First we learned to fear germs, then we learned to love our microbiome, but both sides get the biology basically wrong

Ed Yong in Aeon:

In the 1870s, German physician Robert Koch was trying to curtail an epidemic of anthrax that was sweeping local farm animals. Other scientists had seen a bacterium, Bacillus anthracis, in the victims’ tis­sues. Koch injected this microbe into a mouse – which died. He recovered it from the dead rodent and injected it into another one – which also died. Doggedly, he repeated this grim process for over 20 generations and the same thing happened every time. Koch had unequivocally shown that Bacillus anthracis caused anthrax.

This experiment, and those of contemporaries like Louis Pasteur, confirmed that many diseases are caused by microscopic organisms. Microbes, which had been largely neglected for a couple of centuries, were quickly cast as avatars of death. They were germs, pathogens, bringers of pestilence. Within two decades of Koch’s work on anthrax, he and many others had discovered that bacteria were also associated with leprosy, gonorrhoea, typhoid, tuberculosis, cholera, diphtheria, tetanus, and plague. Microbes became synonymous with squalor and sickness. They became foes for us to annihilate and repel.

Today, we know this view is wrong – as I explain in my new book I Contain Multitudes.

More here.



The strange survival of Guinness World Records

Imogen West-Knights in The Guardian:

It is strange to think of Guinness World Records – a business named after a beer company, which catalogues humanity’s most batshit endeavours – as the kind of entity that could sell out. At first glance, it seems like accusing Alton Towers or Pizza Express of selling out. But the deeper I delved into the world of record breaking, the more sense it made. In spite of its absurdity, or maybe because of it, record breaking is a reflection of our deepest interests and desires. Look deeply enough at a man attempting to break the record for most spoons on a human body, or the woman seeking to become the oldest salsa dancer in the world, and you can find yourself starting to believe that you’re peering into humanity’s soul.

More here.

Daniel Ellsberg Is Dying, And He Has Some Final Things to Say

Michael Hirsh in Politico:

Ellsberg, snowy-haired but energetic despite the cancer — renowned for his eloquence, he still speaks in perfect paragraphs — was calm, even jovial, during what his son, Robert Ellsberg, said would be his last interview. Based on his experience in the covert world, Ellsberg sees a direct line between the deceptions and lies that led to the Vietnam War — and 58,000 American deaths — and the deceptions and lies that justified the Iraq war. This high-level deceit, Ellsberg says, extends to America’s current drone war policy around the world, in which the government has allegedly covered up the number of civilian deaths it causes.

“The need for whistleblowing in my area of so-called national security is that we have a secret foreign policy, which has been very successfully kept secret and essentially mythical,” he says. “I’m saying there’s never been more need for whistleblowers … There’s always been a need for many more than we have. At the same time, it’s become more and more dangerous to be a whistleblower. There’s little doubt about that.”

More here.

Sunday Poem

Bread and Salt

If it was a wedding instead of war,
Dobropillia would be welcoming us
with a kobzar, bread, and salt.
Wheat fields would be glowing like golden flames
beside the road, alight with dignity and freedom.

The loam in those fields is free.
But now deep trenches as high as one man standing
on top of another extend from one end to the other
while craters just as deep pock the chornozem
from so many rounds of howitzer shells.
Europe, what more evidence, what more words do you need?
Humanity has always been divided into those
who love life and those who kill.

