Finding and Losing Schizophrenia

Paul Broks at Literary Review:

Madness is deep-rooted in the human imagination. The mad are unreachable, unfathomable, alarmingly other. They unsettle us. Yet we also romanticise madness. Great poetry and art spring from transcendent states at the edge of sanity, don’t they? And falling in love is a kind of madness, a stumbling into a dream world of irrationality and delusion. The lunatic, the lover and the poet are of imagination all compact. One line of thought is that madness is the price Homo sapiens has paid for the jewel of human consciousness. Perhaps it is.

There have always been alienated individuals marked out as ‘mad’ by the rest of society on account of their bizarre beliefs and eccentric behaviour, but it was not until the late 19th century that Emil Kraepelin established a formal taxonomy of signs and symptoms.

more here.

Liz Johnson Artur’s Vibrant Chronicle of the African Diaspora

Anakwa Dwamena at The New Yorker:

There is so much sound, movement, and energy in Liz Johnson Artur’s first solo museum show, “Dusha,” at the Brooklyn Museum, that walking through the galleries feels like attending a party at a local Pan-African community center. The exhibit showcases Artur’s “Black Balloon Archive,” which consists of images of the global African diaspora captured in the course of decades. Here are two boys spinning each other on the sidewalk, surrounded by a crowd of onlookers. Nearby is Brother Michael, in a black suit and white tie, selling Nation of Islam newspapers. A group of women show off their matching head wraps, and precocious schoolgirls relax outside a classroom. A man wearing Ankara prints and sunglasses mugs for the camera. All that is missing is the line for jollof and the music of Fela Kuti.

more here.

My Seditious Heart by Arundhati Roy – powerful, damning essays

Bidisha in The Guardian:

With its gold-striped spine, crimson endpapers and silky leaves, My Seditious Heart is a handsome edition of previously published essays by Booker-winning writer Arundhati Roy. Despite the stately presentation and the fact that some of the essays first appeared 20 years ago, these studies are trenchant, still relevant and frequently alarming. Roy reveals some hard truths about modern India and makes powerful analytical forays into American and British foreign policy, aid, imperialism and attitudes.

Roy’s India is one of extreme wealth and extreme poverty; opportunity and exploitation; cynicism and hypocrisy; ambition and greed; dynamism and thuggery. “India lives in several centuries at the same time. Somehow we manage to progress and regress simultaneously.” She describes emaciated workers toiling by candlelight through the night to lay broadband cable to accelerate the country’s digital revolution. The Greater Common Good looks at (futile) resistance to the Sardar Sarovar Dam in the Narmada valley, the forced displacement of local people and the slandering of activists as troublemakers. Another essay looks at uranium mining in Jadugoda, while in another piece Roy accompanies tribal anti-government fighters in the forests of Dantewada in Chhattisgarh. Certain areas of interest emerge clearly. Roy covers the aggressive appropriation of tribal rural lands for mining and water projects, the expansion of nuclear weapons programmes, the privatisation and commercialisation of Indian services, the legacies and continuation of colonisation and imperialism in various forms, government corruption, American warmongering and national hypocrisy. The essays are also prescient in their early sensitivity to environmental damage and to indigenous rights.

More here.

How personalized medicine is transforming your health care

Fran Smith in National Geographic:

Precision medicine flips the script on conventional medicine, which typically offers blanket recommendations and prescribes treatments designed to help more people than they harm but that might not work for you. The approach recognizes that we each possess distinct molecular characteristics, and they have an outsize impact on our health. Around the world, researchers are creating precision tools unimaginable just a decade ago: superfast DNA sequencing, tissue engineering, cellular reprogramming, gene editing, and more. The science and technology soon will make it feasible to predict your risk of cancer, heart disease, and countless other ailments years before you get sick. The work also offers prospects—tantalizing or unnerving, depending on your point of view—for altering genes in embryos and eliminating inherited diseases.

More immediately, the research points the way to customized therapies for the most recalcitrant cancers. Last spring, researchers at the National Cancer Institute reported the dramatic recovery of a woman with metastatic breast cancer, Judy Perkins, after an experimental therapy using her own immune cells to attack her tumors. The team, led by Steven Rosenberg, an immunotherapy pioneer, had sequenced her tumor’s DNA to analyze the mutations. The team also extracted a sampling of immune cells called tumor-infiltrating lymphocytes and tested them to see which ones recognized her tumor’s genetic defects. The scientists reproduced the winning lymphocytes by the billions and infused them into Perkins, along with a checkpoint inhibitor, pembrolizumab. More than two years later, Perkins, a retired engineer from Florida, shows no signs of cancer.

