Archa Fox in The Scientist:

I have a clear memory of presenting my initial results about a “failed” protein at a lab meeting with my postdoctoral advisor Angus Lamond at the University of Dundee in Scotland and the rest of his group. It was the summer of 2000, and for the first few months of my postdoc I had been fusing green fluorescent protein with novel proteins that had recently been identified by mass spectrometry as residing in the nucleolus. I engineered HeLa cells to produce copious amounts of these fusion proteins, and watched where they went. Most migrated to the nucleolus, as expected, but one protein steadfastly refused. Instead, it formed nuclear dots that were much smaller than the large and obvious nucleoli. I was really worried about the messiness of this result, but also intrigued. To my relief, instead of being disappointed that the protein was not doing what we had expected, Angus and my lab mates encouraged me to explore it further. The group had access to antibodies against many cellular structures, so I quickly established that these nuclear dots were different from any known nuclear bodies. But having generated much of my data with overexpressed protein, it was critical to make sure that the endogenous form of the protein also localized to the same nuclear dots, and that what I had seen were not simply artifacts of my approach.

We created an antibody against the protein and incubated it with HeLa cells. It was an incredibly nerve-wracking moment looking down the microscope to see what the antibody had stained. Thankfully, it worked. I was ecstatic when I saw that it had picked out the same small nuclear dots that I had identified with GFP. In 2002, I published a manuscript introducing the scientific community to paraspeckles— orbs of protein and nucleic acid 360 nanometers in diameter, squeezed next to the more famous and larger structures called nuclear speckles. Since then, paraspeckles have become an established part of cell biology; there are more than 250 articles on them, and they have already found their way into some textbooks. We now know they are membraneless organelles seeded by a long noncoding RNA (lncRNA), formed through a well-characterized physical phenomenon known as liquid-liquid phase separation, and composed of numerous proteins and RNA molecules. We also know that they can alter gene regulation when cells get stressed, an important mechanism for maintaining cell homeostasis and one that appears to be disrupted in many diseases.

More here.

Holly Case in Aeon:

In August 1989, just a few weeks before the Berlin Wall came down, the East German writer Christa Wolf offered her view on the possibility of German reunification. Wolf had remained a communist party member until June that year, and even thereafter she espoused her Leftist convictions to the shrinking number of people who openly shared them. She firmly stated her opposition to the merger of the two Germanys. ‘[R]eunification – as the annexation of the smaller, poorer part of Germany to the larger, wealthier one – would render the self-critical treatment of our past much more difficult,’ she argued. The people of the German Democratic Republic (GDR) should instead try on their own terms to realise the dream of a truly ‘democratic socialism’ in a state where ‘contradiction’ can be not only ‘tolerated’ but even ‘made productive’. If the GDR were to simply disappear, the necessary opposite – Germany’s own ‘double meaning’ (a recurring theme in her literary work) – would disappear along with it, to catastrophic effect. Collapsing the two Germanys into one, in other words, would destroy it.

Just as Wolf decried the merger of the two Germanys, several decades earlier Herbert Marcuse mourned the merger of two dimensions in his book One-Dimensional Man (1964). Marcuse, a German philosopher of the Frankfurt School whose members devised a form of Western Marxist philosophy known as critical theory, offered an analysis of the homogenising effects of consumerism.

More here.

Adolph Reed Jr. in The New Republic:

People who embrace anti-racist politics now regularly denounce the New Deal as a model for universalist social and economic reform on the grounds that many of its signature programs discriminated against African Americans. Some of these detractors simply dismiss the New Deal as racist and have gone further to argue that all universal programs—i.e., initiatives that are officially designed to benefit everyone—are racist and will not help black Americans. They argue instead that only government and market interventions targeted solely to African Americans should count as benefits for black people.

