Why Don’t We Know the Age of the New Ancient Human?

Ed Yong in The Atlantic:

ScreenHunter_1372 Sep. 18 19.22Last Thursday, the world said hello to Homo naledi, a new species of ancient human discovered in South Africa’s Rising Star cave. As I reported at the time, scientists extracted 1,550 fossil fragments from the cave, which were then assembled into at least 15 individual skeletons—one of the richest hauls of hominid fossils ever uncovered.

But one significant problem clouded the excitement over the discovery: The team doesn’t know how old the fossils are. And without that age, it’s hard to know howHomo naledi fits into the story of human evolution, or how to interpret its apparent habit of deliberately burying its own kind. Everyone from professional paleontologists to interested members of the public raised the same question: Why hadn’t the team dated the fossils yet?

The simple answer is: Because dating fossils is really difficult. Scientific papers and news reports about new fossils so regularly come with estimates of age that it’s easy forget how hard-won such data can be. I asked John Hawks, a biologist at the University of Wisconsin and one of the heads of the Rising Star expedition, to talk me through the various available methods—and why they have been difficult to apply to the latest finds.

More here.



A Queer Excess: the Supplication of John Wieners

Nat Raha in The Critical Flame:

ScreenHunter_1371 Sep. 18 19.13The poetry of John Wieners is lyric, bold, shameless. It is a poetry of dereliction in the face of the artist’s almost religious devotion to verse and its inherent magic. His early work—the era between The Hotel Wentley Poems (1958) to Ace of Pentacles (1964)—swings with blues and sexual desire, the glamour of drugs and counter-cultures, gay subculture, celebrities and starlets, and tarot, all sources to feed his magical art. Wieners’s work in subsequent years contends with romantic loss and poverty, juxtaposed with moments of pleasure in sexual and gender transgression, and a political awakening in the face of state harassment and psychiatric incarceration. In his 1958 breakthrough volume, Wieners announces his radical poetics coolly, almost objectively:

I find a pillow to
muffle the sounds I make.
I am engaged in taking away
from God his sound.

The erasure of God’s articulation is achieved by the young poet’s flawed articulation of worlds that negate the very premise of an all-loving God—worlds that the popular morality of that era would certainly describe as vice-ridden, worlds that were outside the bounds of sanctioned activities. Supplication to lyric poetry, in light of the failure of God, is a necessity of survival, the “last defense” of the poet.

More here.

Why the Rich Are So Much Richer

James Surowiecki in the New York Review of Books:

Surowiecki_1-092415_jpg_250x1887_q85Today, the landscape of economic debate has changed. Inequality was at the heart of the most popular economics book in recent memory, the economist Thomas Piketty’sCapital. The work of Piketty and his colleague Emmanuel Saez has been instrumental in documenting the rise of income inequality, not just in the US but around the world. Major economic institutions, like the IMF and the OECD, have published studies arguing that inequality, far from enhancing economic growth, actually damages it. And it’s now easy to find discussions of the subject in academic journals.

All of which makes this an ideal moment for the Columbia economist Joseph Stiglitz. In the years since the financial crisis, Stiglitz has been among the loudest and most influential public intellectuals decrying the costs of inequality, and making the case for how we can use government policy to deal with it. In his 2012 book, The Price of Inequality, and in a series of articles and Op-Eds for Project Syndicate, Vanity Fair, and The New York Times, which have now been collected in The Great Divide, Stiglitz has made the case that the rise in inequality in the US, far from being the natural outcome of market forces, has been profoundly shaped by “our policies and our politics,” with disastrous effects on society and the economy as a whole. In a recent report for the Roosevelt Institute called Rewriting the Rules, Stiglitz has laid out a detailed list of reforms that he argues will make it possible to create “an economy that works for everyone.”

Stiglitz’s emergence as a prominent critic of the current economic order was no surprise. His original Ph.D. thesis was on inequality. And his entire career in academia has been devoted to showing how markets cannot always be counted on to produce ideal results. In a series of enormously important papers, for which he would eventually win the Nobel Prize, Stiglitz showed how imperfections and asymmetries of information regularly lead markets to results that do not maximize welfare.

