The Chance Discovery that Revolutionized Neuroscience

Kamal Nahas in The Scientist:

Peter Hegemann, a biophysicist at Humboldt University, has spent his career exploring interactions between proteins and light. Specifically, he studies how photoreceptors detect and respond to light, focusing largely on rhodopsins, a family of membrane photoreceptors in animals, plants, fungi, protists, and prokaryotes.1 Early in his career, his curiosity led him to an unknown rhodopsin in green algae that later proved to have useful applications in neuroscience research. Hegemann became a pioneer in the field of optogenetics, which revolutionized the ways in which scientists draw causal links between neuronal activity and behavior.

In the early 1980s during his graduate studies at the Max Planck Institute of Biochemistry, Hegemann spent his days exploring rhodopsins in bacteria and archaea. However, the field was crowded, and he was eager to study a rhodopsin that scientists knew nothing about. Around this time, Kenneth Foster, a biophysicist at Syracuse University, was investigating whether the green algae Chlamydomonas, a photosynthetic unicellular eukaryote related to plants, used a rhodopsin in its eyespot organelle to detect light and trigger the algae to swim. He struggled to pinpoint the protein itself, so he took a roundabout approach and started interfering with nearby molecules that interact with rhodopsins.2

More here.



Deeper Into Ozu

various authors at The Current:

Beloved for his poetic observations of domestic life and intergenerational conflict, Yasujiro Ozu is an icon of international art-house cinema whose patient, exquisitely restrained style has influenced filmmakers around the world. But even though he directed more than fifty features over the course of his nearly four-decade career, the Japanese auteur is still primarily associated with two midcentury classics, Tokyo Story and Late Spring, both of which regularly appear on lists of the greatest films of all time. To commemorate the 120th anniversary of the director’s birth, we invited six writers to explore the retrospective of his films now playing on the Criterion Channel and shine a spotlight on a lesser-known gem. Covering different periods in Ozu’s career, from his beginnings in the silent era to the end of his life in the early 1960s, this series of essays foregrounds underacknowledged elements of his artistry, including his love of classic Hollywood comedy, his flair for melodrama, the various forms of masculinity depicted in his work, and the queer resonances of his family portraits.

more here.

Wolfgang Tillmans: “Art Doesn’t Have A Purpose”

Ellen Peirson-Hagger at the New Statesman:

The development of his body of work is “completely collapsed and over-arching”, Tillmans said. To map out a logical timeline would be reductive. Though there are issues that recur, such as “the politics of representation”, women’s rights and gay rights. Tillmans came out as gay when he was 16, the summer Bronski Beat’s “Smalltown Boy” – which he describes as “the first fully out gay pop song” – was in the charts. “I feel a great sense of gratitude for having been born when and where I was,” he said, though his life has been touched by tragedy: his boyfriend, the painter Jochen Klein, died of Aids-related illnesses in 1997. Tillmans lives with HIV. He does not tend to make work specifically about the disease – 17 Years’ Supply (2014), which depicts a box full of empty pill bottles, is an exception – but his photographs have accrued a political significance in the public sphere. The Cock (Kiss), a 2002 portrait of two men kissing, was the subject of a homophobic attack when it was exhibited in Washington DC in 2006. Ten years later, when 49 people were murdered at Pulse, a gay nightclub in Florida, the image was widely circulated online by way of protest. The photograph was most recently used as the cover for Young Mungo, a gay love story by the Scottish Booker Prize winner Douglas Stuart.

more here.

Wednesday Poem

The End and the Beginning

After every war
someone’s got to tidy up.
Things won’t pick
themselves up, after all.

Someone’s got to shove
the rubble to the roadsides
so the carts loaded with corpses
can get by.

Someone’s got to trudge
through sludge and ashes,
through the sofa springs,
the shards of glass,
the bloody rags.

Someone’s got to lug the post
to prop the wall,
someone’s got to glaze the window,
set the door in its frame.

No sound bites, no photo opportunities
and it takes years.
All the cameras have gone
to other wars.

The bridges need to be rebuilt,
the railroad stations, too.
Shirt sleeves will be rolled
to shreds.

Someone, broom in hand,
still remembers how it was.
Someone else listens nodding
his unshattered head.
But others are bound to be bustling nearby
who’ll find all that
a little boring.

