Maayan Jaffe-Hoffman in the Jerusalem Post:

The potentially game-changing anti-cancer drug is based on SoAP technology, which belongs to the phage display group of technologies. It involves the introduction of DNA coding for a protein, such as an antibody, into a bacteriophage – a virus that infects bacteria. That protein is then displayed on the surface of the phage. Researchers can use these protein-displaying phages to screen for interactions with other proteins, DNA sequences and small molecules.

In 2018, a team of scientists won the Nobel Prize for their work on phage display in the directed evolution of new proteins – in particular, for the production of antibody therapeutics.

AEBi is doing something similar but with peptides, compounds of two or more amino acids linked in a chain. According to Morad, peptides have several advantages over antibodies, including that they are smaller, cheaper, and easier to produce and regulate.

More here.

Scott Atran in Scientific American:

With support from Minerva Research Initiative of the U.S. Department of Defense and National Science Foundation, we recently published the first neuroimaging study of a radicalizing population. The research used ethnographic surveys and psychological analysis to identify 535 young Muslim men in and around Barcelona—where ISIS-supporting jihadis killed 13 people and wounded 100 more in the city center in August 2017.

Half of these young men (267) scored higher that the other half (268) on all measures of vulnerability to recruitment into violent extremism. From the more vulnerable group, 38 men, second-generation immigrants of Moroccan origin who had already “expressed a willingness to engage in or facilitate violence associated with jihadist causes,” agreed to have their brains scanned.

The young men selected for the neuroimaging study then played a ball-throwing game (Cyberball) with fellow Spaniards, and half of them were abruptly and deliberately excluded from being passed the ball. Their brains were then scanned while asking them questions about behavior and policies they considered sacred and inviolable (e.g., forbidding cartoons of the Prophet, preventing gay marriage) as well non-sacred but important values (e.g., women wearing the veil, unrestricted construction of mosques).

More here.

Nick Barrowman at The New Atlantis:

The word data is derived from the Latin meaning “given.” Rob Kitchin, a social scientist in Ireland and the author of The Data Revolution (2014), has argued that instead of considering data as given it would be more appropriate to think of it as taken, for which the Latin would be capta. Except in divine revelation, data is never simply given, nor should it be accepted on faith. How data are construed, recorded, and collected is the result of human decisions — decisions about what exactly to measure, when and where to do so, and by what methods. Inevitably, what gets measured and recorded has an impact on the conclusions that are drawn.

For example, rates of domestic violence were historically underestimated because these crimes were rarely documented. Polling data may miss people who are homeless or institutionalized, and if marginalized people are incompletely represented by opinion polls, the results may be skewed. Data sets often preferentially include people who are more easily reached or more likely to respond.

more here.

Katherine Coldiron at 3:AM Magazine:

How do you recommend an experience you never want to have again? How does a film critic say, for instance, that Requiem for a Dream is a must-watch, when it’s infused with such ugliness and despair? When a piece of art is unapologetically dark and unpleasant but of objectively excellent quality, finding a way to push audiences toward it is a challenge.

In this vein is Thirty-Seven, by American novelist Peter Stenson, an intense, exceptionally well-made, unforgettable book. I loved every word, but I can’t suggest it’s an enjoyable read. It’s a horror story without ghosts or beasts, a book that continually evokes Rorschach, in Watchmen, saying “as dark as it gets.” Meticulously constructed, Hitchcockian in its layering of tension, Faulknerian in its network of ideas, wise and strange as an angel, black as a night in a dungeon. Certainly one of the best books I read in 2018. But difficult to recommend. At least, not if you’re looking for a comfortable ride.

more here.

Geoff Dyer at the New Statesman:

The best parts of “Art and Morality” (1925) are not about art or morality but – via an extraordinary speculative detour into the lives of ancient Egyptians – about how the “Kodak” habit of photographing oneself all the time has fundamentally changed our sense of ourselves: a prophetic diagnosis of a defining malaise of the iPhone era. In an editorial note to “Introduction to Pictures” the scholar James T Boulton rightly points out that the essay “does not once refer to pictures”. This tendency to stray from stated intentions was best expressed by Lawrence himself on 5 September 1914. “Out of sheer rage I’ve begun my book about Thomas Hardy. It will be about anything but Thomas Hardy I am afraid – queer stuff – but not bad.”

Intended as part of a series called “Writers of the Day”, the manuscript, which had veered far from any template, was not accepted for publication. Lawrence wanted it to leave the original brief still further behind and began recasting something that had been “mostly philosophicalish, slightly about Hardy” into a more explicit statement of his “‘philosophy’ (forgive the word)”.

more here.

