Smriti Mallapaty in Nature:
Molecules in urine and blood can reveal how much of a person’s diet comes from ultra-processed foods, according to a study published in PLOS Medicine today1. The paper suggests that these measurements provide an objective way to track consumption of ultra-processed food — and would be useful for investigating links to diseases such as diabetes and cancer.
Ultra-processed foods are industrially manufactured and often contain ingredients, such as additives and emulsifiers, that are not typically found in home-cooked food. From sweetened yogurts to factory-made bread and packaged snacks, “it’s a really wide range of foods”, says study co-author Erikka Loftfield, an epidemiologist at the US National Cancer Institute in Rockville, Maryland. Studies have linked high consumption of ultra-processed food to an increased risk of obesity2, cardiovascular disease, diabetes and some types of cancer3. But these investigations have typically relied on asking individuals to remember what they have eaten, which can be unreliable. Studies have also shown the potential of studying the products of metabolism excreted in the blood and urine, but only for a small number of such metabolites4,5. Loftfield and her colleagues have now expanded that analysis to include more than 1,000 metabolites, which are produced when the body converts food into energy.
More here.
Enjoying the content on 3QD? Help keep us going by donating now.

A novel about a Palestinian woman who participates in a pyramid scheme reselling Birkin bags has won this year’s Swansea University
The announcement last week that a nine-month-old baby in Philadelphia has been cured of a rare genetic disorder by gene editing is a great moment in medical history. For the first time, doctors have altered a gene inside many cells in the liver of a living human being using CRISPR, the molecular tool borrowed from microbes that can
Ideally, policy and program design is a straightforward process: a decision-maker faces a problem, turns to peer-reviewed literature, and selects interventions shown to work. In reality, that’s rarely how things unfold. The popularity of “evidence-based medicine” and other “evidence-based” topics highlights our desire for empirical approaches — but would the world actually improve if those in power consistently took social science evidence seriously? It brings me no joy to tell you that, at present, I think the answer is usually “no.”
It was the finger seen around the world. In 2008, archaeologists working in Denisova Cave in southern Siberia, Russia, uncovered a tiny bone: the tip of the little finger of an
Art criticism is thriving. It’s taking on new forms, shedding old skin, and adapting to novel venues. It’s as alive and relevant as ever, still generating conversation and controversy. Instead of fizzling out, it’s being embraced by new generations of critics, whether in these pages or on Substack, Instagram, YouTube, and TikTok (no matter the platform, it always comes down to writing). It’s a buzzing genre that attracts readers of all ages, from septum-pierced college students to cigar-puffing art collectors.
After her adventures in Wonderland, the fictional Alice stepped through the mirror above her fireplace in Lewis Carroll’s 1871 novel Through the Looking-Glass to discover how the reflected realm differed from her own. She found that the books were all written in reverse, and the people were “living backwards,” navigating a world where effects preceded their causes.
For much of the 20th century, young Americans were seen as free speech’s fiercest defenders. But now, young Americans are growing more skeptical of free speech.
Meet my patient Mrs. L. R. She’s 98 years young and has never suffered a day of serious illness in her long life. She was referred to me by her primary care physician to assess her
It was a cold, gray afternoon in December, and at the American Museum of Natural History, a half million leaf-cutter ants were hunkered down in their homes. The ants typically spend their days harvesting slivers of leaves, which they use to grow expansive fungal gardens that serve as both food and shelter. On many days, visitors to the
What is the history of bureaucracies? Where did the concept originate, and how has it evolved?
Wintour is the longtime editor in chief of Vogue and the chief content officer for the publishing behemoth Condé Nast, whose stable of magazines includes Bon Appetit, Teen Vogue and New Yorker. She is the mastermind behind the Met Gala, which lit up the pop culture cosmos earlier this month. In many respects, Wintour, at 75, remains the most recognizable face of the fashion establishment. But fashion, at the level where Wintour has long served as gatekeeper, and with its subjective assessment of aesthetics, has struggled more than most industries with diversity and inclusivity, from the pages of its magazines to its corporate boardrooms. And despite moments of intense focus on racial justice, big changes have often been superficial and real change has been slow.
A pandemic is never only about biological contagion. Much of what we feel, think, and do—far more than I want to admit—is the product of what we perceive or unconsciously mimic in the world around us. Laughter is contagious, and yawns—even chimpanzees find yawns contagious. I realize only now, in the enforced quiet, how I absorbed the pace and values of the society around me. My mind was quiet, if concerned, as I watched the infectiousness of fear, panic, and hysteria; of rationalization or mystification; of courage. Ideas and beliefs, good information and bad information, enthusiasm and advice and funny memes spread as fast as the virus.
The system, called AlphaEvolve, combines the creativity of a large language model (LLM) with algorithms that can scrutinize the model’s suggestions to filter and improve solutions. It was described in a white paper