the power of CRISPR: Replacing a defective gene with a correct sequence to treat genetic disorders

From KurzweilAI:

CrispUsing a new gene-editing system based on bacterial proteins, MIT researchers have cured mice of a rare liver disorder caused by a single genetic mutation. The findings, described in the March 30 issue of Nature Biotechnology, offer the first evidence that this gene-editing technique, known as CRISPR, can reverse disease symptoms in living animals. CRISPR, which offers an easy way to snip out mutated DNA and replace it with the correct sequence, holds potential for treating many genetic disorders, according to the research team. “What’s exciting about this approach is that we can actually correct a defective gene in a living adult animal,” says Daniel Anderson, the Samuel A. Goldblith Associate Professor of Chemical Engineering at MIT, a member of the Koch Institute for Integrative Cancer Research, and the senior author of the paper.

The recently developed CRISPR system relies on cellular machinery that bacteria normally use to defend themselves from viral infection. Researchers have copied this cellular system to create new gene-editing complexes, which include a DNA-cutting enzyme called Cas9 bound to a short RNA guide strand. The strand is programmed to bind to a specific genome sequence, telling Cas9 where to make its cut. At the same time, the researchers also deliver a DNA template strand. When the cell repairs the damage produced by Cas9, it copies from the template, introducing new genetic material into the genome. Scientists envision that this kind of genome editing could one day help treat diseases such as hemophilia, Huntington’s disease, and others that are caused by single mutations.

More here.

Thursday Poem

Astronomy Lesson

The two boys lean out on the railing

of the front porch, looking up.
Behind them they can hear their mother
in one room watching “Name That Tune,”
their father in another watching
a Walter Cronkite Special, the TVs
turned up high and higher till they
each can’t hear the other’s show.
The older boy is saying that no matter
how many stars you counted there were
always more stars beyond them
and beyond the stars black space
going on forever in all directions,
so that even if you flew up
millions and millions of years
you’d be no closer to the end
of it than they were now
here on the porch on Tuesday night
in the middle of summer.
The younger boy can think somehow
only of his mother’s closet,
how he likes to crawl in back
behind the heavy drapery
of shirts, nightgowns and dresses,
into the sheer black where
no matter how close he holds
his hand up to his face
there’s no hand ever, no
face to hold it to.

Read more »

What plaster casts from Pompeii tell us about death…and life

Morgan Meis in The Smart Set:

ID_IC_MEIS_POMPE_AP_001Sometime during the late summer, or perhaps the early fall, of the year 79 C.E., Mount Vesuvius erupted near Naples. The result was instant death for the people, plants, and animals in the Roman town of Pompeii, which is about five miles from Mount Vesuvius. A Volcanologist named Giuseppe Mastrolorenzo recently (2010) published a definitive study of death in Pompeii. The living things, he concluded, died from the intense heat of the volcanic blast. Basically, they were flash fried. In one of the multiple pyroclastic surges produced by the eruption, “temperatures outdoors — and indoors,” wrote Mastrolorenza, “rose up to 570°F and more, enough to kill hundreds of people in a fraction of a second.”

The ash and the volcanic mud came a little later. Pompeii was buried under this ash and volcanic matter, preserving the town in the instant in which it had been flash fried. The world then gradually forgot about Pompeii. It had been wiped from the face of the earth. Then, at the end of the 16th century, Pompeii began to resurface. The accidents of weather, of rain and flood and earthquake and further volcanic eruptions brought bits of the city back into the light of day. It took many years for people to realize that what was down there was Pompeii. It wasn’t until the mid-18th century that excavation of the city was begun in earnest. The excavation has been going on ever since. There are still objects and structures being discovered.

In the 1860s, something else incredible happened at Pompeii. A man named Giuseppe Fiorelli was named director of excavations at the site. Ingrid D. Rowland writes about Fiorelli in her new book, From Pompeii: The Afterlife of a Roman Town (Harvard University Press, 2014). Fiorelli, Rowland writes, “was one of the first archeologists to excavate stratigraphically, that is, by removing layers of earth from the top down.” With this method of archeology, Fiorelli and his team began to notice “oddly shaped bubbles” in the layers of ash. Fiorelli came up with an ingenious idea. He shot liquid plaster down into those bubbles. When the plaster hardened, the shapes could be dug out from the earth and ash. The bubbles, it turned out, were the molds created in the ash from the objects and physical bodies (people, animals) that had been covered in the ash after the eruption, and which had then decomposed. The bubbles didn’t collapse, since the ash had hardened over the centuries. As Rowland puts it, “the organic remains of the town survived as hollow voids within the pumice.”

