The surprising link between gut bacteria and devastating eye diseases

Saima Sidik in Nature:

Eye diseases long thought to be purely genetic might be caused in part by bacteria that escape the gut and travel to the retina, research suggests1. Eyes are typically thought to be protected by a layer of tissue that bacteria can’t penetrate, so the results are “unexpected”, says Martin Kriegel, a microbiome researcher at the University of Münster in Germany, who was not involved in the work. “It’s going to be a big paradigm shift,” he adds. The study was published on 26 February in Cell.

Crumbling dogma

Inherited retinal diseases, such as retinitis pigmentosa, affect about 5.5 million people worldwide. Mutations in the gene Crumbs homolog 1 (CRB1) are a leading cause of these conditions, some of which cause blindness. Previous work2 suggested that bacteria are not as rare in the eyes as ophthalmologists had previously thought, leading the study’s authors to wonder whether bacteria cause retinal disease, says co-author Richard Lee, an ophthalmologist then at the University College London. CRB1 mutations weaken linkages between cells lining the colon in addition to their long-observed role in weakening the protective barrier around the eye, Lee and his colleagues found. This motivated study co-author Lai Wei, an ophthalmologist at Guangzhou Medical University in China, to produce Crb1-mutant mice with depleted levels of bacteria. These mice did not show evidence of distorted cell layers in the retina, unlike their counterparts with typical gut flora.

More here.



Justice for Ralph Ellison

David Denby in The New Yorker:

One of the greatest of all American books, Ralph Ellison’s “Invisible Man,” was published by Random House sixty years ago, on April 14, 1952, and became an immediate sensation. Almost everyone who cared about such things knew that something remarkable had happened. Ellison, a passionate reader of Twain, Dostoyevsky, Faulkner, Hemingway, Joyce, Malraux, T. S. Eliot, and Richard Wright, had marshalled a good part of the literary past and broken new ground as a novelist. His novel moves back and forth between stern realism and fantasia, despair and rhapsody, formal syntax and jazzy, impassioned riffs. Ellison pushed black folklore into surrealism and play—both sombre play and the most exuberant shenanigans.

Explicitly, he rejected the limited point-of-view strategies of Henry James and the stylized austerity and gruffness of the hard-boiled writers. “Invisible Man” is a tumultuous book, an enormous book, liberated and responsible at the same time, a novel that, even now, turns readers upside down. I’ve just read it with a group of eleventh-graders in New York who seemed a little overwhelmed, at times, but, under the guidance of a good teacher (not me; a pro), they hung in there and did well by it. Ellison presents American experience with a luscious eloquence and an abandon corralled by a stern sense of form, and the students responded to both the wildness and the control.

More here. (Note: In honor of Black History Month, at least one post will be devoted to its 2024  theme of “African Americans and the Arts” throughout the month of February)

Sunday, February 25, 2024

US Media Is Collapsing, Here’s How to Save It

Alissa Quart at Jacobin:

The requests from independent journalists for grants, including personal emergency grants, have been coming in extra fast lately. Receiving them, me and my staff at the Economic Hardship Reporting Project feel like Lucille Ball grabbing the chocolates on the conveyor belt in that factory episode of I Love Lucy. The pace is picking up as publication closures and media layoffs push many into the world of full-time freelancing, where they compete for dwindling payouts against mounting competition. And as of last week, the Intercept, where my husband Peter Maass worked for ten years, has laid off fifteen of its staffers — including him. The media emergency just got even more personal.

Our family is far from alone. Sports Illustrated, formerly beefy with articles and bodacious with ads, has laid off its staff. Pitchfork, long my go-to for tart and encyclopedic endorsements or takedowns of music, has been folded, in a much-reduced form, into GQ — two media entities that, if they were people, would have never spoken to each other in high school. Meanwhile, the venerable Los Angeles Times announced it would be laying off at least 115 people, more than 20 percent of its staff.

More here.

