by Jenny White
I’m a faithful reader of the New York Times Science Section, cover to cover, because I want to know about things, not be caught flatfooted. Somehow it seems necessary for survival to know about quarks and bosons, the social structure of ants, scientific explanations of the smile, and the sexual life of grapes. I had a fling with books explaining how to endure being stranded in snow (make an igloo) and identify edible weeds in the park. What does this say about me? I never kept any extra food in the house beyond what was fresh in the fridge until after 9/11 when I laid in some canned beets and tomato sauce and a gallon jug of water. The tomato sauce exploded and the water leaked, so clearly I am batting zero as a survivalist. Perhaps knowing things about the world lets me feel that nothing can surprise me, jump out of the dark corners beyond my peripheral vision. Illness is like that. Two months ago I saw spots and flashes in my right eye and was told I had a partially detached retina. Why? No reason. Out of the blue. Once I was allowed to read again after the repair, I read a lot about retinas. But what do we really learn about how illnesses and the body work from reading popular science? Recently, I had a long conversation with a prominent scientist at Harvard, the molecular biologist Michael R. Freeman, who explained to me what cancer was. It wasn’t anything I expected, even after years of reading science stories. It was as if he had opened a door into an alternate universe. Below is a transcript of part of our conversation.
Jenny White: Tell me what we should know about cancer?
Michael Freeman: Cancer is an uncontrolled proliferation of cells, so a tumor is actually is a swelling or a cyst, something that isn’t necessarily life-threatening, but a malignancy is something that has the potential to grow and spread in the body and its the spreading in the body as well as the growth that is lethal. We’re still trying to understand fundamental processes that are part of cancer. A recently recognized process involved in cancer, for instance, is autophagy, which means “self-eating.” This is a normal way that cells use to conserve energy and nutrients, and it’s a process that can be used by cancer cells to progress to malignant states. Tumor cells generally are in a very stressful environment, so there’s a Darwinian pressure to select for variants that can overcome various stresses. So if you’re a tumor cell and your descendants have the ability to take in nutrients from this process of autophagy, then you have a selective advantage over other cells that might be killed in the stressful environment.
JW: So basically the Pac-Man cells survive because they eat the cells surrounding them.
MF: They actually eat themselves.
JW: Are there any other cool concepts that are out there? Autophagy, self-eating Pac-Man cells. What else is going on?
MF: There’s another concept that was very new when I was a postdoctoral fellow, but is now very much understood to be a fundamental process in tumor biology, which is apoptosis or programmed cell death. This is a program that cells initiate that causes them to die. It’s basically cell-suicide. There are signaling molecules that can initiate the suicide program that’s built into the cell. This is a normal process that takes place during development. The fingers on your hand were created in part through an apoptopic mechanism, where the webbing between the digits was formed by cells killing themselves. In development, in the formation of the body plan, there’s growth as well as loss of structure. It even happens during normal life as an adult. It’s like what a sculptor does, right? A sculptor creates form by removing things.