More here.

Wednesday, April 9, 2014

Rich People Rule!

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Larry Bartels in The Washington Post (via Andrew Sullivan):

Everyone thinks they know that money is important in American politics. But howimportant? The Supreme Court’s Gilded Age reasoning in McCutcheon v. FEC has inspired a flurry of commentary regarding the potential corrosive influence of campaign contributions; but that commentary largely ignores the broader question of how economic power shapes American politics and policy. For decades, most political scientists have sidestepped that question, because it has not seemed amenable to rigorous (meaning quantitative) scientific investigation. Qualitative studies of the political role of economic elites have mostly been relegated to the margins of the field. But now, political scientists are belatedly turning more systematic attention to the political impact of wealth, and their findings should reshape how we think about American democracy.

A forthcoming article in Perspectives on Politics by (my former colleague) Martin Gilens and (my sometime collaborator) Benjamin Page marks a notable step in that process. Drawing on the same extensive evidence employed by Gilens in his landmark book “Affluence and Influence,” Gilens and Page analyze 1,779 policy outcomes over a period of more than 20 years. They conclude that “economic elites and organized groups representing business interests have substantial independent impacts on U.S. government policy, while mass-based interest groups and average citizens have little or no independent influence.”

Average citizens have “little or no independent influence” on the policy-making process? This must be an overstatement of Gilens’s and Page’s findings, no?

More here.

The Mathematical World

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James Franklin in Aeon:

To the question: ‘Is mathematics about something?’ there are two answers: ‘Yes’ and ‘No’. Both are profoundly unsatisfying.

The ‘No’ answer, whose champions are known as nominalists, says that mathematics is just a language. On this view, it is just a way of talking about other things, or a collection of logical trivialities (as Singer claims), or a formal manipulation of symbols according to rules. However you cut it, it is not really about anything. Those whose encounter with mathematics at school was less than happy (‘Minus times minus equals plus/The reason for this we need not discuss’) might feel some sympathy with the nominalist picture. Then again, it is also a view that appeals to physicists and engineers who regard serious propositions about reality as their business. They look on tables of Laplace transforms and other such mathematical paraphernalia as, in the words of the German philosopher Carl Hempel, ‘theoretical juice extractors’: useful for getting extra sense out of meaty physical propositions, but not contentful in themselves.

Nominalism might have a certain down-to-earth appeal, but further reflection suggests that it can’t be right. Although manipulation of symbols is useful as a technique, we also have a strong sense that mathematics makes objective discoveries about a terrain that is in some sense ‘out there’. Take the subtleties of the distribution of primes. Some numbers are prime, some not. A dozen eggs can be arranged in cartons of 6 × 2 or 3 × 4, but eggs are not sold in lots of 11 or 13 because there is no neat way of organising 11 or 13 of them into an eggbox: 11 and 13, unlike 12, are prime, and primes cannot be formed by multiplying two smaller numbers. The idea is very easy to grasp. But this doesn’t mean there’s nothing to discover about it.

More here.

Why Only Half of Venezuelans Are in the Streets

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Dorothy Kronick in FiveThirtyEight:

One year after the death of former president Hugo Chávez, these six weeks of protest reveal a country still profoundly split over Chávez’s political project. On one side are those protesting his successor, Nicolás Maduro, who narrowly won last year’s presidential election; on the other are government supporters who see no viable alternative to Chavismo. Asking, “If not this, then what?” Venezuelans cannot find a common answer.

They disagree over a political vision for their country in part because they measure Chavismo against two different benchmarks: Chavistas compare the present to Venezuela’s pre-Chávez past, while the opposition contrasts the current economic situation with more recent developments in the rest of Latin America.

