Single molecule controls unusual ants’ switch from worker to queen-like status

From Phys.Org:

Depending on the outcome of social conflicts, ants of the species Harpegnathos saltator do something unusual: they can switch from a worker to a queen-like status known as gamergate. Now, researchers reporting in the journal Cell on November 4th have made the surprising discovery that a single protein, called Kr-h1 (Krüppel homolog 1), responds to socially regulated hormones to orchestrate this complex social transition.

“Animal brains are plastic; that is, they can change their structure and function in response to the environment,” says Roberto Bonasio of the University of Pennsylvania Perelman School of Medicine. “This process, which also takes place in human brains—think about the changes in behavior during adolescence—is crucial to survival, but the molecular mechanisms that control it are not fully understood. We determined that, in ants, Kr-h1 curbs brains’ plasticity by preventing inappropriate gene activation.”

In an ant colony, workers maintain the colony by finding food and fighting invaders, whereas the queen’s main task is to lay eggs. And, yet, it is the same genetic instructions that give rise to these very different social roles and behaviors. By studying ants, Bonasio and colleagues, including Shelley Berger, also at the University of Pennsylvania, wanted to understand how turning certain genes “on” or “off” affects brain function and behavior. Because Harpegnathos adults can switch from a worker to a gamergate, they were perfect for such studies.

More here.



Madame De La Fayette in 1558 from Lapham’s Quarterly:

“Ever since I have been at court,” exclaimed the vidame, “the queen has always treated me with much distinction and amiability, and I have reason to believe she has had a kindly feeling for me. Yet there was nothing marked about it, and I had never dreamed of other feelings toward me than those of respect. I was even much in love with Madame de Themines. The sight of her is enough to prove that a man can have a great deal of love for her when she loves him—and she loved me.

“Nearly two years ago, when the court was at Fontaine­bleau, I happened to talk with the queen two or three times when very few people were there. It seemed to me that I pleased her and that she was interested in all I said. One day especially we were talking about confidence. I said I did not confide wholly in anyone; that one always repented absolute unreserve sooner or later; and that I knew a number of things of which I had never spoken to anyone. The queen said she thought better of me for that; that she had not found anyone in France who had any reserve; and that this had troubled her greatly, because it had prevented her confiding in anyone; that one must have somebody to talk to, especially persons of her rank. The following days she several times resumed the same conversation and told me many tolerably secret things that were happening. At last it seemed to me that she wanted to test my reserve and wished to entrust me with some of her own secrets. This thought attached me to her. I was flattered by the distinction, and I paid her my court with more assiduity than usual. One evening, when the king and all the ladies had gone out to ride in the forest, she remained at home, because she did not feel well, and I stayed with her. She went down to the edge of the pond and let go of the equerry’s hand, to walk more freely. After she had made a few turns, she came near me and bade me follow her. ‘I want to speak to you,’ she said, ‘and you will see from what I wish to say that I am a friend of yours.’ Then she stopped and gazed at me intently. ‘You are in love,’ she went on, ‘and because you do not confide in anyone, you think your love is not known. But it is known even to the persons interested. You are watched. It is known where you see your mistress; a plan has been made to surprise you. I do not know who she is, I do not ask you. I only wish to save you from the misfortunes into which you may fall.’ Observe, please, the snare the queen set for me, and how difficult it was to escape it. She wanted to find out whether I was in love, and by not asking with whom, and by showing that her sole intention was to aid me, she prevented my thinking that she was speaking to me from curiosity or with premeditation.

More here.

Thursday, November 4, 2021

Essays on Mad Magazine’s Humor and Legacy

Thomas Larson in Another Chicago Magazine:

In 1966, I was a junior at St. Louis’s Kirkwood High. After the teachers let us monkeys out at 2:50, I lazed about, often trekking to a friend’s home to talk antiwar politics or Salinger stories. I was a serious kid, some days lying on one of the twin beds in Ken Klotz’s room (his unlucky brother off in Vietnam) where we were hypnotized by Bob Dylan’s Blonde on Blonde and the literary dazzle of “Visions of Johanna”: “The ghost of electricity howls from the bones of her face.” But then some days I needed a break.

