Ivermectin, the Crate Challenge, and the Danger of Runaway Memes

Kyle Chayka in The New Yorker:

Memes become omnipresent for a variety of reasons. They might be fodder for entertaining video footage. They might provide a tool for people to express themselves, or cater to deep-seated hopes or anxieties. Ivermectin, which is used for some human applications as well as horse deworming, answered the desire for a covid miracle cure in the face of the United States’ recent surge in infections caused by the Delta variant. The drug has been the subject of medical studies for its supposed efficacy in treating covid-19, but there is little rigorous data on the subject, and one recent study found that it does not alleviate mild coronavirus symptoms. Still, over the past few months it has been publicized by figures such as Rand Paul, Ron Johnson, and the Fox News hosts Laura Ingraham and Tucker Carlson. Joe Rogan, who hosted the ivermectin advocate Bret Weinstein on his podcast in June, announced on Wednesday that he had tested positive for covid-19, and claimed that he had been treated with a number of medications, including the dewormer. (YouTube has deleted some of Weinstein’s content promoting the drug.) The ivermectin phenomenon is a successor to Donald Trump’s obsessive touting of hydroxychloroquine, but the newly popular drug is even more dangerous because it can be self-administered without prescriptions. Indeed, some users have taken highly concentrated versions made specifically for animals. On August 26th, the C.D.C. released a health advisory warning of “severe illness” caused by ivermectin overdoses, including vomiting, diarrhea, and hallucination. Rather than accepting a free vaccine with minimal documented risk of side effects, people are buying a way to poison themselves—one man cited in the C.D.C. bulletin landed in the hospital for nine days.

Fuelled by viral misinformation, the mania has been countered through memetic channels in turn. On TikTok, hashtags like #ivermectin4covid and #ivermectinworks were becoming popular and netting millions of views.

More here.

Why are only some cells ‘competent’ to form cancer?

From Phys.Org:

Right now, in your body, lurk thousands of cells with DNA mistakes that could cause cancer. Yet only in rare instances do these DNA mistakes, called genetic mutations, lead to a full-blown cancer. Why? The standard explanation is that it takes a certain number of genetic “hits” to a cell’s DNA to push a cell over the edge. But there are well-known cases in which the same set of mutations clearly causes cancer in one context, but not in another. A good example is a mole. The cells making up a mole are genetically abnormal. Quite often, they contain a mutated DNA version of the BRAF gene that, when found in cells located outside of a mole, will often lead to melanoma. But the vast majority of moles will never turn cancerous. It’s a conundrum that has scientists looking to cellular context for clues to explain the difference.

The scientists say their results offer an important new perspective on cancer formation, one that contrasts with conventional wisdom. “The standard idea that has been around for decades is that you basically need two types of DNA mutations to get cancer: an activated oncogene and a disabled tumor suppressor gene,” Dr. White says. “Once you clear those two hurdles, cancer will form. Now we have this entirely other thing—oncogenic competence—which adds a third layer to the mix.” Dr. Baggiolini, a lead author on the study and a postdoctoral fellow in the Studer lab, likens the situation to starting a fire. “The DNA mutations are like a lit match: If you have the wrong wood or if the wood is wet, you might get a bit of flickering but no fire. But if you have the right wood, and maybe some kindling, the whole thing burns up.” In this example, ATAD2 is the kindling. Developing a drug to remove this kindling would be another way to treat the cancer besides targeting the DNA mutations.

More here.

Four Hurricanes

Lauren Stroh at n+1:

I AM ON MY FOURTH HURRICANE in 367 days. My protocol at this point has become routine: you prep for hours, and then you wait. You buy your water, you fill the bathtub so you can pressure flush the toilet, you bulk up on flashlights and candles, you throw out your perishable food, you secure your belongings and your property, you cool the house as much as possible before the power goes out. I choose to stockpile cigarettes, beer, and votive candles of Catholic saints, but that is my individual pleasure. Everyone has their own.

I helped out in Lake Charles, where I grew up, last year in the aftermath of Hurricanes Delta and Laura, and I live in New Orleans where I rode out our last two storms. Then in Lake Charles there was last winter’s ice storm, a hundred-year’s flood in May, and still no federal aid. Those people lost everything. My mom was knocked off her feet: sixty years of shit, thirty-three years of flood insurance, six inches of water, and just a couple hours.

more here.

