Isaac Chotiner in The New Yorker:
In his new book, “Last Best Hope: America in Crisis and Renewal,” George Packer writes that the United States is in a state of disrepair, brought about primarily by the fact that “inequality undermined the common faith that Americans need to create a successful multi-everything democracy.” The book opens with an essay on the state of the U.S. during the pandemic, and then offers sketches of four different visions of the country: Free America, of Reaganism; Smart America, of Silicon Valley and other professional élites; Real America, of Trumpist reaction; and Just America, of a new generation of leftists. “I don’t much want to live in the republic of any of them,” Packer writes. He proposes a different vision, which he thinks offers brighter possibilities, centered around the concept of equality and non-demagogic appeals to patriotism.
I recently spoke by phone with Packer, who is a staff writer at The Atlantic and was previously a staff writer at The New Yorker. He is also the author of the books “The Assassins’ Gate” and “The Unwinding.” During our conversation, which has been edited for length and clarity, we discussed why Barack Obama failed to change the direction of the country, whether a more progressive form of patriotism is possible, and whether the cultural controversies roiling American institutions are an inevitable result of inequality.
Why did you decide to structure this book around four Americas?
We’ve all lived with the red-blue division for about twenty years. And it’s true. We are divided that way. Every passing year makes that clearer. But I felt that in the last few years, politically and culturally, things have happened that showed that there are divisions within, as well as between, those two big blocks of Americans. The basic division that I began to see begins with libertarianism, which I call Free America, which is Reagan’s America. And this is really the story of my adult life, from the late nineteen-seventies onward. It’s been the most dominant narrative in our society. And it says, “We’re all individuals.” We all have a chance to make it. The best way to make it is to get government out of the way and to cut taxes and deregulate and set us free in order to use our industry and talent to make something new. And that was a really potent story that Reagan told, and that the Republican Party lived by for decades, and to some extent still does.
More here.
Preliminary results from a landmark clinical trial suggest that CRISPR–Cas9 gene-editing can be deployed directly into the body to treat disease. The study is the first to show that the technique can be safe and effective if the CRISPR–Cas9 components — in this case targeting a protein that is made mainly in the liver — are infused into the bloodstream. In the trial, six people with a rare and fatal condition called transthyretin amyloidosis received a single treatment with the gene-editing therapy. All experienced a drop in the level of a misshapen protein associated with the disease. Those who received the higher of two doses tested saw levels of the protein, called TTR, decline by an average of 87%.
A long time ago, when I was around the age my kids are now— so if you were to ask them, that’d put it well after the dinosaurs but slightly before woolly mammoths— I had to write a book report about a biography. For whatever reason, I ended up picking Enrico Fermi, a scientist who was featured in exactly one book in the elementary school library, a choice that maybe foreshadowed my eventual career. A few details of that have stuck with me ever since: Fermi getting reprimanded by Oppenheimer for taking bets on whether the Trinity test would ignite the atmosphere, Fermi estimating the size of the blast by dropping pieces of paper, and, weirdly, Fermi mocking signs with Fascist slogans back in Italy by shouting “Burma Shave!” when driving past them (probably because I had to get my parents to explain the joke). I was a little hazy on what, exactly, he contributed to physics, but he definitely made an impression as both an important scientist and a colorful character.
Depending on who you listen to, quantum computers are either the biggest technological change coming down the road or just another overhyped bubble. Today we’re talking with a good person to listen to: John Preskill, one of the leaders in modern quantum information science. We talk about what a quantum computer is and promising technologies for actually building them. John emphasizes that quantum computers are tailor-made for simulating the behavior of quantum systems like molecules and materials; whether they will lead to breakthroughs in cryptography or optimization problems is less clear. Then we relate the idea of quantum information back to gravity and the emergence of spacetime. (If you want to build and run your own quantum algorithm, try the 
The law has failed Britney Spears. The nearly 40-year-old celebrity has been locked in a “conservatorship”—which is the state of California’s word for a “legal guardianship” designed for the very old, very young, or mentally incapacitated—for 13 years, against her will. That conservatorship, controlled by her father, again, against her will, has been allowed to control Spears’s life in minute detail—including allegedly forcing unwanted birth control upon her—and none of the lawyers or judges involved has done a damn thing to stop it. Spears appeared in court, via telephone, this week to voice her objections to her continued conservatorship, and her story should lead to immediate lawmaking and change.
