Tilda Wilson in NPR:
Fatimah Asghar is the first recipient of the Carol Shields prize for fiction for their debut novel When We Were Sisters. The award was announced Thursday evening at Parnassus Books in Nashville, Tenn. They will receive $150,000 as well as a writing residency at Fogo Island Inn in Newfoundland and Labrador.
Asghar’s When We Were Sisters is a coming-of-age novel that follows three orphaned Muslim-American siblings left to raise one another in the aftermath of their parents’ death. The prize jury wrote that Asghar “weaves narrative threads as exacting and spare as luminous poems,” and their novel is “head-turning in its experimentations.” When We Were Sisters reflects some of Ashgar’s own experiences both as a queer South Asian Muslim and a person whose parents died when they were young. In October, they told NPR’s Scott Simon that being on the margins of society and vulnerable from such a young age was a window into “a certain kind of cruelty that I think most people don’t have a reference point for.”
Ashgar said that the stories they read about orphans while growing up never really rang true — that they’d always think “this doesn’t feel accurate.”
More here.
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Now comes a new novella, “Death of an Author,” a murder mystery published under the pseudonym Aidan Marchine. It’s the work of the novelist and journalist Stephen Marche, who coaxed the story from three programs, 
During his response, Snoop described how conversing with a large language model (such as 
The phrase « it’s not too late », for me, brings an artificial smile. I stumble onto it as I walk into a bookstore and see the flashy Carbon Almanac (2022) promoted at the entrance, one of many such books to appear in the last, late year. It shouts from the cover: « It’s not too late. » The foreword was written by Seth Godin, a marketing guru out of the dot-com avantgarde. What will save us is « the hope that comes from realizing that it’s not too late. » The refrain is a staple of the genre. Another entry, a new report from the Club of Rome entitled Earth for All: A Survival Guide for Humanity, offers a kindred burst of optimism about the future against the backdrop of a bleak present. Greater planetary health and social well-being are within reach. The authors will « show you that this is indeed fully possible ». Meanwhile the heavy-weight United Nations Intergovernmental Panel on Climate Change (IPCC), released two punchy reports of its own in 2022. They hammered the message that countries’ pledges to cut emissions fall far below climate change targets, and that the impact of climate change is already devastating for many parts of humanity, the ecosystem, and for the biodiversity that now suffers a mass extinction.
The International Monetary Fund approved a 
A little history never hurt anybody. We can start the clock in 1920. In February of that year, the journal Nature reported the 
So many times, in listening to you, I have had the feeling that the word neurosis is a very inadequate one to describe the struggle which you are waging with yourself. “With yourself”—there perhaps is the only link with the process which has been conveniently dubbed a malady. This same malady, looked at in another way, might also be considered a preparatory stage to a “higher” way of life. That is, as the very chemistry of the evolutionary process. In the course of this most interesting disease the conflict of “opposites” is played out to the last ditch. Everything presents itself to the mind in the form of dichotomy. This is not at all strange when one reflects that the awareness of “opposites” is but a means of bringing to consciousness the need for tension, polarity. “God 
When we talk about artificial intelligence, we rely on metaphor, as we always do when dealing with something new and unfamiliar. Metaphors are, by their nature, imperfect, but we still need to choose them carefully, because bad ones can lead us astray. For example, it’s become very common to compare powerful A.I.s to genies in fairy tales. The metaphor is meant to highlight the difficulty of making powerful entities obey your commands; the computer scientist Stuart Russell has cited the parable of King Midas, who demanded that everything he touched turn into gold, to illustrate the dangers of an A.I. doing what you tell it to do instead of what you want it to do. There are multiple problems with this metaphor, but one of them is that it derives the wrong lessons from the tale to which it refers. The point of the Midas parable is that greed will destroy you, and that the pursuit of wealth will cost you everything that is truly important. If your reading of the parable is that, when you are granted a wish by the gods, you should phrase your wish very, very carefully, then you have missed the point.
Antibodies are among the immune system’s key weapons against infection. The proteins have become a darling of the biotechnology industry, in part because they can be engineered to attach to almost any protein imaginable to manipulate its activity. But generating antibodies with useful properties and improving on these involves “a lot of brute-force screening”, says Brian Hie, a computational biologist at Stanford who also co-led the study.
In a lab mouse version of 
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Recently, a friend and I went to a screening of one of our favorite movies, Moonstruck, followed by a conversation with the screenwriter, now in his early seventies. Onstage he was quick-witted and charming, just the kind of person I’d expected to pen such a smart, savory love story. Afterward, as we headed home on the packed subway, I mentioned to my friend that I’d found the screenwriter to be very handsome. She agreed. We wondered aloud if he had grown into his good looks or if he’d always possessed them. Then we took to Google for the answer.
Democrats were once the party of the working class. From the New Deal era through the mid-1960s, clear majorities of