Gaia Vince in The Guardian:
For every stoner who has been overcome with profound insight and drawled, “Reality is a construct, maaan,” here is the astonishing affirmation. Reality – or, at least, our perception of it – is a “controlled hallucination”, according to the neuroscientist Anil Seth. Everything we see, hear and perceive around us, our whole beautiful world, is a big lie created by our deceptive brains, like a forever version of The Truman Show, to placate us into living our lives. Our minds invent for us a universe of colours, sounds, shapes and feelings through which we interact with our world and relate to each other, Seth argues. We even invent ourselves. Our reality, then, is an illusion, and understanding this involves tackling the thorny issue of consciousness: what it means to, well, be.
Consciousness has long been the preserve of philosophers and priests, poets and artists; now neuroscientists are investigating the mysterious quality and trying to answer the hard question of how consciousness arises in the first place. If this all sounds a bit hard going, it’s actually not at all in the masterly hands of Seth, who deftly weaves the philosophical, biological and personal with a lucid clarity and coherence that is thrilling to read.
Consciousness, which Seth defines as “any kind of subjective experience whatsoever”, is central to our being and identity as animate sentient creatures. What does it mean for you to be you, as opposed to being a stone or a bat? And how does this feeling of being you emerge from the squishy conglomeration of cells we keep in our skulls? Science has shied away from these sorts of intrinsically experiential questions, partly because it’s not obvious how science’s tools could explore them. Scientists are fond of pursuing “objective” truths and realities, not probing the perspectival realms of subjectivity to seek the truth of nostalgia, joy or the perfect blueness of an Yves Klein canvas. Also, it’s hard. Seth might use other words, but essentially, he is exploring the science of people’s souls – a daunting task.
More here.


Macbeth is a creepy play.
Economies in the modern world are incredibly complex systems. But when we sit down to think about them in quantitative ways, it’s natural to keep things simple at first. We look for reliable relations between small numbers of variables, seek equilibrium configurations, and so forth. But those approaches don’t always work in complex systems, and sometimes we have to use methods that are specifically adapted to the challenges of complexity. That’s the perspective of W. Brian Arthur, a pioneer in the field of complexity economics, according to which economies are typically not in equilibrium, not made of homogeneous agents, and are being constantly updated. We talk about the basic ideas of complexity economics, how it differs from more standard approaches, and what it teaches us about the operation of real economies.
Encouraged by the election of Joe Biden, the COVID-19 vaccine, and the so-called “major opportunity” of smart technology, commentators and investors now predict that the economy will rebound from the pandemic downturn, or even accelerate, once the “exogenous” shock caused by the coronavirus has been absorbed. But is this a plausible future scenario?
In the popular imagination, the name Leonardo da Vinci conjures many things. In traditional textbooks, he epitomizes the concept of the “Renaissance man,” capable of knowing and doing everything. Another view has it that he was a prototypical engineer and scientist—inventor of tanks, helicopters, self-perpetuating machines, and urban infrastructure—and thus the forerunner of much of what we deem essential in our supposedly secular, technology-driven world. Art historians generally describe him as the key figure in a new phase in European painting, attuned to the portrayal of psychology and the subjectivity of sight, all while exercising an unparalleled naturalism. But, despite these things, there has always been another image of Leonardo, one that associated him with hidden things, esoteric knowledge beyond common perceptions. In Dan Brown’s The Da Vinci Code (2003), Leonardo figures as a guardian of a forbidden secret, keeping alive the dangerous knowledge that Christ married Mary Magdalene and had a child by her. In the context of Brown’s thriller, Leonardo is a knower of the unknown, a keeper of truths that must remain encrypted by means of his famous mirror writing. Because Leonardo’s secret could potentially overturn orthodox Christian beliefs, his perpetuation of it paradoxically meshes with his reputation as a harbinger of the modern world. Like a Nostradamus, he anticipates history, hiding the keys to understanding things that are beyond the grasp of his contemporaries and a challenge for more enlightened ages.
Last year I became fascinated with an artificial intelligence model that was being trained to write human-like text. The model was called GPT-3, short for Generative Pre-Trained Transformer 3; if you fed it a bit of text, it could complete a piece of writing, by predicting the words that should come next.
Are you someone who enjoys the unsolicited opinions of strangers and acquaintances? If so, I can’t recommend cancer highly enough. You won’t even have the first pathology report in your hands before the advice comes pouring in. Laugh and the world laughs with you; get cancer and the world can’t shut its trap. Stop eating sugar; keep up your weight with milkshakes. Listen to a recent story on NPR; do not read a recent story in Time magazine. Exercise—but not too vigorously; exercise—hard, like Lance Armstrong. Join a support group, make a collage, make a collage in a support group, collage the shit out of your cancer. Do you live near a freeway or drink tap water or eat food microwaved on plastic plates? That’s what caused it. Do you ever think about suing? Do you ever wonder whether, if you’d just let some time pass, the cancer would have gone away on its own?
A major focus of modern medicine is treating existing conditions, but a promising approach is to try to detect elevated susceptibility to a condition before it becomes a diagnosable disease. “The pre-disease state, where someone has increased susceptibility to developing diseases, such as cancer, is widely considered the best period for intervening,” explains Yoshinori Kono, project leader at Kewpie. “Treating disease is important, but preventing disease before it strikes will reduce healthcare costs and improve quality of life.”
Edward Holmes does not like making predictions, but last year he hazarded a few. Again and again, people had asked Holmes, an expert on viral evolution at the University of Sydney, how he expected SARS-CoV-2 to change. In May 2020, 5 months into the pandemic, he started to include a slide with his best guesses in his talks. The virus would probably evolve to avoid at least some human immunity, he suggested. But it would likely make people less sick over time, he said, and there would be little change in its infectivity. In short, it sounded like evolution would not play a major role in the pandemic’s near future.
Exactly one year ago, I did not die from poisoning by a chemical weapon, and it would seem that corruption played no small part in my survival. Having contaminated Russia’s state system, corruption has also contaminated the intelligence services. When a country’s senior management is preoccupied with protection rackets and extortion from businesses, the quality of covert operations inevitably suffers. A group of FSB agents applied the nerve agent to my underwear just as shoddily as they incompetently dogged my footsteps for three and a half years – in violation of all instructions from above – allowing