Imad-ad-Dean Ahmad in Atlantis:

The history of Islam’s relation to science has largely been one of harmony. It offers no real parallel to the occasional bouts of suspicion toward science that the Christian world experienced. Today, many Muslims can be found in the fields of medicine and engineering. Even the ultraconservative Muslims who long for a return to the ethical norms of the seventh century see no need to abandon cell phones to do so, and even the most extreme of Islamic extremists envies the high-tech oil-extraction techniques and the weaponry of the West. Muslims, both conservative and liberal, issue fatwas (legal opinions) over the Internet without any hesitation over the technology they employ and with no fear that it may be haram (prohibited).

However, although contemporary Muslims tend not to be averse to science or technology, their strong belief in the compatibility of science and Islam may leave them vulnerable to dubious efforts to equate the two. The effort to harmonize modern technical knowledge and practice with Islamic teaching is part of a project known as the “Islamization of knowledge,” and is quite popular among Muslim intellectuals today. The most visible area of this intellectual work has been in the world of finance, with the development of so-called “Islamic banking.” A wide variety of venture-capital investments, joint-development projects, and partnership financing have been devised to avoid the appearance of charging interest, a practice forbidden by traditional Muslim jurisprudence. On a smaller scale, there has been a rising interest in bringing the sciences into a conversation with Islamic teachings.

An offshoot of this project takes an absurd turn: it attempts to demonstrate, in effect, that the Koran is a scientific textbook — that it is not merely compatible with science but actually foretells and validates specific modern scientific theories. This movement is troubling in part because it is becoming associated with the term “Islamic science,” which has long been used to refer to the medieval Golden Age during which the Muslim world made important contributions to natural philosophy, medicine, and mathematics. Confusing this new movement with that important period is a disservice to history. Moreover, this new movement to seek out science in the Koran is contrary to the scientific method and, in ignoring the Koran’s warning against confusing allegory with basic facts (3:7), is contrary to Islamic teaching.

More here.

Carl Zimmer in The New York Times:

In 2014 John Cryan, a professor at University College Cork in Ireland, attended a meeting in California about Alzheimer’s disease. He wasn’t an expert on dementia. Instead, he studied the microbiome, the trillions of microbes inside the healthy human body. Dr. Cryan and other scientists were beginning to find hints that these microbes could influence the brain and behavior. Perhaps, he told the scientific gathering, the microbiome has a role in the development of Alzheimer’s disease. The idea was not well received. “I’ve never given a talk to so many people who didn’t believe what I was saying,” Dr. Cryan recalled. A lot has changed since then: Research continues to turn up remarkable links between the microbiome and the brain. Scientists are finding evidence that microbiome may play a role not just in Alzheimer’s disease, but Parkinson’s disease, depression, schizophrenia, autism and other conditions.

For some neuroscientists, new studies have changed the way they think about the brain. One of the skeptics at that Alzheimer’s meeting was Sangram Sisodia, a neurobiologist at the University of Chicago. He wasn’t swayed by Dr. Cryan’s talk, but later he decided to put the idea to a simple test. “It was just on a lark,” said Dr. Sisodia. “We had no idea how it would turn out.” He and his colleagues gave antibiotics to mice prone to develop a version of Alzheimer’s disease, in order to kill off much of the gut bacteria in the mice. Later, when the scientists inspected the animals’ brains, they found far fewer of the protein clumps linked to dementia.

Just a little disruption of the microbiome was enough to produce this effect. Young mice given antibiotics for a week had fewer clumps in their brains when they grew old, too.

More here.

Matt Davis in Big Think:

Lab-grown beef may very well be the path forward. In 2008, it was estimated that just half a pound of lab-grown beef would cost $1 million. Then, on August 5, 2013, the first lab-grown hamburger was eaten. It cost $325,000 and took two years to make. Just two years later, the same amount of lab-grown beef costs about $11 to make.

Lab-grown beef checks almost all of the boxes: it doesn’t require animal cruelty, and a study in Environmental Science and Technology showed that it could cut emissions from conventionally produced meat by up to 96 percent and cut down on the land use required for meat production by 99 percent. In the U.S., where cow pastures take up 35 percent of available land — that’s about 654 million acres — this could be huge. Imagine having 647 million acres for development, housing, national parks, anything at all!

But does lab-grown beef pass the most crucial test? Does it taste like an honest-to-goodness hamburger?

More here.

Henry Farrell in Crooked Timber:

Attention conservation notice: long (nearly 5,000 words long) essay on the economic power of ideas. To its credit, the questions discussed are plausibly important. To its detriment, the arguments are less arguments than gestures, and the structure is decidedly baggy.