The Growing Environmental Footprint Of Generative AI

David Berreby at Undark:

AI use is directly responsible for carbon emissions from non-renewable electricity and for the consumption of millions of gallons of fresh water, and it indirectly boosts impacts from building and maintaining the power-hungry equipment on which AI runs. As tech companies seek to embed high-intensity AI into everything from resume-writing to kidney transplant medicine and from choosing dog food to climate modeling, they cite many ways AI could help reduce humanity’s environmental footprint. But legislators, regulators, activists, and international organizations now want to make sure the benefits aren’t outweighed by AI’s mounting hazards.

More here.

Rebecca Solnit on the Perennial Divisions of the American Left

Rebecca Solnit at Literary Hub:

In late 1936 George Orwell, like so many young idealists from Europe and the USA, went off to fight fascism in Spain. By the spring of 1937 he realized he was in a war with not two but three sides. The USSR was holding back a full Spanish revolution while attacking the socialists and anarchists outside its control.

Facing prison and possible execution himself, not from the fascists, but the Soviet-allied forces, Orwell fled Spain. His immediate commander, Georges Kopp, was imprisoned, and the leader of his militia unit, Andres Nin, was tortured and assassinated by an agent of Stalin’s secret police. Orwell would spend the rest of his life trying to clarify that in his time the left meant both idealists committed to human rights, equality, and justice and supporters of a Stalinism that was the antithesis of all those things.

More here.

Disappearing tongues: the endangered language crisis

Ross Perlin in The Guardian:

Language is a universal and democratic fact cutting across all human societies: no human group is without it, and no language is superior to any other. More than race or religion, language is a window on to the deepest levels of human diversity. The familiar map of the world’s 200 or so nation-states is superficial compared with the little-known map of its 7,000 languages. Some languages may specialise in talking about melancholy, seaweed or atomic structure; some grammars may glory in conjugating verbs while others bristle with syntactic invention. Languages represent thousands of natural experiments: ways of seeing, understanding and living that should form part of any meaningful account of what it is to be human.

More here.

Saturday, February 24, 2024

Living in Arendt’s World

Blake Smith in The Ideas Letter:

Michael Denneny, the recently deceased co-founder and co-editor of the pioneering gay magazine Christopher Street , gay newspaper New York Native , and the gay publishing line at St. Martin’s Press, Stonewall Inn Editions, began his recently published collection of essays On Christopher Street  with a quotation from his mentor, Hannah Arendt:

“Only in our speaking with one another does the world, as that about which we speak, emerge in its objectivity and visibility from all sides. Living in a real world and speaking with one another about it are basically one and the same.”

Denneny’s career as a gay cultural activist was a way of putting into practice Arendt’s thought as condensed in this citation. Across writings collected in On Christopher Street, which range in date from the beginnings of the magazine in 1976 to just before his death last year, he grounded his view of gay culture and politics in her work. Yet the importance of her example for their emergence—and of her philosophy to a key moment in the rise of what we now call “identity politics”—remains almost totally ignored in the field of gay history and in the ever-growing number of academic and popular reappraisals of Arendt. It is hardly known that her thinking and milieu were vital elements in intellectual matrix of the American gay movement.i

From academic and popular genealogies of gay identity and gay politics, whether written by progressive academics or conservatives pundits like Jamie Kirchick or Chris Rufo, readers could be forgiven for mistakenly believing misunderstanding that it was “radical” post-structuralist thinkers like Michel Foucault and Judith Butler who supplied that movement’s theoretical legitimation, resisted all the way by “mainstream” “assimilationists” (who are often portrayed by defenders and critics as anti-theoretical voices of “common sense”). Such genealogies misunderstand Foucault (who was much closer to the positions of Arendt and Denneny, an early champion of his, than to Butler and today’s “woke” activists)ii—although this is a subject for another essay. Moreover, they obscure the deep, and deeply Arendtian, thinking behind the cultural and political work that brought gay male life towards the center of American consciousness.

More here.

