The new science of psychedelics

Tim Martin in New Statesman:

Seventy-five years ago, in April 1943, the research chemist Albert Hofmann did something distinctly out of scientific character. Impelled by what he later called a “peculiar presentiment”, he resolved to take a second look at the 25th in a series of molecules derived from the ergot fungus, a drug he had discovered some years earlier and dismissed as of no scientific interest. As he synthesised it for the second time, it made contact with his skin, giving rise to an unprecedented experience: a “stream of fantastic pictures [and] extraordinary shapes with intense, kaleidoscopic play of colours”. Five days later, on 19 April, he decided to test the chemical on himself under controlled conditions, thus becoming the first person in history knowingly to embark on an acid trip.

Intermittently ever since, psychonauts and countercultural enthusiasts have celebrated 19 April as “Bicycle Day”, in recognition of this Ground Zero of Western psychedelia. After cautiously ingesting a dose of LSD-25, Hofmann enlisted the help of a lab assistant and wobbled home on his bicycle, while his vision “wavered and distorted as though in a curved mirror”. Sprawled on the sofa, he underwent a “severe crisis” that, viewed through the telescope of 75 years of psychedelic experience, looks endearingly familiar: one in which demonic terrors, mystical encounters and loss of ego alternated with fantastic imagery, synaesthetic perception and a desire to drink “more than two litres” of the milk provided by a neighbour. This year, however, those celebrating Bicycle Day did so against a new background. After decades in the shadow of the 1960s counterculture, psychedelic drugs have emerged once again into the light of scientific orthodoxy. Researchers at major universities – Johns Hopkins in the US, Imperial College in London – have, over the past 20 years, been conducting experiments at growing scale to assess the effects of substances such as LSD, MDMA and psilocybin, the psychedelic compound in magic mushrooms. Their results suggest that these powerful molecules, long stigmatised as drugs of self-gratification or abuse, may instead be miracle treatments for the most intractable disorders of our time: depression, isolation, addiction and post-traumatic stress.

More here.

On the use and misuse of civility

Lewis H. Lapham in Lapham’s Quarterly:

The storms of rivalry and feud currently blowing through America’s internet portals rise to the wind-scale force of Wagnerian opera, but it’s hard to know whether the sound and fury is personal, political, or pathological. The stagings of vengeful lies to destroy a graven Facebook image, or the voicing of competitive truth that is the vitality of a democratic republic? The problem doesn’t yield to zero-sum solution. Hesiod’s twin Strifes are permanent members of the human condition; neither of them can be impeached. The pagan Greek poet was clear on the point. During his own lifetime, he was familiar with the news and fake news of the Trojan War wandering around on the eastern Mediterranean lecture circuit, and he would have known that cursed Strife “brings forth discord, nurtures evil war,” killed Hector, Agamemnon, and Achilles, bears “great honors to…gift-guzzling kings”; known also that blessed Strife launched a thousand ships, “spurs a man who otherwise would shirk” to surpass his neighbor in “racing to reach prosperity.” The difficulty is the knowing which one is which, with which one a man is better advised to keep company—with “mischief making,” “eavesdropping in the marketplace,” and the “spying on quarrels,” or trying to do his best with the Strife that is nearer to hand.

Machiavelli during his lifetime was personally acquainted with the cursed Strife inflicted on Florence by gift-guzzling Medici princes, also with the bonfiring of the city’s beloved vanities at the behest of Friar Girolamo Savonarola, a vengeful Dominican monk preaching the word of God as a howl of rage against the world, the flesh, and the devil. The history books tend to portray Machiavelli as a cynical Italian courtier supplying despots with murderous raisons d’état. The spin is travesty. Machiavelli was an idealistic civil servant who was also a poet and playwright seeking to provide early sixteenth-century Florence with a republican form of government. He rated the task as the most worthy of human endeavors when supported by a citizenry animated with the will to act instead of the wish to be cared for. To promote his effort to equip Florence with a civilian militia, and acting on his authority as second chancellor of the Florentine republic, Machiavelli in 1503–4 encouraged both Michelangelo and Leonardo da Vinci to burnish the walls of the Great Council Hall with the scene of a famous battle in which the free city of Florence defeated a rival city dependent for its freedoms on hired mercenaries.