For the last couple of weeks, I’ve been wanting to write a response to Aaron Major’s (paywalled) article on ideas and economic power for Catalyst. Now there’s a second piece by Jeremy Adelman in Aeon on Thomas Piketty and Adam Tooze. I think they’re both wrong, but in different ways. Major’s piece suggests that economic ideas don’t really matter very much – it’s the economic base, not the superstructure that’s doing the work. Adelman, in contrast, think that ideas are super important – he just thinks that Piketty and Tooze have ones that are leading us in the wrong direction.

These arguments come from radically different places, but they have one thing in common. They both substantially underestimate the role that ideas have played in getting us to where we are on the left, and what they they’re likely to do for us in the near future.

More here.

Dani Rodrik in Project Syndicate:

The main political beneficiaries of the social and economic fractures wrought by globalization and technological change, it is fair to say, have so far been right-wing populists. Politicians like Donald Trump in the United States, Viktor Orbán in Hungary, and Jair Bolsonaro in Brazil have ridden to power by capitalizing on the growing animus against established political elites and exploiting latent nativist sentiment.

The left and progressive groups have been largely missing in action. The left’s relative weakness partly reflects the decline of unions and organized labor groups, which have historically formed the backbone of leftist and socialist movements. But ideological abdication has also played an important role. As parties of the left became more dependent on educated elites instead of the working class, their policy ideas aligned more closely with financial and corporate interests.

The remedies on offer from mainstream leftist parties remained correspondingly limited: more spending on education, improved social-welfare policies, a bit more progressivity in taxation, and little else. The left’s program was more about sugarcoating the prevailing system than addressing the fundamental sources of economic, social, and political inequities.

More here.

Joshua Rothman in The New Yorker:

For around a decade, people who think critically about the media have worried about filter bubbles—algorithmic or social structures of information flow that help us see only the news that we want to see. Filter bubbles make it easy to ignore information that could change our views. But the Covington story is an example of a different problem. It’s a story that’s disproportionately talked about and hard to avoid. It’s relatively inconsequential, but also inescapable. There is no bubble strong enough to keep it out.

The Covington saga isn’t fake news, strictly speaking. The events on the Mall really happened; what’s more, the surrounding story raises many questions of broad, genuine interest. How much should we hold teen-agers accountable for their political views? Would a group of nonwhite demonstrators have been permitted to behave as the Covington boys did? What is the moral status of Catholicism, and of socially conservative religious institutions generally? (What if the boys had been students at a Jewish or Muslim school?) How reactive should journalists be? These subjects are interesting to debate, as are the reputations of Sandmann and Phillips. All of this lends the Covington video a kind of moral momentum. As more people weigh in, the momentum builds.

It would be wrong, however, to take the moral interest of the Covington video at face value.

More here.  [Thanks to Dan Dennett.]

https://www.youtube.com/watch?v=Rq0yhizu0y8

https://www.youtube.com/watch?v=_qj-LMIsM8c

By a poverty of vision a
wealth of calamity occurs.
…….…………….—Roshi Bob

I Know a Man

As I sd to my
friend, because I am
always talking, —John, I
sd, which was not his
name, the darkness sur-
rounds us, what

can we do against
it, or else, shall we &
why not, buy a goddamn big car,

drive, he sd, for
christ’s sake, look
out where you’re going

Robert Creeley
from Contemporary American Poetry
Penguin Books, 1966

Joshua Rapp Learn in Smithsonian:

When Lake Xochimilco near Mexico City was Lake Texcoco, and the Aztecs founded their island capital city of Tenochtitlan in 1325, a large aquatic salamander thrived in the surrounding lake. The axolotl has deep roots in Aztec religion, as the god Xolotl, for whom the animal is named, was believed to have transformed into an axolotl—although it didn’t stop the Aztecs from enjoying a roasted axolotl from time to time. The custom of eating axolotl continues to this day, although the species has become critically endangered in the wild. Saving the salamander that Nature called “biology’s beloved amphibian” takes on a special significance given the animal’s remarkable traits. Axolotls are neotenic, meaning the amphibians generally do not fully mature like other species of salamander, instead retaining their gills and living out their lives under water as a kind of juvenile. On rare occasions, or when stimulated in the lab, an axolotl will go through metamorphosis and develop lungs to replace its gills.

Accompanying these unique traits is a remarkably complex genome, with 32 billion base pairs compared to about 3 billion base pairs in human DNA. The axolotl has the largest genome ever fully sequenced, first completed last year by a team of European scientists. The University of Kentucky, which heads axolotl research in the United States, today announced that researchers have added the sequencing of whole chromosomes to the European effort—“about a thousand-fold increase in the length of assembled pieces,” according to Jeremiah Smith, an associate biology professor at the University of Kentucky. Scientists hope to use this new data to harness some of the axolotl’s unique abilities.