Many government supporters measure life under Bolivarian socialism — as Chávez called his political program — against life under Chávez’s immediate predecessors. Mismanagement of Venezuela’s 1970s oil boom and of the ensuing collapse made the 1980s and 1990s one long economic nightmare. Severe deprivations led to riots, multiple coup attempts and, eventually, to the election of Chávez, then a political outsider. Relative to the foregoing disaster, Venezuelans did fare well under Bolivarian socialism: Incomes grew and poverty declined.

More here. Over at Jacobin, Mark Weisbrot responds:

The thesis of the article is strange. Correctly noting that the political polarization in Venezuela is overwhelmingly along class lines, with the upper-income groups tending to support the protests and lower-income Venezuelans supporting the government, she asks rhetorically, “Why the divide?” and answers:

They disagree over a political vision for their country in part because they measure Chavismo against two different benchmarks: Chavistas compare the present to Venezuela’s pre-Chávez past, while the opposition contrasts the current economic situation with more recent developments in the rest of Latin America.

I think what she means to say is that Chavismo looks better as compared with Venezuela’s pre-Chávez era than it does compared with the rest of Latin America. The first part is a no-brainer: per capita GDP actually fell by more than fifteen percent in the twenty years prior to Chávez (1978-98). However, there is no evidence that the two sides are making any such different comparisons. Do voters anywhere in the world judge their government based on a comparison to its peers? If that were the case in the US, for example, President Obama’s approval ratings would be very high and the Democrats would be sailing to a landslide victory in November’s congressional elections because the relevant income-level comparison for the US is Europe, which has done vastly worse in the recovery from the Great Recession since 2009.

More here.

an interview with artist Sheila Hicks

Hicks-web4Danielle Mysliwiec interveiws Shiela Hicks for The Brooklyn Rail:

Rail: The woven works and paintings in your M.F.A. thesis exhibition lean heavily toward abstraction. When you began at Yale, Clement Greenberg gave the Ryerson lecture at Yale entitled “Abstract and Representational,” attempting to make a case for abstraction. Given the climate, do you remember your first explorations in abstraction? Did you experience a debate in your own practice?

Hicks: The first year was a compulsory course conducted by Sewel Sillman. We made watercolors of melons or onions. We did figure drawing, exercises in perception of all kinds, and I took Albers’s course on color, Interaction of Color.Anyone who’s ever taken Interaction of Color, or taught it, which I taught to young architects when I had my Fulbright in Chile, inevitably thinks in terms of color as an exercise. Color is an emotion, it’s an idea, but it’s also a visual exercise. What happens if a color like this slice of lemon is next to this hot chocolate and then moves next to bougainvillea? Consider what kind of emotional response it evokes. When I exhibited both my paintings and weavings for my M.F.A.evaluation, there were definitely landscape references from Chile. Chilean landscape is overwhelmingly beautiful. I traveled with the photographer Sergio Larrain all the way down into the Beagle Canal and Strait of Magellan where there are immense manganese blue glaciers. I saw spectacular landscapes and seascapes. Inevitably I think that migrated into my work—not seeking to represent it, not seeking to portray it, but to emulate the sense, the feeling one has in perceiving that aura.

more here.

what does “atheism” really mean?

Atheists_t-shirtMike Dobbins at Killing the Buddha:

But there is another definition of atheism available to us: “a: a disbelief in the existence of a deity. B: the doctrine that there is no deity.” (Merriam-Webster), or even Urban Dictionary’s second definition, “A person who believes no god or gods exist.” This is a meaningful definition of atheism one can sink their teeth into. This accurately informs me and the world what atheists actually do believe about God. Most important for the atheist, it is in line with reality. Atheists do have beliefs or disbeliefs regarding God, just as they have beliefs and disbeliefs regarding heaven, the soul, and the afterlife.

When approached with such celestial concepts, an atheist does not try to conceal their actual beliefs by saying they have a ‘lack of belief in’ a soul. They properly state either a positive belief that there is no soul, a negative belief that they don’t believe in a soul, or on rare occasion, a belief in a soul. The atheist is perfectly willing, and able, to state their beliefs regarding this and other supernatural propositions. Should God be an exception? Of course he shouldn’t be.