More here.

Thursday Poem

Two Guitars

Two guitars were left in a room all alone
They sat on different corners of the parlor
In this solitude they started talking to each other
My strings are tight and full of tears
The man who plays me has no heart
I have seen it leave out of his mouth
I have seen it melt out of his eyes
It dives into the pores of the earth
When they squeeze me tight I bring
Down the angels who live off the chorus
The trios singing loosen organs
With melodious screwdrivers
Sentiment comes off the hinges
Because a song is a mountain put into
Words and landscape is the feeling that
Enters something so big in the harmony
We are always in danger of blowing up
With passion
The other guitar:
In 1944 New York
When the Trio Los Panchos started
With Mexican & Puerto Rican birds
I am the one that one of them held
Tight    like a woman
Their throats gardenia gardens
An airport for dreams
I’ve been in theaters and cabarets
I played in an apartment on 102nd street
After a baptism pregnant with women
The men flirted and were offered
Chicken soup
Echoes came out of hallways as if from caves
Someone is opening the door now
The two guitars hushed and there was a
Resonance in the air like what is left by
The last chord of a bolero.
.
by Victor Hernández Cruz
from”Two Guitars” from Maraca: New and Selected Poems, 1965-2000.
Coffee House Press. 2001

What We Talk About When We Talk About Liberalism

Helena Rosenblatt in the Boston Review:

Recent primaries have given Democrats reasons for hope, but they have also exposed fault lines within the party. Divisions are visible in the very labels used to describe them. Many use the word “liberal” as a catchall to describe left-of-center politics in general, but self-described leftists and members of the Democratic Socialists of America often characterize liberals and Democrats as their opponents—viewing them as the compromising centrists standing in the way of a more progressive or socialist agenda.

The language is telling. Some are “liberal Democrats,” others “establishment liberals.” Then there are “leftist” liberals and “progressive” ones. Alexandria Ocasio-Cortez, who ousted incumbent Joe Crowley in the Democratic primary for New York’s fourteenth congressional district, calls herself a “democratic socialist,” but she favors “progressive” policies. Andrew Gillum, by contrast, winner of the Democratic gubernatorial primary in Florida, favors a “progressive” platform, but categorically denies being a “socialist.” And Ayanna Pressley’s win in the seventh congressional district in Massachusetts has been described as the victory of an “unapologetic liberal” against the more “quiet” Michael Capuano—who is, nevertheless, “more liberal than Nancy Pelosi.”

Is this semantic murkiness a problem? Historian Sean Wilentz thinks it is, arguing recently in Democracy Journal that the confusion of terms reflects the “momentous muddle” in which Democrats find themselves.

More here.

Online Bettors Can Sniff Out Weak Psychology Studies, So why can’t the journals that publish them?

Ed Yong in The Atlantic:

Psychologists are in the midst of an ongoing, difficult reckoning. Many believe that their field is experiencing a “reproducibility crisis,” because they’ve tried and failed to repeat experiments done by their peers. Even classic results—the stuff of textbooks and TED talks—have proven surprisingly hard to replicate, perhaps because they’re the results of poor methods and statistical tomfoolery. These problems have spawned a community of researchers dedicated to improving the practices of their field and forging a more reliable way of doing science.

These attempts at reform have met resistance. Critics have argued that the so-called crisis is nothing of the sort, and that researchers who have failed to repeat past experiments were variously incompetentprejudiced, or acting in bad faith.

But if those critiques are correct, then why is it that scientists seem to be remarkably good at predicting which studies in psychology and other social sciences will replicate, and which will not?

Consider the new results from the Social Sciences Replication Project, in which 24 researchers attempted to replicate social-science studies published between 2010 and 2015 in Nature and Science—the world’s top two scientific journals.

More here.

With a single scholarly article, Lina Khan, 29, has reframed decades of monopoly law

David Streitfeld in the New York Times:

The dead books are on the top floor of Southern Methodist University’s law library.

“Antitrust Dilemma.” “The Antitrust Impulse.” “Antitrust in an Expanding Economy.” Shelf after shelf of volumes ignored for decades. There are a dozen fat tomes with transcripts of the congressional hearings on monopoly power in 1949, when the world was in ruins and the Soviets on the march. Lawmakers believed economic concentration would make America more vulnerable.

