Linda Nordling in Undark:
In February of last year, 64 healthy adult Kenyans checked into a university residence in the coastal town of Kilifi. After a battery of medical tests, they proceeded, one by one, into a room where a doctor injected them with live malaria parasites. Left untreated, the infection could have sickened or even killed them, since malaria claims hundreds of thousands of lives every year.
But the volunteers — among them casual laborers, subsistence farmers, and young mothers from nearby villages — were promised treatment as soon as infection took hold. They spent the next few weeks sleeping, eating, and socializing together under the watchful eye of scientists, giving regular blood samples and undergoing physical exams. Some grew sick within a couple of weeks, and were treated and cleared of the parasite before being sent home. Those who did not fall ill were treated after three weeks as a precaution and discharged, too.
As compensation, the volunteers received between $300 and $480 each, or roughly $20 a day, a rate based on the minimum wage for casual laborers in Kenya and the out-of-pocket allowance set for overnight stays by KEMRI, the Kenya Medical Research Institute.
More here.

Brains are important things; they’re where thinking happens. Or are they? The theory of “
Admiring the great thinkers of the past has become morally hazardous. Praise Immanuel Kant, and you might be reminded that he believed that ‘Humanity is at its greatest perfection in the race of the whites,’ and ‘the yellow Indians do have a meagre talent’. Laud Aristotle, and you’ll have to explain how a genuine sage could have thought that ‘the male is by nature superior and the female inferior, the male ruler and the female subject’.
Give people a sugar pill, they have shown, and those patients — especially if they have one of the chronic, stress-related conditions that register the strongest placebo effects and if the treatment is delivered by someone in whom they have confidence — will improve. Tell someone a normal milkshake is a diet beverage, and his gut will respond as if the drink were low fat. Take athletes to the top of the Alps, put them on exercise machines and hook them to an oxygen tank, and they will perform better than when they are breathing room air — even if room air is all that’s in the tank. Wake a patient from surgery and tell him you’ve done an arthroscopic repair, and his knee gets better even if all you did was knock him out and put a couple of incisions in his skin. Give a drug a fancy name, and it works better than if you don’t.
Deborah Chasman: The book focuses on the 2016 election and what made the public sphere so vulnerable to what you call “disinformation, propaganda, and just sheer bullshit.” You resist the idea that technology was the primary driver of that problem, that the manipulation of Facebook’s platform, the Russian intervention, and fake news led to a Trump victory. What did you find in your research that led you to challenge the now common story that extreme polarization has been technologically driven?
The main attraction in the
François-Marie d’Arouet was the kind of precocious teen who always got invited to the best parties. Earning a reputation for his wit and catchy verses among the elites of 18th-century Paris, the young writer got himself exiled to the countryside in May 1716 for writing criticism of the ruling family. But Arouet—who would soon adopt the pen name “Voltaire”—was only getting started in his takedowns of those in power. In the coming years, those actions would have far more drastic repercussions: imprisonment for him, and a revolution for his country. And it all started with a story of incest. In 1715, the young Arouet began a daunting new project: adapting the story of Oedipus for a contemporary French audience. The ancient Greek tale chronicles the downfall of Oedipus, who fulfilled a prophecy that he would kill his father, the king of Thebes, and marry his mother. Greek playwright Sophocles wrote the earliest version of the play in his tragedy, Oedipus Rex. As recently as 1659, the famed French dramatist Pierre Corneille had adapted the play, but Arouet thought the story deserved an update, and he happened to be living at the perfect time to give it one.
The theory produces a good deal but hardly brings us closer to the secret of the Old One,’ wrote Albert Einstein in December 1926. ‘I am at all events convinced that He does not play dice.’
The book was supposed to end with the inauguration of Barack Obama. That was Jill Lepore’s plan when she began work in 2015 on her new history of America, These Truths (W.W. Norton). She had arrived at the Civil War when Donald J. Trump was elected. Not to alter the ending, she has said, would have felt like “a dereliction of duty as a historian.”
Europe’s outlook can appear bleak these days: the Brexit downward spiral continues, both Emmanuel Macron and Angela Merkel are weakened, and Italy’s
I think much of my body awareness, in addition to my literary awareness, comes from Joan Didion. In Play It As It Lays, her 1970 novel (less popular than Slouching Towards Bethlehem, but still beloved), bodies are unpredictable geodes. Protagonist Maria’s (Mar-eye-ah’s) insides are vibrant with colour and edges and productive capability, but also completely invisible. She mines for menstruation in there, hoping she isn’t pregnant, which of course she is. A doctor ‘scrapes’ her zygote (a geological-seeming name in itself) out in an abortion scene that is refreshingly without either cynicism or romanticised maternal strickenness. But it doesn’t particularly matter (at least superficially) what goes on in there, in the novel’s bright and weird physical and psychological interiors. Didion is more interested in the woman’s outside, and what it can control. Maria has dreams that a “shadowy Syndicate” occupy her home in an illicit disposal operation. The grey flesh of victims clogs sinks, and water in drains begins to rise. So, certainly, a fear of the watery interior banishes Maria from her home into a tiny apartment, and structures several chapters of the novel. But my impression is that, despite being a clear-eyed writer of insides (especially those of women like herself) and a notable mid-century explorer of what Maggie Nelson has called “a situation of meat”, the disturbing softness and fallibility of the body and of consciousness, Didion is more interested in the hard geological outside, and whether it is hard, and how hard it is. What is women’s hardness? In the end, Maria—whose character is a variation on and also a criticism of the ‘madwoman in the attic’ trope—smokes half a joint, accrues a new psychosis or fixation, and moves back into that fleshy house with a life of its own, braving the interior.
Toward the end of the Obama presidency, the work of James Baldwin began to enjoy a renaissance that was both much overdue and comfortless. Baldwin stands as one of the greatest American writers of the twentieth century, and any celebration of his work is more than welcome. But it was less a reveling than a panic. The eight years of the first black president were giving way to some of the most blatant and vitriolic displays of racism in decades, while the shooting deaths of Trayvon Martin, Michael Brown, and others too numerous to list sparked a movement in defense of black lives. In Baldwin, people found a voice from the past so relevant that he seemed prophetic.
In our house, it has always been the most dreaded part of Thanksgiving. More painful than hand-scrubbing the casserole pan. More excruciating than listening to our libertarian cousin. I speak of the custom of forced gratitude — of going around the table and telling everyone what we’re thankful for.
The first ever “solid state” plane, with no moving parts in its propulsion system, has successfully flown for a distance of 60 metres, proving that heavier-than-air flight is possible without jets or propellers.
During nine years as dean of Harvard Medical School, I enthusiastically supported efforts to enhance diversity, equity and inclusion. Two years after leaving that role, I recently