More here.

How the Future Will Tell Bill Cosby’s Story

Christina Cauterucci in XXFactor:

BillIt’s been nearly a year since a joke from Hannibal Buress’ stand-up routine—augmenting a February Gawker post—reminded the public of the many women who’ve accused Bill Cosby of sexual assault. Since dozens more allegations and a damning deposition testimony have surfaced, it’s hard to believe there were days when we still wondered if Cosby’s legacy could survive the alleged monstrosities of his past. Thursday night, A&E will premiere an hourlong special about the conservative apologist’s fall from public favor. Framed by a chronological telling of his career arc, it plays as a damning biographical documentary—a profoundly unflattering look back at how, at every step in his professional life, Cosby used his money, fame, and paternal reputation to manipulate young women.

It also offers a glimpse at how future cultural critics might analyze his life. Video is an effective means of exposing Cosby’s hypocrisies: Disturbing personal accounts from 13 women he allegedly assaulted cut even deeper when paired with audio of his 1960s stand-up (including one boding bit about slipping women a purported aphrodisiac, Spanish fly) and footage from his moralizing speeches, in which he’d vilify pregnant black teens for having sex. Viewed from above, Cosby’s downfall seems inevitable from the start, even though plenty of other men in power have gone peacefully to their graves after a history of physical and sexual abuse.

More here.

fights about object-oriented ontology

OOOSymposiumPosterGraham Harman and Andrew Cole at Artforum:

THERE ARE SEVERAL strange elements in Andrew Cole’s recent polemic against speculative realism and object-oriented ontology [Artforum, Summer 2015]. First, in a piece written specifically for Artforum, Cole never bothers to address our views on art, choosing instead to treat the magazine’s readership to a long lesson on the philosophy of Immanuel Kant. Second, after trying to make us look disrespectful by likening us to vandals who spray-painted “Kant is a moron” on a house in Kaliningrad, Russia, Cole himself takes a crude and macabre dig at Kant’s personal life: “Yes, Kantian moral philosophy leaves something to be desired, as when the philosopher exemplifies the categorical imperative by asking readers to imagine having sex near the gallows—easy to say for a person who never got laid.” It’s also strange that while Cole only cites one of my publications (The Quadruple Object [2011]) by name, he laments unanswered questions that are addressed not only in other publications, but even in the one book that he seems to have read.

Forgetting for now these unsettling signals, let’s briefly consider Cole’s argument, which is really an attempted counterpoint of two separate arguments. The first is that we have either misunderstood Kant or deliberately distorted his ideas to conceal the fact that we have stolen most of our insights from him. The second—always a crowd-pleaser—is that object-oriented philosophy is hopelessly complicit with capitalism and the “commodity fetishism” that Marx linked with the capitalist system. Cole handles the second point more impressionistically than the first, and a similar argument was already made by his sometime collaborator Alexander R. Galloway in a widely read but dreadful 2013 Critical Inquiry article entitled “The Poverty of Philosophy: Realism and Post-Fordism.” In what follows, I will therefore focus on Cole’s remarks on Kant.

more here.

on Colm Tóibín’s ‘ON ELIZABETH BISHOP’

Colm_cover_3261518aFiona Green at the Times Literary Supplement:

“What must it be to be someone else?” Gerard Manley Hopkins wondered. It is a question that has occupied Colm Tóibín before, whether the someone else was Henry James, or the mother of Christ. What must it be to be someone else in a book that is not a novel, and in which the someone else is a poet who specialized in solitariness, who could be “chilly” in person, and who did not hesitate to turn away uninvited guests. When Mary McCarthy threatened to visit Elizabeth Bishop, she replied: “I’d be grateful if you didn’t come over”.

