Where the Grass Is Greener: Leaving academia to advance biomedical research

Jonathan Shaw in Harvard Magazine:

Not infrequently, companies lure professors to highly paid positions directing scientific research in pharmaceuticals, technology, and related fields. But the recent departures of some leading Harvard scientists deeply committed to improving human health point to a different phenomenon: challenges to conducting translational life-sciences research in academic settings. Given the University’s emphasis on and investment in the life sciences and biomedical discovery, these scientists’ differing decisions suggest emerging issues and concerns about current constraints and the future of such research.

Applying for National Institutes of Health (NIH) grants can take a substantial portion of an investigator’s time, and as much as a year can pass between a submission deadline and the point when funds are received and disbursed by the recipient’s home institution.

More here.

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Why kids need to take more risks: science reveals the benefits of wild, free play

Julian Nowogrodzki in Nature:

Over the past two decades, research has emerged showing that opportunities for risky play are crucial for healthy physical, mental and emotional development. Children need these opportunities to develop spatial awareness, coordination, tolerance of uncertainty and confidence.

Despite this, in many nations risky play is now more restricted than ever, thanks to misconceptions about risk and a general undervaluing of its benefits. Research shows that children know more about their own abilities than adults might think, and some environments designed for risky play point the way forwards. Many researchers think that there’s more to learn about the benefits, but because play is inherently free-form, it has been logistically difficult to study. Now, scientists are using innovative approaches, including virtual reality, to probe the benefits of risky play, and how to promote it.

More here.

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Auden’s Island

Alan Jacobs at The Hedgehog Review:

When, on January 19, 1939, W.H. Auden boarded at Southampton a ship bound for New York City, he could not have known that he would never live in England again. But some months earlier, he had told his friend Christopher Isherwood that he wanted to settle permanently in the United States. Almost as soon as he arrived in New York, he began to rethink his calling as a poet, and, moreover, to reconsider the social role and function of poetry. (He also began a spiritual pilgrimage that would lead him to embrace the Christian faith of his childhood.)

His work of this period combined a proclamation of the value of microcultures with a commitment to an intellectual cosmopolitanism. He celebrated the “local understanding” achieved in the informal salon run by a German émigré, Elizabeth Mayer, from her home on Long Island, but what bound the members of that salon to one another was the combination of cultural and national diversity with moral sympathy. In a poem composed immediately after the Nazis invaded Poland in September 1939, he wrote:

Defenceless under the night
Our world in stupor lies;
Yet, dotted everywhere,
Ironic points of light
Flash out wherever the Just
Exchange their messages….

more here.

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Thursday Poem

…. New Exile Poems

1.
I am a writer,
the light burns late
into the night in my room.
My friend cycles past my house on his way to work
at Casey Industrial Park at 4 AM.
When we meet he asks whether I could not
sleep last night because of thoughts of homeland.

2.
In the album on the bookshelf was a photo of
my father and me together,
beside a yellow taxi.
Behind us, the departure terminal
of Dhaka International Airport.
A friend said,
‘‘Where’s your mother? You don’t exist without her.’’

3.
It is the rainy season in Bangladesh now.
Three out of four parts of my country
are under water.
Outside the City Council Building
I saw the other day a teenager holding,
all by herself,
an environmental placard.
She’s our representative.
She wants a world everyone can live in.
Come, let’s all go stand next to her.

by Tuhin Das
from Split This Rock
Translation from Bengali by Arunava Sinha

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On Psychoanalysis And Therapeutic Culture

Christian R. Gelder at the Sydney Review of Books:

To seek out a therapeutic practice, we are sometimes told, is often the expression of a desire for change. But ‘therapy’ is hardly separate from the culture it intersects with, and may end up changing that very culture. If the poet W. H. Auden could describe Freud as ‘no more a person / now but a whole climate of opinion’, then surely that was because Freud’s language eventually became our own; phrases like ‘acting defensively’ or ‘feeling conflicted’, as John Forrester notes, have been absorbed into everyday speech. A particular therapeutic practice can thereby help to bring into being the self it seeks to describe (such as the epochal emergence of what Philip Rieff once called ‘psychological man’), as its models of successful treatment and its language for the mind, emotions, and behaviour become part of culture’s common-sense. Even the use of ‘therapy’ tells us something about its contemporary cultural status, indexing far more than any individual therapeutic act. ‘You should talk to a therapist’ is a refrain regularly printed on t-shirts, worn by internet celebrities of all stripes, and the remark trades off the sense that recommending therapy could be seen as an act of care just as it could also be a moral corrective for bad behaviour (‘go to therapy, you naughty boy!’).

more here.