The two dialectical modes—call them determinate and indeterminate negation—are unevenly distributed throughout Fried’s work. (There is probably more to be said about that.) From the standpoint of Jacques-Louis David’s Intervention of the Sabine Women, the approach he had taken in Oath of the Horatii just over a decade earlier appears as superseded. But while Rineke Dijkstra’s bathers mobilize facingness and an awareness of the camera, there is no sense in Fried’s interpretation of them that they supersede, negate, or critique Andreas Gursky’s preference for figures that are oblivious to the camera or viewed from behind. One can imagine formulating a claim that Dijkstra’s bathers do in fact represent an advance over some of Gursky’s pictures—a deepening or reduplication of the photographic tension between automatism and intention—but that would be an additional claim, beyond the essentially dialectical one that the two photographers are working in the context of a self-critical normative or institutional field; that both artists are engaged in confronting a problem or contradiction that is understood to be constitutive of photography itself, a “hidden motor” of dialectical development (AO 50). Dialectical movement can be expansive or lateral—even rhizomatic (“well-grubbed”)—as well as determinately directional.
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In “Visible Republic,” his essay on Dylan winning the Nobel Prize in Literature, Robbins extracts himself from the pro/con squad and tries to isolate the nature of the songwriter (rather than isolate the most literary thing about Dylan because what would that be?). “That’s it, that’s the thing—Dylan isn’t words,” Robbins writes. “He’s words plus [Robbie] Robertson’s uncanny awk, drummer Levon Helm’s cephalopodic clatter, the thin, wild mercury of his voice.” Meaning, one thinks, that by all means win some prizes, who cares, but don’t make one form do another’s work. This exhibits the generosity in both Robbins’s poems and essays. The glittering trash of the world needs itemizing but not sorting. His essay on 
Three decades ago, a small group from within the AIDS activist organization ACT UP changed the course of medicine in the United States. They employed what they called “the outside/inside strategy.” The activists staged large, noisy demonstrations outside the Food and Drug Administration and other federal government agencies, demanding an acceleration of the drug-approval process. Others learned the minutiae of the science and worked quietly with receptive bureaucrats, bringing the patient’s perspective to the table toward the same goal of faster drug approval. These were desperate young people dying from a new disease for which there were few treatments and no cure. At first, federal bureaucrats and drug companies resisted, but eventually more AIDS drugs became available.
Is there any bit of popular philosophical wisdom more useless than the pseudo-Epictetian injunction to “live every day as if it were your last”? If today were my last, I certainly would not have just impulse-ordered an introductory grammar of Lithuanian. Much of what I do each day, in fact, is premised on the expectation that I will continue to do a little bit more of it the day after, and then the day after that, until I accomplish what is intrinsically a massively multi-day project. If I’ve only got one more day to do my stuff, well, the projects I reserve for that special day are hardly going to be the same ones (Lithuanian, 
It’s a nightmare we should have seen coming. In Germany, nuclear power formed around a third of the country’s power generation in 2000, when a Green party-spearheaded campaign managed to secure the gradual closure of plants, citing health and safety concerns. Last year, that share fell to 11%, with all remaining stations scheduled to close by next year. A recent paper found that the last two decades of phased nuclear closures led to an increase in CO2 emissions of 
Iran’s presidential election on June 18 was the most farcical in the history of the Islamic regime – even more so than the 2009 election, often called an “electoral coup.” It was less an election than a chronicle of a death foretold – the death of what little remained of the constitution’s republican principles. But, in addition to being the most farcical, the election may be the Islamic Republic’s most consequential.
The name of the initiative was Project Cassandra: for the next two years, university researchers would use their expertise to help the German defence ministry predict the future.
Last October, while waging the government’s new campaign against Islamic forms of “separatism,” French Interior minister Gérald Darmanin complained on television that he was frequently “shocked” to enter a supermarket and see a shelf of “communalist food” (cuisine communautaire).
To live on a day-to-day basis is insufficient for human beings; we need to transcend, transport, escape; we need meaning, understanding, and explanation; we need to see over-all patterns in our lives. We need hope, the sense of a future. And we need freedom (or, at least, the illusion of freedom) to get beyond ourselves, whether with telescopes and microscopes and our ever-burgeoning technology, or in states of mind that allow us to travel to other worlds, to rise above our immediate surroundings. We may seek, too, a relaxing of inhibitions that makes it easier to bond with each other, or transports that make our consciousness of time and mortality easier to bear. We seek a holiday from our inner and outer restrictions, a more intense sense of the here and now, the beauty and value of the world we live in.