More here.

The Puzzle of Cicero’s Philosophy of Religion

by Scott F. Aikin and Robert B. Talisse

Cicero’s philosophical dialogues are notoriously difficult.  In some cases, as with the Academica and the Republic, their fragmentary state exacerbates the challenge of interpretation. In other cases, as with On Ends, the breadth of the discussion makes it difficult to locate the thread. In every case, Cicero stays true to his Academic skeptical training of opposing every argument with another argument. In some instances, one line of reasoning comes out clearly best, but in others, it is not so clear. And then there is On the Nature of the Gods. It is a special case. Let us explain.

The overall structure of On the Nature of the Gods is quite simple. The theologies of three philosophical schools are represented, each with a Roman mouthpiece. Epicureanism is represented by Velleius, Stoicism by Balbus, and Academic skepticism by Cotta. Cicero writes himself into the dialogue, too, as listening in and promising not to tilt the verdict in favor of his fellow Academic, Cotta. Velleius proceeds to give an outline of Epicurean theology, complete with an account of how it is possible to know things about the gods, what the gods are like, and how we should live in light of these truths. In short, Epicureans believe that we know about the gods because we have deeply held conceptions of them, which must have antecedent causes. The gods have human bodies and they live lives free of care for eternity. Consequently, we should not fear the gods, because they take no notice of us. Cotta the Academic skeptic then proceeds to demolish the Epicurean case. Why trust preconceptions when they are so often wrong? If the gods have human-like bodies, how can they be immortal? And if the gods don’t care about us, then what’s the point of religion or piety at all? Isn’t Epicureanism really just atheism? Read more »

Making ice in Vietnam

by Jonathan Kujawa

I just returned from the joint Vietnam-US math conference held at the International Center for Interdisciplinary Science and Education in beautiful Quy Nhon, Vietnam.

Math in Space!

While it is a human endeavor, mathematics doesn’t care about gender, race, wealth, or nationality. One of the great pleasures of the math community is finding yourself on common ground with people from around the world. It is for good reason movie aliens usually first communicate using prime numbers and we chose to include math on the Voyager spacecraft’s Golden Record  [1].

Quy Nhon, Vietnam

In this spirit, the American Mathematical Society and the Vietnamese Mathematical Society organized a joint meeting to encourage connections, collaborations, and friendship between the two countries’ mathematical communities. Given the fraught history between the two countries, the importance and symbolism of the conference were especially notable. During the cold war, even innocuous communication between mathematicians on the two sides was quite difficult. Even sending a letter, nevermind a conference to meet in person, was a rare event. More than a few results were discovered independently on both sides of the Iron Curtain. Progress was often held up due to not knowing of the latest advances on the other side. The Soviet Union, for example, made it difficult for its citizens to participate in the International Congress of Mathematicians. In an age where internationalism and science are treated with skepticism, building direct connections between countries’ citizens is a wonderful thing. The conference even made the local evening news!

Another great thing about these sorts of conferences is the breadth of mathematics covered. This meeting covered everything from topology to mathematical physics, from modeling natural gas flows in pipelines to groups and representations (my own area of research). As part of this, the meeting had six plenary talks by eminent mathematicians covering the various fields represented at the conference.

One of the speakers was Henry Cohn, arguably the world expert on sphere packings. Dr. Cohn gave a fantastic talk about the latest breakthroughs in this area. Nearly three years ago here at 3QD we talked about an amazing breakthrough in sphere packing. This included work by Dr. Cohn. As we’ll see, Dr. Cohn and his collaborators haven’t been napping. Read more »

Adrift On A Music Stream

by Anitra Pavlico

What has happened to music? To the joy of cozying up with your records, tapes, or CDs and your music source, whether it was a boom box, or stereo with faux-wood speakers taller than a small child, or Walkman? It used to be simple to figure out where to buy music and how to listen to it. You went to the local record store, and then you brought it home and absconded to your bedroom, where you cranked your new purchase as loud as you could before your parents knocked on the door and told you to turn it down. There was a spatial aspect to music, as the music store was obviously circumscribed in space, with different sections for different tastes. Listening also usually took place in an intimate setting, layered like a palimpsest with memories of years past. Well before five-disc (and then 100-plus-disc) CD changers, we listened to one album at a time, and usually with the songs in the same order that the artist or the producer intended. It was a form of communion, however illusory, with the musician. There were also visual and tactile elements, as you had something to hold in your hands and pore over–liner notes, album credits, lyrics, glossy pictures of the band members. Did anyone ever vote to relinquish these sensory companions to the music-listening experience?