Tóibín’s On Elizabeth Bishop introduces the poet in new company – he likens her to James Joyce, and more persuasively to Thom Gunn – and alongside old acquaintances (Robert Lowell, Marianne Moore). Mostly, Tóibín recognizes in Bishop aspects of himself. Both writers are drawn to grey, muted coastlines; both invest feeling in “things withheld”. Like Bishop, Tóibín found himself returned to childhood by the experience of “elsewhere”: Bishop’s fifteen-year sojourn in Brazil prompted her to recall and reimagine Nova Scotia; having “escaped Ireland” to write his first novel in Southern Europe, Tóibín found his proper “melancholy tone” in memories of Wexford. These childhood haunts were, for both writers, places of profound loss. Tóibín is particularly good on estrangement, and puts his finger right on it when he says that Bishop’s life in Brazil – at least as retold in her letters and poems – seemed “a parody of ‘normal life’”, “a comedy she had invented”.

more here.

fear

Robinson_1-092415_jpg_600x627_q85Marilynne Robinson at the New York Review of Books:

There is something I have felt the need to say, that I have spoken about in various settings, extemporaneously, because my thoughts on the subject have not been entirely formed, and because it is painful to me to have to express them. However, my thesis is always the same, and it is very simply stated, though it has two parts: first, contemporary America is full of fear. And second, fear is not a Christian habit of mind. As children we learn to say, “Yea, though I walk through the valley of the shadow of death, I will fear no evil, for Thou art with me.” We learn that, after his resurrection, Jesus told his disciples, “Lo, I am with you always, to the close of the age.” Christ is a gracious, abiding presence in all reality, and in him history will finally be resolved.

These are larger, more embracing terms than contemporary Christianity is in the habit of using. But we are taught that Christ “was in the beginning with God; all things were made through him, and without him was not anything made that was made….The light shines in the darkness, and the darkness has not overcome it.” The present tense here is to be noted. John’s First Letter proclaims “the eternal life which was with the Father and was made manifest to us.” We as Christians cannot think of Christ as isolated in space or time if we really do accept the authority of our own texts. Nor can we imagine that this life on earth is our only life, our primary life. As Christians we are to believe that we are to fear not the death of our bodies but the loss of our souls.

more here.

Use of personalized cancer drugs runs ahead of the science

Asher Mullard in Nature:

TrialAs the costs of genetic sequencing fall, oncologists are starting to prescribe expensive new drugs that target the genetic profiles of their patients’ tumours, even when those treatments have not been approved for the particular cancer involved. But such 'off-label' use is running ahead of the state of scientific knowledge, suggests the first randomized clinical trial to test the idea. The study, published in Lancet Oncology, found that using personalized cancer drugs off-label provides no benefit over conventional chemotherapy1. “This study is important because many oncologists have already adopted the personalized approach,” says Daniel Catenacci, an oncologist at the University of Chicago, Illinois, who was not involved in the trial. “Why have they abandoned the science?” Lead author of the study Christophe Le Tourneau, an oncologist at the Curie Institute in Paris, says that he sees such off-label treatments “quite often” in practice. “I understand why it happens: patients want to live and physicians want to offer help,” he says. But Le Tourneau adds that patients whose tumours have genetic alterations that might be targeted by a non-approved drug are better served by entering clinical trials.

Precision treatments

A small but growing number of personalized cancer drugs have been approved for treating particular cancers that involve specific mutations, but oncologists hope that these drugs will also work against related mutations in other cancers. By some counts, more than 30% of cancer drugs are prescribed off-label2, 3. To test the benefits of off-label tailored drug regimens, researchers at eight French hospitals analysed their patients’ tumours to look for genetic or molecular abnormalities that might be amenable to precision medicine. The researchers randomly assigned 195 suitable patients either to one of 10 potentially relevant targeted treatment regimens, or to chemotherapy. There was no significant difference between the effects of the treatments.

More here.

Thursday, September 17, 2015

The Truth about Mass Incarceration

Correctional-facility-2

Stephanos Bibas makes the conservative case for prison reform, in National Review:

Two centuries ago, the shift from shaming and corporal punishments to imprisonment made punishment an enduring status. Reformers had hoped that isolation and Bible reading in prison would induce repentance and law-abiding work habits, but it didn’t turn out that way. Now we warehouse large numbers of criminals, in idleness and at great expense. By exiling them, often far away, prison severs them from their responsibilities to their families and communities, not to mention separating them from opportunities for gainful work. This approach is hugely disruptive, especially when it passes a tipping point in some communities and exacerbates the number of fatherless families. And much of the burden falls on innocent women and children, who lose a husband, boyfriend, or father as well as a breadwinner.