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Wednesday, January 8, 2025

In “You’ll Never Believe Me,” Kari Ferrell details going from internet notoriety to self-knowledge in a captivating, sharp and very funny memoir

Amanda Hess in the New York Times:

In 2009, The New York Observer published “The Hipster Grifter,” an article identifying a small-time scammer prowling the Brooklyn scene, extracting cash from unsuspecting men. Her name was Kari Ferrell, and she was 22 and immensely charming. She left a flurry of notes in her wake, cocktail napkins etched with sexually explicit jokes, sometimes signed “Korean Abdul-Jabbar.” It worked as long as her marks didn’t Google her name and find that she was wanted for felony fraud in Utah.

Once exposed (and detained), Ferrell became a recurring obsession on Gawker.com. Napkins were auctioned on eBay. Nude photos appeared online without her consent. Though she briefly penned a jailhouse column, her motivations remained mysterious. She was flattened into a filthy erotic character, and then she disappeared.

In fact, Ferrell herself did not know why she was driven to lie and steal, but she seems to have spent much of the next 15 years figuring it out. She has re-emerged with “You’ll Never Believe Me,” her captivating, sharp and very funny memoir.

More here.

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Renowned neurologist Richard Cytowic exposes the dangers of multitasking in the digital age

Richard Cytowic at The MIT Press Reader:

Watching television while using another smart device is so common that over 60 percent of U.S. adults regularly engage in “media multitasking.” Compared to controls, media multitaskers have more trouble maintaining attention and a propensity to forget; their anterior cingulate cortex (a brain structure involved in directing attention) is physically smaller than controls’Another study found that the more minutes children engaged in screen multitasking at age 18 months, the worse their preschool cognition and the more behavioral problems they exhibited at four and six years. The authors advise positive parenting and avoidance of media screen multitasking before the age of two.

The challenges of multitasking are especially acute in fields like medicine, where attention to detail can mean the difference between life and death. A powerful example comes from a training session with George Washington University medical students in which we scrutinize an incident that reportedly occurred at another well-known teaching hospital.

More here.

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Tyler Cowen talks to Yascha Mounk about everything

Yascha Mounk at his own Substack:

Yascha Mounk: One of the things that I’ve really been trying to wrap my head around is the impact of AI. The launch of easily publicly accessible AI was now a little over two years ago, and it is clear that AI has tremendous capacities. At the same time, so far, its impact on the world has been a little bit more limited than might have been imagined two years ago. How do you see this panning out over the course of the next few years?

Tyler Cowen: I think it will take a long time to have a major impact. There are some areas such as programming where it’s already doing well over half the work, or in some parts of graphic design. You use Midjourney and you get something quite nice for free and you own the intellectual property rights to it. But when it comes to institutions, they’re not in general arranged so that there’s some easy way to slot in extra intelligence that’s not attached to a body.

I think, slowly, a lot of institutions will be rebuilt. But in some sectors, it’s an immediate revolution—students cheating on tests, that’s happened very quickly. Again, when it can happen quickly, it will. But I think it will be a protracted process.

More here.