At the end of the antitrust stacks is a table near the window. “This is my command post,” said Lina Khan.

It’s nothing, really. A few books are piled up haphazardly next to a bottle with water and another with tea. Ms. Khan was in Dallas quite a bit over the last year, refining an argument about monopoly power that takes aim at one of the most admired, secretive and feared companies of our era: Amazon.

More here.

Jack Whitten’s Sculpture

Albert Mobilio at Bookforum:

In 1969 the painter Jack Whitten arrived in the town of Agia Galini, on the Greek island of Crete. Shortly before leaving New York he’d had a dream in which he was commanded to find a tree and carve it. From the bus window he spied the tree from his dream. He approached the owner, but because Whitten couldn’t speak Greek, the man thought he was saying he wanted to cut it down. Whitten came up with a plan to communicate his aim: “I went into the surrounding hills, found some wood and set up shop on the harbor beneath some trees.” The owner understood immediately and even lent Whitten his tools. The totem he carved still stands in the town—a fisherman looks to the sea, an octopus winds around the trunk, and at the very top “is a large fish with its tail pointing to the sky.” This account, published in Notes from the Woodshed, a volume of the artist’s reflections on his art and practice, provides a key to understanding the gestural, communicative power of Whitten’s sculpture. Just as he was able to impart meaning by doing rather than speaking that first day on Crete, his sculptures—currently exhibited for the first time in a show that has arrived at the Met Breuer (New York)—express their strong emotional and spiritual content by foregrounding the physical acts of their creation. Carved, chiseled, polished, and hammered into insinuating, assertive shapes, these pieces make viewers feel the actual work, and sense the very grip of the artist’s hand on the hammer as it finds the chisel’s head.

more here.

Becoming Kathy Acker

Chris Kraus interviews Olivia Laing at The Paris Review:

Yes, it was incredibly liberating, both to invent the character and to help myself to the ravishing grab-bag of Acker’s own work. Crudo is probably the only book I’ve really enjoyed writing, because it was so fast and so free. It was such a relief to ditch the I, but to keep all the real details of the world, to collage it together rather than inventing it afresh. I definitely have a horror of making shit up, but I also have a horror of confessional writing. It’s like the case studies in I Love Dick, I do want to write about the personal (mine, Acker’s, David Wojnarowicz’s and so on), but for political reasons.

What do you think of autofiction as a term? It makes me feel a bit sick, but I don’t quite know why. I think it’s the idea that it’s some vogueish new style, rather than something writers have always done. Is Proust writing autofiction? Is Virginia Woolf? What do you think about it, and roman-a-clef? Is that what you see yourself as doing? And why anyway do people feel such an urge to pin things down in terms of genre?

more here.

The Jobs Problem

Matthew Desmond at the New York Times:

Democrats may scoff at Republicans’ work requirements, but they have yet to challenge the dominant conception of poverty that feeds such meanspirited politics. Instead of offering a counternarrative to America’s moral trope of deservedness, liberals have generally submitted to it, perhaps even embraced it, figuring that the public will not support aid that doesn’t demand that the poor subject themselves to the low-paying jobs now available to them. Even stalwarts of the progressive movement seem to reserve economic prosperity for the full-time worker. Senator Bernie Sanders once declared, echoing a long line of Democrats who have come before and after him, “Nobody who works 40 hours a week should be living in poverty.” Sure, but what about those who work 20 or 30 hours, like Vanessa?

Because liberals have allowed conservatives to set the terms of the poverty debate, they find themselves arguing about radical solutions that imagine either a fully employed nation (like a jobs guarantee) or a postwork society (like a universal basic income).

more here.

Wednesday Poem

Forgive me, distant wars, for bringing
flowers home.
…………… –Wisława Szymborska

Why I Don’t Mention Flowers When Conversations
with My Brother Reach Uncomfortable Silences

In the Kashmir mountains,
my brother shot many men,
blew skulls from brown skins,
dyed white desert sand crimson.

What is there to say to a man
who has traversed such a world,
whose hands and eyes have
betrayed him?

