about being an American?” Historically, there’s always been a certain political disconnect at play with Americans, due to less armed conflict on our own soil and a certain comfort level. Read more »

On the Road: Wildebeest Crossing

by Bill Murray

The crocodiles know. They form pincers on either side of the crossing point. Richard says they feel the vibration of all those hooves along the riverbank above them.

Waves of animals surge toward the river then fall away. If they all go we’ll witness a frightful, deadly crush of beasts in motion, mad energy, herd hysteria, dust and confusion, the cries of mortally wounded beasts rising to the heavens, birds of prey gaggling and swooping and squawking, kinetic intensity unbound.

We have come to see the sprawling, real life spectacle of wildebeests crossing the Mara River. It is the largest overland migration in the world. Read more »

Bergen Arches: Living for the City

by Bill Benzon

“We’re in one of those great historic periods…when people don’t understand the world anymore…when the past is not sufficient to explain the future.”
–Peter Drucker

Fasten your seatbelts, we’re going for a ride. We start over 300 million years ago and arrive at the present in a mere six paragraphs. We remain here for the rest of the tour, looking at pictures and talking about a strange urban paradise situated in the middle of one of the most densely populated areas on the planet.

From Pangea to Hurricane Sandy

Roughly 335 million years ago, during the late Paleozoic and early Mesozoic eras, the Earth’s existing continental masses formed themselves into the supercontinent Pangea. Pangea began to breakup roughly 175 million years ago giving rise to the Palisades Sill, most visible as a series of cliffs running 50 miles along the west bank of the Hudson River in New York and New Jersey. The Palisades tapers down to sea level in what is now Jersey City.

Roughly 14,000 years ago the first humans settled in North America, spreading quickly across the continent and south through Central to South America. In 1609 the Lenape greeted Henry Hudson when he set foot in that area on his search for a Northwest Passage to China. Two centuries later railroads began emerging in North America. In the second quarter of the 19th Century and Camden and Amboy Railroad became the first in New Jersey, completing its first line in 1834. In the middle of the century the Erie and the Delaware-Lackawanna railroads completed the Long Dock Tunnel in 1861. It conveyed freight trains from the Meadowlands through the Palisades Sill to freight terminals on the Hudson River. By the early 20th century Jersey City had become a bustling port.

In 1906 the Erie Railroad began blasting a cut through the Palisades less than a football field’s width south of the Long Dock Tunnel. The Erie Cut was completed in 1910. It is between, say, 50 and 80 feet deep and 70 to 100 feet wide at the bottom. In four places the cut becomes short tunnels so that roads and buildings could go atop it; short bridges cross the cut at three other points. Collectively these are the Bergen Arches, the name by which this feature is known today. Read more »

Not necessarily the best ambient and space music of 2018

by Dave Maier

No, it’s not that time of year just yet! However, since my yearly lists aren’t always exactly best-of-year lists anyway, I thought I might get the jump on everyone else, before we’re all best-of-year’ed out. (I should do sets more often anyway …) About half of these tracks are from 2018, and the rest are recent-ish, so that’s something.

Ethernet – Birds of Paradise (From Here to Tranquility Vol. 7 [Silent])

I don’t know a whole lot about Ethernet (I didn’t bother googling, because I bet you get a bazillion hits for, you know, Ethernet), but this track is a gloriously bubbly spacy ambient number of the sort Silent does very well (although there are all kinds of things on their samplers, of which they are up to Vol. 10 now, I see).

Fastus – Dream Within a Dream (Terra Incognito)

Fastus is a guy named Ian from Jersey City, NJ in the USA. He does great demos for particular synth modules, which is how I know about him. Most if not all of this track was done on a Eurorack modular system, perhaps the very one pictured in blue above. It can be difficult to make modular synths sound musical, so hats off to Ian for this compelling track. Check out the Bandcamp link for a sweet deal on all three of Ian’s records.

Erik Wollo – Traverse (Threshold Point [Projekt])

This is Erik’s 23rd album, some of which, he tells us, was composed “under special and tragic circumstances,” which he says make it “more ethereal and humble” than some of his other music. I haven’t heard all 22 of his other records, so I can’t really say, but this one sounds to me pretty much like the ones I know from his early days (classics like Traces and Images of Light). This particular track may also be an homage to fellow Norwegian guitarist Terje Rypdal, as the chord progression sounds a whole lot like that from the track “Avskjed” from Rypdal’s 1980 album Descendre. If I ever meet Erik again, I will ask him. Read more »