We’ve never been against giving grain to the hungry,
but we have always been against expropriations,
violence, and robbery.
Europe!
You need to choose between MV and BAU
without it being the kiss of Judas.

by Volodymyr Tymchuk
from Plume Magazine, Issue #142 June 2023
Translation from Ukrainian, Dzvinia Orlowsky and Chard deNiord

*MV: moral values, BAU: business as usual

Saturday, June 3, 2023

Female Foundering

Sarah Arkebauer in The Baffler:

“THIS ISN’T JUST MY JOB. This is who I am. Anyone who doubts my company doubts me,” says Amanda Seyfried as Elizabeth Holmes in the last year’s Hulu show The Dropout. It’s a claim the real-life Holmes managed to make work for her, until it didn’t, tying the success of Theranos, the company she founded in 2003, to her own personal brand as a serious-minded female science genius. Her rhetoric implied that any criticism of the “Edison,” the blood-testing device that promised to diagnose numerous diseases using only a single drop of blood, ought to be brushed off as sexist bias rather than legitimate critique. In making herself the face of this tech, she cultivated an image of authority, power, innovation, and promises kept though the adoption of the black turtleneck made famous by Apple icon Steve Jobs, her low voice, no-nonsense bun, and (when called for) red lipstick.

The Dropout’s title figures the drop of blood through which Theranos supposedly could accomplish never-yet-seen feats of science in the context of what kicked off the whole endeavor: Holmes’s dropping out of Stanford. Her status as a dropout both fueled her success—she was a genius with no time for formal education, à la Mark Zuckerberg—and also invited doubt. And while dropping out of school is neither a harbinger of failure writ large, nor should it be pathologized in a society that ties college education so tightly to a lifetime of debt, in this case, the choice indicated Holmes’s willingness to step beyond her ken. That is to say, to make claims for which she had no scientific chops or backing. In naming its show, then, Hulu relied on its audience coming to Holmes’s story from the skepticism brought on by her downfall.

More here.

Hollow States

Cedric Durand in Sidecar:

The return of industrial policy is unmissable, catalyzed by the cumulative shocks of Covid-19 and the war in Ukraine as well as longer-term structural issues: the ecological crisis, faltering productivity and alarm at the dependence of Western states on China’s productive apparatus. Together, these factors have steadily undermined governments’ confidence in the ability of private enterprise to drive economic development.

Of course, the ‘entrepreneurial state’ never disappeared, especially in the US. The deep pockets of the Defense Advanced Research Projects Agency and the National Institutes of Health have been crucial in maintaining the country’s technological advantage – funding research and product development over the past few decades. Still, it is clear that a substantial shift is taking place. As a group of OECD economists noted, ‘So-called horizontal policies, i.e. interventions available to all firms and which include business framework conditions such as taxes, product or labour market regulations, are increasingly questioned’. Meanwhile, ‘the case for governments to more actively direct the structure of the business sector is gaining traction’. Hundreds of billions of targeted funding is now flooding businesses in the military, high-tech and green sectors on both sides of the Atlantic.

This pivot is part of a broader macro-institutional reconfiguration of capitalism, in which a high-pressure post-pandemic economy has tightened labour markets while the centrality of finance continues to wane. These phenomena are highly complementary: public funding stimulates the economy and may boost job creation, while the administrative allocation of credit serves as an admission that financial markets are unable to attract the investment necessary to meet major conjunctural challenges. At a very general level, this neo-industrial turn should be welcomed, since it implies that political deliberation may play a somewhat greater role in investment decisions. More concretely, though, there is much to worry about.

More here.

Industrial Transformations

Isabel Estevez in Phenomenal World:

The latest US experiment with industrial policy—comprised primarily by the Inflation Reduction Act (IRA), the CHIPS and Science Act, and the Infrastructure Investment and Jobs Act—has sparked outright opposition and pleas for restraint, but also calls for far more ambitious action.

The divergent responses are representative of the lack of consensus about the nature of the challenges that US industrial policy could or should address. In the broadest sense, industrial policy refers to the deployment of policy tools in order to influence how we create value—what goods (and services) we produce and how we produce them. In economist Ha-Joon Chang’s words, it is a set of “policies aimed at particular industries (and firms as their components) to achieve outcomes that are perceived by the state to be efficient for the economy as a whole.” Mario Cimoli, Giovanni Dosi, and Joseph Stiglitz argue that industrial policies “come together with processes of ‘institutional engineering’ shaping the very nature of the economic actors, the market mechanisms and rules under which they operate, and the boundaries between what is governed by market interactions, and what is not.” These different understandings of industrial policy all recognize the government as a key actor in shaping the world of production in line with a public purpose.