The Whole Country Is The Reichstag

Adolph Reed, Jr. at nonsite:

I know that many liberals, and not a few leftists, will dismiss this account as wildly hyperbolic. Liberals have an abiding faith in the solidity of American democratic institutions; leftists have internally consistent arguments demonstrating why a putsch can’t happen because it wouldn’t be in capital’s interests. It always seems most reasonable to project the future as a straight-line extrapolation from the recent past and present; inertia and path dependence are powerful forces. But that’s why political scientists nearly all were caught flat-footed by the collapse of the Soviet Union. To be clear, I’m not predicting the possible outcome I’ve laid out. My objective is to indicate dangerous, opportunistic tendencies and dynamics at work in this political moment which I think liberals and whatever counts as a left in the United States have been underestimating or, worse, dismissing entirely. If forced to bet, based on the perspective on American political history since 1980, or even 1964, that I’ve laid out here, I’d speculate that the nightmare outline I’ve sketched is between possible and likely, I imagine and hope closer to the former than the latter.

more here.

After a 70-year effort China has eradicated malaria. Could other countries replicate their success?

David Byrne in Reasons to be Cheerful:

At the end of June, the World Health Organization certified China as having eliminated malaria. The announcement may have gotten a little drowned out by the mass spectacles surrounding the Communist Party’s 100th birthday, but make no mistake: going from 30 million cases annually to zero really is a reason to be cheerful.

There are a lot of places that would like to emulate China — malaria is one of the top public health threats around the world, with 200 million cases and 400,000 deaths per year. And while a number of other countries are malaria-free — most recently El Salvador, Algeria, Argentina, Paraguay and Uzbekistan — many more are eager to know how the Chinese did it.

The scope of China’s achievement is hard to overstate.

More here.

Steven Weinberg as remembered by his Nobel co-winner, Sheldon Lee Glashow

Sheldon Lee Glashow in Inference Review:

Steven Weinberg and I knew each other for seventy-four of our eighty-eight years. He was my friend and classmate throughout high school and college. We met at the Bronx High School of Science, where, together with Gerald Feinberg, Morton Sternheim, and Menasha Tausner, we decided to become theoretical physicists—as we all became.

Steve and I and a few friends created the first high-school science-fiction fanzine, Etaoin Shrdlu, writing and illustrating it ourselves; but we did manage to secure a contribution from Alfred Bester, who was already admired as a writer of science fiction. Feinberg was our science editor. Our zine did not outlive our tenure at Bronx Science. To satisfy our fearsome senior class public-speaking requirement, Steve and I submitted a wire recording we made of our production of Orson Welles’s 1938 radiocast, “The War of the Worlds.” Steve was the narrator and I, the scientist, Dmitri Shostakovich’s Seventh Symphony serving as background music.

We aced the course.

As graduation approached, Steve and I were both rejected by Harvard, but accepted by Cornell, MIT, and Princeton.

More here.

What the global flow of guns tells us about how states fail

Pratap Bhanu Mehta in The Indian Express:

There is an old adage that if you want to understand state building or state breakdown, follow the guns. In conflict zones like Afghanistan, it is all too easy to take recourse to debates over development and culture, while ignoring the dynamics of armed conflict, and the presence of weaponry that militarises society and embeds violence. Even a casual perusal of databases at Small Arms Survey, Geneva, that tracks violent conflict and the proliferation of arms, brings home some basic facts about state building and violence.

In their last year of comparative data base 2018, Afghanistan has a rate of 59.8 violent deaths per 1,00,000, below other conflict zones like Syria (187.9), and El Salvador (87). But this data base is also a reminder of two other large trends. First, violence tends to be sticky. Once embedded, it is hard to dislodge. South Africa has a rate of 40.6; Brazil 36.3. Most countries with relatively lower rates are in Asia, or are European social democracies. In Asia, India has a violent death rate of 3.9 per 1,00,000; Pakistan is at 5.9 while big countries like Indonesia, China and Japan are lower than 1. This contrast between Asia and the Americas on this aspect of state building and prevalence of violent death is striking, and rarely made as central to the development literature as poverty.

More here.

Thursday Poem

California Love Song

To ride the Ferris wheel on a winter night in Santa Monica,
playing nostalgic songs on a Marine harmonica,
thinking about the past, thinking about everything
Los Angeles has meant to me, is that too much to ask?

To kiss on the calliope and uproot world tyranny
and strum a rhythm guitar Ron Wood would envy,
to long for the lost, to love what lasts, to sing
idolatrous phrases to the stars, is that too much to ask?

