Elaine Scarry, The Art of Nonfiction

Margaret Ross talks to Elaine Scarry at The Paris Review:

Elaine Scarry lives in a pale pink house near the Charles River in Cambridge, Massachusetts. A tall hedge runs along the front, rising to the second story and nearly engulfing the white picket gate through which one passes into Scarry’s garden. Flowers thrive in dense beds overlooked by crabapple trees and yews. Toward the back of the house, a curved wall of windows divides the garden from the garden room. Scarry’s longtime partner, the writer and scholar Philip Fisher, keeps a house nearby and they split their time between the two. Fisher does the cooking, and they eat dinner at his place. When it’s nice out they like to go for a drive.

Both teach a few blocks away in Harvard’s English department, where they’ve been on the faculty for more than thirty years. Scarry’s title is Walter M. Cabot Professor of Aesthetics and General Theory of Value. Since The Body in Pain (1985), her iconic debut examining language in the context of torture and war, she has published eight books spanning literary criticism, moral and political philosophy, social theory, cognitive psychology, and neuroscience, sometimes within the same volume.

more here.

Enjoying the content on 3QD? Help keep us going by donating now.

Tuesday, July 16, 2024

Welcome to the new post-genomic biology

Philip Ball in Aeon:

The genome sequence reveals the order in which the chemical building blocks (of which there are four distinct types) that make up our DNA are arranged along the molecule’s double-helical strands. Our genomes each have around 3 billion of these ‘letters’; reading them all is a tremendous challenge, but the Human Genome Project (HGP) transformed genome sequencing within the space of a couple of decades from a very slow and expensive procedure into something you can get done by mail order for the price of a meal for two. Since that first sequence was unveiled in 2000, hundreds of thousands of human genomes have now been decoded, giving an indication of the person-to-person variation in sequence. This information has provided a vital resource for biomedicine, enabling us, for example, to identify which parts of the genome correlate with which diseases and traits. And all that investment in gene-sequencing technology was more than justified merely by its use for studying and tracking the SARS-CoV-2 virus during the COVID-19 pandemic.

Nonetheless, as with the Apollo Moon landings – with which the HGP has been routinely compared – the decades that followed the initial triumph have seemed something of an anticlimax. For all its practical value, sequencing in itself offers little advance in understanding how the genome – or life itself – works.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

Bird flu could become a human pandemic. How are countries preparing?

Smriti Mallapaty in Nature:

“This virus in its current state does not look like it has the characteristics of causing a pandemic. But with influenza viruses, that equation could entirely change with a single mutation,” says Scott Hensley, an immunologist at the University of Pennsylvania in Philadelphia.

The highly pathogenic avian influenza H5N1 has so far been detected in 145 cattle herds and 4 farm workers in a dozen states across the United States. Researchers say many more cases in cows and people have probably gone undetected. The chances of quashing the outbreak get “more slim by the day”, says Angela Rasmussen, a virologist at the University of Saskatchewan in Saskatoon, Canada.

Studies suggest that the virus is spreading between cows through contaminated milking equipment1,2, rather than airborne particles. The biggest risk is that it could evolve to infect mammals more effectively, including through the respiratory system, which would make it more difficult to contain. Given the close and regular contact that cows have with people, airborne transmission could spark a pandemic.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

A little-understood fact: There’s not that much wealth in the world

Noah Smith at Noahpinion:

Most economic debates are about income, not wealth. When we talk about income taxes, or welfare benefits, or labor’s share of national income, we’re talking about the amount of goods and services that get created every year, and how those goods and services get allocated among the various people in a society. But in the 2010s, we saw a lot of debate about wealth instead — wealth taxes, wealth inequality, and so on.

I always felt that these debates were a bit of a distraction. That’s partly because — for reasons I’ll explain in a bit — I think income is a lot more important than wealth. It’s also because from a policy perspective, dealing with income is a lot easier than dealing with wealth. But the biggest reason is that I think that wealth is a lot harder for regular people to understand than income.

