Jim Kozubek in Nautilus:
Johann Wolfgang von Goethe, the 18th-century poet and philosopher, believed life was hardwired with archetypes, or models, which instructed its development. Yet he was fascinated with how life could, at the same time, be so malleable. One day, while meditating on a leaf, the poet had what you might call a proto-evolutionary thought: Plants were never created “and then locked into the given form” but have instead been given, he later wrote, a “felicitous mobility and plasticity that allows them to grow and adapt themselves to many different conditions in many different places.” A rediscovery of principles of genetic inheritance in the early 20th century showed that organisms could not learn or acquire heritable traits by interacting with their environment, but they did not yet explain how life could undergo such shapeshifting tricks—the plasticity that fascinated Goethe.
A polymathic and pioneering British biologist proposed such a mechanism for how organisms could adapt to their environment, upending the early field of evolutionary biology. For this, Conrad Hal Waddington became recognized as the last Renaissance biologist. This largely had to do with his idea of an “epigenetic landscape”—a metaphor he coined in 1940 to illustrate a theory for how organisms might regulate which of their genes get expressed in response to environmental cues or pressures, leading them down different developmental pathways. It turned out he was onto something: Just a few years after coining the term, it was found that methyl groups—a small molecule made of carbon and hydrogen—could attach to DNA, or to the proteins that house it, and alter gene expression. Changing how a gene is expressed can have drastic consequences: Every cell in our body has the same genes but looks and functions differently only due to the epigenetics that controls when and how genes get turned on. In 2002, one development biologist wondered whether Waddington’s provocative “ideas are relevant tools for understanding the biological problems of today.”
More here.

Today’s selection — from Zora and Langston by
Butler was 58 when Fledgling was published, and barely a year later, she fell and hit her head on an icy pavement and died. Her papers arrived at the Huntington in 2008: two filing cabinets and 35 large cardboard boxes, containing drafts, notes, sums, receipts and bills, an order form for men’s-size Star Trek jerseys; to-do lists and to-get lists – ‘Potatoes
Madlib has always seemed more concerned with making music than with the question of what to do with it. The forty-seven-year-old producer and multi-instrumentalist has estimated that he makes hundreds of beats a week, many of which he never shares with anyone. His beats are a form of homage. He listens carefully to an old record, trying to squeeze every musical possibility out of it, to follow every path not taken. Sometimes it’s therapeutic. The week that Prince died, Madlib mourned by making tracks built on Prince samples. Following the death of his collaborator J Dilla, and then that of MF DOOM, he stayed awake for days, making hundreds of hours of music. Since the nineties, Madlib has essentially been building a private, ever-expanding library of beats, which spans everything from hip-hop, jazz, and soul to German rock, industrial music, Brazilian funk, and Bollywood. He has released dozens of albums under just as many aliases. Sometimes the aliases splinter off to form side projects. For Madlib, making music is as elemental as eating or sleeping, though he claims to do very little of the latter.
The Democratic Party’s repudiation of these voters’ views as “deplorable” or “racist” stoked resentment of urban elites, driving many in search of a new political home. When Donald Trump appeared before workers and farmers in his red baseball cap, he articulated their antipathies coarsely but effectively. A louche product of a milieu in which shady real-estate deals skirted the world of organized crime, Trump shared some of the class resentment of people who could only dream of his wealth. Trump became their savior, and tied the Republican Party firmly to hard-right populism. Even without Trump as president, the GOP will remain his party for a long time.
By the time Mudassir Azeemi wrote to Apple CEO Tim Cook in 2014, he’d tried everything he could think of to make it easier to type in his native language, Urdu. In 2010, the now 42-year-old Pakistani-American developed a keyboard app you could use on iOS devices; within two years, it had been downloaded over 165,000 times. But even with an Urdu-language keyboard, the characters appeared on the screen in an entirely different font.
Third Wave Antiracism is losing innocent people jobs. It is coloring, detouring and sometimes strangling academic inquiry. It forces us to render a great deal of our public discussion of urgent issues in doubletalk any 10-year-old can see through. It forces us to start teaching our actual 10-year-olds, in order to hold them off from spoiling the show in that way, to believe in sophistry in the name of enlightenment. On that, Third Wave Antiracism guru Ibram X. Kendi has written a book on how to raise antiracist children called Antiracist Baby. You couldn’t imagine it better: Are we in a Christopher Guest movie? This and so much else is a sign that Third Wave Antiracism forces us to pretend that performance art is politics. It forces us to spend endless amounts of time listening to nonsense presented as wisdom, and pretend to like it.
Sophie Blind is dead. Her head was cut clean off her shoulders as she made a dash for a taxi and was hit by a car. She doesn’t seem to mind, though it is a little awkward. “I knew I was dead when I came,” she admits, “but I didn’t want to be the first to say it.” Besides, the event didn’t leave much of a mark: “in less than half an hour,” she informs us, “normal traffic was resumed.” Though death and decapitation seem like straightforward facts, Sophie is the heroine of a novel: “
Robin DiAngelo’s book, White Fragility, has been on the New York Times best-seller list for over two years, much of that time ranked number one. The book is assigned frequently in college courses, and DiAngelo is in great demand as a “diversity” consultant to help corporations, universities, government agencies, and other institutions purge themselves of their white privilege. DiAngelo’s core message is that white Americans need to acknowledge their unconscious racial biases which make them, unwittingly in most cases, complicit in what she deems the U.S. racial caste system.
A graduate student recently posed this question to me: What is the most common mistake that scholars make when they try to write about contemporary issues? Questions like this usually make me nervous, since the offices of cultural commentator and public intellectual remain very mysterious to me. But in this case, I had a ready answer because we all make the same mistake when writing about contemporary issues: Our writing process lacks sufficient resistance, hesitation, reconsideration—in short, friction.
As early as March, the Muon g-2 experiment at Fermi National Accelerator Laboratory (Fermilab) will report a new measurement of the magnetism of the muon, a heavier, short-lived cousin of the electron. The effort entails measuring a single frequency with exquisite precision. In tantalizing
Countless academic articles and self-help books sing to the same tune – characterising immediate gratification as a short-sighted hitch while praising the virtues of long-term thinking as a means for overcoming temptation. Many people have heard of the marshmallow
Years ago, when my body simply was what it was, soft and long, before I had even contemplated changing it into anything else, I came across Martin Schoeller’s Female Bodybuilders on a bookstore display table. In it were studio-lit portraits of women whose faces had been reduced to bone and socket and vein, whose skin had been stained with spray tan and eyes outlined in shadow. Enormous muscles rose up to enclose their necks. They looked prehistoric, fossilized and eternal. I thought they had destroyed their chances at love. My mistake was to assume they were living under the star of sexual capital, as I was. After all, they wore the rhinestones and velvet of showgirls. What I didn’t yet understand was that bodybuilders are ruled by a different star, the same star that would later rule me, if only temporarily. It was dim and solitary, with enormous gravity. I still don’t have a name for it.
IN 1527, THE VENETIAN EXPLORER