More here.

The Art of Compression: Conjuring a fiction out of almost nothing

Richard Gibson in The Hedgehog Review:

What exactly separates the short story from the novel? As the contemporary Scottish writer William Boyd has observed, the issue is more complicated than it might at first appear. Novelists and short story writers, Boyd points out, rely on the same “literary tools,” including character, plot, setting, title, and dialogue, and their outputs—sentences and paragraphs—look the same on the page. The tempting answer is to fall back on the obvious difference: short stories are just shorter than novels.

Already in the late nineteenth century, critics argued that that answer wasn’t good enough. In one of the earliest attempts to define the genre, “The Philosophy of the Short-Story” (1885), Brander Matthews made the case that the short story’s distinctive trait is not length per se. (“The story which is short can be written by anybody who can write at all.”) In Matthews’s view, the short story is defined by its originality, ingenuity, and, above all, “vigorous compression.”

More here.

The healthspan revolution: how to live a long, strong and happy life

John Harris in The Guardian:

Twenty years ago, Peter Attia was working as a trainee surgeon at Johns Hopkins hospital in Baltimore, where he saved countless people facing what he calls “fast death”. “I trained in a very, very violent city,” he tells me. “We were probably averaging 15 or 16 people a day getting shot or stabbed. And, you know, that’s when surgeons can save your life. We’re really good at that.”

What got to him, he says, were the people he treated who were in the midst of dying much more slowly. “All the people with cardiovascular disease, all the people with cancer: we were far less effective at saving those people. We could delay death a little bit, but we weren’t bending the arc of their lives.” Attia and his colleagues often worked 24-hour shifts, leaving him starved of sleep. When he managed to get some rest, he had an endlessly recurring dream, in which he found himself in the middle of the city, holding a padded basket and staring up at a nearby building. Eggs rained down on him, and though he tried to catch as many as he could, most of them inevitably smashed on the pavement.

More here.

Saturday Poem

The Clothes Shrine

It was a whole new sweetness
In the early days to find
Light white muslin blouses
On a see-through nylon line
Drip-drying in the bathroom
Or a nylon slip in the shine
Of its own electricity-
As if St. Brigid once more
Had rigged up a ray of sun
Like the one she’d strung on air
To dry her own cloak on
(Hard-pressed Brigid, so
Unstoppably on the go)-
The damp and slump and unfair
Drag of the workday
Made light of and got through
As usual, brilliantly.

by Seamus Heaney
from
Electric Light
farrar, Straus and Giroux, 2001

Orwell: A Very English Socialist

Blake Morrison at The Guardian:

The key to his reading of Orwell is what happened to him in Spain. Though married to Eileen only six months before, he was determined to fight for the Republican cause (“Good chaps, the Spaniards, can’t let them down”) and on his return became far more politically engaged: “at last [I] really believe in Socialism, which I never did before”. But he’d seen bullying and infighting too. For the rest of his life and in his two great novels, this was the war he fought, on behalf of a wholesome, English, sweetly C of E brand of socialism, as opposed to Stalinist totalitarianism.

Equally crucial was that sniper’s bullet, which along with damp Catalan trench warfare damaged his already frail health. Born with defective bronchial tubes, he’d had bouts of pneumonia; after Spain he looked gaunt, haggard, primed for death. He hung on for 12 more years, but ill health is Taylor’s refrain throughout. If he resists making Orwell a caricatural bohemian consumptive, doomed to die young, he can’t disguise the stress and exhaustion Orwell endured in completing Nineteen Eighty-Four.

more here.

Deborah Levy Embodies Strangeness

Simran Hans at the NY Times:

“August Blue” is Levy’s eighth novel, and since her 20s, she has been refining her ability to evoke feeling through writing rather than to narrate it. Her work is deeply influenced by art forms that express the embodied experience, like cinema and dance. “The body in the world,” she said. “How difficult. It is my subject.”