It is certainly true that black Americans received less than whites on the average from many New Deal programs, but it’s not true that they didn’t receive benefits. Often, critics who dismiss the New Deal as racist focus on racial disparity—the fact that in many programs, smaller overall percentages of African Americans benefited than the percentages of whites, or that African Americans received lower benefits on average—and ignore the degree to which African Americans actually did benefit.

J. Daniel Elam in Public Books:

The most telling chant of the 2019 Hong Kong protests is “Liberate Hong Kong, the revolution of our times” (光復香港 時代革命), not because it offers a vision for “revolution,” but because it reveals the protesters’ accurate assessment of “our times.”

Very few protesters expect that Hong Kong will be “liberated” from its status as a special administrative region of the People’s Republic of China. Although the protest movement borrows the language of Cold War decolonization movements, the demand for Hong Kong’s “liberation” is not quite a demand for national sovereignty. It is, more accurately, a plea to let Hong Kong remain liberal: to let Hong Kong remain the island of unregulated global capitalism that it has been since the 19th century. This is why “revolution” seems, at first glance, an ill-fitting term: this is not a revolutionary politics in the traditionally optimistic or utopian sense.

But that is not to say that the protesters are conservative, naive, or uninformed. Indeed, to claim that the pro–Hong Kong protesters have no overarching political vision or historical perspective is to grossly underestimate their intelligence. The protesters offer a clear-eyed assessment of the global present—“our times”—and their demands are designed for the compromised world that we have made. Liberation and revolution can no longer promise us that we “have nothing to lose” or a “world to win,” in Marx and Engels’s formulation. “Our times” require a revised revolutionary vision that is merely necessary, dismally insufficient, and ultimately impossible: liberation for a future in which there’s nothing left to win or lose, for anyone.

More here.

Anna Deavere Smith in the New York Review of Books:

Elwood Curtis is a junior at Lincoln High School in Tallahassee, Florida, when we meet him in Colson Whitehead’s latest novel, The Nickel Boys. It’s 1962, and Elwood’s prized possession is a Martin Luther King at Zion Hill record that his grandmother, Harriet, bought him for a dime outside the Richmond Hotel, the fancy establishment where she works. He listens to King’s speeches and thinks about them often: “Throw us in jail and we will still love you,” King says, his voice reverberating in Elwood’s head:

But be assured that we will wear you down by our capacity to suffer, and one day we will win our freedom. We will not only win freedom for ourselves, we will so appeal to your heart and your conscience that we will win you in the process and our victory will be a double victory.

Elwood lives with his grandmother in the predominantly black neighborhood of Frenchtown. His parents left him with her when he was six and moved to California without saying goodbye; he hasn’t heard from them since. Now a teenager, he likes to hang out at Marconi’s tobacco store. He has “a curious habit where he read every comic front to back before he bought it, and he bought every one he touched.” When Mr. Marconi asks why he goes through all that if he’s going to buy them whether they are good or not, Elwood says, “Just making sure.” But a more telling sign of his personality is that he buys what he touches because that’s the right thing to do.

More here.

Alex Preston at The Guardian:

“Am I a real addict now? I ask. Yes, he says, with his shy, tentative smile, now you are a real addict.” The Copenhagen trilogy, Tove Ditlevsen’s majestic memoir of art and addiction, was originally published in Danish in the late 1960s and early 70s, and now appears in English for the first time, translated by Tiina Nunnally and Michael Favela Goldman. The three novella-length books are called Childhood, Youth and Dependency and trace the arc of Ditlevsen’s story from birth to literary stardom to the seamy, grasping years of addiction that ended with her suicide in 1976. The trilogy is stridently honest, entirely revealing – she makes no effort to hide the many shameful episodes of a shambolic, drug-addled existence – and, in the end, devastating.

Ditlevsen was born in Vesterbro, Copenhagen, in 1917, the daughter of a fretful, socially ambitious mother and a socialist father who was fired from one job after another for his politics. Their down-at-heel neighbourhood is full of drunks, and the future for Ditlevsen is – at best – one of marriage to a “stable skilled worker”.

more here.

