Wise and Lawrence in Nature:

The major cause of cancer-related deaths is the spread of cancer cells from their primary site to other parts of the body¹. This spreading process, known as metastasis, typically involves cellular stressors and environmental shocks that induce dramatic changes in cancer cells. One such change is a fierce resistance to current therapies, which means that new ways to combat metastatic disease are urgently needed. Writing in Nature, Priestley et al.² use whole-genome sequencing (WGS) to illuminate the genomic changes that underpin metastasis in 22 types of solid tumour. Although previous studies^3,4 have unearthed some hints of such changes, this is perhaps the first pan-cancer metastasis study of its size to exploit the power of WGS.

Priestley et al. characterized 2,520 samples of metastatic tumours from people with cancer (Fig. 1). In each case, they also analysed a sample of non-cancerous blood cells from the same person. Using WGS, the authors produced a rich catalogue of the genetic mutations found in each metastasis. This catalogue complements existing inventories from both metastasis-sequencing studies and genomic databases of primary tumours, and offers several interesting insights. For example, the authors reveal frequent mutations in the gene MLK4; this is consistent with a previous study that connected an increased number of copies of MLK4 with metastasis⁵.

More here.

Raven

Listen, I’m not going to say this twice.
The sum and product of words
is no mark of intelligence.
Case in point – cousin Crow,
not half as smart as all his talk.

So listen,
I know three things:
Sky, that small kiss of warm air
that rises through my primaries;

the Water on its breath, ridgeblown mist
that bathes us all and makes springs
overflow into Inadu Creek;

and Earth, slope and cup of cove,
the steep that gathers with wide black wings
to draw down Sky,
draw Water up,
that sets free all things green
into a world first fledged.

But listen.
I know from twenty circles
of snowdeep and hungry moons
and twenty circles of fresh shoots
that Sky . . . Water . . . Earth . . .
none of them are mine.

And I know none are yours.

by Bill Griffin
from Snake Den Ridge —a beastiary
March Street Press 2008

David L. Ulin at Literary Hub:

Here’s where it begins for me: a four-panel strip, Lucy and Linus, simplest narrative in the universe. As the sequence starts, we see Lucy skipping rope and, like an older sister, giving Linus a hard time. “You a doctor! Ha! That’s a big laugh!” she mocks. “You could never be a doctor! You know why?” Before he can respond, she turns away, as if to say she knows him better than he knows himself. “Because you don’t love mankind, that’s why!” she answers, seeking (as usual) the final word. Linus, however, he defies her, standing alone in the last frame, shouting his rejoinder out into the distance: “I love mankind . . . it’s people I can’t stand!!”

When I say begins for me, I mean it figuratively; that strip ran on November 12, 1959, nearly two years before I was born. What I’m describing, rather, is a sensibility, a way of looking at, or engaging with, the world. I still remember the moment I stumbled across that set of images, entirely by accident—which is as it should be. It was the middle of June 1968, and I was in the finished basement of a cousin’s house in suburban Michigan. I still remember encountering the punchline with the flash of recognition someone else might call epiphany.

More here.

Ilana Yurkiewicz in Undark:

As a doctor who treats cancer, I think a lot about how to frame new treatments to my patients. I never want to give false hope. But the uncertainty inherent to my field also cautions me against closing the door on optimism prematurely. We take it as a point of pride that no field of medicine evolves as rapidly as cancer — the FDA approves dozens of new treatments a year. One of my biggest challenges is staying up to date on every development and teasing apart what should — and shouldn’t — change my practice. I am often a mediator for my patients, tempering theoretical promises with everyday realism. To accept a research finding into medical practice, I prefer slow steps showing me proof of concept, safety, and efficacy.

CAR-T, nearly three decades in the making, systemically cleared these hurdles. Not only did the product work, its approach was also unique among cancer treatments. Unlike our usual advances, this wasn’t a matter of prescribing an old drug for a new disease or remixing known medications. CAR-T isn’t even a drug. This is a one-time infusion giving a person a better version of her own immune system. When the FDA approved its use, it wasn’t a question of whether my hospital would be involved, but how we could stay ahead. We weren’t alone.

More here.

Michael Ruse in Aeon:

I was raised as a Quaker, but around the age of 20 my faith faded. It would be easiest to say that this was because I took up philosophy – my lifelong occupation as a teacher and scholar. This is not true. More accurately, I joke that having had one headmaster in this life, I’ll be damned if I want another in the next. I was convinced back then that, by the age of 70, I would be getting back onside with the Powers That Be. But faith did not then return and, as I approach 80, is nowhere on the horizon. I feel more at peace with myself than ever before. It’s not that I don’t care about the meaning or purpose of life – I am a philosopher! Nor does my sense of peace mean that I am complacent or that I have delusions about my achievements and successes. Rather, I feel that deep contentment that religious people tell us is the gift or reward for proper living.

