Limit on lab-grown human embryos dropped by stem-cell body

Nidhi Subbaraman in Nature:

The international body representing stem-cell scientists has torn up a decades-old limit on the length of time that scientists should grow human embryos in the lab, giving more leeway to researchers who are studying human development and disease. Previously, the International Society for Stem Cell Research (ISSCR) recommended that scientists culture human embryos for no more than two weeks after fertilization. But on 26 May, the society said it was relaxing this famous limit, known as the ‘14-day rule’. Rather than replace or extend the limit, the ISSCR now suggests that studies proposing to grow human embryos beyond the two-week mark be considered on a case-by-case basis, and be subjected to several phases of review to determine at what point the experiments must be stopped.

The ISSCR made this change and others to its guidelines for biomedical research in response to rapid advances in the field, including the ability to create embryo-like structures from human stem cells. In addition to relaxing the ‘14-day rule’, for instance, the group advises against editing genes in human embryos until the safety of genome editing is better established.

More here.

Thursday Poem

i ask them about birth

about splitting

inevitable tiny laugh
oh it’s not so bad
your body was built

for thiswe have mothered
for centuries. i gesture
to the line of women

behind me. my great
great grandmother
died giving light
my other great
great grandmother
gave light and lived
but not willingly
and that is death too
my other other
great great grandmother
drank (my grandfather
her son was the little boy
retrieving his sleeping mother
from the velvet kentucky
lounges) and my other
other other great great
grandmother i know nothing

of her. all i have
is a picture of a woman
seated, her hands braided
black hair meticulous
middle parted, a face
like medicine, a face
that says I have always been

i am this last woman’s namesake
estefania, meaning –  a crown
a garland. that which surrounds or
encircles. the first martyr

a man i love enters the poem
and asks me to put the picture away

she upends him
she upends me too

i tuck her into a tiny
corner of myself

by Estefania Stout Larios
from
The Rumpus, 5/27/21

 

Wednesday, May 26, 2021

Mind over matter: the contradictions of George Berkeley

Alex Dean in Prospect:

George Berkeley is one of the greatest philosophers of the early modern era. Along with John Locke and David Hume, he was a founder of Empiricism, which championed the role of experience and observation in the acquisition of knowledge. He influenced Kant and John Stewart Mill, and even pre-empted elements of Wittgenstein. His book The Principles of Human Knowledge is a masterwork still set on university philosophy courses the world over, and indeed there is a famous university named after him in California. The celebrated Irishman even inspired a limerick.

Yet Berkeley is also widely misunderstood. Different aspects of his thinking, not to mention his character, seem to clash quite spectacularly. His most famous doctrine was viewed as heretical in its day, yet Berkeley was a bishop and fierce believer in the supremacy of the Anglican church. He simultaneously advanced radically counter-intuitive and staunchly conservative arguments. He was a passionate social reformer but was complicit in appalling social evils. This makes Berkeley a fascinating subject. He appears a study in contradiction—but stick with him long enough and you realise that maybe there is no contradiction at all.

More here.

The Lost Novel of Richard Wright

Elias Rodriquez at The Nation:

A surrealist and existentialist tale, The Man Who Lived Underground was rejected by several publishers, but the novel found an afterlife via a series of winding roads. The rejections led Wright to condense the narrative, in particular cutting the lengthy description of police violence in the novel’s opening, and turn it into a short story that was published in 1944. That story was admired by Wright’s friend and mentee, Ralph Ellison. Later, after winning the National Book Award in 1953 for Invisible Man, Ellison stated that his novel had been inspired by Fyodor Dostoevsky’s Notes From Underground. While he and Wright had fallen out by this time, Wright’s influence on the novel was hard to deny. Despite this fact, Invisible Man entered the American literary canon, while Wright’s story languished in obscurity. In the popular imagination, he became known as the author of Native SonBlack Boy, and (for those interested in anti-colonialism) The Color Curtain, but not as the originator of invisible men living underground. That honor remained Ellison’s.

more here.