I did not have access to the ultimate in high fidelity as a kid, and I remember practically gluing my ear to my Sony Dream Machine clock radio’s speaker. When my parents bought me my first “boom box” they managed to find one with only one speaker. It hardly boomed, but it was still more than sufficient. In my mind’s ear, even these devices had much better sound quality than the digital music we have come to rely on. At the source, at least, the sound was fuller, less broken down or compressed into heartless bits and bytes. We did also have a lot of vinyl, not because we were hipsters, but because it was the 1970s.

I can’t pretend that it always makes a difference, today’s lesser sound quality. It was a trade-off that didn’t trouble me for years as I joined the rest of the world in celebrating the fact that virtually my entire music collection could fit on an iPod that I could carry around with me. As years go by, and you simply lose the memory of what music used to sound like, you don’t realize that convenience has supplanted most of the other elements of the experience of listening to music. Read more »

What if Equality of Opportunity is a Bad Idea?

by Tim Sommers

In the first scene of the first episode of “The Wire”, McNulty asks the Corner Boy who witnessed the murder of his friend “Snotboogie”, for stealing the money from the pot in a crap game, why they let Snotboogie play, since he always tried to steal the money. The Corner Boy replies, “Got to. This is America, Man.”

This is America. Everybody gets to play. More than that, everybody gets an equal, or at least a fair, shot. Everybody deserves equal opportunity. Justice itself demands that we strive for equality of fair opportunity. Right?

I’m not sure. But I think not. I think equality of opportunity is a bad idea – all the worse because it seems so obviously like a good idea.

But how can one deny that we should strive for equality of fair opportunity? Here’s one way. If you think property rights override everything else, and you always have the right to do what you will with your property no matter what; then it follows that you don’t have to hire gay people if you don’t want to and you don’t have to serve people of color at your restaurant if you don’t want to. This is how Rand Paul, who fancies himself a libertarian, got in trouble – questioning the Civil Rights Act of 1964.

I have no sympathy for this way of being against equal opportunity. Of course, nondiscrimination, what is often called “formal” equality of opportunity, is a requirement of justice. I just don’t think we should call that equal opportunity. I would prefer that we treat the right not to be discriminated against as a basic liberty on par with free speech or the right to vote – maybe, even as part of, or an extension, of equality before the law. Read more »

The Last Chance

by Adele A. Wilby

Shade from the mango tree blocked out the light to my room. I felt into the darkness of my wardrobe, and as I did so I hoped a confused cobra had not gotten lost and slithered in and curled itself up and taken temporary residence in a corner amongst my clothes.  I walked my fingers down my pile of shirts until I recognised the texture of the one I wanted to wear, and dragged it out. Nervous excitement whirled around in my stomach.  Today could be the day, I thought, as my fingers fumbled to button up my shirt.  Perhaps I was being foolish: perhaps I shouldn’t go.

‘Let’s go. Let’s go.  It’s getting late,’ shouted the driver, as he gestured to the group of guerrillas languishing on the veranda waiting to get into the vehicle for their ride home. The murky green of the pick-up made it look more like a battle tank than a transport vehicle.

The four young men threw their carry bags into the back and clambered onto the vehicle and perched themselves on the seat. The cool breeze would fan their hair and their faces as they made their way along to their homes, and from where they could be on guard also. They held their Kalashnikovs tight and upright between their legs. They knew their lives depended on keeping a firm grip of that rifle as they passed through the jungle road where the known that lurked amongst the tangled foliage posed as great a threat as the unknown. Read more »

My Bauhaus: A tale of two cities

by Brooks Riley

Racing down a German autobahn at impossible speeds is like running past a smorgasbord when you don’t have time to eat. Exit signs fly by, pointing to delicious, iconic destinations that whet the appetite but that one has no time for: Hameln, Wittenberg, Quedlinburg, Eisenach, Erfurt, Altenburg, Jena, Weimar, Dessau—markers of histories whose tentacles reach into the present in ways that belie their sleepy status on the map. You suppress the urge to slow down and take the off-ramp instead of moving right along to a big-city destination You opt to remain on the asphalt treadmill with arrival anxiety, telling yourself that one day you will take the time to explore all this, just not right now.