Were there flowers there? I asked.

This is what he told me:

In a village, many men
wrapped a woman in a sheet.
She didn’t struggle.
Her bare feet dragged in the dirt.

They laid her in the road
and stoned her.

The first man was her father.
He threw two stones in a row.
Her brother had filled his pockets
with stones on the way there.

The crowd was a hive
of disturbed bees. The volley
of stones against her body
drowned out her moans.

Blood burst through the sheet
like a patch of violets,
a hundred roses in bloom.

by Natalie Diaz
From When My Brother Was an Aztec
Copper Canyon Press, 2012

Video games are an underrated art form

Tim Cross in More Intelligent Life:

For those who believe in the distinction between high art and low, video games have long been near the bottom of the pile. Fortunately, that has not stopped some of the world’s great art museums from putting on exhibitions. The Museum of Modern Art, in New York, began acquiring games in 2012 and a year later invited visitors to play some of them in a show called “Applied Design”. The most recent video-games exhibition, “Videogames Design/Play/Disrupt”, takes place at an even grander instituion – the Victoria and Albert Museum in London. The arriviste status of video games means that exhibitions about them – and especially those that take place in marbled bastions of established culture – risk coming across as cringing and defensive. The V&A, to its credit, mostly manages to avoid that trap. Instead it unapologetically addresses video games on their own terms, as a medium that, more than any other, combines art and storytelling with engineering and technology. The show kicks off with a quote from Frank Lantz, an academic and developer, that neatly summarises the blend of skills required. “Making games combines everything that’s hard about building a bridge with everything that’s hard about composing an opera. Games are operas made out of bridges.”

Parts of the process look like storyboarding for a film. The concept art and character sketches for the protagonists of “The Last of Us”, a post-apocalyptic survival game, show the attention to detail present in the designers’ creation of Ellie, the teenage girl that is the focus of the story. Other parts have no real parallel with other forms of art. Books and films, for instance, railroad readers and viewers along the plotlines invented by their authors. Games are different. Even those that focus on narrative rather than gameplay must give players enough choice and freedom to maintain the illusion that they are influencing a coherent, believable world – but not so much that anarchy reigns and storytelling becomes impossible. “Journey”, which puts players in the shoes of a pilgrim travelling towards a mysterious mountain, nudges its players towards interesting encounters with subtle tricks of light and shadow.

More here.

How Jocks and Mathletes Are Alike

Sarah Zhang in Nautilus:

From bulging biceps to 7-foot wingspans to a striking paucity of fat, elite athletes’ bodies often look quite different from those of the rest of us. But it’s not only athletes’ bodies that are different; their brains are just as finely tuned to the mental demands of a particular sport. Here are seven areas of the brain that enable seven different athletes to pull off extraordinary feats.

Winning a Battle of Wills

When the 1988 World Series started, Kirk Gibson, the best hitter on the underdog Los Angeles Dodgers, had injured both legs. He wasn’t even supposed to play. But at a key moment in Game 1, he was nevertheless called to pinch hit. He promptly took on one of a baseball player’s most challenging jobs: getting inside the head of the opposing pitcher. It was the bottom of the ninth, and the Dodgers were down by one, with a runner on base and two outs. Dennis Eckersley, one of the greatest closers in baseball history, was pitching. The count on Gibson went to three balls and two strikes. Douglas recalled a bit of advice from Mel Didier, a Dodgers scout. “Now remember, and don’t ever forget this, if you’re up in the ninth inning and we’re down or it’s tied and you get to 3-and-2 against Eckersley,” said Didier retelling the conversation later in ESPN, “Partner, sure as I’m standing here breathing, you’re going to see a 3-2 backdoor slider.” Sure enough, a slider came breaking toward Gibson. He swung awkwardly, unable to use his legs, but he had the advantage of knowing exactly what pitch was coming. The ball sailed into the stands in right field. The Dodgers won the game and, eventually, the series.

More here.

Academic Activists Send a Published Paper Down the Memory Hole

Theodore P. Hill in Quillette:

In the highly controversial area of human intelligence, the ‘Greater Male Variability Hypothesis’ (GMVH) asserts that there are more idiots and more geniuses among men than among women. Darwin’s research on evolution in the nineteenth century found that, although there are many exceptions for specific traits and species, there is generally more variability in males than in females of the same species throughout the animal kingdom.