Whether it be heaven, a soul, God, or a favorite atheist God, The Flying Spaghetti Monster, one takes a belief or disbelief on the concept. The introduction of the idea forces the conscious and intelligent human brain to automatically deliberate the proposition, especially ones of such magnitude.

more here.

defending John Updike

UpdikeRobert Wilson at The American Scholar:

Begley records the harsh things writers like James Wood and David Foster Wallace said about Updike late in his career—the former writing, “Updike is not, I think, a great writer” and the latter accusing Updike in 1997 of being, along with Roth and Norman Mailer, in his “senescence.” As for himself, Begley says, “Predicting his eventual place in the pantheon of American literature is an amusing pastime, but no more useful than playing pin-the-tail with the genius label.” Still, I wish he had said more about the influence of Updike’s own criticism when he was not writing about novelists he saw as potential rivals. Updike reintroduced an American audience to the 20th-century British novelist Henry Green (Party Going; Loving) and wrote thoughtful and generous reviews of other novelists from safely distant shores, ranging from John McGahern and William Trevor in Ireland to Christina Stead in Australia, to Wole Soyinka and a raft of other African writers. Any book by Vladimir Nabokov, whom Updike admired and at times emulated, was sure to get his notice. No other American writer of Updike’s stature contributed so much to the literary culture of our time.

Even if fixing Updike’s place in the firmament is only an amusing and useless pastime, it is hard to resist. I suspect that readers down the years will return to Updike as we do to Balzac, not for the single masterpiece, perhaps, but for the cumulative power of his close attention to his world (“he was enthralled by the detail of his own experience,” as Begley gracefully puts it).

more here.

Private parts: writers and the battle for our inner lives

Josh Cohen in New Statesman:

WriteAt the end of last year, an international group of writers drafted a petition decrying the escalation of state surveillance and calling for a digital bill of rights to protect the privacy of all global citizens. Scattered among the numerous expressions of solidarity in the online comment boxes were a good few barbs aimed at the presumption of a self-appointed elite of “arch-pseuds” that their writerly status conferred on them some special authority to speak on this question. Why, after all, should a petition of writers carry any more weight in the debate on privacy than one of welders or florists? A few weeks later, I had an encounter with an author that brought to life the specific and urgent link between literature and privacy. The writer was Otto Dov Kulka, the winner of this year’s Jewish Quarterly-Wingate Prize, for which I was on the judging panel. A distinguished Czech-born Israeli historian of the Nazi genocide, Kulka received the prize for Landscapes of the Metropolis of Death (2013), a personal and philosophical meditation on his experience as a child survivor of Auschwitz.

Receiving the prize, Kulka spoke of having dedicated his life after Auschwitz to documenting Nazism’s crimes in the rigorously disinterested language of the historian. But alongside this contribution to the public record, he had silently amassed a personal archive of memories, dreams and images of his time as an inmate of the so-called family camp at Auschwitz, which he called his “private mythology”. No one could fail to be moved by the undisguised delight and incredulity with which this slight yet robust old man received the award. The source of that incredulity was not false modesty but the genuine conviction he’d had when writing the book that the experience to which he was giving voice was too private to be shared – echoing the terrible recurring dream related by Primo Levi, of telling his experiences of Auschwitz to a group of oblivious listeners. Landscapes is the fruit not of any long-held literary ambition on Kulka’s part but of his search for a language that would do justice to the terrible singularity of his story. The form of the book wasn’t so much chosen as imposed on him by the privacy of the experience he sought to convey.

More here.

Stress alters children’s genomes

Jyoti Madhusoodanan in Nature:

ChromoGrowing up in a stressful social environment leaves lasting marks on young chromosomes, a study of African American boys has revealed. Telomeres, repetitive DNA sequences that protect the ends of chromosomes from fraying over time, are shorter in children from poor and unstable homes than in children from more nurturing families. When researchers examined the DNA of 40 boys from major US cities at age 9, they found that the telomeres of children from harsh home environments were 19% shorter than those of children from advantaged backgrounds. The length of telomeres is often considered to be a biomarker of chronic stress. The study, published today in the Proceedings of the National Academy of Sciences1, brings researchers closer to understanding how social conditions in childhood can influence long-term health, says Elissa Epel, a health psychologist at the University of California, San Francisco, who was not involved in the research.