Some Comments on the Claims Made For and Against Painting

Jeff Wall at nonsite:

I am going to try to account for the reasons painters have consistently felt it OK to take note of the critiques aimed at the validity of their art form but almost always dismiss them in practice. A lot of what I have to say here is well-known in the mainly unspoken way things can get well-known. So I am trying to spell out what I think many people already know, and what I believe most painters do think.

The critiques were aimed at all the traditional art forms, not just painting, but the debate has focused on painting more than on sculpture, even though the same claims have been made for both arts.

I’ll reiterate those claims, as briefly as I can (and I apologize in advance if its not brief enough). They’ve been elaborated over a long historical period, beginning probably with Vasari and concluding, or being substantially interrupted, in the 1970s.

more here.

Critics say Nobel laureate was dangerously misleading on Covid

Eric Boodman in Stat News:

One day last August, as they struggled to figure out whether to lift Covid-19 restrictions, the supervisors of Placer County, California, convened a panel of experts. It was a reasonable move. If being a local official could be thankless in normal times, the pandemic had made it nearly impossible. Federal messaging had been hopelessly muddled. Rules meant to stop viral spread came with painful side effects. One constituent insisted the sheriff enforce lockdowns; another called stay-at-home-orders an economic death sentence. Wanting advice from doctors and professors was hardly surprising.

What was surprising was that the first invited speaker had chosen to frame himself as an authority on Covid-19 at all. His name was Michael Levitt. His credentials were stellar — an endowed Stanford professorship, one-third of the 2013 Nobel Prize in Chemistry — but utterly unrelated to infectious disease outbreaks. He’d won his honors with the computer-programming work he’d done in the 1960s and 70s, revealing the intricate origami of proteins, modeling how they fold and form the tiny machinery of life. Prior to those papers, the chair of the Nobel selection committee had said, studying chemical reactions was “like seeing all the actors before Hamlet and all the dead bodies after, and then you wonder what happened in the middle.” Levitt and his colleagues had described “the whole drama,” showing how each character died.

Now, though, dead bodies weren’t a metaphor. They were horrifyingly literal, their bagged bulk filling hospital morgues and refrigerated trucks. Public health specialists begged politicians and citizens to do what they could to slow transmission. Levitt, a biophysicist, had different ideas. He derided policies proposed by the vast majority of epidemiologists as “politically correct.”

More here.

Yanis Varoufakis: Austerity’s Hidden Purpose

Yanis Varoufakis in Project Syndicate:

Back in the 1830s, Thomas Peel decided to migrate from England to Swan River in Western Australia. A man of means, Peel took along, besides his family, “300 persons of the working class, men, women, and children,” as well as “means of subsistence and production to the amount of £50,000.” But soon after arrival, Peel’s plans were in ruins.

The cause was not disease, disaster, or bad soil. Peel’s labor force abandoned him, got themselves plots of land in the surrounding wilderness, and went into “business” for themselves. Although Peel had brought labor, money, and physical capital with him, the workers’ access to alternatives meant that he could not bring capitalism.

Karl Marx recounted Peel’s story in Capital, Volume I to make the point that “capital is not a thing, but a social relation between persons.” The parable remains useful today in illuminating not only the difference between money and capital, but also why austerity, despite its illogicality, keeps coming back.

More here.

Wednesday Poem

Alz Ghazal

—for my sister

It’s the same house, same rugs, same wallpaper, and bedroom repeating;
same dresser; same rocker. Same window and frame, repeating.
.
Same birds at the pane, same pots and pans, and—on the alarm clock,
the wall clock, the phone clock—the same time, repeating
.
each hour’s increment in a lived life. But, This is no life, each day like
before and to come, repeating.
.
The furniture set in a known pattern. The rugs there, like always, inking
the blueprint of home, repeating
.
jewel tones on the floor, but what was once north–south now seems to lie
east–west—who moved the rugs?—in sum, repeating
.
the familiar, but sideways. Your inner axis has shifted, the landmarks
somehow changed but the same, you repeating
.
Why do they keep moving the rugs?  The desk, the chair, your keys?
Home its own balm, repeating
.
the familiar, but neither keys nor your purse can be found—I know
I just had them—repeating
.
the questions yields the same, that is, no real answers. Your sense of taste
gone, like eating chum, repeating
.
the same million small motions: fork to plate then mouth, then back down,
always the same, repeating
.
the flavor of cardboard. You used to love to cook, that joyous jazz variation-
on-a-theme now a repeating