Arm in arm to gallivant, to lark, to crow, to bask
in a wigwam of circus-colored atomic smog,
to quaff a plastic cup of nepenthean eggnog
over one more round of boardwalk Skee-Ball,
to trade my ocean for a waterfall,
to live with you or not at all, is that too much to ask?

by Campbell McGrath
from
Nouns and Verbs, New and Selected Poems
Harper Collins, 2019

Wednesday, September 1, 2021

Salman Rushdie to bypass print and publish next book on Substack

Shelley Hepworth in The Guardian:

Out of the gloom Salman Rushdie floats into view, his familiar face with short beard and glasses hovering on screen in front of a library that should win any competition for the most impressive Zoom bookshelf backdrop.

From his New York apartment he is here to share three things: he has made a deal to publish his next work of fiction as a serialised novella on Substack; he intends to fulfil a long held, once thwarted desire to be a film critic; and he still doesn’t have the courage to write poetry.

“I got very attracted to the idea recently, in this strange year and a half, of trying out things I’ve never done before,” he says.

“It’s to do with this enforced condition we’ve all been in of being pushed inwards … I published this book of essays [which was] the 20th book and I’m already writing the 21st book, which is a novel. I just thought: do something else. And exactly the moment I was thinking that this project cropped up.”

“This project” is Substack and came about after the newsletter platform wrote to Rushdie’s literary agent, Andrew Wylie, who asked him if it was something he wanted to do.

More here.  And you can read and subscribe to Salman Rushdie’s Substack Newsletter here.

Sean Carroll’s Mindscape Podcast: Leidy Klotz on Our Resistance to Subtractive Change

Sean Carroll in Preposterous Universe:

There is no general theory of problem-solving, or even a reliable set of principles that will usually work. It’s therefore interesting to see how our brains actually go about solving problems. Here’s an interesting feature that you might not have guessed: when faced with an imperfect situation, our first move to improve it tends to involve adding new elements, rather than taking away. We are, in general, resistant to subtractive change. Leidy Klotz is an engineer and designer who has worked with psychologists and neuroscientists to study this phenomenon. We talk about how our relative blindness to subtractive possibilities manifests itself, and what lessons might be for design more generally.

More here.

Why Mass Immigration Is the Key to American Renewal

Deepak Bhargava and Ruth Milkman in The American Prospect:

Could admitting millions more immigrants over the next decade be the jolt the U.S. needs to revive its economy, culture, and politics? After four years of restrictionism under President Trump, ongoing border controversies, and an escalating culture war led by nativists, this idea may seem counterintuitive or even far-fetched. But recent labor market trends, demographic changes, and even accelerating climate change all point to dramatically increased immigration as a logical catalyst for national renewal. Becoming the most welcoming country on Earth for migrants—breathing new life into our most flattering, if too often inaccurate self-image—could be our salvation.

To see the potential upside of increased immigration requires us to examine current realities with fresh eyes. For decades, advocates of restriction have dominated the national conversation around immigration, cloaking their xenophobia under the false claim that immigrants pose a threat to U.S.-born workers. Liberals have too often failed to challenge this claim, fearing that expansive immigration policies are a path to political oblivion. But our research shows that the conventional wisdom underlying both parties’ policies is wrong: Expanding immigration is the key to economic revitalization and the most effective means to counter the continuing authoritarian threats we face in the post-Trump era.

More here.

On Janet Malcolm

David Salle at Artforum:

One of Janet’s themes as a writer was self-delusion in all its guises—the propensity we all share for telling ourselves stories that, at the very least, reconfigure events to cast ourselves in a more favorable light. I was stung by one line in the profile: that (I paraphrase) in all our time together, nothing I said about my work was of the slightest interest to her. Once my vanity recovered from the dismissal of my “thinking,” the veracity of Janet’s verdict was clear. (The passage continued to insist that nothing any artist ever says about their work is of interest.) I eventually came to feel more or less the same way—that nothing anybody says about their intentions or “process” is of any particular relevance unless it’s a one-liner by de Kooning. Who cares? This attitude is at odds with the prevailing reverence for that peculiar literary artifact, the artist’s statement, but such was the incontrovertible nature of Janet’s contrarianism. Like any good analyst, she was only interested in the story behind the story. The fact that a belief is widely held should be enough to raise our suspicions.

more here.