I come to my present state for two separate reasons. As a student of Charles Darwin, I am totally convinced – God or no God – that we are (as the 19th-century biologist Thomas Henry Huxley used to say) modified monkeys rather than modified mud. Culture is hugely important, but to ignore our biology is just wrong. Second, I am drawn, philosophically, to existentialism. A century after Darwin, Jean-Paul Sartre said that we are condemned to freedom, and I think he is right. Even if God does exist, He or She is irrelevant. The choices are ours.

More here.

Deborah Blum at the NYT:

Ptacin, the author of the memoir “Poor Your Soul,” herself hovers somewhere between curiosity and the edge of belief. As she tells us, she wants to believe, wishes she could see the ghosts that float so readily around the Maine mediums in this “enchanted hamlet.” But the hovering serves a purpose. She is on a quest to understand the peculiar nature of belief, the power of faith — pure, unquestioning and even unreasoning — to shape the way we see the world around us.

To that end, Ptacin collects insights and highlights from the history of spiritualism but mostly concentrates on Etna’s current practitioners. Her interactions with the community’s mediums and psychics include a ceremony to cleanse her home of a suspected ghost, a session of table talking in which the oak-legged furniture apparently dances around the room and an experiment in dowsing.

more here.

Sarah Watling at The Guardian:

It’s not just that Nesbit’s books are brilliant: her life is also brilliant material for one. She was in person at once quite awe-inspiring and a bit of a nightmare, able to weather tragedy and yet a queen of melodrama, a self-supporting writer who opposed women’s suffrage. Vibrantly attractive and adored by her many proteges and readers, she was what they called in those days “advanced” – a committed socialist (she and her husband Hubert Bland were among the earliest members of the Fabian Society) who wore free-flowing clothes, gave charitably and wrote ferociously against poverty, and let her children play barefoot in the garden. Her home at Well Hall, in Eltham, was a lively hub for young writers, artists and Fabians; a place, HG Wells recalled, “to which one rushed down from town at the week-end to snatch one’s bed before anyone else got it”. She was generous with her time, her money and her husband.

more here.

Dimitrina Petrova in Dissent:

The ideological victory of liberal democracy over communism shaped the way in which historians, politicians, and social scientists made sense of the events of 1989. But there is a strong case today for a revised look at the revolutions of 1989—a critique of the way the prevailing narratives and theories have presented these revolutions as essentially a transition from the tyranny of the party-state to a free and democratic society. A more complex picture of that momentous year reveals not only the eclipse of different possibilities, but how frustrated expectations have shaped post-communist societies in subsequent decades, contributing to the upsurge of illiberal populism in the region over the last decade.

Today’s dominant narrative of 1989 gets one important thing right: liberty was the lodestar for many revolutionaries, in particular the intellectual elite. But the majority of the people were more annoyed by the betrayal of the communist promise of equality than by the lack of civil liberties. They came out in the streets and squares of Central and Eastern Europe in the hundreds of thousands because elites that had promised equality had instead built a world of privilege for themselves. The paradox of 1989 is that communism was stormed and brought down from the left, by people with unfulfilled egalitarian aspirations, but the revolutionary road led to a new society that has been experienced as more unfair than communism.

More here.

Over at the Next System Project’s podcast:

This week, we’re talking about how Social Wealth Funds can play a role in empowering both individuals and communities in the economy. Joining us is Maryland House of Delegates member Gabriel Acevero, Vice President at the Insight Center for Community and Economic Development Jhumpa Bhattacharya, and President of the People’s Policy Project, Matt Bruenig.

The Next System Podcast is available on iTunes, Soundcloud, Google Play, Stitcher Radio, Tune-In, and Spotify. You can also subscribe independently to our RSS feed here.

Also Peter Gowan in Jacobin on Rudolph Meidner, who once proposed one of the more ambitious proposals to broaden the distribution of wealth:

Rudolf Meidner, one of the primary architects of Sweden’s famed social-democratic model, once described private ownership as “a gun pointed at the temple of the labor movement.” He spent his career as a union economist trying to resolve the standoff in labor’s favor.

Meidner’s economic model — given form by an exceptionally strong Social Democratic Party (SAP) and labor movement — delivered sustained material gains to workers in the decades after World War II (and, because of robust growth, private business). Swedish workers enjoyed the fruits of an expanding welfare state while exercising unprecedented influence and control over a developed economy.

It was not enough — the gun remained in place, and by the 1970s, Meidner had concluded, along with the Swedish labor movement, that an alternative model of ownership was needed. “We want to deprive the owners of capital of the power which they wield,” Meidner explained.