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Frederick Wiseman, Restored

David Hudson at The Current:
Whether embedded in a hospital, a high school, a zoo, a welfare center, an army training camp, a public library, a city hall, or an entire neighborhood, his films are “stylistically ur-vérité,” as Errol Morris put it in the Paris Review in 2011. “No narration. Available light. Fly-on-the-wall. But Wiseman’s films prove a simple principle. Style does not determine content. He may be a direct-cinema guy in form, but the content is not valetudinarian but visionary and dystopian. Wiseman has never been a straight vérité ‘documentarian.’ He is a filmmaker and one of the greatest we have.”
Most of Wiseman’s films are “long, strange, and uncompromising,” wrote Mark Binelli. “They can be darkly comic, uncomfortably voyeuristic, as surreal as any David Lynch dream sequence. There are no voice-overs, explanatory intertitles, or interviews with talking heads, and depending on the sequence and our own sensibility, we may picture the ever-silent Wiseman as a deeply empathetic listener or an icy Martian anthropologist.”
more here.

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Wednesday Poem

For Gaza

—with a battle cry from Kamehameha Nui

We drink this and share the same taste with you.
We mixed the kava in the parking lot, face-to-face with you.

What becomes of children who drink war instead of water?
The rubble, a chronic obituary. I will never waste a name with you.

Today an elder dreams in the long arms of his olive trees.
Home, he sings. To put hands to the light and fill crates with you.

The drone wind whips, grief wraps a country’s throat.
We find your hands and keep our place with you.

E inu i ka wai ʻawaʻawa. Histories of bitter waters and love,
love, love. E Palesetina ē, Hawaiʻi stays and fights with you.

by Noʻu Revilla
from Split This Rock

AUTHOR’S NOTE: This ghazal incorporates famous words of Kamehameha Nui, who united the Hawaiian islands. Before a battle on Maui, he implored his warriors: “I mua e nā pōkiʻi a inu i ka wai ʻawaʻawa (Forward, my siblings, and drink the bitter waters).” Throughout Oceania, Indigenous Pasifika people believe that if we drink the same thing before taking collective action, we go forward with the same stomach. As an ʻŌiwi aloha ʻāina, I am proud of the historic and ongoing connections between Hawaiʻi and Palestine. We stand with Palestine.

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The Uses and Abuses of Manet’s Olympia

Todd Cronan at nonsite:

When Édouard Manet exhibited Olympia in the Salon of 1865, it unleashed a firestorm. Viewers were shocked by the subject matter—the sheer nakedness of the sitter—and by his formal treatment of the subject: critics lamented the lack of finish, the sharp contrast between light and dark, and, above all, the starkness of the model’s outward look at the viewer. For critics at the time, Manet’s shocking way with form went hand in hand with a sense of moral outrage, around gender and class. Olympia subtly but powerfully broke all the unspoken rules about the nude in painting and set the standard for a new form of revolutionary modern art.

Olympia has been subject to countless interpretations for over a century, but one subject has seemingly eluded critical commentary: race. If the white model Victorine Meurent has been at the center of many interpretations, what about the other, equally central character, the model’s black maid, Laure (we don’t know her last name).

more here.

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Why Alzheimer’s Scientists Are Re-thinking the Amyloid Hypothesis

Joshua Cohen in Undark Magazine:

For decades, scientists have been trying to develop therapeutics for people living with Alzheimer’s disease, a progressive neurodegenerative disease that is characterized by cognitive decline. Given the global rise in cases, the stakes are high. A study published in The Lancet Public Health reports that the number of adults living with dementia worldwide is expected to nearly triple, to 153 million in 2050. Alzheimer’s disease is a dominant form of dementia, representing 60 to 70 percent of cases.

Recent approvals by the Food and Drug Administration have focused on medications that shrink the sticky brain deposits of a protein called amyloid beta. The errant growth of this protein is responsible for triggering an increase in tangled threads of another protein called tau and the development of Alzheimer’s disease — at least according to the dominant amyloid cascade hypothesis, which was first proposed in 1991.

Over the past few years, however, data and drugs associated with the hypothesis have been mired in various controversies relating to data integrity, regulatory approval, and drug safety.

More here.

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Sean Baker’s screwball Cinderella tale vaults him towards greatness

Xan Brooks in The Guardian:

Her name is Anora but everyone calls her Ani. She’s fluent in Russian but prefers to speak English. She dances at a strip club, which means she’s emphatically not a sex worker, even if she occasionally moonlights as one on the side. Ani, it’s clear, is smarter and tougher than she lets on to her clients. But the woman’s a mess; she’s compromised and conflicted. Probably the world around her is too.