I got one hanging out with Clay Benton. Clay, a wunderkind with a reel-to-reel tape machine, recorded parodies of Superman—the Caped Crusader of comic book, radio drama, TV show. His sendup was Space-O-Ace Man, a half-doofus, half-hippie hero who also flew in to fight crime but whose dorky moves ruined everything. After he and I roughed up a script, we’d record a show with daffy voices and sound effects. We mimicked a big-bosomed girl Clay and I salivated over in class, who needed rescuing. We shielded her from Ming the Merciless with our own bodies in response to her cries of Help!

More here.

Thursday Poem

Where Do You Search For Me, Man

Where do you search for me, Man, I am here next to you.
Not in pilgrimage, nor in idols, no, nor in your solitude either
I am not in your temple, not in a mosque, nor in the Kaaba, no, not in Benaras
I am here next to you, Man, I am here next to you.

I am not in meditation, not in austerity, not in asceticism, not in trances
I do not reside in actions nor in inaction, no, not in renunciation
I am here next to you, Man, I am here next to you.

I am not in the nether regions, nor in the celestial skies above
I am not manifest nor hidden, I am not in the breath of all breaths
I am here next to you, Man, I am here next to you.

Search for me and I am yours to find, now, in one instant of search
Says Kabir listen O wise Man: I am present, always, in your faith.
I am here next to you, Man, I am here next to you.

by Kabir
translation by: Ajit Dutta

***

Moko Kahan Dhundhe re Bande

Moko Kahan Dhundhe re Bande, Main To Tere Paas Mein
Na Teerath Mein, Na Moorat Mein Na Ekant Niwas Mein
Na Mandir Mein, Na Masjid Mein Na Kabe Kailas Mein
Mein To Tere Paas Mein Bande Mein To Tere Paas Mein

Na Mein Jap Mein, Na Mein Tap Mein Na Mein Bhrat Upvaas Mein
Na Mein Kiriya Karm Mein Rehta Nahin Jog Sanyas Mein
Mein To Tere Paas Mein Bande Mein To Tere Paas Mein

Nahin Pran Mein Nahin Pind Mein Na Brahmand Akas Mein
Na Mein Prakuti Prawar Gufa Mein Nahin Swasan Ki Swans Mein
Mein To Tere Paas Mein Bande Mein To Tere Paas Mein

Khoji Hoye Turat Mil Jaoon Ik Pal Ki Talas Mein
Kahet Kabir Suno Bhai Sadho Mein To Hun Viswas Mein
Mein To Tere Paas Mein Bande  Mein To Tere Paas Mein

Kabir

Berlin Views

Marek Zagańczyk at New England Review:

But Berlin is also a city receptive to wanderers conversing with death, loners who find themselves at the end of the road. For the Polish reader, there is no more important description of Berlin, of its mood, people, and places—all of them passed by with equal haste—than the fragments, from 1963, of Witold Gombrowicz’s diary. These pages offer a valuable introduction to the city; reading them carefully sends shivers down the spine. It is necessary to treat them as a standard of free writing and of a literature always on the side of life, though also one that is drawn towards life’s final moments.

It is impossible to forget his metaphor for death, which, lurking, “perches on the arm like a bird.” In these fragments, hands are presented as protagonists of the first order, as if their pantomimes embodied the spirit of the city. The hands of Berliners are always moving: they manufacture, produce, spin—avoiding inaction at all costs.

more here.