From time to time someone still must
dig up a rusted argument
from underneath a bush
and haul it off to the dump.

Those who knew
what this was all about
must make way for those
who know little.
And less than that.
And at last nothing less
than nothing.

Someone’s got to lie there
in the grass that covers up
the causes and effects
with a cornstalk in his teeth,
gawking at clouds.

by Wislawa Szymborska
from
The Vintage Book of
Contemporary World Poetry, 1996
translation: Stanislaw Baranczak & Clare Cavanaugh

Adam Tooze: War, peace and the return of history in 2023

Adam Tooze in Chartbook:

In 2023 the escalation of violence around the world was horrifying. As the FT remarked:

The anecdotal evidence that war is surging round the world is confirmed by the numbers. A recent report by the International Institute for Strategic Studies documented 183 ongoing conflicts around the world, the highest number in more than three decades. And that figure was arrived at before the outbreak of the war in Gaza.

How do we locate this surge in violence in contemporary history? One can, as the FT does, point to a variety of contingent causes, such as failures of intelligence and deterrence, weak state power and the perception that Western power is fading.

Whilst recognizing the diversity of causes, we should go deeper than this.

More here.

The Year in Cheer: 177 ways the world got better in 2023

From Reasons to be Cheerful:

The ozone layer will be completely recovered within the next 40 years.

The Inflation Reduction Act set aside $1.5 billion for urban tree planting in 2023.

Four-day work weeks helped reduce commuting hours by 10 percent in the UK and 27 percent in the US, leading to a decrease in carbon emissions.

All 140 whisky distilleries in Scotland have pledged to be carbon-neutral by 2040.

More than 15 million people living in Brazil’s densely populated favelas are getting street addresses.

Volunteers have given new life to more than 100,000 abandoned bicycles, shipping them across the globe to people who need them.

More here.

Democrats and Climate Activists Are on a Collision Course in 2024

Aaron Gell in The New Republic:

Ali Zaidi, the White House’s thirtysomething national climate adviser, stood before a lectern in a packed conference hall at the NYU School of Law wearing a crisp navy suit, a blue tie, and just enough stubble to look roguish and anti-establishment but not slovenly. It was September 18, day 2 of Climate Week NYC, and Zaidi was in town to tout the administration’s environmental accomplishments. He began by highlighting the critical role the nation’s youth, like the law students arrayed before him, were playing in the climate movement. “It’s really been the voices of young people who have organized and agitated for change—” he was saying when audience member Sim Bilal, 21, rose to his feet.

A member of the newly launched pressure group Climate Defiance, Bilal, an L.A.-based community organizer, wearing a black watch cap and an overstuffed backpack, had come to make his own voice heard. He was young. He was agitating.

“Will you publicly ask Biden to oppose the Willow project?” he demanded, referring to Conoco­Phillips’s plan to drill for oil in a 499-acre patch of Alaskan tundra. “You guys have protected 13 million acres of the Arctic, but that’s not enough. So, yes or no?”

More here.

Tuesday, January 2, 2024

Behind the New Iron Curtain

Marzio G. Mian at Harper’s Magazine:

Russia has become, to observers in the West, a distant, mysterious, and hostile land once again. It seems implausible, in the age of social media, that so little should be known about the country that has shattered the international order, but the shadows surrounding Russia have only grown since the days of the Soviet Union. Of course, it is one thing to observe the country from the outside; it is another to try to understand how Russians experience the war and react to sanctions from within, and what they hope the future holds. If Russia seems to have become another planet, it is largely because its regime has also waged war on foreign journalists, preventing them from straying beyond established perimeters.

Over the summer, hoping to do precisely that, I spent a month traveling down the Volga River. In a land of great rivers, the Volga is the river. They call it matushka, the mother; it flows from the Valdai Hills to the land of the Chuvash, the Tatars, the Cossacks, the Kalmyks, and into the Caspian Sea.

more here.

