How gut microbes contribute to good sleep

From Medical News Today:

Internal and external cues, such as circadian rhythms and eating, significantly affect sleep. Circadian rhythms are essential biological processes or functions that follow a 24-hour cycle based on the body’s internal clock. One of the most important circadian rhythms is the sleep-wake cycle. Factors that alter or throw off the sleep-wake cycle can cause sleep disturbances. Intestinal metabolism is closely connected to brain function by way of the circulatory system and vagus nerve, which create a network called the “brain-gut axis” or “microbiota-gut-brain axis.” Research shows that the gut microbiome (the community of bacteria, viruses, and fungi that live in the gut) has an effect on elements of cognitive function, brain development, memory formation, circadian rhythmicity, and mental health.

When and what people eat affects the composition, size, and daily rhythms of the gut microbiota. Changes to the gut microbiota can alter intestinal metabolism because microbes belonging to the microbiota produce many gut metabolites — the molecules that result from the chemical reactions that occur during the process of digestion. Therefore, changing their diet may potentially improve a person’s sleep or reduce sleep problems. Should this prove to be the case, it would serve as a natural, fairly simplistic alternative treatment to sleep medications, which can have a range of negative side effects, including daytime drowsiness and gastrointestinal problems.

More here.



Thursday Poem

Naming

Like a blur of rain on the real world.
And no one denies the great utility
For comptrollers of imperial households,
For quartermaster-sergeants,
For grocer’s assistants,
For museum curators;
For taxonomists and schoolboys,
Pundits and critics.

And if the name becomes the thing,
The rain it raineth every day
And anyhow: could we bear it?
Could we bear the light of a world
Of things without names?

by John Fowles
from
Poems
The Ecco Press, 1973

Wednesday, September 28, 2022

How do good conversations work? Philosophy has something to say

Stephanie Ross in Psyche:

Consider the many different purposes that can be served by conversation. Of course, we speak with others – and to ourselves! – to impart information. But we also exchange words to ask questions, forge connections, vent emotions, change attitudes, gain status, urge action, share stories, pass the time, advise, amuse, comfort, challenge, and much, much more. Examining what makes conversation work, and looking at how philosophers have thought about conversation, opens a window on to how language functions and how we function with language. So it is well to ask: what makes someone a good conversant? What makes conversation work?

British philosophers from the 18th century, who were fixated on impressions and ideas, would have taken successful conversations to be those that moved the relevant cluster of ideas from one conversant’s head to another’s. This idea, though tempting, turns out to be inadequate.

More here.

When meta-analysis goes wrong

Stuart Ritchie in Science Fictions:

Six years ago, the psychologist Michael Inzlicht told Slate magazine that “meta-analyses are fucked”.

It’s always stuck with me – the clash between that statement and how we’re meant to feel about meta-analyses. They’re supposed to be the highest form of evidence – a systematic review of all the studies on a particular scientific question, followed by a quantitative estimate of where the evidence points as a whole. No mere opinions, like in a narrative “review” article; no reliance on a single study. A meta-analysis tells us what we really want to know.

And indeed, if you roll out a meta-analysis in a debate over some scientific matter, it’s a powerful finishing move. That’s why those strange advocacy groups for ivermectin and hydroxychloroquine set up those (dodgy) meta-analysis websites during the pandemic – they knew the power of being able to say “meta-analytically, the evidence supports my view”.

And yet meta-analyses are fucked.

More here.

The Late-Night Circuit: Why Do Politicians Do It?

Aida Amoako in JSTOR Daily:

In the past, hosts like Johnny Carson and Jay Leno avoided taking partisan stances so they wouldn’t alienate half their viewers. Letterman and his successor, Conan O’Brien, did the same for the most part. In more recent years, journalists have discussed what is perceived as an increasing politicization and partisanship of late-night, tracing this phenomenon back to Jon Stewart taking over The Daily Show. Stewart “injected point of view,” writes Bill Carter for CNN. “Late night has not looked back since.”

During the 2004 presidential primaries, most Democratic candidates appeared on shows like: The Jay Leno ShowLetterman, and The Daily ShowAccording to Variety, politicians made more than 100 appearances on late-night during the 2008 presidential cycle. Obama became the first sitting president to appear on late-night, and Biden has followed his example, appearing on Jimmy Kimmel Live! for his presidential late-night debut.

More here.

Paulin Soumanou Vieyra And The Birth Of African Cinema

Akin Adeṣọkan at The Current:

Birago Diop was a brilliant high-school student in Senegal. During his final exam, he made the unusual mistake of misconjugating a French verb, an error that was to prove fateful for his career. With a wry, self-deprecating smile past the camera, Diop, now an acclaimed poet and short-story writer, declares that what happened to him followed “the law of destiny.” The professional paths open to colonial students in the French system were narrow: they could become teachers if they passed a critical test, or doctors or civil servants if they didn’t. Diop went on to study veterinary medicine in France, and his collections are filled with animal tales.