Peter Weiss And The Political Novel

Ryan Ruby at The Point:

It seemed like a good idea to avoid the screen, but my resolve didn’t last long. The book I was reading at the time, On the Natural History of Destruction, a collection of W. G. Sebald’s lectures and essays about the literature of the Second World War, concludes with a piece on the German-Swedish writer Peter Weiss. Like most English-speakers who had heard of him, I knew of Weiss only as the author of the play The Persecution and Assassination of Jean-Paul Marat as Performed by the Inmates of the Asylum of Charenton Under the Direction of the Marquis de Sade (Marat/Sade for short), which had been made into a film starring Patrick Magee and Glenda Jackson during the brief vogue for interwar European aesthetic programs—in this case Brecht’s Epic Theater and Artaud’s Theater of Cruelty—among the countercultures of Britain and the United States in the 1960s. Sebald, however, mentions Marat/Sade only in passing. Instead, he discusses Weiss’s early career as a painter; his surreal autobiographical novella, Leavetaking; his controversial documentary play about the Frankfurt Auschwitz trials, The Investigation; and, at greatest length, his late three-volume novel about the German anti-fascist underground, The Aesthetics of Resistance.

more here.

‘Are we not humans?’ Pakistan’s domestic workers confront abuse

Shakeeb Asrar in The Christian Science Monitor:

Last month, when Samina Farooq, a domestic worker, learned that a fellow female worker in Lahore had been beaten by her employer for spilling milk on the floor, she went to see her. Her message: You should quit now. “Bibis [female employers] beat us for dropping milk on the floor or deduct a portion of our salary if we mistakenly burn a piece of cloth when ironing. Are we not humans? Can’t we make mistakes?” says Ms. Farooq. After the employer acknowledged that she had treated her maid unfairly, the maid agreed to stay on. The International Labor Organization (ILO) estimates that Pakistan has more than 8.5 million domestic workers, mostly women and children. Some suffer appalling abuse at the hands of their employers. Last year an 8-year-old girl was beaten to death by her employers in Rawalpindi for letting their parrots escape.

Activists have long complained that in addition to high-profile abuses, domestic workers are routinely exploited behind closed doors, without any of the protections and benefits provided to formal workers. So, when the province of Punjab, Pakistan’s most populous, passed a law in 2019 that barred child labor in homes and extended labor law and social security to all domestic staff, it was hailed as a landmark reform. But the Domestic Workers Act, a first for Pakistan, hasn’t lived up to its promise because of resistance from employers, lax government oversight, and, perhaps surprisingly, lukewarm support from domestic workers themselves.

More here.

Why You May Have More Friends Than Your Friends Do

Joshua Holden in Nautilus:

There’s a rude charm to the title, “Why Your Friends Have More Friends Than You.” It’s catchy, like the title of an antagonistic explainer: Here are the causes of your lackluster social life. It sounds more like a New York Times op-ed than an academic paper. But in fact, “Why Your Friends Have More Friends Than You” is a 1991 paper from Scott Feld published in the American Journal of Sociology. It now has some claim to fame for introducing into popular culture the so-called “friendship paradox,” which researchers have used to detect the early onset of contagious outbreaks and design effective vaccination strategies. New research, published in the Journal of Complex Networks, suggests the paradox is more nuanced than Feld figured it to be.

The paradox stems from our poor intuitions about networks and averages. If you were to guess how many friends you have, compared to the number of friends your friends have, how would you fare? You may say it’s your friends that have more friends than you, if you’re feeling modest. But it’s also the case that some of those friends who have more friends than you also have friends who have more friends than them, and so on. The friendship paradox says that this is true for everyone—on average, everyone has friends with more friends than they have.

More here.

Wednesday Poem

Before the cosmos – my love there was you

Long before there were
…. any stars

When the great empty void
…. was packed full of a hundred-thousand
other even emptier voids

There was a soft whisper in the dark
…. ..~ and maybe this whisper was more like a song
…. ~ and maybe this song was more like a poem
~ and maybe this poem was more like a prayer

And this soft whisper that was
a song that was a poem
that was a prayer
kept uttering your
name and saying

“I can’t wait for the
day you come to find me”

yes, even before
the first crack of
Genesis lightning
spread its dandelion
seed across the cosmos
you were the first thing
on the mind of a waking God

please hold on
…. you matter more than matter itself

please hold on
…. you have more time than time itself

please hold on
…. you have existed before existence

please hold on

by John Roedel
from
John’s Website