Which Neurons Go to Sleep First in Humans?

Alejandra Manjarrez in The Scientist:

In the last decades, science has taught us that the mammalian brain isn’t always entirely awake or asleep. Dolphins can swim with one hemisphere asleep while the other is alert, and some neurons in sleep-deprived rats can “switch off” while the animals are still awake. In humans, this so-called “local sleep,” in which specific neuronal populations take a nap while the rest of the brain is awake, has been more challenging to study, since the invasive methods used to track it in other mammals cannot be used on people.

A new study published July 21 in PNAS seems to have overcome this challenge. By simultaneously mapping human brain signals measured with two different methods (one with good temporal resolution and the other with good spatial resolution), the team pinpointed the waking or sleeping state of neuronal populations at the local level. The achievement made it possible to identify which brain regions are the first to fall asleep and which are the first to wake up, and experts say it promises to be a valuable tool for studying sleep in humans.

More here.