Participants’ DNA samples and socio-economic data were collected as part of the Fragile Families and Child Wellbeing Study, an effort funded by the US National Institutes of Health to track nearly 5,000 children, the majority of whom were born to unmarried parents in large US cities in 1998–2000. Children's environments were rated on the basis of their mother's level of education; the ratio of a family’s income to needs; harsh parenting; and whether family structure was stable, says lead author Daniel Notterman, a molecular biologist at Pennsylvania State University in Hershey. The telomeres of boys whose mothers had a high-school diploma were 32% longer compared with those of boys whose mothers had not finished high school. Children who came from stable families had telomeres that were 40% longer than those of children who had experienced many changes in family structure, such as a parent with multiple partners.

More here.

Tuesday, April 8, 2014

The Eye of the Mind

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J. Mae Barizo on The Poetry of Derek Walcott, 1948-2013, in the LA Review of Books:

The collection, published by FSG and edited by Glyn Maxwell, is not the first selected by Walcott, but it is the most comprehensive. It includes seldom-seen poems written by the teenage Walcott, and provides a sweeping yet thorough examination of the octogenarian’s work. Walcott is usually referred to as a Caribbean poet (he was born in St. Lucia, educated in Jamaica), but that classification alone diminishes the breadth and significance of his oeuvre. Walcott embraces the formal English tradition to elucidate his Caribbean experience. The uniqueness of his voice stems from its hybrid of formal extravagance and graceful simplicity. This is apparent even in his 25 Poems, published when he was 18:

Where you rot under the strict gray industry
Of cities of fog and winter fevers, I
Send this to remind you of personal islands
For which Gauguins sicken, and to explain
How I have grown to know your passionate
Talent and this wild love of landscape.

(from “Letter to a Painter in England,” 25 Poems)

Walcott absorbs the world as a painter. He has always excelled with his lush collection of visual details (“flare of the ibis, rare vermilion”; “darkening talons of the tide;” “roads as small and casual as twine”), but his poetry is not simply a meditation on art and nature. His work devotes itself not to interpretations, but to intimacies. That is, he uses nature to explore his poetic experience. Walcott noted in a 1986 Paris Review interview that “the body feels it is melting into what it has seen,” and “if one thinks a poem is coming on […] you do make a retreat, a withdrawal into some kind of silence that cuts out everything around you.” So, while Walcott’s work is sometimes rooted in heady descriptions, his poems indulge both in transitory moments and the quiet after something has been seen, in the wake of astonishment.

More here.

Kripke’s Unfinished Business

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Richard Marshall interviews Scott Soames in 3:AM Magazine:

3:AM: You argue that a theory of meaning needs propositions but also needs to account for the cognitive stance of a person towards a proposition and also how propositions manage to represent the world and have truth conditions. Is that right? So firstly, can you explain why you find Russell’s attempts to account for them not right?

SS: Yes, a theory of meaning for a language L needs propositions that represent the world and so have truth conditions. Yes, it also needs an account of cognitive stances agents take to propositions – if L has sentences – e.g. attitude ascriptions – that predicate properties of propositions. My answer to your question about Russell is explained in chapter 9 of my newThe Analytic Tradition in Philosophy, Vol. 1. Here is the gist of it. Between 1900 and 1910 Russell believed in propositions constituted by objects and properties, but he couldn’t explain their “unity”. Just as sentences aren’t collections of unrelated expressions, but have a structural unity that distinguishes them from mere lists and allows us to use them to represent the world truly or falsely, so propositions aren’t collections of unrelated meanings of the words used to express them, but have a unity that endows them with truth conditions that mere aggregations of their parts don’t have. Russell struggled unsuccessfully to explain this unity until he rejected propositions in 1910 in favor of his multiple relation theory of judgment. Although that theory was disastrous, the insight behind it was brilliantly correct. The intentionality of agents can’t be derived from the supposed sui generis intentionality of propositions to which agents bear attitudes. Instead, the unity that brings together Desdemona and being unfaithful in Othello’s belief that Desdemona was unfaithful is provided by the sui generis fact that the agent predicates being unfaithful of Desdemona. What Russell failed to see was how this insight can be used to reconstruct genuinely unified (i.e. representational) propositions by deriving the intentionality of propositions from the intentionality of agents who entertain them.

More here.

