From Phys.Org:
Johns Hopkins University-led researchers, working with the Biomarkers for Older Controls at Risk for Dementia (BIOCARD) cohort, have found that certain factors are linked to faster brain shrinkage and quicker progression from normal thinking abilities to mild cognitive impairment (MCI). People with type 2 diabetes and low levels of specific proteins in their cerebrospinal fluid showed more rapid brain changes and developed MCI sooner than others.
Long-term studies tracking brain changes over many years are rare but valuable. Previous research mostly provided snapshots in time, which can’t show how individual brains change over the years. By following participants for up to 27 years (20-year median), this study offers new insights into how health conditions might speed up brain aging.
More here.
Enjoying the content on 3QD? Help keep us going by donating now.


In Vermeer’s Woman in Blue Reading a Letter, the observer is drawn into a simple domestic scene: the titular woman stands illuminated in the light of, we presume, an unseen window. The expression on her face as she reads is perhaps one of surprise, certainly one of concentration. In this vivid, static painting, she seems even more still and more rooted, unmoving though clearly moved by what she is reading. And the observer is similarly absorbed by this intimate moment.
JAMIE HOOD: Hello!
When, on January 19, 1939, W.H. Auden boarded at Southampton a ship bound for New York City, he could not have known that he would never live in England again. But some months earlier, he had told his friend Christopher Isherwood that he wanted to settle permanently in the United States. Almost as soon as he arrived in New York, he began to rethink his calling as a poet, and, moreover, to reconsider the social role and function of poetry. (He also began a spiritual pilgrimage that would lead him to embrace the Christian faith of his childhood.)
An important goal for Prothero is to explain how we know what we know so that readers understand how the climate works and why it changes. As such, much attention is given to the numerous lines of evidence on which palaeoclimatology draws. The fossils that show
In a landmark study, the psychologist Philip Tetlock evaluated several decades of predictions about political and economic events. He
I want to make the case for the power of thinking in the third person. The first person, of course, comes quite naturally to us. We have a vivid sense of our experiences and perspectives: This is who and what I am. People will live their lives with “main character energy.” Yet, with a little more work, we can also view ourselves the way historians and social scientists might: as creatures shaped by larger forces and bound by a culture’s pre-written scripts. That means seeing ourselves as the inheritor and inhabitant of various social identities — and, therefore, as a person like every other.
When Sam Rodriques was a neurobiology graduate student, he was struck by a fundamental limitation of science. Even if researchers had already produced all the information needed to understand a human cell or a brain, “I’m not sure we would know it”, he says, “because no human has the ability to understand or read all the literature and get a comprehensive view.”
In all of English there are few words rich enough in their history and variety of use to warrant a dedicated dictionary that runs to hundreds of pages and multiple editions. That fuck is at the same time one of the most notorious, popular, and emotive words in the language makes it all the more fascinating—and deserving of the attention given to it in this volume.
Weren’t they bothered that Trump is a convicted felon? An adjudicated rapist? Didn’t his invocation of violence against Liz Cheney, or 50 other examples of his disgusting imprecations, obviously disqualify him? And couldn’t they see that Harris, whatever her shortcomings, was a fundamentally smart, honest, well-meaning person who would show basic respect for the Constitution and wouldn’t do anything weird as president?
L
As a young boy growing up in the Netherlands in the 1990s, Sander van der Linden learned that most of his mother’s relatives, who were Jewish, had been killed by the Nazis, in the grip of racist ideology. At school, he was confronted with antisemitic conspiracy theories still circulating in Europe. It all got him wondering about the power of propaganda and how people become convinced of falsehoods.
Fiction about young girls has often been in thrall to silence, secrecy, and evasion. In Jane Austen’s Mansfield Park, for example, young Fanny Price moves on tiptoe, daring anyone to notice her. Instead, all the noticing is done by her. Her duty is not merely to stay in the shadows but also to remain quietly pleasant and accommodating. So, too, the young Catherine Sloper in Henry James’s Washington Square shares her feelings with no one, and thus her feelings deepen. She is at her most interesting when she is at her most silent and withdrawn.