Read more »

Why more Democrats are pressing Biden to support Palestinian rights

Howard LaFranchi in The Christian Science Monitor:

For decades, the Democratic Party has stood by Israel in times of war and peace.

Today, that support no longer looks so solid. In the Democratic-controlled Congress, more lawmakers are calling out Israel for its actions in its latest conflict with Hamas that ended in a cease-fire last week. And this poses a dilemma for President Joe Biden, a staunch ally of Israel who has vowed to make human rights a priority, not an afterthought in his administration. On May 15, after the U.S. blocked United Nations efforts to seek a cease-fire in Gaza, where Israeli airstrikes had leveled residential buildings in retaliation for Hamas rockets, New York Rep. Alexandria Ocasio-Cortez, a Democrat, issued a caustic tweet. “If the Biden administration can’t stand up to an ally,” meaning Israel, “who can it stand up to? How can they credibly claim to stand for human rights?”

Ms. Ocasio-Cortez and other Democratic critics say the United States looks hypocritical for standing unwaveringly by Israel even as it took actions in Jerusalem, the West Bank, and Hamas-controlled Gaza that a mounting international chorus condemned as gross violations of Palestinian rights. And it’s not just firebrands in Congress who are challenging Mr. Biden to steer away from a traditional “Israel first and unquestioned” approach to the Israeli-Palestinian conflict and toward a more nuanced and balanced approach that puts human rights at the fore.

Democratic Sen. Bob Menendez of New Jersey, chairman of the Senate Foreign Relations Committee and a longtime staunch Israel supporter, issued a statement on the same day as Ms. Ocasio-Cortez’s tweet. He called out Israel for “the death of innocent civilians” and for targeting a Gaza high-rise in which international media outlets had offices. Taken together, this amounts to a wake-up call for the White House that the Democratic Party has now shifted on how it sees the Israeli-Palestinian conflict and the U.S. role in addressing it.

More here.

How army ants’ iconic mass raids evolved

From Phys.Org:

Army ants form some of the largest insect societies on the planet. They are quite famous in popular culture, most notably from a terrifying scene in Indiana Jones. But they are also ecologically important. They live in very large colonies and consume large amounts of arthropods. And because they eat so much of the other animals around them, they are nomadic and must keep moving in order to not run out of food. Due to their nomadic nature and mass consumption of food, they have a huge impact on arthropod populations throughout tropical rainforests floors.

Their mass raids are considered the pinnacle of collective foraging behavior in the animal kingdom. The raids are a coordinated hunting swarm of thousands and, in some species, millions of ants. The ants spontaneously stream out of their nest, moving across the forest floor in columns to hunt for food. The raids are one of the most iconic collective behaviors in the animal kingdom. Scientists have studied their ecology and observed their complex behavior extensively. And while we know how these raids happen, we know nothing of how they evolved.

A new study in Proceedings of the National Academy of Sciences led by Vikram Chandra, postdoctoral researcher, Harvard University, Asaf Gal, postdoctoral fellow, The Rockefeller University, and Daniel J.C. Kronauer, Stanley S. and Sydney R. Shuman Associate Professor, The Rockefeller University, combines phylogenetic reconstructions and computational behavioral analysis to show that army ant mass raiding evolved from a different form of coordinated hunting called group raiding through the scaling effects of increasing colony size.

More here.