Anora, the brilliant new picture from American writer-director Sean Baker, is a screwball Cinderella tale – frenetic and funny, fiery and profane. While Baker has already won plaudits for his previous work (TangerineThe Florida Project, 2021’s Red Rocket), this boisterous New York caper vaults him towards greatness. Anora combines instinctual deft handling of its volatile subject matter with a jubilant, swing-for-the-fences ambition. But the film’s a joint triumph and shares the spoils with its star. Cast in the title role, 25-year-old Mikey Madison gives a performance for the ages. She rustles up a flawed, fearsome heroine who’s as gorgeous and grubby as life.

More here.

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Tuesday, January 7, 2025

An unserious culture lacks the ability to sustain high art

William Deresiewicz at Persuasion:

Now I’ll never have a chance to impress Arlene Croce.

Croce, who died last month at 90, was the dean of American dance critics during the heyday of American dance. I started my writing career as a dance critic, too, and for many years that’s all I ever dreamed of being as a writer. My first sixty-plus published articles were dance reviews, and their intended audience consisted, in its entirety, of Arlene Croce. She was the lodestar, the queen, the presence around which the field arranged itself. I’ve wanted few things more in life—wanted it with the ardor of youth and the thirst for praise of the apprentice writer—than to win her approval.

I never did. In fact, I’ve no idea if she ever saw a word I wrote. But her death brought me back to that time. In retrospect, it was the waning days of the golden age of an American art form whose achievements bear comparison to those of Florentine painting or Viennese music. Not many remember this now, for dance leaves little to posterity.

More here.

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A survey of recent works in Oulipo

Ben Orlin at Math With Bad Drawings:

“Oulipans are rats who build the labyrinth from which they will try to escape.” Raymond Queneau

It brings me no joy to report the rebirth (or the renewed undeadness) of the zombie literary movement known as OuLiPo.

Oulipo’s first birth came in 1960, from the vibrant and idle minds of Raymond Queneau and François Le Lionnais. They dubbed it ouvroir de littérature potentielle (“workshop of potential literature”). A self-conscious experiment in applying strict mathematical constraints to art, its results (such as George Perec’s La Disparition, a novel that avoids the letter e) were spectacles of virtuosity, triumphs of ingenuity, and, at their very best, passable works of art. No coincidence, I say, that the name “potential literature” stands opposed to actual literature.

I believed this volcano had gone dormant. I was wrong. The last year witnessed four eruptions. I offer brief comments on each species of ash.

More here.

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A science writer on loss and letting go of rationalism

Sumit Paul-Choudhury in The Guardian:

People reacted in different ways to my wife Kathryn’s diagnosis: an aggressive, fast-spreading ovarian cancer discovered after the miscarriage that ended our first and only pregnancy. A few understood that her future was likely to be grim and short; those people mostly kept quiet or stayed away. But many professed to believe that things would somehow work out – sometimes out of superstition, sometimes out of a desire to reassure, but most often simply because they could think of no other way to react.

Kathryn, for her part, insisted that those around her – her family, her friends, her colleagues and her doctors – only express hope. Naturally, that applied to me most of all, but I struggled to know how to accommodate her wishes. On the one hand, I’d always been inclined to look on the bright side, and some part of me believed it would all work out fine. On the other, I was an empirically minded rationalist. I read the medical reports and the scientific literature, and realised that her odds of surviving more than a couple of years were vanishingly small. But since I wasn’t the one with the terminal illness, I concluded that I should keep my mouth shut and be supportive in the way my wife had chosen, while hoping against hope for a statistical miracle.

No miracle came. Kathryn’s cancer overran her body’s defences in less than a year; she endured an unrehearsed and graceless death.

When it came to rebuilding my own life, the piece of advice I was given, over and over, was to “take it one day at a time”. No long-term plans, no significant life changes. I found that unsatisfactory.

More here.

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