Gina Kolata in The New York Times:
When Georgia Bowen was born by emergency cesarean on May 18, she took a breath, threw her arms in the air, cried twice, and went into cardiac arrest. The baby had had a heart attack, most likely while she was still in the womb. Her heart was profoundly damaged; a large portion of the muscle was dead, or nearly so, leading to the cardiac arrest. Doctors kept her alive with a cumbersome machine that did the work of her heart and lungs. The physicians moved her from Massachusetts General Hospital, where she was born, to Boston Children’s Hospital and decided to try an experimental procedure that had never before been attempted in a human being following a heart attack. They would take a billion mitochondria — the energy factories found in every cell in the body — from a small plug of Georgia’s healthy abdominalmuscle and infuse them into the injured muscle of her heart. Mitochondria are tiny organelles that fuel the operation of the cell, and they are among the first parts of the cell to die when it is deprived of oxygen-rich blood. Once they are lost, the cell itself dies. But a series of experiments has found that fresh mitochondria can revive flagging cells and enable them to quickly recover.
…The idea for mitochondrial transplants was born of serendipity, desperation and the lucky meeting of two researchers at two Harvard teaching hospitals — Dr. Emani at Boston Children’s and James McCully at New England Deaconess Hospital. Dr. Emani is a pediatric surgeon. Dr. McCully is a scientist who studies adult hearts. Both were wrestling with the same problem: how to fix hearts that had been deprived of oxygen during surgery or a heart attack. “If you cut off oxygen for a long time, the heart barely beats,” Dr. McCully said. The cells may survive, but they may never fully recover. While preparing to give a talk to surgeons, Dr. McCully created electron micrographs of damaged cells. The images turned out to be revelatory: The mitochondria in the damaged heart cells were abnormally small and translucent, instead of a healthy black.
…Dr. McCully moved to Boston Children’s, and he and Dr. Emani prepared to see if the new technique might help tiny babies who were the sickest of the sick — those surviving on Ecmo.
…He injected a billion mitochondria, in about a quarter of a teaspoon of fluid. Within two days, the baby had a normal heart, strong and beating quickly. “It was amazing,” Dr. Emani said.
More here.




It turns out you learn a lot when you write a book. This may seem counterintuitive. Perhaps you think, “Well, that’s dumb. If you write a book about something you should already be an expert on it.”
When we were teaching at Stanford in the late 2000s, the terms “techie” and “fuzzy” became cultural touchstones: The “techies” majored in engineering and the sciences, the “fuzzies” in arts and the humanities. Faculty and administrators deplored those words, and students furiously debated them, but the terms — and the split they describe —
For scientists, pain has long presented an intractable problem: it is a physiological process, just like breathing or digestion, and yet it is inherently, stubbornly subjective—only you feel your pain. It is also a notoriously hard experience to convey accurately to others. Virginia Woolf bemoaned the fact that “the merest schoolgirl, when she falls in love, has Shakespeare or Keats to speak her mind for her; but let a sufferer try to describe a pain in his head to a doctor and language at once runs dry.” Elaine Scarry, in the 1985 book “The Body in Pain,” wrote, “Physical pain does not simply resist language but actively destroys it.”
“My ideal is the cocktail-party chat,” [Jim Holt] writes in the preface to his new essay collection, “When Einstein Walked with Gödel,” “getting across a profound idea in a brisk and amusing way to an interested friend by stripping it down to its essence (perhaps with a few swift pencil strokes on a napkin). The goal is to enlighten the newcomer while providing a novel twist that will please the expert. And never to bore.”
In 1997, when Dani Rodrik, a Turkish-born professor at Harvard’s Kennedy School of Government, published his brief book Has Globalization Gone Too Far?, progressive economists widely embraced his arguments that many free trade policies adopted by the US, which reduced tariffs and other protections, also weakened the bargaining power of American workers, destabilized their wages, and encouraged social conflict. “The danger,” Rodrik wrote presciently, “is that the domestic consensus in favor of open markets will ultimately erode to the point where a generalized resurgence of protectionism becomes a serious possibility.” I remember that Robert Kuttner, the coeditor of The American Prospect, was particularly enthusiastic about the book. Almost twenty years later, he again praised Rodrik for his continued devotion to an empirically grounded skepticism of what Rodrik now calls “hyperglobalization.”
Novelist, poet, and essayist
Some nightmares, the worst ones, move so slowly that you don’t wake up from them right away. The terror feels normal, even though you may know something’s not right. It’s a usual sort of bad feeling, typical enough to fool the mind into believing that you may be awake. That is, until the monster shows up. Only then does the brain recognize it is inside something that isn’t real. “Sharp Objects,” HBO’s latest limited series from “Dietland” creator Marti Noxon and Jean-Marc Vallée, and based on a novel by Gillian Flynn (“Gone Girl”), reproduces that sensation throughout the seven of its eight episodes that were provided for review.
ON JUNE
In spite of the obsession with Soros, there has been surprisingly little interest in what he actually thinks. Yet unlike most of the members of the billionaire class, who speak in platitudes and remain withdrawn from serious engagement with civic life, Soros is an intellectual. And the person who emerges from his books and many articles is not an out-of-touch plutocrat, but a provocative and consistent thinker committed to pushing the world in a cosmopolitan direction in which racism, income inequality, American empire, and the alienations of contemporary capitalism would be things of the past. He is extremely perceptive about the limits of markets and US power in both domestic and international contexts. He is, in short, among the best the meritocracy has produced.
Spiders have no wings, but they can take to the air nonetheless. They’ll climb to an exposed point, raise their abdomens to the sky, extrude strands of silk, and float away. This behavior is called ballooning. It might carry spiders away from predators and competitors, or toward new lands with abundant resources. But whatever the reason for it, it’s clearly an effective means of travel. Spiders have been found two-and-a-half miles up in the air, and 1,000 miles out to sea.
The starkest example of the many racist and anti-poor measures directed at African Americans and passed during his administration was the 1996 welfare reform bill, which transformed welfare from an exclusive and unequal cash assistance system that stigmatized its recipients into one that actually criminalized them.