Evidence for this hypothesis is fairly robust and has been reported in species ranging from adders and sockeye salmon to wasps and orangutans, as well as humans. Multiple studies have found that boys and men are over-represented at both the high and low ends of the distributions in categories ranging from birth weight and brain structures and 60-meter dash times to reading and mathematics test scores. There are significantly more men than women, for example, among Nobel laureates, music composers, and chess champions—and also among homeless people, suicide victims, and federal prison inmates.

Darwin had also raised the question of why males in many species might have evolved to be more variable than females, and when I learned that the answer to his question remained elusive, I set out to look for a scientific explanation.

More here.  And here is a rebuttal by the Fields Medalist Sir Tim Gowers writing in his own blog:

I was disturbed recently by reading about an incident in which a paper was accepted by the Mathematical Intelligencer and then rejected, after which it was accepted and published online by the New York Journal of Mathematics, where it lasted for three days before disappearing and being replaced by another paper of the same length. The reason for this bizarre sequence of events? The paper concerned the “variability hypothesis”, the idea, apparently backed up by a lot of evidence, that there is a strong tendency for traits that can be measured on a numerical scale to show more variability amongst males than amongst females. I do not know anything about the quality of this evidence, other than that there are many papers that claim to observe greater variation amongst males of one trait or another, so that if you want to make a claim along the lines of “you typically see more males both at the top and the bottom of the scale” then you can back it up with a long list of citations.

You can see, or probably already know, where this is going: some people like to claim that the reason that women are underrepresented at the top of many fields is simply that the top (and bottom) people, for biological reasons, tend to be male. There is a whole narrative, much loved by many on the political right, that says that this is an uncomfortable truth that liberals find so difficult to accept that they will do anything to suppress it. There is also a counter-narrative that says that people on the far right keep on trying to push discredited claims about the genetic basis for intelligence, differences amongst various groups, and so on, in order to claim that disadvantaged groups are innately disadvantaged rather than disadvantaged by external circumstances.

I myself, as will be obvious, incline towards the liberal side, but I also care about scientific integrity, so I felt I couldn’t just assume that the paper in question had been rightly suppressed.

More here.

Sean Carroll’s Mindcast Podcast: Neha Narula on Blockchain, Cryptocurrency, and the Future of the Internet

Sean Carroll in Preposterous Universe:

For something of such obvious importance, money is kind of mysterious. It can, as Homer Simpson once memorably noted, be exchanged for goods and services. But who decides exactly how many goods/services a given unit of money can buy? And what maintains the social contract that we all agree to go along with it? Technology is changing what money is and how we use it, and Neha Narula is a leader in thinking about where money is going. One much-hyped aspect is the advent of blockchain technology, which has led to cryptocurrencies such as Bitcoin. We talk about what the blockchain really is, how it enables new kinds of currency, and from a wider perspective whether it can help restore a more individualistic, decentralized Web.

More here.

Dumb Messenger

Anjuli Fatima Raza Kolb at the Poetry Foundation:

In halls and moods of violent possession, we speak of languages as things we “have.” This mood comes easy when the books are small and green—a Loeb’s fits in the palm like a secret jewel, a perfect bun. Its loose-woven ribbon reminds us the gift is inside, our reading an unwrapping—happy birthday to our most serious, our highest mind. In the early aughts, I was often high haha.

In those days, when I was still a teenager, I went over and over the lines in the Timaeus that told me what we might be about. Our atoms and waves, our tides and our matter. I didn’t know then how much of this is in Lucretius, too, from the Atomists, and also in a lot of hokey theory that comes out now about mycology and the end times. I worry that if these idiot dialogues are the kind of philosophy that covers up its poetry—lets people forget about, well, people and their errors, language and its habit of always running away and wild, which also means forgetting about justice—then maybe the Timaeus is also bad, since it telegraphs messages about ideal forms and eternal essences, whether it wants to or not. I mostly think philosophy is bad when we forget it’s poetry. Don’t talk to me about Plato on this subject.