Even though wrongdoers may deserve to have the book thrown at them, it is not always wise to exact the full measure of justice. There is evidence that prison turns people into career criminals. On the one hand, it cuts prisoners off from families, friends, and neighbors, who give them reasons to follow the law. Responsibilities as husbands and fathers are key factors that tame young men’s wildness and encourage them to settle down: One longitudinal study found that marriage may reduce reoffending by 35 percent. But prison makes it difficult to maintain families and friendships; visiting in person is difficult and time-consuming, prisons are often far away, and telephone calls are horrifically expensive.

On the other hand, prison does much to draw inmates away from lawful work. In the month before their arrest, roughly three quarters of inmates were employed, earning the bulk of their income lawfully. Many were not only taking care of their children but helping to pay for rent, groceries, utilities, and health care. But prison destroys their earning potential. Prisoners lose their jobs on the outside. Felony convictions also disqualify ex-cons from certain jobs, housing, student loans, and voting. Michigan economics professor. Michael Mueller-Smith finds that spending a year or more in prison reduces the odds of post-prison employment by 24 percent and increases the odds of living on food stamps by 5 percent.

Conversely, prisons are breeding grounds for crime. Instead of working to support their own families and their victims, most prisoners are forced to remain idle. Instead of having to learn vocational skills, they have too much free time to hone criminal skills and connections. And instead of removing wrongdoers from criminogenic environments, prison clusters together neophytes and experienced recidivists, breeding gangs, criminal networks, and more crime. Thus, Mueller-Smith finds, long sentences on average breed much more crime after release than they prevent during the sentence. 

More here.

Fear

Robinson_1-092415_jpg_600x627_q85

Marilynne Robinson in the NYRB:

Calvin had his supernumeraries, great French lords who were more than ready to take up arms in his cause, which was under severe persecution. He managed to restrain them while he lived, saying that the first drop of blood they shed would become a torrent that drowned France. And, after he died, Europe was indeed drenched in blood. So there is every reason to suppose that Calvin would have thought his movement had lost at least as much as it gained in these efforts to defend it, as he anticipated it would. Specifically, in some degree it lost its Christian character, as Christianity, or any branch of it, always does when its self-proclaimed supporters outnumber and outshout its actual adherents. What is true when there is warfare is just as true when the bonding around religious identity is militantly cultural or political.

At the core of all this is fear, real or pretended. What if these dissenters in our midst really are a threat to all we hold dear? Better to deal with the problem before their evil schemes are irreversible, before our country has lost its soul and the United Nations has invaded Texas. We might step back and say that there are hundreds of millions of people who love this nation’s soul, who in fact are its soul, and patriotism should begin by acknowledging this fact. But there is not much fear to be enjoyed from this view of things. Why stockpile ammunition if the people over the horizon are no threat? If they would in fact grieve with your sorrows and help you through your troubles?

At a lunch recently Lord Jonathan Sacks, then chief rabbi of the United Kingdom, said that the United States is the world’s only covenant nation, that the phrase “We the People” has no equivalent in the political language of other nations, and that the State of the Union Address should be called the renewal of the covenant. I have read that Americans are now buying Kalashnikovs in numbers sufficient to help subsidize Russian rearmament, to help their manufacturers achieve economies of scale. In the old days these famous weapons were made with the thought that they would be used in a land war between great powers, that is, that they would kill Americans. Now, since they are being brought into this country, the odds are great that they will indeed kill Americans. But only those scary ones who want to destroy all we hold dear. Or, more likely, assorted adolescents in a classroom or a movie theater.

I know there are any number of people who collect guns as sculpture, marvels of engineering. When we mount a cross on a wall, we don’t do it with the thought that, in a pinch, we might crucify someone. This seems to be a little different when the icon in question is a gun.

More here.