Jasper Johns Remains Contemporary Art’s Philosopher King

Peter Schjeldahl at The New Yorker:

His styles are legion—well organized in this show by the curators Scott Rothkopf, in New York, and Carlos Basualdo, in Philadelphia, with contrasts and echoes that forestall a possibility of feeling overwhelmed. Each place tells a complete story. Regarding early work, New York gets most of the Flags and Philadelphia most of the Numbers. Again, looking rules, as in the case of my favorite paintings of Johns’s mid-career phase, spectacular variations on color-field abstraction that present allover clusters of diagonal marks—that is, hatchings. These are often misleadingly termed “crosshatch,” even by Johns himself, but the marks never cross. Each bundle has a zone of the picture plane to itself, to keep his designs stretched flat, while they are supercharged by plays of touch and color and sometimes poeticized with piquant titles: “Corpse and Mirror,” for example, or “Scent.”

more here.

Energy, and How to Get It

Nick Paumgarten in The New Yorker:

For months, during the main pandemic stretch, I’d get inexplicably tired in the afternoon, as though vital organs and muscles had turned to Styrofoam. Just sitting in front of a computer screen, in sweatpants and socks, left me drained. It seemed ridiculous to be grumbling about fatigue when so many people were suffering through so much more. But we feel how we feel. Nuke a cup of cold coffee, take a walk around the block: the standard tactics usually did the trick. But one advantage, or disadvantage, of working from home is the proximity of a bed. Now and then, you surrender. These midafternoon doldrums weren’t entirely unfamiliar. Even back in the office years, with editors on the prowl, I learned to sneak the occasional catnap under my desk, alert as a zebra to the telltale footfall of a consequential approach. At home, though, you could power all the way down.

Still, the ebb, lately, had become acute, and hard to account for. By the standards of my younger years, I was burning the candle at neither end. Could one attribute it to the wine the night before, the cookies, the fitful and abbreviated sleep, the boomerang effect of the morning’s caffeine and carbs, a sedentary profession, middle age? That will be a yes. And yet the mind roamed: covid? Lyme? Diabetes? Cancer? It’s no hipaa violation to reveal that, as various checkups determined, none of those pertained. So, embrace it. A recent headline in the Guardian: “Extravagant eye bags: How extreme exhaustion became this year’s hottest look.”

It was just a question of energy. The endurance athlete, running perilously low on fuel, is said to hit the wall, or bonk. Cyclists call this feeling “the man with the hammer.” Applying the parlance to the Sitzfleisch life, I told myself that I was bonking. At hour five in the desk chair, the document onscreen looked like a winding road toward a mountain pass. The man in the sweatpants had met the man with the mattress.

More here.

Paul McCartney knew he’d never top The Beatles — and that’s just fine with him

Terry Gross as heard on NPR:

It’s been more than 50 years since The Beatles disbanded, and Paul McCartney wants to set the record straight: “It’s always looked like I broke up The Beatles, and that wasn’t the case,” he says. McCartney traces the rumor to the 1970 documentary Let It Be, which followed the bandmates as they wrote, rehearsed and recorded the songs for their final album. The film and the subsequent press coverage created a narrative that pointed to Paul as the instigator of the breakup, and the story was so pervasive that McCartney even began to doubt himself. “I kind of bought into that a little bit,” he says. “And although I knew it wasn’t true, it affected me enough for me to just be unsure of myself.”

…”We were just like most young guys. We just wanted to have a girlfriend and basically do as much as we could, was the idea. So as we got fans, that became our motivation, which was, we were trying to be attractive in any way you like — visually, physically, sexually. We didn’t mind, as long as we were attractive, because as kids, we were apparently not very attractive and we certainly weren’t the big kind of quarterback who attracted all the girls in town. It was kind of the opposite for us, so I suppose, as we got more and more popular and the girls started screaming, to tell you the truth, we just enjoyed it. It was the fulfillment of all our dreams. … It really was just we young guys trying to get laid, as Americans would say.”

On how the screaming of Beatlemania got old

“Later then, it got a bit worrying because now the first sort of flush of the excitement had been going for quite a few years and we were maturing and we were sort of out of that phase. It was like, OK, it would be quite nice to be able to hear the song we’re playing. And we couldn’t because it was just a million seagulls screaming.”