Tuesday, May 25, 2021

Salman Rushdie: Ask Yourself Which Books You Truly Love

Salman Rushdie in the New York Times:

I believe that the books and stories we fall in love with make us who we are, or, not to claim too much, the beloved tale becomes a part of the way in which we understand things and make judgments and choices in our daily lives. A book may cease to speak to us as we grow older, and our feeling for it will fade. Or we may suddenly, as our lives shape and hopefully increase our understanding, be able to appreciate a book we dismissed earlier; we may suddenly be able to hear its music, to be enraptured by its song.

When, as a college student, I first read Günter Grass’s great novel “The Tin Drum,” I was unable to finish it. It languished on a shelf for fully 10 years before I gave it a second chance, whereupon it became one of my favorite novels of all time: one of the books I would say that I love. It is an interesting question to ask oneself: Which are the books that you truly love? Try it. The answer will tell you a lot about who you presently are.

More here.

Sean Carroll’s Mindscape Podcast: Henry Farrell on Democracy as a Problem-Solving Mechanism

Sean Carroll in Preposterous Universe:

Democracy posits the radical idea that political power and legitimacy should ultimately be found in all of the people, rather than a small group of experts or for that matter arbitrarily-chosen hereditary dynasties. Nevertheless, a good case can be made that the bottom-up and experimental nature of democracy actually makes for better problem-solving in the political arena than other systems. Political theorist Henry Farrell (in collaboration with statistician Cosma Shalizi) has made exactly that case. We discuss the general idea of solving social problems, and compare different kinds of macro-institutions — markets, hierarchies, and democracies — to ask whether democracies aren’t merely politically just, but also an efficient way of generating good ideas.

More here.

Three fundamental misconceptions about China

Rana Mitter and Elsbeth Johnson in the Harvard Business Review:

When we first traveled to China, in the early 1990s, it was very different from what we see today. Even in Beijing many people wore Mao suits and cycled everywhere; only senior Chinese Communist Party (CCP) officials used cars. In the countryside life retained many of its traditional elements. But over the next 30 years, thanks to policies aimed at developing the economy and increasing capital investment, China emerged as a global power, with the second-largest economy in the world and a burgeoning middle class eager to spend.

One thing hasn’t changed, though: Many Western politicians and business executives still don’t get China. Believing, for example, that political freedom would follow the new economic freedoms, they wrongly assumed that China’s internet would be similar to the freewheeling and often politically disruptive version developed in the West. And believing that China’s economic growth would have to be built on the same foundations as those in the West, many failed to envisage the Chinese state’s continuing role as investor, regulator, and intellectual property owner.

Why do leaders in the West persist in getting China so wrong?

More here.

How A Virtual World Went To The Edge Of Apocalypse And Back

Simon Parkin at The Guardian:

Along with fish, aluminium and Björk, Eve Online is one of Iceland’s biggest exports. Launched in 2003, it is a science-fiction project of unprecedented scale and ambition. It presents a cosmos of 7,500 interconnected star systems, known as New Eden, which can be travelled in spaceships built and flown by any individual. In-game professions vary. There are miners, traders, pirates, journalists and educators. You are free to work alone or in loose-knit corporations and alliances, the largest of which are comprised of tens of thousands of members.

As a microcosm of human activity, the game has been studied by academics interested in creating political models, and by economists interested in testing financial ones. In a universe where every bullet, trade, offer of friendship and betrayal can be tracked and its impact logged and measured, Eve offers a new way to understand our species and the social systems of our world.

more here.

Incidental Structures Along The Utah-Nevada Border

The Center for Land Use Interpretation at Cabinet Magazine:

The American Land Museum is a network of landscape exhibition sites being developed across the United States by the Center for Land Use Interpretation and other agencies. The purpose of the museum is to create a dynamic contemporary portrait of the nation, a portrait composed of the national landscape itself. Selected exhibition locations represent regional land use patterns, themes, and development issues. Within each exhibit location are a number of specified experiential zones with collections of material artifacts in the landscape, landmarks selected from among the field of existing structures.