Brian Greene: How Einstein Changed the World

Brian Greene in Scientific American:

CAFB090E-2C90-4D40-872C5D649BAD568C_articleEinstein shot to fame within the scientific community in 1905, a year christened as his annus mirabilis. While working eight hours days, six days a week at the Swiss patent office in Bern, he wrote four papers in his spare time that changed the course of physics. In March of that year he argued that light, long described as a wave, is actually composed of particles, called photons, an observation that launched quantum mechanics. Two months later, in May, Einstein's calculations provided testable predictions of the atomic hypothesis, later confirmed experimentally, cinching the case that matter is made of atoms. In June he completed the special theory of relativity, revealing that space and time behave in astonishing ways no one had ever anticipated—in short, that distances, speeds and durations are all relative depending on the observer. And to cap it off, in September 1905 Einstein derived a consequence of special relativity, an equation that would become the world's most famous: E = mc2.

Science usually progresses incrementally. Few and far between are contributions that sound the scientific alert that a radical upheaval is at hand. But here one man in one year rang the bell four times, an astonishing outpouring of creative insight. Almost immediately, the scientific establishment could sense that reverberations of Einstein's work were shifting the bedrock understanding of reality. For the wider public, however, Einstein had not yet become Einstein.

That would change on November 6, 1919.

More here.

Why Isis fights

Martin Chulov in The Guardian:

ScreenHunter_1370 Sep. 17 20.33For more than a century, Dabiq was one of northern Syria’s forsaken villages, a speck on a vast agricultural plain between the Turkish border and the deserts of Iraq, which hardly seemed likely to shape the fate of nations. A weathered sign at its entrance said 4,000 people lived there, most of whom appeared to have left by 2013, driven out over time by a lack of work – and lately by insurrection. For the first three years of Syria’s civil war, the arrival of a strange car would lure bored children to the town’s otherwise empty streets, scattering cats and chickens as they scampered after it. Little else moved.

Dabiq’s few remaining men worked on the odd building project: a half-finished mosque, a humble house for one local who had just returned after 10 years labouring in Lebanon, or a fence for the shrine that was the town’s only showpiece – the tomb of Sulayman ibn Abd al-Malik. The Ummayad caliph was buried under a mound of earth in 717, which over many centuries had somehow grown into a small hill. The war was happening elsewhere, it seemed.

That was until the jihadists of Islamic State (Isis) arrived in early 2014, an event that the Dabiq elders had feared from the moment the war began – and which the new arrivals had anticipated for much longer. To the foreigners, and the leaders of the new militant juggernaut who were beckoning them, the war had by then entered a new phase that would transform the tussle for power in Syria into something far more grand and important. For them, the conflict that was slicing the country apart was not merely, as the Syrian opposition had seen it, a modern struggle between a ruthless state and a restive underclass. The jihadis instead saw themselves at the vanguard of a war that many among them believed had been preordained in the formative days of Islam.

More here.

Moynihan, New Orleans, and the Making of the Gentrification Economy

Blackjobs400Megan French-Marcelin at nonsite:

In 1969, Daniel Patrick Moynihan sent a rushed note to then secretary of Housing and Urban Development (HUD) George Romney. Unfazed by the backlash some four years prior to The Negro Family: The Case for National Action, Moynihan, now Richard Nixon’s counselor on Urban Affairs, enumerated the obstacles city mayors were up against on the eve of the 1970s. Armed with a slew of new statistics, the academic-turned-policy wonk doubled down on his thesis that the disintegration of black family structure was at the root of urban poverty.1 However, as the impact of deindustrialization and stagnation came into focus, Moynihan now observed other discouraging elements at work in cities as well. In little more than a few years, the failure of antipoverty programs had contributed to a more serious urban crisis motivated now by two “opposing trends”: the flight of white families and “just as clearly, the social structure of the Negro poor [which] continues to deteriorate.”2 As antithetical sides of the same crisis, city administrators must now consider how dual threats—white flight and black poverty—undermined urban stability, the academician warned.

Over the course of the next decade, local administrators in New Orleans embraced these twinned crises as means to pivot focus from inequality to matters of urban demography—conveniently ignoring broader structural economic shifts. Planners argued that the consequences of this binary left local administrators with few achievable pathways to urban stability. The city, Mayor Moon Landrieu argued, had become a “city of minorities,” “poor” and “weak.”3 Consequently, the mayor said, the fiscal crisis with which American cities contended was exacerbated in New Orleans by the sheer number of residents who “require[d] services but who [we]re less capable of paying for them.”4

more here.