More here.

Wednesday, November 3, 2021

Teju Cole on the Wonder of Epiphanic Writing

Teju Cole in Literary Hub:

The idea of epiphany summons two thoughts, generally. One is religious: the sudden and overwhelming appearance of the Divine into everyday life, as experienced, for instance, by Julian of Norwich, Teresa of Avila, and many holy figures through the ages. The other is literary. Epiphany is now perhaps as strongly, or even more strongly, connected to a certain idea expressed in European modernism, and emphasized in its aftermath. The idea is especially prominent in Joyce’s two early prose works, Dubliners—which includes “The Dead”—and Portrait of the Artist as a Young Man. Epiphany, as understood by Joyce, and practiced thereafter, has to do with heightened sensation and flashes of insight, often of the kind that helps a character solve a problem. This is the definition he gave the term, in an early version of Portrait of the Artist as a Young Man: “a sudden spiritual manifestation.”

“The Dead” begins at an annual Christmas gathering for friends and family in Dublin early in the 20th century. After the party, we are with a couple, the Conroys, heading to their hotel. And then we are with just the troubled thoughts of Gabriel Conroy, who is ruminating on what his wife Gretta has just told him about something in her deep past: when she was a girl, she loved a boy and the boy loved her.

More here.

Yanis Varoufakis: A Progressive Monetary Policy Is the Only Alternative

Yanis Varoufakis in Project Syndicate:

As the coronavirus pandemic recedes in the advanced economies, their central banks increasingly resemble the proverbial ass who, equally hungry and thirsty, succumbs to both hunger and thirst because it could not choose between hay and water. Torn between inflationary jitters and fear of deflation, policymakers are taking a potentially costly wait-and-see approach. Only a progressive rethink of their tools and aims can help them play a socially useful post-pandemic role.

Central bankers once had a single policy lever: interest rates. Push down to revitalize a flagging economy; push up to rein in inflation (often at the expense of triggering a recession). Timing these moves, and deciding by how much to move the lever, was never easy, but at least there was only one move to make: push the lever up or down. Today, central bankers’ work is twice as complicated, because, since 2009, they have had two levers to manipulate.

Following the 2008 global financial crisis, a second lever became necessary, because the original one got jammed: Even though it had been pushed down as far as possible, driving interest rates to zero and often forcing them into negative territory, the economy continued to stagnate. Taking a page from the Bank of Japan, major central banks (led by the US Federal Reserve and the Bank of England) created a second lever, known as quantitative easing (QE).

More here.

On Edward Said’s Love Of Music And Late Beethoven

Teju Cole at Bookforum:

Edward Said loved music, and I loved his love of music as well as the musicality that characterized everything he did. Because of his writings on late style, I think of him in connection with Beethoven’s String Quartet no. 15, op. 132. This was Beethoven’s thirteenth quartet, but the fifteenth in order of publication. It’s the kind of work that tempts one to agree with the strange notion that there is such a thing as pure music, music better than any possible performance. This is a romantic idea, and it’s probably not true, since music exists in the hearing, not on the page. But listening to Beethoven’s Op. 132, you can see why people think so. Within the written tradition of Western classical music, as in all genres of music, there is music that exhausts superlatives. Late Beethoven emerges coherently out of mature Beethoven, and mature Beethoven is an extension and fulfillment of early Beethoven. These are major shifts and distinct modes of evolution, but they are not radical breaks.

more here.

Can The Memoir Capture The Mysteries Of Childhood?

John Banville at The Nation:

Any account of childhood written by an adult might quickly become a work of adult art, presenting the child’s world, its highlights and its shadows, with a sensibility foreign to the experiences of being young. With his intensely concentrated gaze and voluptuous yet exact prose style, however, Wollheim offers us a work of vivid immediacy. Reading it, one experiences the kind of embarrassment that the critic Christopher Ricks identified in Keats’s poetry: Brought this close up to what it feels like to be a child, or for that matter an adult, Wollheim helps us see with awful clarity what an emotional and moral predicament it is to be alive.