More here.

How Teeth Became Tusks, and Tusks Became Liabilities

Natalie Angier in The New York Times:

GORONGOSA NATIONAL PARK, Mozambique — We are flying in a Bat Hawk aircraft — which may be named for a raptor that preys on bats but looks more like a giant, lime-green dragonfly — and my hair, thanks to the open cockpit, has gone full Phyllis Diller. Scudding above flood plains the color of worn pool table felt and mud flats split like jigsaw puzzles, we dip toward the treetops and see herds of waterbuck scatter with an impatient flash of their bull’s-eye rumps. We are searching for the elusive tuskless elephants of Gorongosa, elephants that naturally lack the magnificent ivory staffs all too tragically coveted by wealthy collectors worldwide. Tuskless elephants can be found in small numbers throughout Africa, but Gorongosa is known to harbor a sizable population of them, the legacy of a violent 15-year civil war. Tusked elephants were slaughtered for their ivory at a harrowing rate, and the park’s rare tusk-free residents thus gained a sudden Darwinian advantage. Today, about a quarter of the park’s 700 or so elephants are tuskless, all of them female, and I am determined to catch a glimpse of at least one. Yet a week of ground searches has proved fruitless, and now we are circling in a plane and still nothing and, holy mother of Horton, how can such massive creatures go missing?

“There!” Alfredo Matavele, the pilot, cries triumphantly, pointing toward a cluster of trees. “And there!” pointing toward a watering hole. And there and there. “Do you see them?” he demands. Oh yes, I see them. Dozens, scores, cliques and claques of elephants, ears flapping like flags, trunks slowly swinging, and many of their faces decidedly free of ivory eruptions. I have found them at last, my sisters in dental deprivation. Other people may admire elephants for their brains or their complex social lives; I feel a bond with this mutant crew. After all, I’ve learned that we share a basic developmental anomaly, which may well be traceable to the same underlying glitches in our DNA. Elephant tusks happen to be overgrown versions of the upper lateral incisors — the teeth right next to the front teeth, before you get to the canines. Simply put, tuskless elephants lack lateral incisors.

More here.

Anatomy of a beep

Eric Boodman in Stat News:

WASHINGTON — As deals struck by health care behemoths go, this was one of the stranger ones. On one side, you had a medical device giant, with a phalanx of PR professionals carefully guarding the company’s image. On the other, you had a consultant who didn’t sound much like a consultant:

“I am synthetic life form ‘Yoko K.,’ assembled in the US with components made in Japan,” one of her websites explained. “I am designed to assume the role of an ‘electronic musician.’ I am one of many secret agents sent to this time to plant magical thinking in people through the use of ‘pre-22nd century nostalgia Mars pop music.’”

In other words, Yoko K. Sen is an ambient electronic musician, born in Japan but transplanted to the United States, where she’s layered her breathy, machine-modulated vocals over ethereal blooms of synth at galleries, in concert halls, and on award-winning albums. In recent years, though, she’s created a new, more corporate niche for herself: revamping the soundscape in hospitals. Medtronic had hired her, late in 2017, for a related project, to help design the beeps patients would hear from their cardiac monitors at home.

We live in an era of constant redesigns, and health care — with its cheerless institutional bent and vomit-like color palette — has proven especially ripe for reimagining. Fashion icons have taken on the hospital gown. Architects have gone after the hospital room, and celebrity chefs have barged into the cafeteria. One bigwig San Francisco designer even tried to rebrand death. You name it, there’s probably someone out there working to give it a makeover. And sometimes, these aesthetic changes might just save lives. As the New York Times reported in 2014, when patients moved into homier hospital rooms as a test, they not only felt more comfortable but also requested less pain medication.

More here.

Tuesday Poem

Violets

Down by the rumbling creek and the tall trees—
…. where I went truant from school three days a week
…….. and therefore broke the record—
there were violets as easy in their lives
….. as anything you have ever seen
……… or leaned down to intake the sweet breath of.
Later, when the necessary houses were built
…… they were gone, and who would give significance
………. to their absence.
Oh, violets, you did signify, and what shall take
…… your place?

by Mary Oliver
from Evidence
Beacon Press, 2009