In general, regular people’s intuitive “folk” understanding of income is pretty close to the way economists think about it.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

Percival Everett Refashions A Mark Twain Classic

Zain Khalid at Bookforum:

KARL KRAUS WROTE THAT EVERYTHING FITS WITH EVERYTHING ELSE. Maybe. Maybe everything in an artist’s corpus, no matter how incongruous, reflects, repeats, rhymes. Yet this is not the case for Percival Everett. No thematic or formal schema is suitable. He climbs the stairs sideways. His patently ridiculous conceits seem like challenges to his own mischievousness, bids to marry his uniquely sweeping curiosities to a bardic impulse. Charmingly, he’d never admit as much. “I know nothing,” he said in a recent New Yorker profile. “I’m just a dumb old cowboy.” Sure. It remains a considerable feat for Everett to have remained eccentric in the increasingly rational and prefabricated business of literature. He has his prevailing modes—racial satires, Westerns, crime procedurals, retellings of ancient myths, despondent autobiographical metafiction—but all of them are in flux, appearing in different admixtures. It’s hard to imagine another author pulling off, or even attempting, Glyph (1999),a novel about a toddler with a farcically high IQ; in Everett’s hands, the gambit is hilarious, bone-dry, and tragic. Erasure (2001), a canny parody of writers and racial fetishization, is even more affecting as a portrait of senescence. I Am Not Sidney Poitier (2009), a hysterical abuse of Ted Turner, the media, and various social structures, is also a repudiation of Everett’s previous work. (About Erasure, the author-character, Percival Everett, remarks, “I didn’t like writing it, and I didn’t like it when I was done with it.”) To apply superficial categories is to miss the point; Everett understands that each person is witness to a series of absurd debacles, and his fiction poses the question: What, if anything, is there to be made of our continued looking?

more here.

Enjoying the content on 3QD? Help keep us going by donating now.

The Young Women Challenging Iran’s Regime

Forough Alaei in Time Magazine:

Of the many paradoxes presented by the Islamic Republic of Iran, the most confounding remains its stubborn preoccupation with regulating women. The 1979 revolution that brought fundamentalist clerics to power in an ancient, diverse, and cosmopolitan nation also stripped women there of the right to hold a job without the permission of her husband, or wear what she chooses in public. The friction from that grinding repression ignited a conflagration in the last months of 2022 that threatened to destroy the regime. Being spontaneous, the rebellion gathered behind the slogan “Woman, Life, Freedom” and was billed as leaderless. In truth, it was led by thousands.

“Oppression is the norm in a society as long as it lacks a role-model who breaks the taboo,” says photojournalist Forough Alaei. “This project is the story of Iranian role models.” Over the course of two years, Alaei traveled her native country documenting the women who, like the late Mahsa Amini facing arrest by “morality police,” simply refused. Her subjects are the generation who came of age online, seeing on their phones how people lived elsewhere, with no hope of joining them. Many have found an outlet in sports—for decades a testing ground for gender equality in the Islamic Republic, where women were not even allowed in the same stadium as men.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

How Poor Sleep Affects Your Risk of Dementia

Dana Smith in The New York Times:

Getting too little sleep later in life is associated with an increased risk for Alzheimer’s disease. But paradoxically, so is getting too much sleep. While scientists are confident that a connection between sleep and dementia exists, the nature of that connection is complicated. It could be that poor sleep triggers changes in the brain that cause dementia. Or people’s sleep might be disrupted because of an underlying health issue that also affects brain health. And changes in sleep patterns can be an early sign of dementia itself. Here’s how experts think about these various connections and how to gauge your risk based on your own sleep habits.

Sleep acts like a nightly shower for the brain, washing away the cellular waste that accumulates during the day. During this process, the fluid that surrounds brain cells flushes out molecular garbage and transfers it into the bloodstream, where it’s then filtered by the liver and kidneys and expelled from the body.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

On Stones

Ellyn Gaydos at Harper’s Magazine:

On a tour of Barre’s E. L. Smith quarry, one of the deepest working granite quarries in the world, Roger, a thirty-five-year veteran of the operation, led us past piles of grout to a fence. We looked over it and down into the nearly six-hundred-foot-deep hole, where the machines and their sounds, the whine of the saws and the belch of dump trucks, were more readily apparent than any human presence. The quarry was not one deep hole but a series of descending plateaus. Plants clung to the rock that gave way to penetratingly blue water that had collected in the basin, the chalky granite dust turning the pool into a false image of glacial melt. Our guide told us that in 1970, when he began working in the hole, he was one of two hundred men. Today there are only thirteen. If they were to keep going at this rate, they could continue to quarry here for the next 4,500 years. Roger told us that the company that owns the quarry will not dig any deeper—the pressure builds the farther down they go, and could begin to crack the stone—so instead they shave away at the sides of the opening. These formations were created approximately 330 million years ago, as magma from below the mantle rose and cooled. The result is uniquely uniform plugs of hard, clean-breaking Barre granite, one of the densest of carvable rocks. It bears distinct smudges of white and coal-black shavings, marred by nicks of gray and glassy dots of quartz. Combined, these minerals give the stone an indistinct solidity, as if seen through a blurred lens. Its sparkle comes from the mica exposed by a carver’s chisel.

more here.