THE DIVINE INSPIRATION OF JIM JONES

Article_morrisAdam Morris at The Believer:

Though obscure in popular memory, the “cause” advocated by the Peoples Temple was nothing less than total revolution: the Jonestown agricultural settlement was intended as a utopian social experiment in communism. Jones adapted the notion of “revolutionary suicide” from Huey Newton’s autobiographical account of the early days of the Black Panther Party and his personal crusade against American imperialism and racism. The young Reverend Jones may have started out preaching in the McCarthy-era Midwest, but he claimed to have held socialist and communist convictions ever since he was a child. He was a notorious liar, but if this was one of Jones’s overstatements, it was only a slight one: his wife, Marceline, recalled that her husband had privately expressed his admiration for Mao Zedong just after they were married, in 1949, when Jones was only eighteen years old.

Peoples Temple was nominally a church that originated with a core of Pentecostal followers in Indianapolis. But the Temple’s classification as a religious organization overdetermined its representation in the American media in the 1970s. Indeed, the conservative media watchdog Accuracy in Media complained that the group’s radical Marxist objectives were mostly lost in the general confusion surrounding the Jonestown massacre.

more here.

figuring out László Krasznahorkai

Lazlo Kraznahorkai SELECTS-8487.fl copyPeter Marshall at The Point:

This May, after decades of steadily gaining acclaim in the English speaking world, the Hungarian author László Krasznahorkai was awarded the Man Booker International Prize. Even with this honor, and although he has packed venues in London and New York, Krasznahorkai’s reputation for difficulty will likely continue to limit his audience. Open one of his books and you will be greeted by pages of unbroken text that take readers into a labyrinth of ideas and minute details, contradictions and verbal energy that is unlike anything else in contemporary literature.

In contrast to the overriding trend in contemporary American literature, which can be crudely, though not inaccurately, generalized as being concerned with the psychological and emotional lives of individuals in specific sociopolitical settings, Krasznahorkai’s fiction is populated by ideas, and boiling through his flood of language is a very philosophic conflict with time. Teetering on the brink of madness, characters devise systems of meaning, devote themselves to art, follow charlatans and place their faith in absurd causes in the ultimately futile attempt to halt the onslaught of change.

more here.

ON WALDEN POND

Paul Richardson in More Intelligent Life:

Walden%2001%20cropIt is one of the great American sententiae, as sonorous and moving as the Gettysburg Address. “I went to the woods because I wished to live deliberately, to front only the essential facts of life, and see if I could not learn what it had to teach, and not, when I came to die, discover that I had not lived.” Henry David Thoreau went to the woods in 1845, living for two years and two months in a cabin he had built on the north shore of Walden Pond. The book resulting from his experiment in simplicity was published in 1854, to lukewarm reviews. A century and a half later, however, “Walden” is a fundamental text of the ecological movement, and the pond, a crucial topos of American history, has become a place of pilgrimage. I come to the woods in a taxi from Logan Airport, leaving Boston on Route 2. My taxi driver is a young Ethiopian woman with a printed headscarf wound around her head, nervous on her first day of work. We leave the highway at the turn-off for Lincoln, and up there on the exit sign I see the name in big letters: Walden Pond. It has become a destination in itself.

…Thoreau went to Walden out of conviction, but also out of necessity. In March 1845 the poet William Ellery Channing, his companion on the week-long boating trip on the Concord and Merrimack rivers that would form the basis for his first book, wrote to him, “I see nothing for you on this earth but that field which I once christened ‘Briars’; go out upon that, build yourself a hut, and there begin the grand process of devouring yourself alive.” At 27, Thoreau’s published writings had been limited to essays in the Dial, the in-house magazine of the Transcendentalists, and the Democratic Review. He was close to penniless, with no immediate prospects. Helping out in the pencil-making workshop alongside his father was far from a dream job. He was comfortable enough but feared the effects of his too easeful life. More than anything, he realised, he needed to strike out on his own. In the autumn of 1844 he had helped to raise the family’s new house on Texas Street. Now that he knew something about foundations, rafters and roofing, perhaps he would be able to build something much smaller by and for himself.