More here.

Colin Dickey in The New Republic:

Every so often a book comes along and changes the way you see a classic of literature. The Diary of Virginia Woolf, published between 1977 and 1984, came out decades after Woolf’s death in 1941, and added a stunning lens through which to view her long and dynamic career. Her husband Leonard had carefully edited a volume initially in 1953, one that focused entirely on Woolf’s writing process and avoided personal details, but it was only when Woolf’s diaries were released in their totality that readers gained a precious glimpse inside a complicated mind at work.

They revealed a Woolf unexpectedly playful and at times mundane: “So now I have assembled my facts,” she wrote on August 22, 1922, “to which I now add my spending 10/6 on photographs, which we developed in my dress cupboard last night; & they are all failures. Compliments, clothes, building, photography—it is for these reasons that I cannot write Mrs Dalloway.” They also reveal a Woolf at times both vicious and shitty: her cattiness, her casual racism. Ruth Gruber, who wrote the first PhD dissertation on Woolf, had a short, pleasant correspondence with her in the 1930s, only to discover, when the diaries were later published, Woolf referring to her dismissively as a “German Jewess” (Gruber was born in Brooklyn). As Gruber would write of the experience, “Diaries can rip the masks from their creators.”

Unlike many writers’ diaries, The Diary of Virginia Woolf has become more than just a gloss on her novels; it is a work of literature in and of itself, a powerful and startling look into the inner life of a woman writer during a dramatic time. “I will not be ‘famous,’ ‘great,’” she wrote in 1933. “I will go on adventuring, changing, opening my mind and my eyes, refusing to be stamped and stereotyped. The thing is to free one’s self: to let it find its dimensions, not be impeded.” Woolf began writing in a diary in 1897, when she was just 14 years old; she would continue on and off again, for the rest of her life; she would write the final entry four days before her death in March 1941. In total, she wrote over 770,000 words in her diaries alone.

More here.

Cheryl Misak in Aeon:

Vienna in the 1920s was an exciting place. Politically, it was the time of Red Vienna, when the municipal government experimented with radical democratic reforms in housing, healthcare, education and worker’s rights. There was optimism in the air, despite postwar hyperinflation and rising conservatism. It was also an exciting time intellectually, for one of the most influential movements in the history of philosophy was in full swing: the Vienna Circle.

They were a group of philosophers, mathematicians and physicists who gathered around the German philosopher Moritz Schlick, and included luminaries such as Rudolf Carnap, Otto Neurath and Herbert Feigl. The Circle put forward an ambitious programme that would have all knowledge constructed out of an objective foundation of observation and deductive logic. Their ‘verifiability principle’ would assert that a meaningful sentence had to be reducible, via truth-preserving logic, to a basic language of observation statements. Metaphysics, ethics, religion and aesthetics were either to be revised so as to be stated in this scientific language, or else declared meaningless – mere nonsense. These new scientific philosophers were socially progressive, at home in Red Vienna, and they saw themselves as intellectually progressive as well. Unfortunately, others all too readily concurred, such as the fascist student who gunned down Schlick on the steps of the University of Vienna in 1936.

Theirs was an idea whose time had come. A similar group was developing in Berlin, with Hans Reichenbach and Carl Hempel as its most prominent members. In Cambridge, Bertrand Russell had also been arguing that philosophy must proceed by a logical analysis that bottoms out in simple, metaphysically fundamental existents in the world. But it was Russell’s Viennese student Ludwig Wittgenstein who most intrigued the Circle with his first book, written mostly during the First World War on the perilous Eastern and Italian fronts, where he was ultimately taken as a prisoner of war.

More here.

Ed Yong in The Atlantic:

At first glance, the hagfish—a sinuous, tubular animal with pink-grey skin and a paddle-shaped tail—looks very much like an eel. Naturalists can tell the two apart because hagfish, unlike other fish, lack backbones (and, also, jaws). For everyone else, there’s an even easier method. “Look at the hand holding the fish,” the marine biologist Andrew Thaler once noted. “Is it completely covered in slime? Then, it’s a hagfish.”

Hagfish produce slime the way humans produce opinions—readily, swiftly, defensively, and prodigiously. They slime when attacked or simply when stressed. On July 14, 2017, a truck full of hagfish overturned on an Oregon highway. The animals were destined for South Korea, where they are eaten as a delicacy, but instead, they were strewn across a stretch of Highway 101, covering the road (and at least one unfortunate car) in slime.

Typically, a hagfish will release less than a teaspoon of gunk from the 100 or so slime glands that line its flanks. And in less than half a second, that little amount will expand by 10,000 times—enough to fill a sizable bucket.

More here.