Tim Vernimmen in Nautilus:

You don’t often see the word beautiful in scientific articles. Yet it’s easy to see why cell biologists Niccolò Banterle and Pierre Gönczy used the word when describing a crucial cell structure called the centriole in a recent review. The scientists, of the Swiss Federal Institute of Technology Lausanne, are helping to provide a more precise view of how our cells construct this microscopic marvel.

Seen in the image in cross section, the centriole is a cylindrical cell organelle built of nine elegant groupings of three hollow tubes known as microtubules. Each centriole is about one-300th the width of a thickish human hair (about 250 nanometers) in diameter and as much as twice as long. It sits in an area of the cell that looks distinctly fuzzy under the microscope; that fuzzy spot plus the centriole are together known as the centrosome. Each human body contains trillions of them. Centrosome disorders have been implicated in a variety of birth defects, such as certain forms of dwarfism and microcephaly, and may have a role in cancer. Centrioles have existed for over two billion years and are found in a wide variety of life forms that may use them in different ways. In single-celled organisms such as Euglena or Trypanosoma brucei (the parasite that causes sleeping sickness), centrioles form the core of a flagellum, a whipping appendage that enables cells (including human sperm cells) to propel themselves. That’s probably the job that centrioles first evolved to do, says Gönczy. Over time, though, the same structure was adapted for another function: fine-tuning the orderly division of cells. Every one of us starts out as a single fertilized egg cell, which then divides into two daughter cells that each produce two daughters of their own, and so on. Getting enough divisions done in the right way and in adequate time is crucial for correctly structuring developing tissues.

More here.

Vann R. Newkirk II at The Atlantic:

If the Great Migration could be condensed into a single personal narrative, it might be Aretha Franklin’s. Born in 1942 in Memphis, Tennessee, to a traveling, womanizing preacher and a gospel-singing mother, Franklin was whisked north by the same currents that brought millions of black souls to the great industrial and financial centers of the country. Settling with her father in Detroit, she received just about as formal a training in gospel music as was possible back then, singing in her father’s church and on revival tours, and learning from Mahalia Jackson, who stopped in to check on the Franklin household at times.

At 18, Franklin cast off the gospel and embarked on a pop career that would span nearly six decades, spawn a legion of hits, garner countless awards, and see her enshrined as the Queen of an art she helped build.

more here.

Dustin Illingworth at the Paris Review:

The themes of John Cheever’s journals—God, sex, guilt, and nature—manage to instill genteel ennui with the anguished moral passion of a Russian novel. Published in 1990, eight years after his death from lung cancer, and decades after he had been enshrined as America’s premiere bourgeois fabulist, the journals shocked in their revelation of the self-lacerating, booze-addled voluptuary hiding in the fine suit of a country squire. “Rarely has a gifted and creative life seemed sadder,” a chastened John Updike wrote upon their publication. But though the gap between Cheever the cultural effigy and Cheever the man was received with surprise and consternation, the ambiguity of his work had always betrayed such a fissure. Cheever’s greatest fiction enacts a kind of doubleness, a yearning for grace darkly marbled with lust and duplicity. The rapturous moments—one thinks of the beautiful early story “Goodbye, My Brother,” with its darkness and iridescence, the naked women walking out of the sea—barely conceal the saturnine streaks.

more here.

Garry Wills at the NYRB:

Those who still want to stand with their Catholic brothers and sisters should not merely dissent in private ways, but should also speak up and demand what opinion polls show they really want for the church as the people of God. It is mandatory celibacy and male-only priesthood that is “unnatural.” Even an admired spiritual leader like Thomas Merton, who thought he could get away from temptation by sealing out “the world” in a monastery, fell madly in love with a young nurse when he had to go to a hospital. It was a love that Kaya Oakes, in a new book of tributes to Merton, thinks made him fully human for the first time.

That story is worth contemplating when we think of all the gay priests studied by the late monk, psychotherapist, and author Richard Sipe who were forced into a dishonesty by the church teaching against homosexuality that condemned them and sometimes made them cover up for other, pedophile priests committing vile acts against children because they had their own little hierarchy-imposed secret.

more here.

Why I Love Being Married to a Chemist

Because he can still cause a reaction in me
when he talks about SN2 displacements,
amines and esters looking for receptor sites
at the base of their ketones. Because he lugs
home serious tomes like The Journal of the American
Chemical Society or The Proceedings of the Society
of the Plastics Industry, the opposite of the slim volumes
of poetry with colorful covers that fill my bookshelves.
Because once, years ago, on a Saturday before our
raucous son rang in the dawn, he was just
standing there in the bathroom, out of the shower.
I said Honey, what’s wrong? and he said Oh,
I was just thinking about a molecule.

