Benjamin Mueller and Gina Kolata in The New York Times:
Katalin Karikó and Drew Weissman, who together identified a chemical tweak to messenger RNA, were awarded the Nobel Prize in Physiology or Medicine on Monday. Their work enabled potent Covid vaccines to be made in less than a year, averting tens of millions of deaths and helping the world recover from the worst pandemic in a century.
The approach to mRNA the two researchers developed has been used in Covid shots that have since been administered billions of times globally and has transformed vaccine technology, laying the foundation for inoculations that may one day protect against a number of deadly diseases like cancer. The slow and methodical research that made the Covid shots possible has now run up against a powerful anti-vaccine movement, especially in the United States. Skeptics have seized in part on the vaccines’ rapid development — among the most impressive feats of modern medical science — to undermine the public’s trust in them. But the breakthroughs behind the shots unfolded little by little over decades, including at the University of Pennsylvania, where Dr. Weissman runs a lab.
More here.

In 2019, the literary magazine NOON published a story by Lydia Davis called “The Language of Armagnac,” a quietly comic meditation on the difficulties of translating “the patois of the city of Auch, which is a local form of the language of Gascon, which is in turn a dialect language of Occitan.” A second version of the story much like the first was included in Davis’s “Essays Two,” a collection of her writings on translation, a career that parallels her work as a writer of fiction. A third and notably different version appears in her story collection “Our Strangers,” under the title “Bothered Scholar on Train.” It refashions Davis’s elaborate philological commentaries as the tirade of a scholar whose attempt to read in the language of Armagnac is disrupted by noisy passengers. Davis designed the story to open with an exclamation—“Oh, can’t you quiet down, please!”—and end with an exclamation mark, too (“So, please!”). This symmetry would clue readers in to an irony underlying the scene. The bothered shouts at others to be quiet. He—or she—annoys strangers while insisting that they are the annoying ones.
‘We’re getting no support on this national crisis,’ Mayor Eric Adams said in September at a town-hall-style gathering on Manhattan’s Upper West Side. He was talking about the influx of transnational migrants who have landed in the city’s shelter system: more than 118,000 since the spring of last year, with about 10,000 more arriving each month. There are now about 115,000 people in the city’s care, and more than half of them are migrants. In August, the city projected that it would spend $5 billion caring for migrants during this fiscal year.
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This varies by pathogen and is known as a microbe’s “infectious dose.” Usually it takes quite a few, but some microbes require an incredibly small number of organisms to start an infection. Take norovirus for example, the stomach bug notorious for spreading whenever people are in close contact and touch the same surfaces, such as on
Birds dip between low branches that hang over glittering brooks along the drive from Jalalabad heading south toward the Achin district of Afghanistan’s Nangarhar province. Then, the landscape changes, as lush fields give way to barren land.
Flamboyant, swashbuckling cross-dressing was nothing new in late nineteenth-century France. Paris’s unique and bohemian lesbian subculture
Edith Hall in The Guardian:
Laura Marsh in The New Republic:
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The insurrection failed. The system held — at least for a time. In November 1923, when a young demagogue named Adolf Hitler tried to start a Nazi revolution from a Munich beer hall, his attempted coup was so disorganized that it swiftly degenerated into bumbling confusion. One participant later testified that the operation was such a farce that he whispered to others, “Play along with this comedy.”
The health service is a contradiction. It has been built on immigrant labour from conception to the present day. Walk into many NHS services, and you will find it is Black and Brown faces that are assessing, diagnosing and treating. Yet we find huge race-based health disparities, in maternity, mental health, Covid-19 deaths and more.