Enjoying the content on 3QD? Help keep us going by donating now.

Tuesday Poem

Inshallah My Cellphone

left my phone unlocked
on the taxi’s back seat,
won’t be the last time called it a few times
finally, the driver picked up he had a fare immediately after mine,
and was now headed way downtown,
and would call later
when fate returned him nearer my officeand so it came to pass,
very shortly thereafter,we met on the street,
he rolled down the window
and with the greatest smile of pleasure,
as if he had won the lottery
beaming,
handed me my phoneI had two $20’s to cover any expense he might have incurred,
neatly folded in my hand
and offered it right up, right away;
but the driver repeatedly pushed my hand away
as I insisted,
saying:

“No sir, no no, not necessary!

Allah sent me a fare
that took me soon back close to you, so,
no loss of time did I suffer,
so your offer is kindly unnecessary!”

to which I replied,

“exactly!
Allah sent you to me
so I could reward you!”

and with an equally, beaming smile I continued,

“our ride and meeting today,
together was pre-ordained it was

Inshallah!”

something he could not dispute…
or my knowledge thereof and it’s
proper pronouncement, nor
his amazement, to disguise!

we parted ways
each believing,
each receiving,
a heavenly check plus,
each, credited with a mitzvah
on our respective trip logs,
our humanly divine balance sheets,
kept by the single supreme
taxi dispatcher

by Path Humble
from Hello Poetry

Inshallah: Arabic for ^”God/Allah willing” or “if God/Allah wills,”
frequently spoken by a Muslim

Monday, July 15, 2024

A family’s travelogue from Phnom Penh to Paris and back

Patrick Doan in the European Review of Books:

Where there’s an airport, there’s security, and where there’s China, there’s screening, so here we are at the checkpoint at Baiyun International Airport, where austere officials are checking that we’re not carrying anything suspicious. We go through the scanner first, and A-kong takes his time. When the diaphanous image of his suitcase’s entrails finally appears on the screen, the agents are surprised to see quite clearly a thirty-centimeter knife, lying peacefully alongside twelve boxes of Doliprane (paracetamol) 1000mg, one hundred and eighty COVID masks (which he will later offer to my cousin) and eight camera batteries — for A-kong suffers from a rather severe scopic compulsion. A conversation in Mandarin ensues between the agent and my father, who hopes to convince the woman not to confiscate his « fruit knife ». Meanwhile, while my wife Insa questions the reliability of Luchthaven Schiphol’s security service (we’d flown from Amsterdam), my daughter Elly rolls her eyes, my son Robin pretends to look at his smartphone (without a network), and I watch my father adopt a familiar posture: a man of good faith imploring clemency from his next superior. This time his plea has little effect. But I know it has worked before — at least once.

It was forty-seven years ago, in a sweet potato field on the edge of the jungle. A few days earlier, the Khmer Rouge had entered Phnom Penh as liberators, then started shooting at everyone.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

The Ecology of Collective Behavior

Leon Vlieger at The Inquisitive Biologist:

This is the third of a trio of reviews in which I take a brief detour into ants and collective behaviour more generally. I previously reviewed The Ant Collective, a graphical introduction to ant behaviour, and entomologist Deborah M. Gordon’s Ant Encounters, a primer on how collective behaviour in ants comes about. The Ecology of Collective Behavior is the second book by Gordon that I will examine. It proposes a research programme to figure out both how collective behaviour responds to changing environmental conditions, and how it evolves. Though squarely aimed at professional biologists, this brief and interesting book is nevertheless accessible to a wider interested audience and makes its case with nary an equation in sight.

One of the most familiar examples of collective behaviour is swarming, where large numbers of animals move in a coordinated fashion, whether flocks of birds or schools of fish. However, collective behaviour can take many different forms and it has proven incredibly tricky to develop a general theory that successfully captures the diversity of processes generating it.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

Launching The Edgy Optimist

Zachary Karabell at The Edgy Optimist:

A bit more than a decade ago, I launched a column for The Atlantic and Reuters and then Slate. It was called “The Edgy Optimist.” The goal was to take a weekly look at what might go right, rather than focus relentlessly on all that is going wrong. Now, in a time of deep pessimism bordering on despair, I’m re-launching “The Edgy Optimist,” and I hope you will join me.

When I started the column, the prevailing mood was dark in the United States, but today, arguably, the mood is far darker, with few corners of the world immune from the belief that tomorrow will inevitably and inexorably be worse than the present. Polls of public opinion in country after county confirm that publics everywhere feel a deep sense of unease about politics, the economy, the climate and above all, the future.