Scott Bradfield at the LA Times:

You can take the writer out of California but you can’t take California out of the writer — or at least so I prefer to imagine, in my romantic fashion, during these dark days in which everything beautiful about the Golden State seems to be burning.

Jean Stafford was born and raised in California (on a West Covina walnut farm). While she spent her life continually moving east (to Colorado, Missouri, New York), Stafford often looked back fondly at the West’s wide amenable spaces.

In many further ways, she swung restlessly across extremes. She studied, worked and partied with both members of the Southern-based “Fugitives” (poets and critics like Allen Tate and Robert Penn Warren), who argued that artful writing was more about form than experience, as well as the more East Coast-leaning Partisan Review crowd (Edmund Wilson and Mary McCarthy), who argued, well, the opposite.

more here.

Dwight Garner at the NY Times:

“A sense of humor is just common sense, dancing,” he wrote. “Those who lack humor are without judgment and should be trusted with nothing.”

He said of George W. Bush that he “should not be delivering a State of the Union address. He should be delivering pizza.” He compared Arnold Schwarzenegger’s torso to a “condom full of walnuts.” He made fun of his own looks, comparing himself to a bank robber who forgot to take the stocking off his head.

He told an editor, “Listen, if I wrote like that, I’d be you.” Reviewing a memoir by Leonid Brezhnev, he declared: “Here is a book so dull that a whirling dervish could read himself to sleep with it. If you were to recite even a single page in the open air, birds would fall out of the sky and dogs drop dead.”

more here.

Jennifer Szalai in The New York Times:

Books about mental illness often reflect on how reality is experienced. In addition to the standard questions — What do we know, and how do we know it? — is another layer of inquiry: What do we know about our own minds, and what if it isn’t true? In her first book, “Brain on Fire,” Susannah Cahalan described her horrifying experience of presenting symptoms of mental illness that looked like schizophrenia but turned out to be an autoimmune disease. She eventually received the treatment she needed, but the tortuous ordeal disrupted her assumptions about the medical profession and her sense of self. Her next project promised to be straightforward by comparison: She would use her skills as an investigative journalist to write about somebody else — a scientist and his pathbreaking study. In 1973, the psychologist David Rosenhan published “On Being Sane in Insane Places” in the journal Science, helping to upend the field of psychiatry. He had recruited healthy volunteers to feign symptoms of mental illness and get admitted to hospitals, thereby showing how easily “sane” people could get institutionalized by a profession that had enormous confidence in its diagnoses and had accumulated a vast amount of power. Cahalan decided to track down these volunteers, or “pseudopatients.” She had landed on a puzzle that seemed to be missing only a few pieces.

What she unearthed turned out to be far stranger, as documented in her absorbing new book, “The Great Pretender.” It’s the kind of story that has levels to it, only instead of a townhouse it’s more like an Escher print. On one level: A profile of Rosenhan and his study. On another: Cahalan’s own experience of researching the book. And on a third: The fraught history of psychiatry and the pursuit of scientific knowledge.

More here.

Lewis Lapham in Lapham’s Quarterly:

The warming of the planet currently spread across seven continents, four oceans, and twenty-four time zones is the product of a fossil-fueled capitalist economy that over the past two hundred years has stuffed the world with riches beyond the wit of man to marvel at or measure. The wealth of nations comes at a steep price—typhoons in the Philippine Sea, Category 5 hurricanes in the Caribbean, massive flooding in Kansas and Uttar Pradesh, forests disappearing in Sumatra and Brazil, unbearable heat in Paris, uncontrollable wildfires in California, unbreathable air in Mexico City and Beijing. The capitalist dynamic is both cause of our prosperous good fortune and means of our probable destruction, the damage in large part the work of Adam Smith’s invisible hand, guided by the belief that money buys the future. Nature doesn’t take checks. Who then pays the piper—does capitalism survive climate change, or does a changed climate put an end to capitalism? The question informs this issue of Lapham’s Quarterly, and in place of an answer, it offers observations that follow along the line of my learning to ask it.