The Life and Times of The Paris Metro

Adrienne Raphel at The Paris Review:

In 1974, Harry Stein and Thomas Moore, young editors who’d worked together at New Times, a glossy biweekly in New York, had an idea: Let’s start a magazine—in Paris. Moore had recently come into a windfall when one of his articles, about an bank robbery in Brooklyn, became the basis for the film Dog Day Afternoon. He moved to Paris, following his then girlfriend; the relationship ended, but he stayed. Stein had previously lived in Paris, writing features for the International Herald Tribune, and also had a European girlfriend at the time. At first, the idea seemed impossible: Maybe we should sell baseball caps instead of starting a magazine, Stein thought. But Moore had a vision. He stole the name from the café outside his living room window, stole the masthead logo from the subway sigh, and their publication was born: The Paris Metro.

Stein and Moore called Joel Stratte-McClure, a fellow journalist then in Paris on assignment, to tell him that they had a “scoop” on a nuclear meltdown and ask him to meet them in the Bar Hemingway at the Ritz. (There was no meltdown.) Several martinis in, Stratte-McClure joined the Metro team.

more here.

The Real History Behind Leonard Bernstein and Felicia Montealegre’s Marriage in ‘Maestro’

Ellen Wexler in Smithsonian:

On her 25th birthday in February 1947, Felicia Montealegre sent a giddy letter to her new fiancé. “Lenny, my darling, my darling!” she wrote. “I am a quarter of a century old, a very frightening fact!” Recent developments, she went on, included the arrival of a black cocker spaniel puppy (“She’s mine, my very own!”) and an impending driver’s license exam (“I drive alone all over the place, up hill and down dale, heavy traffic and all—and I’m great! So there!!”).

Felicia, an actress, had been engaged to Leonard Bernstein, the 28-year-old wunderkind composer and conductor, for two months. She was, like most everyone in the man’s orbit, perilously in love with him. Still, beneath the bubbly, starry-eyed adoration, she felt something was amiss. “What’s with you?” she wrote. “You never really tell me how you feel—is it that difficult?” Come fall, the engagement was off. Then, after a four-year interlude, it was back on. A wedding quickly followed.

Yet the biggest obstacle remained: Bernstein, a closeted bisexual man, had always conducted numerous affairs with both men and women. In 1947, the secrecy had been evidently too heavy for the relationship to bear.

More here.

10 Nutrition Tips for a Healthy New Year

Alice Callahan in The New York Times:

As a health reporter who’s been following nutrition news for decades, I’ve seen a lot of trends that made a splash — and then sank. Remember olestra, the Paleo diet and celery juice? Watch enough food fads come and go, and you realize that the most valuable nutrition guidance is built on decades of research, in which scientists have looked at a question from multiple perspectives and arrived at something like a consensus.

Decades of research support the Mediterranean diet — which is centered on fruits and vegetables, whole grains, legumes, olive oil, nuts, herbs and spices — as one of the healthiest ways you can eat. Its heart-health benefits are numerous, and it has been linked to a lower risk of Type 2 diabetes, cognitive decline and certain types of cancer. Here are 10 science-backed pearls to carry you into the new year.

Some people may experience heartburn, but there’s no evidence that drinking coffee on an empty stomach can damage your gastric lining or otherwise harm your digestive system, experts say. And there are reasons to feel good about your morning brew: Drinking coffee has been linked to a longer life and a lower risk of heart disease and Type 2 diabetes.

More here.

Hanif Kureishi: accident ‘completely eradicated’ sense of self and privacy

Jane Clinton in The Guardian:

Hanif Kureishi has spoken candidly of how his sense of self and privacy have been “completely eradicated” after a fall on Boxing Day last year left him unable to use his hands, arms or legs.

As guest editor of BBC Radio 4’s Today programme, the novelist and screenwriter also said he had to adjust to “becoming another person” after the accident, in which he collapsed and fell on his head after a walk in Rome.

The 69-year-old, best known for The Buddha of Suburbia, is still unable to use his limbs and has spent the last year in five different hospitals, according to the programme. Much of the show was recorded at the Royal National Orthopaedic hospital in London.

Kureishi said that since the accident he felt like an “exhibit” being surrounded by doctors, adding: “It is humiliating at the start and then you begin to realise that it doesn’t really matter.

“You realise quite quickly that your body doesn’t belong to you any more … that you are changed, washed, poked and prodded by nurses and doctors, random people all the time.

“You give up any sense of privacy: of your body, of your mind, of your soul, of anything about you … it’s completely eradicated.”

More here.