Drowning in Light

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Dirk Hanson in Nautilus:

In 1996, Yale economist William D. Nordhaus calculated that the average citizen of Babylon would have had to work a total of 41 hours to buy enough lamp oil to equal a 75-watt light bulb burning for one hour. At the time of the American Revolution, a colonial would have been able to purchase the same amount of light, in the form of candles, for about five hour’s worth of work. And by 1992, the average American, using compact fluorescents, could earn the same amount of light in less than one second. That sounds like a great deal.

Except for one thing: We treat light like a drug whose price is spiraling toward zero. In the words of sleep expert Charles A. Czeisler of Harvard Medical School, “every time we turn on a light, we are inadvertently taking a drug that affects how we will sleep and how we will be awake the next day.”1 Our daily metabolic cycles are not precisely 24 hours long, and this turns out to be a crucial evolutionary glitch in the mammalian circadian system. Circadian rhythms must be reset daily to keep us in behavioral synch with the earth’s rotation, so we will sleep when it is dark and wake when it is light. This process is called entrainment, and it is achieved by means of light exposure. In the brain, a region of the hypothalamus called the suprachiasmatic nucleus receives input from the retina, causing specialized “24-hour” cells to oscillate in specific patterns. This affects how we eat, sleep, and work. And in most people, the circadian response is intensity-dependent, meaning the greater the light, the greater the effect on the human circadian system.

To complicate matters, our relationship with light is profoundly psychological as well. In “Psychological processes influencing lighting quality,” published in Leukos, the Journal of the Illuminating Engineering Society of North America in 2001, Jennifer A. Veitch analyzes the available scientific evidence concerning the manner in which lighting conditions affect mood and behavior in office settings. Veitch found that “preferences for illuminance levels are generally higher than the recommended levels.” Researchers in the Netherlands, Sweden, the United Kingdom, the United States, and Canada have all documented the same tendency to “overlight” things.2 Veitch also references studies showing that “people with seasonal affective disorder or the milder, subsyndromal, form of this mood disorder consistently preferred higher room illuminance levels than matched, normal controls.”

More here.

Growing up in Kundera’s Central Europe

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Jonathan Bousfield in Eurozine:

Thirty years ago, Czech novelist Milan Kundera dealt with cultural estrangement and its consequences in his celebrated essay “The Tragedy of Central Europe” (first published in the French journal Débats in November 1983, then in the New York Review of Books the following April), sparking off a long-running debate about the fate of European cultures caught on the “wrong side” of the Cold War divide.

Kundera's essay initially made for pessimistic reading. Not only did it argue that Central Europe constituted a “kidnapped West” abducted by an alien, Byzantine-Bolshevik civilisation, but it also claimed that the rest of the continent was in too deep a state of decadence to be fully aware of what it had lost. What initially looked like a requiem, however, soon gained an altogether more optimistic sheen. Mikhail Gorbachev came to power in the Kremlin, the Soviet Bloc showed signs of opening its windows and then the multi-ethnic, cosmopolitan Central Europe eulogised so evocatively by Kundera was quickly re-spun as a symbol of what Europe could be again, rather than what had forever been left behind.

Thirty years on, most of the countries in Kundera's Central Europe have been integrated into the European Union and NATO, and the very term “Central Europe” is no longer necessary, either as an anti-Soviet rallying cry or a badge of cultural belonging. However, the cultural concerns addressed by Kundera have not necessarily gone away simply because the context has changed. Europe is still sandwiched between two superpowers with differing worldviews, and small nations can still be the bearers of important truths.

More here.

climate change may not be the fault of rapacious humanity

Robert Colvile in The Telegraph:

Lovelock_2870245cAs the inventor of Gaia theory, James Lovelock is used to thinking big. Ever since he came up with the idea that the planet and its inhabitants form one vast, self-regulating system – initially scoffed at, but now taken seriously across a variety of disciplines – his focus has been wider than that of his more hidebound colleagues. In A Rough Ride to the Future, Lovelock outlines a new theory. He argues that since 1712, the year in which the Newcomen steam engine was created, we have moved into a new age, the Anthropocene, in which humanity’s ability to liberate energy and information from the Earth has rapidly outpaced both Darwinian evolution and the planet’s ability to cope.