Why Hitch Still Matters: On Christopher Hitchens’s “A Hitch in Time”

Marius Sosnowski in LA Review of Books:

IT HAS BEEN 12 years since Christopher Hitchens left us. After his spirited showing in the 20th century, the first dozen years of the 21st were something of a reinvention. While Hitchens 2.0 may have left a trail of rubble in his wake, his books remained no less resolute than what had gone before: the vital study Why Orwell Matters (2002); the world-famous polemic God Is Not Great (2007); the best-selling and magisterial memoir Hitch-22 (2010); the compendious and ever-entertaining essay collection Arguably (2011); and his last feint from the edge of death, Mortality (2012). Still, it’s the belligerent terms of his late-in-life split from the Left that has threatened to eclipse a career dedicated to combating tribalist thinking, and fighting to illuminate the difference between what is and what is purported to be. One can’t help but feel a void, a conspicuous silence emanating from the direction of the Wyoming Apartments in Washington, DC, from which his rapier-like perceptions could have added something useful, even necessary, to the understanding of all that has followed.

Now, Twelve Books has published A Hitch in Time: Reflections Ready for Reconsideration, a welcome gathering of 23 mostly uncollected pieces he wrote for the London Review of Books (the volume was released in the United Kingdom in 2021 with an LRB-highlighting subtitle). With the exception of the opening essay, “The Wrong Stuff: On Tom Wolfe,” from 1983, and the closing one, “11 September 1973: Pinochet and Britain,” from 2002, everything herein dates from the 1990s, that thoroughly wacky and jaunty time everyone sorely misses. Hitchens is in memorable form here; his essays range from tackling P. G. Wodehouse, the First Gulf War, and the prevalence (nay, importance) of spanking to Britain’s social order, to the trouble with Bill Clinton, an almost sympathetic (or as close as Hitch could get to sympathy for a royal) portrait of the misunderstood Princess Margaret, and an evisceration of the United States’ charismatic hero JFK (and the comically jowly goons that followed in his presidential wake)—all while displaying the author’s characteristic impatience with courtiers, apologists, and tiresome bellends.

More here.

Shockwaves in the Global Order

Helena Cobban in Boston Review:

Just days before October 7, President Joe Biden’s national security advisor, Jake Sullivan, was radiating confidence that Washington had effectively brought all of West Asia’s long-roiling conflicts under control. Washington could now, he believed, accelerate the pivot of attention, forces, and funding toward what had long topped Biden’s agenda: containing Chinese power in East Asia. Then came the Hamas-led attack on Israel and Israel’s onslaught on Gaza. By late January, Sullivan was flying to Bangkok to plead with top Chinese diplomat Wang Yi for help in defusing the sharp, Gaza-spurred conflict that had erupted in the globally vital waterway of the Red Sea. (Wang politely blew him off.)

Over the past four months, the United States has become increasingly isolated on the world stage. In October and again in November, the United States vetoed resolutions at the UN Security Council that called for an immediate ceasefire in Gaza on the grounds that they did not condemn Hamas. Then, on December 12, a special session of the UN General Assembly—where no country has veto power—voted 153 to 10, with 23 abstentions, in favor of a ceasefire resolution that made no mention of condemning Hamas. Those supporting the resolution included the BRICS group of nations (Brazil, Russia, India, China, and South Africa), nearly all the other nations of the Global South, and some West European states, including France and Spain. The only states that joined the United States and Israel in voting against it were Austria, Czechia, Guatemala, Liberia, Paraguay, Papua New Guinea, and the tiny countries of Micronesia and Nauru.

More here.

The G20 Looks South

Bruno De Conti , Pedro Rossi, Arthur Welle, and Clara Saliba in Phenomenal World:

In December 2023, Brazil began presiding over the G20. The one-year presidency, which will culminate in the annual summit being hosted in Rio de Janeiro in November 2024, is the third of four terms from the global South—following Indonesia in 2022 and India in 2023, and preceding the already decided South African presidency in 2025. When India’s Narendra Modi formally handed over the presidency to Brazil last November, Lula announced three priorities to “place the reduction of inequalities at the center of the international agenda: (i) social inclusion and the fight against hunger (ii) energy transition and sustainable development in its three aspects (social, economic and environmental) and (iii) reform of global governance institutions.” The proposals were well received internationally; now is the time for concrete agendas to build toward the November summit.