Born in South Africa before moving to England as a child, Levy, 63, is a poet, playwright and author. Writing in The New York Times, the critic Parul Sehgal described Levy’s lucid prose as “light-handed” and leaving “a pleasant sting‌,” and ‌Levy has been shortlisted for the Man Booker Prize twice. In 2020 she was awarded France’s prestigious Prix Femina Étranger for her memoirs‌ “Things I Don’t Want to Know‌” and‌ “The Cost of Living. ”

more here.

Friday, June 2, 2023

India’s religious AI chatbots are speaking in the voice of god — and condoning violence

Nadia Nooreyezdan at Rest of World:

In January 2023, when ChatGPT was setting new growth records, Bengaluru-based software engineer Sukuru Sai Vineet launched GitaGPT. The chatbot, powered by GPT-3 technology, provides answers based on the Bhagavad Gita, a 700-verse Hindu scripture. GitaGPT mimics the Hindu god Krishna’s tone — the search box reads, “What troubles you, my child?”

In the Bhagavad Gita, according to Vineet, Krishna plays a therapist of sorts for the character Arjuna. A religious AI bot works in a similar manner, Vineet told Rest of World, “except you’re not actually talking to Krishna. You’re talking to a bot that’s pretending to be him.”

At least five GitaGPTs have sprung up between January and March this year, with more on the way. Experts have warned that chatbots being allowed to play god might have unintended, and dangerous, consequences. Rest of World found that some of the answers generated by the Gita bots lack filters for casteism, misogyny, and even law. Three of these bots, for instance, say it is acceptable to kill another if it is one’s dharma or duty.

More here.

Why do animals keep evolving into crabs?

Laurel Hamers at Live Science:

A flat, rounded shell. A tail that’s folded under the body. This is what a crab looks like, and apparently what peak performance might look like — at least according to evolution. A crab-like body plan has evolved at least five separate times among decapod crustaceans, a group that includes crabs, lobsters and shrimp. In fact, it’s happened so often that there’s a name for it: carcinization.

So why do animals keep evolving into crab-like forms? Scientists don’t know for sure, but they have lots of ideas.

Carcinization is an example of a phenomenon called convergent evolution, which is when different groups independently evolve the same traits. It’s the same reason both bats and birds have wings. But intriguingly, the crab-like body plan has emerged many times among very closely related animals.

More here.

Exploring Gender Bias in Six Key Domains of Academic Science: An Adversarial Collaboration

Stephen J. Ceci, Shulamit Kahn, and Wendy M. Williams at the APS:

We synthesized the vast, contradictory scholarly literature on gender bias in academic science from 2000 to 2020. In the most prestigious journals and media outlets, which influence many people’s opinions about sexism, bias is frequently portrayed as an omnipresent factor limiting women’s progress in the tenure-track academy. Claims and counterclaims regarding the presence or absence of sexism span a range of evaluation contexts. Our approach relied on a combination of meta-analysis and analytic dissection. We evaluated the empirical evidence for gender bias in six key contexts in the tenure-track academy: (a) tenure-track hiring, (b) grant funding, (c) teaching ratings, (d) journal acceptances, (e) salaries, and (f) recommendation letters. We also explored the gender gap in a seventh area, journal productivity, because it can moderate bias in other contexts. We focused on these specific domains, in which sexism has most often been alleged to be pervasive, because they represent important types of evaluation, and the extensive research corpus within these domains provides sufficient quantitative data for comprehensive analysis. Contrary to the omnipresent claims of sexism in these domains appearing in top journals and the media, our findings show that tenure-track women are at parity with tenure-track men in three domains (grant funding, journal acceptances, and recommendation letters) and are advantaged over men in a fourth domain (hiring). For teaching ratings and salaries, we found evidence of bias against women; although gender gaps in salary were much smaller than often claimed, they were nevertheless concerning.

More here.