Afitting epigraph to Germs could be Philip Larkin’s stark yet somehow comic line “Life is first boredom, then fear.”

more here.

AI Generates Hypotheses Human Scientists Have Not Thought Of

Robin Blades in Scientific American:

Electric vehicles have the potential to substantially reduce carbon emissions, but car companies are running out of materials to make batteries. One crucial component, nickel, is projected to cause supply shortages as early as the end of this year. Scientists recently discovered four new materials that could potentially help—and what may be even more intriguing is how they found these materials: the researchers relied on artificial intelligence to pick out useful chemicals from a list of more than 300 options. And they are not the only humans turning to A.I. for scientific inspiration.

Creating hypotheses has long been a purely human domain. Now, though, scientists are beginning to ask machine learning to produce original insights. They are designing neural networks (a type of machine-learning setup with a structure inspired by the human brain) that suggest new hypotheses based on patterns the networks find in data instead of relying on human assumptions. Many fields may soon turn to the muse of machine learning in an attempt to speed up the scientific process and reduce human biases.

In the case of new battery materials, scientists pursuing such tasks have typically relied on database search tools, modeling and their own intuition about chemicals to pick out useful compounds. Instead a team at the University of Liverpool in England used machine learning to streamline the creative process. The researchers developed a neural network that ranked chemical combinations by how likely they were to result in a useful new material. Then the scientists used these rankings to guide their experiments in the laboratory. They identified four promising candidates for battery materials without having to test everything on their list, saving them months of trial and error.

More here.

The developing world has much bigger problems than climate change

From Spiked:

Björn Lomborg, foto Charlotte Carlberg Bärg

Heralding the start of the COP26 climate talks yesterday, UK prime minister Boris Johnson warned that the world is ‘one minute to midnight’ in its fight against climate change. The world leaders gathered in Glasgow say they are saving the planet from an existential threat. But does the fate of humanity really hang in the balance? And could climate alarmism do more harm than good?

Bjorn Lomborg is a climate economist and a self-described sceptical environmentalist. His latest book is False Alarm: How Climate Change Panic Costs Us Trillions, Hurts the Poor, and Fails to Fix the Planet. He joined Brendan O’Neill for the latest episode of his podcast, The Brendan O’Neill Show, to talk about where the world is going wrong on climate change. What follows is an edited extract from their conversation. Listen to the full episode here.

Brendan O’Neill: At COP26, there will be lots of discussion, lots of statements and lots of dashed hopes and ambitions. What do you make of global gatherings of this kind? Do they do any good in terms of tackling climate change or making the world a better place?

Bjorn Lomborg: They probably make the world a slightly better place. But the giveaway is in the number 26 – this is the 26th time that we have tried this. We have been trying since 1992, when we signed the Rio Convention. The entire rich world failed to follow through on it. Then we had the Kyoto Protocol and again most parties failed to live up to their promises. Then we had the Paris Agreement and now we have Glasgow. The Glasgow conference is supposed to go even further than Paris did.

More here.

Wednesday Poem

A Dispatch From Seattle or, Nervous in the Hot Zone

Yes, we’re scared but we also make
zombie apocalypse jokes

By texts. I don’t know when I’ll see
my friends in person again.

We don’t want to panic and overreact
but we don’t want

To underreact. Some of my friends
are still hosting parties.

Some of them are still planning
to take their previously

Scheduled trips overseas. Some are
the polite looters

Who are buying all the toilet paper
in Seattle.

“Good for you,” I text to one of them.
“You’ll be

The most hygienic and well-stocked
shitter in the city.”

Some of my fellow Native Americans
are performing

The highly sacred Indigenous shrug,
as in, “Dude,

They’re not giving us smallpox
blankets.”

But, hey, it’s the Trumps. Their
wicked incompetence

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