The Cause of Depression Is Probably Not What You Think

Joanna Thompson in Quanta:

People often think they know what causes chronic depression. Surveys indicate that more than 80% of the public blames a “chemical imbalance” in the brain. That idea is widespread in pop psychology and cited in research papers and medical textbooksListening to Prozac, a book that describes the life-changing value of treating depression with medications that aim to correct this imbalance, spent months on the New York Times bestseller list.

The unbalanced brain chemical in question is serotonin, an important neurotransmitter with fabled “feel-good” effects. Serotonin helps regulate systems in the brain that control everything from body temperature and sleep to sex drive and hunger. For decades, it has also been touted as the pharmaceutical MVP for fighting depression. Widely prescribed medications like Prozac (fluoxetine) are designed to treat chronic depression by raising serotonin levels.

Yet the causes of depression go far beyond serotonin deficiency.

More here.

Tuesday Poem

“The New Year is not a new year, it’s but a new day.”
___________________________
Roshi Bob

Lamb

Saw a lamb being born.
Saw the shepherd chase and grab a big ewe
and dump her on her side.
Saw him rub some stuff from a bottle on his hands.
Saw him bend and reach in.
Heard two cries from the ewe.
Two sharp quick cries. Like high grunts.
Saw him pull out a slack white package.
Saw him lay it on the ground.
Saw him kneel and take his teeth to the cord.
Saw him slap the package around.
Saw it not move.
Saw him bend and put his mouth to it and blow.
Doing this calmly, half kneeling.
Saw him slap it around some more.
Saw my mother watching this. Saw Angela. Saw Peter.
Saw Mimi, with a baby in her belly.
Saw them standing in a row
by the dry stone wall, in the wind.
Saw the package move.
Saw it was stained with red and yellow.
Saw the shepherd wipe red hands on the ewe’s wool.
Heard the other sheep in the meadow calling out.
Saw the package shaking its head.
Saw it try to stand. Saw it nearly succeed.
Saw it have to sit and think about it a bit.
Saw a new creature’s first moment of thinking.
Felt the chill blowing through me.
Heard the shepherd say:
“Good day for lambing. Wind dries them out.”
Saw the package start to stand. Get half-way. Kneeling.
Saw it push upward. Stagger, push. And make it.
Stand, Standing.
Saw it surely was a lamb. a lamb, a lamb.
Saw a lamb being born!

by Michael Dennis Browne
from
News of the Universe
Sierra Club Books, 1995

The Free-Speech Debate Is a Trap

Andrea Long Chu in New York Magazine:

It is worth remembering the vast majority of what we call free-speech issues have little basis in the First Amendment, which only forbids the abridgment of speech by the government, not private organizations like magazines, cultural centers, or Hollywood production companies. In most states, for instance, it is perfectly legal for employers to fire workers for speech, as a Westchester synagogue did last year after a teacher wrote an anti-Zionist blog post. So when advocates talk of freedom of speech, they are usually referring neither to the Constitution nor to statutory law but to a set of civil norms imagined to promote the health of the republic but which cannot be directly enforced by the government. Had the House committee hauled in the chancellor of Florida’s state schools for his attempts to shut down pro-Palestine campus groups, then it might have found a genuine First Amendment issue — but only because the government cannot set aside its constitutional duties when it steps into the role of educator. By contrast, when a private university promises to safeguard free speech, it does so in excess of its legal obligations.

More here.

Sunday, December 31, 2023

This Year, Make a Resolution About Something Bigger Than Yourself

Roger Rosenblatt in The New York Times:

In “Leaves of Grass,” Walt Whitman writes: “This is what you shall do: Love the earth and sun and the animals, despise riches, give alms to everyone who asks, stand up for the stupid and crazy.” He continues, “Re-examine all you have been told at school or church or in any book, dismiss whatever insults your own soul, and your very flesh shall be a great poem.’’ So there. If you’re looking for a worthwhile resolution, Whitman is not a bad place to start.

The task of improving the world may seem impossible, but it isn’t. All it takes is the proper sequence of correct discrete decisions. Decisions are just resolutions with teeth. An editor of mine told me a story from his childhood on his grandparents’ farm in Iowa. The little boy, looking out over acres and acres of corn, asked his grandfather, “How are we going to shuck all that corn?” His grandfather said, “One row at a time.”

This, too, is how to improve the world. And we can start small.

More here.