Eighty-five percent of the carbon now present in the atmosphere is the value added during the course of my lifetime, 2.5 trillion tons, roughly equivalent to one thousand times the total weight of all the fish in the sea. I was fifty years old before I knew it was there, much less understood it to be a problem. Born and baptized in Rachel Carson’s Neanderthal age of biology and philosophy, I grew up in the city of San Francisco in the 1940s, so far apart from nature I assumed most of it located in Africa, picturesque specimens to be seen in Golden Gate Park and the San Francisco Zoo. The streets in my neighborhood bore the names of trees—Walnut and Cherry, Laurel, Chestnut, and Spruce. I didn’t wonder what the trees themselves might look like; nor was I familiar with the birds, plants, insects, and animals living on the far side of the Presidio wall, half a block from my boyhood home. Like most city-bred children of my generation (especially those among us brought up under the protection of money and machines), I thought bread came from the baker, light from a bulb, milk from a bottle. At grammar school during the Second World War, I devoted the free study periods to sketching the silhouette of every fighter plane and bomber in the American, German, and Japanese air forces.

More here.

The wall dematerializes as a form and allows the name to become the object…
– Maya Lin, designer of the Vietnam Veterans Memorial

Walls and Mirrors, Fall 1982

The English translation of my surname is walls
misspelled, the original s turned to its mirrored
twin, the z the beginning of the sound for sleep.

I’m nearly twelve and the mirror is a disaster I
learn to turn away from, the girl looking back
always looking to extract her pound of flesh.

I had a simple impulse to cut into the earth,
Maya Lin is writing as the mirrored wall
of names she’s made is arranged and laid

against the riven hillside. I never looked
at the memorial as a wall, she writes, but
as an edge to the earth, an opened side.

For a wall to become a mirror it must not
absorb or scatter too much light; for a girl
to become the protagonist she must sleep

with the guy or until he kisses her awake.
Sometimes we know she’s the fairest one
of all because of the mirror on the wall.

Sometimes she must scale the city’s walls
to bury the guy. Antigone cuts into the earth
to give him his proper memorial. She ends

up the heroine and buried alive, an in-be-
tween thing, like someone who’s eleven or
nearly twelve. When I look at the number

11 I see two walls, my name and its mirrored
twin. Sometimes 11 resembles the mirrored
L’s at the end of wall or the beginning of llanto,

the Spanish word for weeping. Sometimes 11
looks like a pair of railway sleepers arranged
and laid along a track that’s always leading me

back to my war-worn father. Sometimes the guy
comes back from battle and has seizures
in his sleep and the girl must shake him awake.

Sometimes the wall and the name are one
and the same. Sometimes the wall is where
we end up to begin letting go our llanto.

by Deborah Paredez
from Split This Rock

Suzanne Raga in Mental Floss:

1. HE MET HIS FIRST WIFE IN KINDERGARTEN.

Born in Indianapolis, Indiana in 1922, Vonnegut met his future wife, Jane, in kindergarten. Although they dated as teenagers in high school, their relationship paused when Vonnegut went to Cornell University, dropped out to serve in World War II, and became a prisoner of war in Germany. After returning to the U.S., he married Jane in 1945. The couple had six children—three biological and three adopted—but divorced in 1971.

2. HIS MOTHER COMMITTED SUICIDE ON MOTHER’S DAY.

When Vonnegut was born, his parents were well-off. Kurt Sr., his father, was an architect and Edith, his mother, was independently wealthy from the brewery that her family owned. But due to Prohibition and the Great Depression, the family struggled to make ends meet, sold their home, and switched their son to a public school. Edith, who suffered from mental illness, became addicted to alcohol and prescription pills. In 1944, when Vonnegut came home from military training to celebrate Mother’s Day, he found Edith dead.