Wendover, Utah, is the American Land Museum’s regional location in the Great Basin. Beyond the Museum’s Information Center, exhibits can be found among the waste disposal industries, explosives plants, survivability training sites, and weapons test areas that have developed within this broad, geomorphologically self-contained region.

more here.

The Magic of Simplicity

Fernanda Melchor at The Paris Review:

Reading Battles in the Desert, one will note the special magic of Pacheco’s writing — that simplicity, so deceptive and so masterful. The narrative voice is a well-calibrated device gliding through the reality of things, stories, and emotions, always giving the impression that memory never betrays. “Pacheco’s craft and mastery make writing look easy,” writes Luis Jorge Boone in “José Emilio Pacheco: Un lector fuera del tiempo” (“José Emilio Pacheco: a reader outside of time”), an essay on the author’s work. “Achieving that almost magical ease took Pacheco years of rewrites, edits, cuts. The layers upon layers of work the author put into his books over the years is legendary.”

Lengthy prose poems he stripped down in their final versions to pithy lines. Translations took years of painstaking transference — his translation of Eliot’s Four Quartets into Spanish, for example, consumed more than two decades.

more here.

Tuesday Poem

Turn Off Your Phone

Turn off your phone.
……………………………. Place it, face down,
on cold sandstone: that oxblood-red back-step
she buffed for sixty years.
…………………………………….. Look out
past the well-kept lawn, its marrow stripes
while radio waves walk through walls,
bark, bone and steel:
……………………………. congregate to a signal.

Rest your eyes beyond the fence
on the trunks of birch that ebb into the wood.
Feel those white trees breathe.
………………………………………………. The entropy
of branch and leaf may offer some relief.

Whether they do or don’t,
after a time you must pick up your phone,
face its empty screen:
……………………………… turn it on again.

by Subhadassi
from The National Poetry Library

 

Are U.S. Officials Under Silent Attack?

Adam Entous in The New Yorker:

During the final weeks of the Trump Administration, a senior official on the National Security Council sat at his desk in the Eisenhower Executive Office Building, across from the West Wing, on the White House grounds. It was mid-November, and he had recently returned from a work trip abroad. At the end of the day, he left the building and headed toward his car, which was parked a few hundred yards away, along the Ellipse, between the White House and the Washington Monument. As he walked, he began to hear a ringing in his ears. His body went numb, and he had trouble controlling the movement of his legs and his fingers. Trying to speak to a passerby, he had difficulty forming words. “It came on very suddenly,” the official recalled later, while describing the experience to a colleague. “In a matter of about seven minutes, I went from feeling completely fine to thinking, Oh, something’s not right, to being very, very worried and actually thinking I was going to die.”

He fell to the ground before he reached his car, and realized that he was in no condition to drive. Instead, he made his way to Constitution Avenue, where he hoped to hail a taxi. He managed to open the Lyft app on his phone, and ordered a driver, who took him to the hospital. When he arrived at the emergency room, the official thought, I’m probably not walking out of here. He approached the reception desk. “Are you on drugs?” a doctor asked him. The official shook his head. He was led to an examination room. Hospital staff found his White House identification card in his pocket, and three cell phones, one of which they used to call his wife. They thought he might be having a stroke, but an MRI ruled it out. Blood tests also turned up nothing unusual. The official, who was in his mid-thirties, had no preëxisting conditions. The doctors were at a loss, but told him they suspected that he had suffered a “massive migraine with aura.”

It took about two hours for his speech to begin to return. When he checked out of the hospital, the next day, he still had a pounding headache, but was soon able to go back to work. Several days later, a colleague called him to discuss suspected cases of the Havana Syndrome, a mysterious ailment that had first affected dozens of U.S. officials in Cuba, and which now appeared to be spreading. The N.S.C. official didn’t think that he was suffering from the Havana Syndrome; it seemed outlandish that someone would be struck while on the grounds of the White House. But, as his colleague described some of the more severe cases that had been reported, it occurred to the official that this might be his problem. “Look, this is probably nothing,” he told his colleague, “but what you described sounds kind of like what happened to me.”

More here.