All experience shows that influence and control is not enough — ownership plays a critical part. I refer to Marx and Wigforss: we cannot fundamentally transform society without also fundamentally changing ownership.

More here.

Steven Wishnia in The Indypendent:

BCDI [The Bronx Cooperative Development Initiative], a network of various Bronx community groups, was formed in 2011, after then-mayor Michael Bloomberg’s administration proposed turning the disused armory into a shopping mall or a big-box store. Community residents opposed that, insisting that the jobs created should pay a “living wage” and arguing that the building would be better used as a school or a community center.

Their campaign brought together community organizations, labor unions, elected officials, and “socially oriented developers,” says Yorman Nuñez, director of the Just Urban Economies Program at the Massachusetts Institute of Technology’s Community Innovators Lab, which works closely with BCDI. They won a “halfway victory”: The mall plan was stopped and they got what BCDI calls “a landmark community benefits agreement,” but the building remains empty.

More here.

Robert Zaretsky in Foreign Affairs:

In early 1919, Germany risked becoming a failed state. Total war had morphed into a civil war that pitted revolutionaries against reactionaries, internationalists against nationalists, and civilians against soldiers. Munich was the bloodiest arena: over a few short months, the city was ruled by a Bavarian king, a socialist prime minister, and a Soviet republic. The first was overthrown, the second murdered, and supporters of the third slaughtered. “Everything is wretched, and everything is bloody,” Victor Klemperer, a professor at the University of Munich, wrote in his diary, “and you always want to laugh and cry at once.”

These events framed the much-anticipated lecture “Politics as a Vocation” that Klemperer’s colleague Max Weber gave that same year. One hundred years later, there are few better texts to serve as a guide for the increasingly wretched and violent events now unfolding in our own time and place. In particular, Weber’s discussion of the charismatic politician, as well as his distinction between the ethics of conviction and the ethics of responsibility, has perhaps even greater relevance in our own era than in his.

More here.

Rowan Williams in New Statesman:

This wonderful book might be read as a long meditation on WH Auden’s notorious throwaway comment in his elegy for WB Yeats: “Poetry makes nothing happen.” John Burnside’s first chapter engages directly with this maxim, patiently showing us what it does and does not mean in its context. Auden is not shrugging his shoulders and accepting a place for poetry at the neglected margins of social life. Rather he is making a stark distinction between the ways in which human beings try to “make things happen” – the feverish efforts at political and technological control – and the tough imperative to find ways of echoing “the music of what is” in word and gesture.

The language that “makes things happen” in this context is the language of the Twitter feed, the advertising pitch, the chanted slogan at the rally or party conference (more and more indistinguishable from the advertising and entertainment world), the oafish put-down in parliamentary “debate”, the incomprehensible burble of policy documents and “values statements”.

As Auden says, poetry is “a way of happening”. It takes the passage of time, the reality of loss, the absorption in a sharpened kind of seeing or hearing, and makes all these into speech that can survive (as Auden also insists) and help others survive. Its task of “turning noise into music” is thus irreducibly political, a sustained resistance to commodified, generalised language and the appalling reductions of human possibility that this brings with it. Far from being a decorative adjunct to social or public life, it represents the possibilities to which all intelligent and humane social life should point. “Poetry saves the world every day.”

More here.

Stephen Corry in Counterpunch:

Supreme art is a traditional statement of certain heroic and religious truths, passed on from age to age, modified by individual genius, but never abandoned. The revolt of individualism came because the tradition had become degraded, or rather because a spurious copy had been accepted in its stead.

– W.B. Yeats^[1]

Who’s the “father” of environmentalism? Now that the human impact on nature is getting more attention than ever, it’s a question worth asking. Is it, for example, the Prussian naturalist, Alexander von Humboldt, as his biographer thinks?^[2] He was born in 1769, 250 years ago and isn’t big in the English-speaking world despite having more species named after him than anyone else in history. It’s not just species: A river, lake, bay, forest, and mountain ranges bear his name in the U.S. where few now know who he was. It’s different in Germany: Posterity has ensured “Humboldt” is plastered on streets, schools, universities, institutes and shops all over the country. Put “Humboldt” into Google Earth with any German city to see the effect.^[3]

Germans laud their famous sons. (They are, of course, almost all sons!) This long predates Hitler-worship,^[4] as one of the oddest of European monuments testifies. Called “Walhalla,“ it’s a faux Greek temple, built by Bavarian King Ludwig I in the 1830s to house busts of famous Germans. Humboldt is in there together with his even more famous friend, Goethe. The two are as prominent to Germans as Darwin (who Humboldt met) and Shakespeare are in England. Big daddies just don’t come any bigger. So what did Humboldt actually father and should it matter now?