More here.

The man who wants to beat back aging

Stephen S. Hall in Science:

AgeOn a blazingly hot morning this past June, a half-dozen scientists convened in a hotel conference room in suburban Maryland for the dress rehearsal of what they saw as a landmark event in the history of aging research. In a few hours, the group would meet with officials at the U.S. Food and Drug Administration (FDA), a few kilometers away, to pitch an unprecedented clinical trial—nothing less than the first test of a drug to specifically target the process of human aging. “We think this is a groundbreaking, perhaps paradigm-shifting trial,” said Steven Austad, chairman of biology at the University of Alabama, Birmingham, and scientific director of the American Federation for Aging Research (AFAR). After Austad’s brief introductory remarks, a scientist named Nir Barzilai tuned up his PowerPoint and launched into a practice run of the main presentation. Barzilai is a former Israeli army medical officer and head of a well-known study of centenarians based at the Albert Einstein College of Medicine in the Bronx, New York. To anyone who has seen the ebullient scientist in his natural laboratory habitat, often in a short-sleeved shirt and always cracking jokes, he looked uncharacteristically kempt in a blue blazer and dress khakis. But his practice run kept hitting a historical speed bump. He had barely begun to explain the rationale for the trial when he mentioned, in passing, “lots of unproven, untested treatments under the category of anti-aging.” His colleagues pounced. “Nir,” interrupted S. Jay Olshansky, a biodemographer of aging from the University of Illinois, Chicago. The phrase “anti-aging … has an association that is negative.” “I wouldn’t dignify them by calling them ‘treatments,’” added Michael Pollak, director of cancer prevention at McGill University in Montreal, Canada. “They’re products.” Barzilai, a 59-year-old with a boyish mop of gray hair, wore a contrite grin. “We know the FDA is concerned about this,” he conceded, and deleted the offensive phrase.

Then he proceeded to lay out the details of an ambitious clinical trial. The group—academics all—wanted to conduct a double-blind study of roughly 3000 elderly people; half would get a placebo and half would get an old (indeed, ancient) drug for type 2 diabetes called metformin, which has been shown to modify aging in some animal studies. Because there is still no accepted biomarker for aging, the drug’s success would be judged by an unusual standard—whether it could delay the development of several diseases whose incidence increases dramatically with age: cardiovascular disease, cancer, and cognitive decline, along with mortality. When it comes to these diseases, Barzilai is fond of saying, “aging is a bigger risk factor than all of the other factors combined.”

More here.

Wednesday, September 16, 2015

AGAINST LOLITA: TRULY, A MINOR WORK

Lolita-lyonsRoxana Robinson at Literary Hub:

Lolita stands as a monument to Nabokov’s resentment: it is not a novel of sexual consummation but of cultural contempt. Contempt is the true driving passion: the landscape, the characters, the narrator, the narrative are all drenched in it. Nabokov despises his characters and their bright vulgar world, with its populist architecture and cheap displays, its tawdry, ersatz culture. Lolita is a raging cry for the world Nabokov lost, which was one of refinement, perception and beauty. It’s a cry of rage at a world that represents his world’s counterpart: young, vulgar, unrefined and irredeemably seductive.

Lolita becomes the object of his perverted desire. Early in his life, in Europe, Humbert had an adolescent fling with a girl who died. Now that he has been exiled from Paradise, now that his first love is dead, America and Lolita are what Humbert must endure. Lolita herself is common, superficial and unintelligent, though Humbert ignores her mind and her sensibility. He despises the vulgar clothes and makeup, snacks and advertisements that entrance her, America’s cheap post-war offerings. He hates these philistine vulgarians for owning this huge green continent across which he drives his unwilling partner, full of meadows and mountains and sunsets, rich and open and empty, “end of the summer mountains, all hunched up, their heavy Egyptian limbs folded under folds of tawny moth-eaten plush… a last rufous mountain, with a rich rug of lucerne at its feet.” These people don’t deserve this place.

more here.