Because he taught me about sublimation, how
a solid, like ice, can change straight to a gas
without becoming liquid first. Because even
after all this time together, he can still
make me melt.
.

by Barbara Crooker
from Les Fauves
C & R Press, 2017

Park MacDougald in The Point:

In late 1979, V. S. Naipaul, then middle-aged and of some literary stature, traveled to the newly declared Islamic Republic of Iran for what would eventually become his travelogue Among the Believers. He hated the place, beginning with his guide, a man named Sadeq:

He was in his late twenties, small and carefully dressed, handsome, with a well-barbered head of hair. I didn’t like him. I saw him as a man of simple origins, simply educated, but with a great sneering pride, deferential but resentful, not liking himself for what he was doing. He was the kind of man who, without political doctrine, only with resentments, had made the Iranian revolution.

Naipaul arrived when the country was still in flux: the revolution had been greeted with optimism, and Iran’s liberals and leftists still believed that the ascendancy of the mullahs was a passing phase. Yet the mood he caught was sinister. In Tehran’s northern suburbs lay wide European boulevards, where the country’s rich and cultivated lived in between shopping trips to London, Paris and Milan. The children of these upper classes—educated, idealistic, English- and French-speaking—had played a key role in the early stages of the revolution and had become, for many in the West, the face of the new Iran. They had scribbled English graffiti on the streets of London (“Down with fascist Shah”) and appeared on American television programs, which Naipaul had watched, to explain their revolution in American terms: freedom realized, a tyrant overthrown.

More here.

Scotty Hendricks in Big Think:

Here’s a fun experiment to try. Go to your pantry and see if you have a box of spaghetti. If you do, take out a noodle. Grab both ends of it and bend it until it breaks in half. How many pieces did it break into? If you got two large pieces and at least one small piece you’re not alone.

Richard Feynman, world-class physicist, bongo player, and writer of letters, once spent an evening trying to break spaghetti into two pieces by bending it at both ends. After hours spent in the kitchen and a great deal of pasta having been wasted, he and his friend Danny Hillis admitted defeat. Even worse, they had no solution for why the spaghetti always broke into at least three pieces.

The mystery remained unsolved until 2005, when French scientists Basile Audoly and Sebastien Neukirch won an Ig Nobel Prize, an award given to scientists for real work which is of a less serious nature than the discoveries that win Nobel prizes, for finally determining why this happens. Their paper describing the effect is wonderfully funny to read, as it takes such a banal issue so seriously.

They demonstrated that when a rod is bent past a certain point, such as when spaghetti is snapped in half by bending it at the ends, a “snapback effect” is created. This causes energy to reverberate from the initial break to other parts of the rod, often leading to a second break elsewhere.

While this settled the issue of why spaghetti noodles break into three or more pieces, it didn’t establish if they always had to break this way. The question of if the snapback could be regulated remained unsettled.

More here.

Charles Kaiser in The Guardian:

The Republican political consultant Rick Wilson has filled his new book with more unvarnished truths about Donald Trump than anyone else in the American political establishment has offered. Wilson never holds back. That is especially refreshing at a moment when so many mainstream journalists still feel compelled to be “fair” to our psychotic president – and so few Democratic officeholders have called for the impeachment that Trump so richly deserves.

A few examples of Wilson’s eviscerations: “Everything about Trump’s opening speech was moral poison to anyone who believed in any part of the American dream. Everything about his nationalist hucksterism smelled like … a knock on the door of authoritarian statism.”

The right is “merrily on board with a lunatic with delusions of godhood”.

“There’s an odds-on chance that our grandchildren will hear this tale while hunched over guttering fires in the ruins of a radioactive Mad Max-style hellscape.”

“Washington is the drug-resistant syphilis of political climates, largely impervious to treatment and highly contagious.”

The tax bill was a masterwork of “gigantic government giveaways, unfunded spending, massive debt and deficits, and a catalogue of crony capitalist freebies”.

More here.