More here.

At Tower Peak

Every tan rolling meadow will turn into housing
Freeways are clogged all day
Academies packed with scholars writing papers
City people lean and dark
This land most real
As its western-tending golden slopes
And bird-entangled central valley swamps
Sea-lion, urchin coasts
Southerly salmon-probes
Into the aromatic almost-Mexican hills
Along a range of granite peaks
The names forgotten,
An eastward running river that ends out in desert
The chipping ground-squirrels in the tumbled blocks
The gloss of glacier ghost on slab
Where we wake refreshed from ten hours sleep
After a long day’s walking
Packing burdens to the snow
Wake to the same old world of no names,
No things, new as ever, rock and water,
Cool dawn birdcalls, high jet contrails.
A day or two or million, breathing
A few steps back from what goes down
In the current realm.
A kind of ice age, spreading, filling valleys
Shaving soils, paving fields, you can walk in it Live in it,
drive through it then
It melts away
For whatever sprouts
After the age of
Frozen hearts. Flesh-carved rock
And gusts on the summit,
Smoke from forest fires is white,
The haze above the distant valley like a dusk.
It’s just one world, this spine of rock and streams
And snow, and the wash of gravels, silts
Sands, bunchgrasses, saltbrush, bee-fields,
Twenty million human people, downstream, here below.

by Gary Snyder
from The Writer’s Almanac, NPR

Jim Farber in The Guardian:

“HU!! HU!! HU!!,” yelled the crowd, at escalating volume, for a full 20 minutes before the Hu kicked off their recent concert at the Brooklyn venue, Warsaw. The fans who packed the place, many of whom were decked out in de rigueur heavy metal gear of black T-shirts and leather, thrust their fists into the air in rhythm to their chants, which grew to a roar the moment the band appeared.

The imposing-looking members of the Hu sported leather too, only theirs bore the elaborate patterns and symbols of their homeland, Mongolia. And instead of singing in English, they sang exclusively in their native tongue, delivered in the ancient art of khoomei, or throat singing. In the same vein, their instruments mixed the slashing electric guitars and pounding drums of the west with the richness of the morin khuur (a two-stringed, horse-head fiddle), the tinniness of the tuvshuur (a Mongolian guitar) and the quaver of the tumor khuur (a jaw harp). The beat they kept didn’t so much punch, a la western metal, as gallop, a reference to the horses prized by the nomadic tribes of the band’s ancestors. With so bracing a combination of sights and sounds, the Hu have been forging a highly improbable connection between the complexities of traditional Mongolian music and the 10-ton force of western metal. Think: Genghis Khan ransacking Judas Priest.

More here.

Brian Resnick in Vox:

Scientists at Google on Wednesday declared, via a paper in the journal Nature, that they’d done something extraordinary. In building a quantum computer that solved an incredibly hard problem in 200 seconds — a problem the world’s fastest supercomputer would take 10,000 years to solve — they’d achieved “quantum supremacy.” That is: Google’s quantum computer did something that no conventional computer could reasonably do.

Computer scientists have seen quantum supremacy — the moment when a quantum computer could perform an action a conventional computer couldn’t — as an elusive, important milestone for their field. There are many research groups working on quantum computers and applications, but it appears Google has beaten its rivals to this milestone.

According to John Preskill, the Caltech particle physicist who coined the term “quantum supremacy,” Google’s quantum computer “is something new in the exploration of nature. These systems are doing things that are unprecedented.”

More here.

Suketu Mehta in Scroll.in:

These days, a great many people in the rich countries complain loudly about migration from the poor ones. But the game was rigged: First, the rich countries colonised us and stole our treasure and prevented us from building our industries. After plundering us for centuries, they left, having drawn up maps in ways that ensured permanent strife between our communities. Then they brought us to their countries as “guest workers” – as if they knew what the word “guest” meant in our cultures – but discouraged us from bringing our families.

Having built up their economies with our raw materials and our labour, they asked us to go back and were surprised when we did not. They stole our minerals and corrupted our governments so that their corporations could continue stealing our resources; they fouled the air above us and the waters around us, making our farms barren, our oceans lifeless; and they were aghast when the poorest among us arrived at their borders, not to steal but to work, to clean their shit, and to sleep with their men.

Still, they needed us. They needed us to fix their computers and heal their sick and teach their kids, so they took our best and brightest, those who had been educated at the greatest expense of the struggling states they came from, and seduced us again to work for them. Now, again they ask us not to come, desperate and starving though they have rendered us, because the richest among them need a scapegoat. This is how the game is rigged today.

More here.