More here.

Taylor Kay Phillips and Felipe Torres Medina in McSweeney’s:

LAIUS: Pardon my delay, Socrates! And thank you for being such a gracious host on this feast of thanks! My chariot got delayed at Crete. I had to wait at Terminal B for two hours and I was not going to pay 43 drachmas for that pita bread with cheese the Etruscans sell.

SOCRATES: Enter, Laius. You must be famished! The turkey is nearly ready, but please help yourself to some sides.

LAIUS: Thank you for being such a gracious host, Socrates, but seeing as I have waited so long I rather will wait for the turkey to be ready.

SOCRATES: Do you not favor the sides? We have casserole of green beans slathered in Campbellios’s cream of mushroom soup and laden with Funyuns, sweet potato candied with sugar, and potatoes mashed and covered with fine goat cheese.

LAIUS: Gracious host, the sides look delicious, but without the central dish of turkey, they and the meal itself are incomplete. The turkey is, as they say, the reason for the season.

More here.

Wilfred M. McClay in The Hedgehog Review:

Food is a many-splendored thing, and its meanings too are manifold. It upholds the life of both our higher and lower selves, and most things in between. Indeed, the ways we think about our food might well be taken as a rough index of what we consider those two words higher and lower to mean more generally, and, in turn, of what our conception of that axial division tells about ourselves and the world picture we carry around in our heads.

Of course, there is always a danger of overinterpretation, and the subject of food, like that of music, notoriously lends itself to untethered reflections and inflationary writing. Sometimes a cigar is just a cigar, and sometimes food is just fuel for the body. But that’s true far less often than one might think, and it’s almost never simply and entirely so. As the sunflower turns its face toward the sun, so our experiences with food tend to turn us toward thoughts of things greater than food, borne up by the power of our cultural and spiritual expectations.

To begin with perhaps the most salient examples of this truth, consider the dietary codes imposed by so many of the world’s great religions—Judaism, Islam, and Hinduism, among others.

More here.

Karl Schlögel at Eurozine:

Looking and listening around today, one sometimes gets the impression that the ‘historical moment’ of 1989, with all its excitement and happiness, never occurred – that the event witnessed by many of us has vanished under a mountain of interpretation and reflection; that ‘in fact’ all that happened on the streets of Berlin, Prague, Warsaw, Bucharest and elsewhere was mere self-deception, an illusion, surreality. Despite all the documentaries, the newsreels and interviews, the experience of people appears to have largely been forgotten – people who first crossed the open border, striding enthusiastically or strolling, exploring a world that had been closed to them their entire lives, the thrill of liberty, of the freedom of movement, of reading newspapers they never had access to before, of visiting relatives in the West.

This ‘historical moment’ had its illusions, but it was not illusory. It cannot be ‘deconstructed’ or undone. It was part of a great movement of European liberation.

more here.

Jonathan C. Creasy at the Paris Review:

Grouping writers into “schools” has always been problematic. The so-called Black Mountain poets never identified themselves as such, but the facts of their union spring from a remarkable instance of artistic community: Black Mountain College and the web of interactions the place occasioned. Founded in the mountains of western North Carolina in 1933 and closed by 1956, the college was one of the most significant experiments in arts and education of the twentieth century. In recent years, a number of international exhibitions and publications have showcased the range of artwork produced at the college’s two campuses, the first situated in the YMCA Blue Ridge Assembly, and the second at Lake Eden in the Swannanoa Valley. The list of famous names associated with Black Mountain is as impressive as it is unlikely, given that the college never housed more than a hundred students and faculty at a time, often far fewer.

Difficult questions persist in attempting to define a “Black Mountain” school of poets. Do we look to the physical and historical circumstances of Black Mountain College, or the complex pattern of friendships, influence, correspondence, publication, and collaboration that constitute the broader notion of this artistic coterie?

more here.