What is refreshing about Lovelock’s approach to these issues is that it is blessedly free of dogma. He does not blame humanity for doing what comes naturally: exploiting the wonders available to it. And he is happy to outline the gaps in our understanding of climate science, not least the role of living beings in helping to regulate the system. This clarity extends to his conclusions. Ultimately, he suggests, climate change is down to ignorance, not negligence – but while we do not yet know its exact contours, the process is both extremely serious and probably unfixable. Unlike the situation with CFCs, or chlorofluorocarbons, a generation ago, there are too many actors – countries, companies and individual humans – that would need to be cudgelled into self-denial if the status quo were to be retained. Where he differs from the consensus, however, is in suggesting that this might not be such a bad thing. What we are seeing around us, Lovelock argues, may be the large-scale destruction of the planet’s ecosystem by rapacious humanity. But it may also be “no more than the constructive chaos that always attends the installation of a new infrastructure”. Humanity is already concentrating itself in bigger and bigger cities, so rather than trying to “save the Earth”, or restore some artificial version of a normal climate, why not live comfortable lives in clustered, air-conditioned mega-cities? This serves ants and termites perfectly well, he argues – as well as the inhabitants of Singapore.

More here.

Pieing for fun and profit

Pietoface-1024x578Rex Weiner at The Paris Review:

Popular belief has it that the pie-in-the-face gag (a word derived from the Norse gagg, meaning “yelp”) originated in the silent-movie era. Performed by the slapstick director Mack Sennett’s Keystone Kops, Fatty Arbuckle, Laurel and Hardy, the Three Stooges, and various imitators then and since, the stunt seems uniquely American. What better enforcer of the democratic dogma than a tossed pie? A gooey face is an instant social equalizer.

Of course, the self-important have always been targets for a takedown; even if pieing is a predominantly American phenomenon, the puncturing of pomposity is universal. I’m reminded of certain graffiti left behind in Egyptian tombs by workers who remarked on the pharaoh’s resemblance to the buttocks of an ox.

The French have a word for it, of course: lèse-majesté, “injured sovereignty,” an ancient crime from the Roman era, still on the books in such countries as Turkey and Thailand. Even in the Netherlands, a man was jailed in 2012 for calling Queen Beatrix a “con woman” and a “sinner,” and demanding abolishment of the monarchy. Royalty has always deserved, short of the guillotine, the pie.

more here.

WHEN YEARS ARE CELEBS

Simon Reid-Henry in More Intelligent Life:

InIn 1970 the great novelist Aleksandr Solzhenitsyn was putting the finishing touches to what he called “the chief artistic design of my life”. Its title, “August 1914”, was intended to convey to readers everything they needed to know about the content, even if they had never heard of the Battle of Tannenberg, the actual focus of the narrative, or read “The Guns of August”, the Pulitzer prize-winning account of the start of the first world war. This was the book with which Solzhenitsyn hoped finally to outdo his literary nemesis, Tolstoy, by blending history and fiction in a manner so “urgent…so hectic and choppy,” wrote his translator, Michael Glenny, that, “at times it almost leaves you breathless”. Alas, breathlessness can be tiresome over 6,000 pages, and “August 1914” never captured the public imagination. Yet Solzhenitsyn, the great inventor, was on to something. Today the market is in full bloom for what the writer Henry Grabar, tongue firmly in cheek, calls “annohistory”. The display tables are groaning with copies of Max Hastings’ “Catastrophe: Europe Goes to War 1914”, Allan Mallinson’s “1914: Fight the Good Fight”, Christopher Clark’s “The Sleepwalkers: How Europe Went to War in 1914” and Mark Bostridge’s “The Fateful Year: England 1914”. Any day now, something similar will happen with 1989.

What is it about some years that they come to hold such a prominent place in our culture, decades after their passing? Are some years really that much more important than others? Was what happened in them so dramatic that the dates themselves have become a rift that lifts up out of the earth, leaving all historical activity merely sloping away—“a drama never surpassed,” as Churchill once put it? What matters in history used to be a matter for the intellectual class to decide. For better and worse, those days are gone. Edinburgh University’s Tom Devine clearly thought he was criticising Britain’s education secretary, Michael Gove, when he said during a recent spat over the teaching of school history: “you cannot [just] pick out aspects of the past that may be pleasing to people”. But that is precisely what many history books do. And it is what readers do every time they walk into the history section of a bookshop.

More here.