Denise Grady in The New York Times:

Drugs that activate the immune system to fight cancer have brought remarkable recoveries to many people in recent years. But one of those drugs seems to have had the opposite effect on three patients with an uncommon blood cancer who were taking part in a study. After a single treatment, their disease quickly became much worse, doctors reported in a letter to The New England Journal of Medicine.  The cases are a sobering reminder that immunotherapy is still in its early days, and can unleash powerful forces that are not fully understood. Patients and doctors are eager to try the treatments when other options have run out, even for cancers in which they haven’t yet been tested. Sometimes those hail-Mary efforts work. But they can backfire. The patients, treated last year at different hospitals, had adult T-cell leukemia-lymphoma, which is caused by a virus. The drug was nivolumab, or Opdivo, which belongs to a class called checkpoint inhibitors. The drugs cost more than $100,000 a year. Nivolumab, made by Bristol-Myers Squibb, has been approved to treat eight types of cancer, but not this type of lymphoma.

…The patients described in the journal were the first three in a nationwide clinical trial meant to test the drug in 20 people with the lymphoma. But after the third got worse instead of better, researchers shut down the study, which was funded by the National Cancer Institute. They wrote to the journal to alert other doctors to the potential risk of giving the drug, a form of immunotherapy, to patients with that type of lymphoma.

More here.

Maggie Doherty at The Nation:

McCarthy’s fiction, collected by the Library of America in two new volumes, shows how her preoccupation with factuality shaped her art. The collection includes all seven of her novels—the first published in 1942, the last in 1979—as well as collected and uncollected stories and an essay on “the novels that got away.” Through it all, we see McCarthy’s fixation on the surface details that distinguish class and character: a middle-aged man from the Midwest who is given to wearing Brooks Brothers suits; a Yale man working at a leftist magazine who sports a “well-cut brown suit that needed pressing”; bohemian couples living on Cape Cod who drink too much and don’t bother keeping house. We learn that it was a status symbol in 1930s New York for a Vassar graduate to serve coffee with real cream.

more here.

Meghan Flaherty at The Paris Review:

As the black-and-white photographer Henri Cartier-Bresson once said to the color photographer William Eggleston: “You know, William, color is bullshit.” In the realism of the black-and-white, gray is every color—without the tartness. The understudies take the stage, and not one seems to miss the headliners. We see the world without distraction. Andre Gide called gray the color of the truth.

Look at enough black-and-white photography and color comes to feel like an intrusion. Eggleston’s photos seem too vital to be real, as though depicting an alternate reality. Each image is delirious with hue, spectacular, delicious, but a little bit too much. The eye craves rest—and mystery, the kind of truth that can be searched only in subtlety. Dorothy may tumble, tornadic, into Technicolor, but still she always wishes to go home.

more here.

Susan Pedersen at the LRB:

The wars and revolutions that took place a century ago were so vastly consequential for peoples and nations that historians have had to deal with centenaries queued up like planes coming into Heathrow: 1914, the Easter Rising, the Battle of the Somme, the Balfour Declaration, the Bolshevik Revolution, not to mention the Armistice, the Treaty of Versailles and the Spanish flu epidemic still circling overhead. Museum exhibitions, conferences and popular histories have exposed a more or less interested public to the slaughter-bench that birthed the 20th century.

Achilles in Jasper, Texas

I know this: a man walked home drunk
along the corduroy of pines
in east Texas, the bronze duff and

the dust and the late light that fell
on him.  Three men gave him a lift

that afternoon and raised him
with their fists and lowered
him with their nigger this and

nigger that and after a while,
when all the fun they could have

with him leaked out into
the ruts of a logging cut,
they tied him to the boat

hitch of their truck and pulled
away.  I know he kept his head up

awhile because his elbows were
ground to the bone; I know enough
was finally enough, and his head

left his body behind,
but I don’t know what to do

with this, America, this rage
like Achilles twitching
Hector behind his chariot

for 12 days until even
the gods were ashamed.

by Jeffrey Thomson
from: Split This Rock 2008

Pankaj Mishra and Nikil Saval discuss V.S. Naipaul in n+1:

Dear Nikil,

You are right: Naipaul did not seek this role of the uniquely positioned reporter on the third world. He found himself in it, and much of his own complicated and tormented relationship with his subjects was bleached out, especially in his writings on Muslim countries. This has at least partly to do with the Anglo-American (and very non-Continental) cult of the no-bullshit, empiricist intellectual—the man who exposes himself to unpleasant or dangerous reality and tells the truth about it, using the clearest of prose. Orwell was the first great figure in this pantheon of cold-war liberalism, and what Raymond Williams said about him in Culture and Society could also be applied to Naipaul.