That was my first brush with Dessau, as I was rushing somewhere else. I knew that it was a home of the Bauhaus and that it had been heavily bombed during the war—more than half of it destroyed. In the distance I could see the amorphous outline of a town I wanted to visit someday.

Destiny must have listened. For reasons that had nothing to do with architecture or the Bauhaus, I ended up spending time in both Weimar and Dessau—the two main locations of a movement that exerted an immeasurable influence on the future of architecture worldwide, and occupied an inordinate amount of downtime in my imaginary life. Read more »

Can the Climate Crisis Continue to Go Begging?

by David Introcaso

Two weeks ago the 9th US Circuit Court heard oral arguments in the Juliana v. the US case filed in 2015 by 21 children who petitioned the federal court to require the government to protect their Constitutional rights to life, liberty and the pursuit of happiness by addressing the climate crisis. In its defense the US argued the plaintiffs have “no fundamental constitutional right to a stable climate system,” or a “climate system capable of sustaining human life.”

It appears plaintiffs’ lives are in fact not protected.  In a just-published essay in The New England Journal of Medicine by Harvard’s Dr. Renee Salas and her colleagues concluded, “climate change is the greatest public health emergency in our time and is particularly harmful to fetuses, children and adolescents.” This is because recent reports including the US’s National Climate Assessment, the United Nations’ (UNs’) Intergovernmental Panel on Climate Change’s (IPCC’s) “Global Warming of 1.5ºC” and Lancet’s “Countdown on Human Health and Climate Change” all describe in agonizing detail rapid atmospheric warming from currently 1º Celsius to 2º Celsius within the next few decades are causing increasing flooding, wildfires, disease, starvation, forced migration and war.  According to a recent Carbon Brief study, the carbon budget of a child born today will have to be one-eighth that of one born in 1950 if they want to live in a world that is less than 2º Celsius warmer.

The Juliana case along with numerous related others was decades overdue.  Since Ronald Reagan, the Republican Party has denied or worked to undermine the life-extinguishing effects of atmospheric warming.  President Trump summarized his recent 90-minute discussion on the topic with Prince Charles by stating, “the US right now has among the cleanest climates.”  He refused to recognize climate science stating, “I believe there’s a change in weather and I think it changes both ways.” Incoherent rhetoric aside, the US Geological Survey recently decided to project climate crisis impacts only through 2040 rather than to the end of the century to avoid detailing the worst impacts of Anthropocene warming. Read more »

Everything you think you know about the death penalty is wrong

Nicholas Kristof in the New York Times:

President Trump is now calling for expanding the death penalty so it would apply to drug dealers and those who kill police officers, with an expedited trial and quick execution. A majority of Americans (56 percent, according to Gallup) favor capital punishment, believing that it will deter offenders or save money and presuming that it will apply only to the vilest criminals and that mistakes are not a serious risk.

All these assumptions are wrong.

My interest in the death penalty arises partly from a mistake of my own. At the beginning of 2000, I spoke to Barry Scheck of the Innocence Project, who told me about a white man on death row in Texas, Cameron Todd Willingham, whom he believed to be innocent. I discussed with editors the possibility of doing a deep dive into the case but let myself be lured away by the sirens of that year’s Iowa caucuses instead. I never wrote about Willingham, and he was executed in 2004.

Subsequent evidence strongly suggests that not only was Willingham innocent but that no crime was even committed.

More here.

Laser Destroys Cancer Cells Circulating in the Blood

Emily Waltz in IEEE Spectrum:

Tumor cells that spread cancer via the bloodstream face a new foe: a laser beam, shined from outside the skin, that finds and kills these metastatic little demons on the spot.

In a study published today in Science Translational Medicine, researchers revealed that their system accurately detected these cells in 27 out of 28 people with cancer, with a sensitivity that is about 1,000 times better than current technology. That’s an achievement in itself, but the research team was also able to kill a high percentage of the cancer-spreading cells, in real time, as they raced through the veins of the participants.

If developed further, the tool could give doctors a harmless, noninvasive, and thorough way to hunt and destroy such cells before those cells can form new tumors in the body. “This technology has the potential to significantly inhibit metastasis progression,” says Vladimir Zharov, director of the nanomedicine center at the University of Arkansas for Medical Sciences, who led the research.