In this maelstrom of negativity, optimism can feel almost offensive. It seems to fly in the face of the intense struggles so many confront. My optimism says not that we are overstating our problems but that we are underestimating our capacity to solve them, and my edginess is that there are dangers in not looking at the upsides.

This is not about firemen saving cats in trees; this is about how we shape our future. Pessimism can create its own dystopian doom loop: the despairing conviction that we lack the ability to create a better world can itself be toxic.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

A Summer With Pascal

Jonathan Egid at Literary Review:

I am precisely the target audience for this small book on the French philosopher and mathematician Blaise Pascal. Although I work on 17th-century philosophy (in a quite different part of the world, in my defence), I knew next to nothing about Pascal save for those things named after him – the unit of pressure, the triangle of binomial coefficients, the famous wager – before starting Compagnon’s elegant, unconventional ‘beach read’.

Years ago, I bought a copy of Pascal’s Pensées in one of those beautiful old Penguin Classics editions, but the image of his stark white plaster death mask set against an all-black background rather scared me off opening it up. A similarly foreboding impression was provided by the one sentence of his that I remembered, from an epigraph in A W Moore’s The Infinite: ‘The eternal silence of these infinite spaces fills me with dread.’

more here.

Enjoying the content on 3QD? Help keep us going by donating now.

Ashura: Why Muslims fast and mourn in Muharram

Abdul-Ilah As-Saadi in Al-Jazeera:

Ashura is marked on the 10th day of Muharram, the first month of the Islamic calendar, by all Muslims. It marks the day Nuh (Noah) left the Ark and the day Musa (Moses) was saved from the Pharaoh of Egypt by God. The Prophet Muhammad used to fast on Ashura in Mecca, where it became a common tradition for the early Muslims. Ashura this year will be marked in most places on August 29. But for the Shia, it is also a major religious event to commemorate the martyrdom of Husayn Ibn Ali al-Hussein, the grandson of the Prophet Muhammad, who died at the Battle of Karbala in 680 AD.

…The death of Imam al-Hussein is considered by the Shia community to be a symbol of humanity’s struggle against injustice, tyranny and oppression. The primary rituals and observances on Ashura consist of public expressions of mourning. Some in the Shia community resort to self-flagellation with chains and the blunt ends of swords. This is intended to exemplify the suffering Imam al-Hussein experienced shortly before his beheading.

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

This kids’ brain cancer is incurable — but immune therapy holds promise

Heidi Ledford in Nature:

Every two weeks at Seattle Children’s Hospital in Washington, a five-year-old child stops by for a fresh dose of genetically engineered immune cells administered directly into the fluid around their brain.

The child has been making these visits for more than three years, after they were diagnosed with a devastating form of brain and spinal cancer called diffuse midline glioma that has no known cure. But the treatment, called CAR-T-cell therapy, appears to have shrunk their tumour and kept it in check. At 70 treatments and counting, this five-year-old might have received more doses of CAR-T-cell therapy than anyone else on the planet.

His oncologist, Nicholas Vitanza, lights up whenever he talks about the results. Still, Vitanza is keenly aware that the child’s response is unusual. Although several children in Vitanza’s clinical trial might also have benefited from the CAR-T-cell regimen, most responses were not as dramatic or long-lasting as the five-year-old’s. Now, the question that keeps Vitanza and others in his field up at night is: how can they make that success less of an outlier?

More here.

Enjoying the content on 3QD? Help keep us going by donating now.

On Marilynne Robinson’s Reading Genesis

Linden K. Smith at The Point:

Robinson opens Reading Genesis with the suggestion that the Bible is a theodicy, a meditation on the problem of evil.” For Robinson, this entails the reconciliation of “the darkest aspects of the reality we experience” with “the goodness of God and of Being itself against which this darkness stands out so sharply.” Already in the third sentence of the book, Robinson is speaking to both religious and secular readers: even if they have no interest in God, there remains the pressing question of the justification of “Being itself.” As in her fiction, Robinson is ecumenical, translating her theological outlook for the religiously alienated. She understands that theodicy is not merely a religious problem but that secular questions about the meaning and worthwhileness of life have the very same structure. 

In Genesis, God walks the selfsame ground as God’s creatures, makes covenants with them, even bargains with them. There is nothing strange, Robinson tells us, in the fact that Genesis moves from cosmology and the origin of the universe to petty human squabbles in just a couple of chapters. 

more here.

Enjoying the content on 3QD? Help keep us going by donating now.