Sitting behind the camera and listening to this story in Birago Diop, conteur (1981), Paulin Soumanou Vieyra, the Beninese-Senegalese filmmaker, historian, critic, and bureaucrat, must have heard something of his own travails. The two men, both outstanding artists, achieved renown despite the constricting educational system of the French colonies.

more here.

Deep Emotion, Plain Speech: Camus’s The Plague

Laura Marris at The Paris Review:

The Plague was not an easy book to write. Camus was ill when he began it, then trapped by the borders keeping him in Nazi-occupied France. Aside from these difficulties, there was the pressure of authentically speaking up about the violence of World War II without falling into the nationalist heroics he deplored. Like with most problems in art, the solution was to address it directly: in one of the most revelatory sections of the novel, the character Tarrou blurs the line between fancy rhetoric and violence. “I’ve heard so much reasoning that almost turned my head,” he says, “and which had turned enough other heads to make them consent to killing, and I understood that all human sorrow came from not keeping language clear.”

All human sorrow! The boldness of this claim hints at how much Camus believed in words.

more here.

Wednesday Poem

Lessons

“What’s a patriot, Dad?
Hey, Dad! ‘Earth to Dad—
Earth to Dad!’
Get your nose out of
the newspaper!
Help me with my homework!
What’s a patriot, Dad?”

“Well, I guess, a person
who loves the land.
Although some people act as if
a patriot’s a man
who hates another land.”

“Hey, Dad! Don’t
give me  a lecture—
all I need’s
a word! Just a word!
What’s a veteran, Dad?
Hey, Dad! DAD!”

“A veteran’s what your
father is—” his mother
chimed in, clear across the room.

“Oh, I got it:
somebody who’s always out
of work, home with us
kids— huh, Dad?
Is that what a veteran is?

“Yep—” Dad got out,
remembering suddenly
the time his youngest son
had stopped breathing
right there at the kitchen table
(with his oldest son screaming,
“Nicky’s dead! Nicky’s dead!”)
and the frantic fight
to find a sign of life,
while dialing the emergency number
for an ambulance.

“What’s war? Dad!
You know, Dad! War—war!
Dad! What the hell’s war?”

And old Dad blurted out,
still thinking of the desperate
battle one desperate night
to save the baby’s life:
“Ten minutes of terror,
after twenty years of anticipation,
and then twenty years of worrying
‘when’s it going to happen
again?”

by Jan Barry
from
Unaccustomed Mercy—
Soldier Poets of the Vietnam War
Texas Tech University Press

Why Do We Die Without Sleep?

Steven Strogatz in Quanta Magazine:

Why do we sleep anyway? We spend about a third of our lives asleep, so it seems like it must be pretty important. But there’s still so much about it that we don’t understand. One thing that sleep researchers are pretty sure of is that every system in our body seems to be impacted by sleep. When we miss out on sleep, it impairs our circulation, our digestion, immune system, metabolism, and of course, brain function. And sleep deprivation doesn’t need to be long term to do damage. In fact, if you go without sleep long enough, you will die. But why, exactly?

Rogulja (02:07): Well, you’re probably sitting right now and kind of resting in some way. But you’re definitely not sleeping, right? So, yeah, what is it that’s so different? And I would say that, for me, what is the kind of most defining characteristic of sleep is that kind of loss of awareness of the external environment and of your internal state, in many ways.

More here.

Which Neurons Go to Sleep First in Humans?

Alejandra Manjarrez in The Scientist:

In the last decades, science has taught us that the mammalian brain isn’t always entirely awake or asleep. Dolphins can swim with one hemisphere asleep while the other is alert, and some neurons in sleep-deprived rats can “switch off” while the animals are still awake. In humans, this so-called “local sleep,” in which specific neuronal populations take a nap while the rest of the brain is awake, has been more challenging to study, since the invasive methods used to track it in other mammals cannot be used on people.

A new study published July 21 in PNAS seems to have overcome this challenge. By simultaneously mapping human brain signals measured with two different methods (one with good temporal resolution and the other with good spatial resolution), the team pinpointed the waking or sleeping state of neuronal populations at the local level. The achievement made it possible to identify which brain regions are the first to fall asleep and which are the first to wake up, and experts say it promises to be a valuable tool for studying sleep in humans.

More here.

Tuesday, September 27, 2022

No one in physics dares say so, but the race to invent new particles is pointless

Sabine Hossenfelder in The Guardian:

Imagine you go to a zoology conference. The first speaker talks about her 3D model of a 12-legged purple spider that lives in the Arctic. There’s no evidence it exists, she admits, but it’s a testable hypothesis, and she argues that a mission should be sent off to search the Arctic for spiders.