It is worth quoting Williams on Orwell at length:

He is genuinely baffling until one finds the key to the paradox, which I will call the paradox of the exile. For Orwell was one of a significant number of men who, deprived of a settled way of living, or of a faith, or having rejected those which were inherited, find virtue in a kind of improvised living, and in an assertion of independence. The tradition, in England, is distinguished. It attracts to itself many of the liberal virtues: empiricism, a certain integrity, frankness. It has also, as the normally contingent virtue of exile, certain qualities of perception: in particular, the ability to distinguish inadequacies in the groups which have been rejected. It gives, also, an appearance of strength, although this is largely illusory. The qualities, though salutary, are largely negative; there is an appearance of hardness (the austere criticism of hypocrisy, complacency, self-deceit), but this is usually brittle, and at times hysterical: the substance of community is lacking, and the tension, in men of high quality, is very great.

Williams then goes on to define Orwell as a vagrant, and tries to understand the nature of his appeal, and this applies to Naipaul as well:

Orwell, in different parts of his career, is both exile and vagrant. The vagrant, in literary terms, is the “reporter,” and, where the reporter is good, his work has the merits of novelty and a certain specialized kind of immediacy. The reporter is an observer, an intermediary: it is unlikely that he will understand, in any depth, the life about which he is writing (the vagrant from his own society, or his own class, looking at another, and still inevitably from the outside). But a restless society very easily accepts this kind of achievement.

More here.

Mona Ali in British Politics and Policy:

Few nations have been as obsessed with their status in the world as Great Britain. Not surprisingly, the Government Statement at Chequers begins with the words that with its departure from the EU, the UK will ‘begin to chart a new course in the world.’ But can it? In recent research, I assess Britain’s macroeconomic resilience and economic power by examining its external balance sheets. As sovereign power only exists relative to that of other countries, I examine the UK’s balance of payments (BoP) against those of the US.

The flexibility of a nation’s external balance sheets is an outcome of its monetary power. Powerful currencies enable softer budget constraints. The US, issuer of the world’s predominant currency, finances its deficits by selling dollar-denominated securities to the rest of the world, and so bypasses the onerous process of deficit-reduction—which may involve devaluation, spending cutbacks, and trade protectionism. But BoP flexibility is not just a matter of monetary power. It could also be the outcome of a sovereign state’s standing in the global régime.

More here.

Steven Levy in Wired:

ON DECEMBER 13, 2011, Paul Allen, the reclusive billionaire and cofounder of Microsoft, stood in front of a group of reporters in Seattle and told them about his wild new plan.

WEARING THE TECH-BRAHMIN uniform of navy blazer, dress shirt, and conspicuously absent tie, Allen made some introductory remarks and then rolled a video simulation of a strange beast of an aircraft leaving an oversize hangar. This was Strato­launch. It would be the largest airplane, by wingspan, ever created. The twin-fuselage, catamaran-style aircraft would be a flying launchpad, its purpose to heave a half-million-pound rocket ship to cruising altitude and then drop it, whereupon the rocket would ignite its engines for a fiery ascent into space. Allen’s hope was that this extraordinary bird would be able to do quick laps between the ground and the stratosphere, making access to space no more exotic than a New York–to–Boston commuter flight.

Burt Rutan took the microphone next. Rutan, a gregarious designer of exotic aircraft, wore a light-blue work shirt and sported huge Elvis-style muttonchops. He was the original architect of the outlandish endeavor and the person who had sold Allen on the project.

More here.

The Editorial Board of the New York Times:

From the start of the Russia investigation, President Trump has been working to discredit the work and the integrity of the special counsel, Robert Mueller; praising men who are blatant grifters, cons and crooks; insisting that he’s personally done nothing wrong; and reminding us that he hires only the best people.

On Tuesday afternoon, the American public was treated to an astonishingsplit-screen moment involving two of those people, as Mr. Trump’s former campaign chief was convicted by a federal jury in Virginia of multiple crimes carrying years in prison at the same time that his longtime personal lawyer pleaded guilty in federal court in New York to his own lengthy trail of criminality, and confessed that he had committed at least some of the crimes “at the direction of” Mr. Trump himself.

Let that sink in: Mr. Trump’s own lawyer has now accused him, under oath, of committing a felony.

More here.

Sean Carroll’s Mindscape podcast at Preposterous Universe:

Quantum mechanics and general relativity are the two great triumphs of twentieth-century theoretical physics. Unfortunately, they don’t play well together — despite years of effort, we currently lack a completely successful quantum theory of gravity, although there are some promising ideas out there. Carlo Rovelli is a pioneer of one of those ideas, loop quantum gravity, as well as the bestselling author of such books as Seven Brief Lessons on Physics and the recent The Order of Time. We talk about how to make progress on this knotty problem, including whether string theory will play a role (Carlo thinks not).

More here.