Though the Brazilian government’s proposals are progressive, the G20’s multilateral dialogue continues within the context of international institutions that long predate it—reflecting the balance of global economic power in the middle of the twentieth century. Forged after World War II, institutions such as the IMF and the World Bank, now undergird an international governance system that does not represent the tremendous changes that have occurred in the world economy since the fiscal rules they prescribed in the 1970s. Dominated by countries whose economies represent a shrinking share of world production and trade, these institutions reproduce asymmetries of power over the subjects of multilateral diplomacy—which are today indispensable for mitigating global climate change and extending social protections over the world’s economically and socially vulnerable populations.

The increased weight of the global South among countries making up the G20 indicates a changing balance of forces within the group—and shows how the moment is conducive for a shift in strategy. The group’s last summit in New Delhi illustrated the enhanced importance of the global South. Under the Indian presidency, this group of global South countries had at least two major victories representing the shift towards multipolarity: the absence of a unilateral position on the war in Ukraine and, more importantly, the inclusion of the African Union (AU) as a permanent member of the group.

More here.

Alphabetical Diaries By Sheila Heti

Hephzibah Anderson at The Guardian:

Canadian writer Sheila Heti’s 2010 breakout novel sought to interrogate its titular puzzler, How Should a Person Be? It’s become a continuing quest, but over the course of a career that now finds her publishing her 12th book, she’s also asked readers to consider again and again another question: how should prose be? Pairing philosophical inquiry with formal experimentation, she’s drawn inspiration from sources as scattered as reality TV, the I Ching and chatbot utterances, expanding our thinking about structure, character and the boundaries between fiction and memoir.

Both lines of investigation are furthered in this latest work, her most radical yet. It began when she decided to upload 10 years of her journal writing – 500,000 words in all – to an Excel spreadsheet, which ordered her sentences alphabetically.

more here.

The ‘Sad, Happy Life’ of Carson McCullers

Dwight Garner at the NYT:

“Carson McCullers: A Life” is a necessary book, though. It builds on Carr’s work and considers newly released material, including letters and journals and, most tantalizingly, transcripts of McCullers’s late-life psychiatric sessions with the female doctor who would become her lover and gatekeeper. It has been seven years since McCullers (1917-67) had her centennial, when the Library of America released her complete works in two volumes. That was an occasion, which many critics took, to revisit her work, which includes the novels “The Heart Is a Lonely Hunter” (1940) and “The Member of the Wedding” (1946), and the story collection “The Ballad of the Sad Café” (1951).

Special notice was paid, and justly so, to McCullers’s gifts for portraying loners and misfits, for addressing taboo topics such as mental illness and alcoholism and same-sex relationships. As Joyce Carol Oates put it in The New York Review of Books, “McCullers seemed to have identified with whatever is trans- in the human psyche, seeing it as the very fuel of desire.”

more here.

This is why blackface is offensive

Harmeet Kaur in CNN:

Blackface isn’t just about painting one’s skin darker or putting on a costume. It invokes a racist and painful history. The origins of blackface date back to the minstrel shows of mid-19th century. White performers darkened their skin with polish and cork, put on tattered clothing and exaggerated their features to look stereotypically “black.” The first minstrel shows mimicked enslaved Africans on Southern plantations, depicting black people as lazy, ignorant, cowardly or hypersexual, according to the Smithsonian’s National Museum of African American History and Culture (NMAAHC). The performances were intended to be funny to white audiences. But to the black community, they were demeaning and hurtful.

One of the most popular blackface characters was “Jim Crow,” developed by performer and playwright Thomas Dartmouth Rice. As part of a traveling solo act, Rice wore a burnt-cork blackface mask and raggedy clothing, spoke in stereotypical black vernacular and performed a caricatured song and dance routine that he said he learned from a slave, according to the University of South Florida Library.

Though early minstrel shows started in New York, they quickly spread to audiences in both the North and South. By 1845, minstrel shows spawned their own industry, NMAAHC says. Its influence extended into the 20th century. Al Jolson performed in blackface in “The Jazz Singer,” a hit film in 1927, and American actors like Shirley Temple, Judy Garland and Mickey Rooney put on blackface in movies too. The characters were so pervasive that even some black performers put on blackface, historians say. It was the only way they could work – as white audiences weren’t interested in watching black actors do anything but act foolish on stage.

More here. (Note: In honor of Black History Month, at least one post will be devoted to its 2024  theme of “African Americans and the Arts” throughout the month of February)