The second speaker has a model for a flying earthworm, but it flies only in caves. There’s no evidence for that either, but he petitions to search the world’s caves. The third one has a model for octopuses on Mars. It’s testable, he stresses.

Kudos to zoologists, I’ve never heard of such a conference. But almost every particle physics conference has sessions just like this, except they do it with more maths. It has become common among physicists to invent new particles for which there is no evidence, publish papers about them, write more papers about these particles’ properties, and demand the hypothesis be experimentally tested. Many of these tests have actually been done, and more are being commissioned as we speak. It is wasting time and money.

More here.

How should we do research on human nature?

Iris Berent in the Los Angeles Times:

Parenting can make you wonder about human nature. If you have kids, you might have noticed their differences early on. When my infant son first heard music, his eyes grew big, and his gaze got intense. My infant daughter was clearly the people person. At 3 months, she was using her single tooth to mischievously bite me and watch my reaction. No wonder my son became a composer and my daughter turned to psychology.

Were they born this way? Does nature shape who we are? Since the advent of cognitive science, neuroscience and behavioral genetics, this age-old question has become the topic of intense scientific research. But in the current social and political climate, the concern with human nature has become dangerously loaded.

More here.

In Pakistan, 33 Million People Have Been Displaced in Floods

Zoha Tunio in Undark:

The southwestern province of Balochistan and the southern province of Sindh have been the worst hit, with more than 500,000 people currently living in shelters. Across the country more than 750,000 livestock have died and over 3 million acres of agricultural land have been completely washed away. Agriculture accounts for more than a quarter of Pakistan’s economy. Of the country’s 154 districts, 116 are severely affected and 80 have been declared “calamity hit.”

Ahsan Iqbal, Pakistan’s minister for planning, development and reform, placed initial flood damages at $10 billion. Two weeks later damages in the country have risen to $30 billion. “I call on the international community that Pakistan needs massive financial support, as according to initial estimates the losses are around $30 billion,” said Antonio Guterres, secretary general of the United Nations, during a news conference in Islamabad. He called on the international community for “massive financial support,” noting all of the country’s losses.

More here.

Miyake’s Layers

Jane Hu and other writers at n+1:

AT EVERY JOB I’ve ever had in fashion there’s always a certain brand or designer or aesthetic that gets adopted by everyone, no matter their taste or preference, for good reason: it’s good. For the job I most recently worked, I still see it the second I step foot out of my apartment. Friends wear it with sneakers on our hikes up the mountain, people on the subway brush nonexistent dust off of it after sitting down, and there is always that moment of eye contact at the coffee shop between two customers dressed in the same pair of pants. The first time I went to a new dentist, recommended by a colleague, I was wearing mine. The dentist looked me up and down above his clipboard, and rather than ask who referred me gestured at my outfit. “SSENSE,” he said, like a statement.

“Yes,” I said, holding the delicate material with a pinch.

more here.

‘And Finally: Matters of Life and Death’ By Henry Marsh

Salley Vickers at Literary Review:

There is a well-attested connection between being a good doctor and being a good writer (think Keats). Neurosurgeon Henry Marsh’s Do No Harm, published in 2014, achieved unlikely but deserved success, and among his many praiseworthy qualities is the ability to write elegant, unpretentious prose. In this and his subsequent book, Admissions (2017), he explored the human brain from the vantage point of the practising surgeon. Now retired from practice in the UK, he has continued to work overseas, particularly in Nepal, Albania and Ukraine, the last a country for which he has a special affection, and whose currently beleaguered state he writes of movingly.

In his latest book, And Finally: Matters of Life and Death, Marsh turns his penetrating mind inwards. 

more here.

Pakistan’s Biblical Floods and the Case for Climate Reparations

Mohammed Hanif in The New Yorker:

We have tried, in various ways, to convey to the world the scale of destruction caused by recent floods in Pakistan, because, apparently, a third of the country underwater and thirty-three million lives upended doesn’t cut it. Pakistan’s climate minister has called it Biblical. We have shot and shared videos in which the landmark New Honeymoon Hotel crumbles in the duration of a TikTok. The U.N. Secretary-General, António Guterres, who is seventy-three and has called the climate crisis a “code red for humanity,” visited Pakistan and said that he hadn’t seen this scale of climate carnage in his life. Some of us have created maps showing that the areas underwater are larger than Britain. We have shown pictures of dead and starving cattle to appeal to animal-lovers. We have posted videos of puppies being heroically rescued from rushing waters.

Maybe when the world seems to be ending, it needs poets. A poet in Khairpur, in southern Pakistan, one of the worst-affected areas, was asked by a journalist if he had received a tent to shelter his family. He found the idea so improbable that he asked, “Why are you making fun of me? Why would anyone give me a tent?”

More here.