Robert Douglas-Fairhurst at the TLS:

He was often in trouble. There was his love of gambling, which he nurtured so carefully that at the Playboy Club in the 1960s he demonstrated how to play three games of pontoon simultaneously, keeping all the mathematical calculations ticking over in his head and accepting his losses as cheerfully as if they belonged to someone else. (Given how often he borrowed money there’s a good chance they did.) There were his regular dips into London’s criminal underworld: at one stage he was rumoured to owe the Krays half a million pounds; on another occasion he rang a friend asking for £1,500, “and if I haven’t got it by twelve o’clock they’re going to cut my tongue out”. Then there were the unpredictable bursts of violence, pushing one girl out of a car when she wouldn’t go home with him, and kicking a man in a pub for talking out of turn. Yet from Lucian Freud’s point of view such events were merely distractions from a far more serious fight, which was the one he had with himself every day. Even catching sight of himself in the mirror he kept in his studio could feel like an encounter between two strangers. “I don’t accept the information I get when I look at myself”, he explained, “and that’s when the trouble starts.”

more here.

Joshua Mitchell in City Journal:

Today, the problem of existential homelessness has become acute. Growing rates of anxiety, loneliness, and suicide offer statistical confirmation. Facebook and Amazon are among the largest and most powerful corporations on the planet, yet the realization is dawning that social media “friends” are poor substitutes for the real thing and that man cannot live by online shopping alone. (See “When Supplements Become Substitutes,” Autumn 2018.) The mobile phone connects us to the world but imprisons us inside ourselves. Human life must be lived at human scale, in the face-to-face relations of everyday life. These flesh-and-blood connections extend from our local neighborhoods to the nation­­—the largest durable community known to man.

Since 1989 and the end of the Cold War, though, we have increasingly tried to build a world without attention to these communities—building it instead around the configuration of what I call “management society and selfie man.” If only populism were the crisis we face. Populism is a political problem. It is something that we can fix—say, by pursuing more beneficial policies for the struggling middle class, or by adjusting trade policy. Homelessness of the existential sort that Tocqueville described is a deeper problem. Tocqueville marveled that American federalism helped address the problem of homelessness by giving citizens “a share in their government.” Yet how can federalism work today if we are so frightened by real-time, everyday dealings with our fellow citizens that we text-message one another to see if it’s okay to talk over the phone?

More here.

Kate Kirkpatrick in iai:

Simone de Beauvoir spent more time talking about inauthentic love than authentic. But that is because she thought authentic love is so hard to achieve. From the vantage point of 2017, aspects of Beauvoir’s view of authentic love look rather dated and pessimistic: for one thing, it presents men and women in binary terms that are unlikely to resound with many readers. Today’s women have greater access to education and employment than women did in 1949, and may be less likely to see love as life, as Beauvoir charged, instead of a part of life. Although structural inequality persists, relationships between men and women – or men and men, or women and women, etc. – theoretically have better chances of proceeding on an equal footing. But nevertheless many cultural portrayals of love (from Puccini to pop) continue to depict it as a game between unequals – as conquest or domination, seduction or entrapment – where the boundaries are drawn along distinctly gendered lines. Such dynamics, on Beauvoir’s view, make authenticity in love impossible – but why?

What Love Meant for Men versus Women

In her watershed feminist book The Second Sex Beauvoir wrote that the word ‘love’ has different meanings for men and women – and that these differences are responsible for many of the disagreements between them. Byron hit the nail on the head, she thought, by saying that for men love is an occupation in life while for women it is life itself. Writing in 1949, Beauvoir believed that men remained ‘sovereign subjects’ in love – that they valued their beloved women alongside other pursuits, as an integral part – but only a part – of their whole life. By contrast, for women love was expected to become their whole life: ‘total abdication for the benefit of a master’ (SS 699). This may sound an alien note in twenty-first century ears. But in Beauvoir’s time she saw many assumptions (implicit and explicit) that for women love involved forgetting themselves as people in their own right.

More here.