More here.  [Thanks to Farrukh Azfar.]

Truth: A Love Story (a scientist discovers his own family’s secrets)

Stuart L. Schreiber in Harvard Magazine:

On July 17, 2017, my world turned upside down when I discovered that the man who raised me was not my biological father. What followed was a challenging path of learning and insight into family truths that ultimately brought great joy and made me a better person.

I am a biomedical truth seeker—looking to gain insights into human biology and our genomes in order to mitigate suffering and death from disease. By analyzing DNA variation in persons with and without disease, my research is providing blueprints for therapeutics that are safe and effective.

Good fortune has offered opportunities to realize my dreams. I’ve run a large lab with many of the best young trainees and scientists in the world during the past four decades at Harvard, and I co-founded the Broad Institute—now a 4,000-person biomedical center seeking “to propel the understanding and treatment of disease.” Following human biology-informed blueprints, my trainees and I are catalyzing the development of new types of medicine in diseases ranging from cancer to malaria. In the past 30 years, I’ve started a half-dozen biotechnology companies that have delivered novel medicines—including ones at Vertex Pharmaceuticals that are closing in on defeating cystic fibrosis. I’ve also been happily married to my true love, Mimi Packman, for 38 years.

These circumstances are highly unlikely. The physical and emotional trauma I experienced as a child and teenager, inflicted by my father, taught me the art of compartmentalization.

More here.  [Thanks to Ashutosh Jogalekar.]

Can Europe Come Together?

Jonathan Guyer in American Prospect:

Across the continent, many had anticipated further gains for far-right parties that masquerade in populism but spit raw racism. Thankfully, the so-called populist surge has been halted for the moment.

The elections offer a tale of two markedly different social democratic results: good in Spain and Portugal, and three of the Nordic countries now have left-led governments. The left recovered in the Netherlands, where the Dutch Labor Party had been comatose, and in national elections the Danish Social Democrats wrested control from the ruling liberal party and served a decisive defeat to the xenophobic Danish People’s Party.

But for socialist or social democratic parties in the largest member nations—Germany, France, and the U.K.—it was a wipeout. In the German EU elections, the Social Democrats came in third with 16 seats, running behind the conservative European People’s Party (29) and the Greens (24 seats). Nahles, the party chair, resigned. In France, the Socialists barely fielded a candidate list. And in Britain, Labour placed third.

Much of the continent-wide debate focused on the global climate emergency, which spelled success for greens. Left-green alliances are possible in several countries. So has the left recuperated across Europe—or simply bottomed out?

More here.

Mankind’s inner ant: why humans swarm together

Bryan Appleyard in New Statesman:

Say you walk into a café. You will be surrounded by strangers but you will not threaten or fight them. This is “one of our species’ most underappreciated accomplishments”. Most other vertebrates would only get their lattes if they recognised everybody in the café; Argentine ants would get a drink as long as everybody smelled the same. Only humans relax among total strangers because that is the way our societies work. On this peculiarity all history is constructed. As Moffett says: “Being comfortable around unfamiliar members of our society gave humans advantages from the get-go and made nations possible.” The human need for such societies shapes all our experience. People may say that the forms that differentiate societies – religious, political, moral, flags, anthems – are irrational, contingent or unreal. And so they are, but without them we are nothing. Humans imagine themselves into the security of their cafés. Moffett quotes the philosopher Ross Poole: “What is important is not so much that everyone imagines the same nation, but that they imagine that they imagine the same nation.”

Like the ants we need markers too, but these alone are not enough. Human societies also need an acceptance of “social control and leadership, along with increasing commitments to specialisations, such as jobs and social groups”. The first contentious implication of this is that, when we move out of our society, we remain always and irrevocably foreigners. In Moffett’s world nobody ever really blends in. From the moment we are born we are bathed in the mores of our society; by adulthood this conferred identity has become an absolute. We may thrive as foreigners but we will always be foreigners. Contemporary believers in fluid identities that float frictionlessly across different societies will find this bleak, even abhorrent. But they should bear in mind the other half of Moffett’s case. The very success of human societies rests on their ability to absorb foreigners. Without that we would still be living in small groups or bands. We are, like the ants, a densely populated species. The ants achieve this by breeding more of themselves; we do it by embracing others.

More here.